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Self-Experimentation
Share your story of trying or designing a promising age-reversal protocol.
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About this forum topic
Hello everyone, Many of us are self-experimenting in an effort to prolong our good health. In this sub-forum, we encourage you to share your own stories of what seems to be working for you.…
Maximus Peto
Researcher, website & forum admin
Maximus
6 yrs ago
1226
15
Self-Experimentation
Fisetin to Clear Senescent Cells
Following studies with mice that showed significant senolytic clearance of senescent cells following large doses of the readily available flavenoid supplement Fisetin,…
JGC
Retired Professor of Physics
JGC
updated
3 yrs ago
766
replies
18974
20
Last reply
Dan Nave
1 yr ago
Self-Experimentation
Rapamycin Cost
Let me clear some things up for people considering rapamycin (generic sirolimus). I am taking it and so are my dogs!! (I have a very open-minded vet who trusts my judgement.) Dr.…
Rob8311
Rob8311
5 yrs ago
599
replies
13986
14
Last reply
Steve Roedde
1 yr ago
Self-Experimentation
Anyone actually experience marked increased energy from NMN?
It's been 2 years now - sublingual. Nothing. I'm ready to throw it in the box with the resveratrol and rapamycin. Please leave your experiences and types/doses as well as how you can differentiate…
Michael
Michael.1
2 yrs ago
139
replies
2763
Last reply
chuck stanley
9 mths ago
Self-Experimentation
Senolytics
I've just finished my third Senolytic cycle. Fisetin 1500 mgs on 2 consecutihve days repeated one month later Dasatinab 180 mgs on 2 consecutive days + Quercitn 2250 mgs on the same days I also take…
Charles Grashow
Charles_Grashow
4 yrs ago
128
replies
4197
8
Last reply
Wil
2 yrs ago
Self-Experimentation
Dasatinib
Hi Brian, On the website "SocietyforAgeReversal.org which is the same as rescueelders.org I think. You mentioned in the blog, "I'm taking a very quick break from the engaging presentations to report…
Snowbird
Snowbird
5 yrs ago
113
replies
2555
2
Last reply
Rob8311
2 yrs ago
Self-Experimentation
How to increase the bioavailability of Fisetin
I'm preparing to do a Fisetin senolytic experiment, but I've read on the article from Mayo Clinic ( https://linkinghub.elsevier.com/retrieve/pii/S2352396418303736 ) that the administration mode was…
JPA
JPA
5 yrs ago
110
replies
6409
3
Last reply
Robert Uomini
2 yrs ago
Self-Experimentation
Photo evidence that the experiment is working
Correct me if I'm wrong. I figured that this deserves it's own discussion topic. More than 5 years ago I started doing age-reversal. Couple of years back when I realized that it was working I…
Andrew P K Yap
Andrew_P_K_Yap
2 yrs ago
109
replies
2294
3
Last reply
Andrew P K Yap
1 mth ago
Self-Experimentation
wrinkle reduction
has anyone noticed wrinkle reduction in systemic use of sirolimus?
curious
curious
3 yrs ago
107
replies
2084
3
Last reply
Hello World
2 yrs ago
Self-Experimentation
GlyNAC
Has anyone tried Glycine/N-acetylcysteine? It appears to have amazing effects on age reversal. Glycine and N‐acetylcysteine (GlyNAC) supplementation in older adults improves glutathione deficiency,…
Qimin You
Qimin_You
2 yrs ago
103
replies
5108
3
Last reply
martino lorenzon
8 mths ago
Self-Experimentation
Preparations for self-treating COVID-19
The mortality rate of the aged population from COVID-19 is very high, around 20% for the over-80 group of which I and my wife are members. Further, if medical facilities are limited and physicians…
JGC
Retired Professor of Physics
JGC
4 yrs ago
88
replies
1113
3
Last reply
Vic Emmay
2 mths ago
Self-Experimentation
Rapamycin - progress so far
Hi all, About me: I'm 46 y.o. medical doctor based in Europe and started taking weekly rapamycin 4 months ago. I go to the gym regularly and am in average physical condition for a guy of my age.…
Diamond Tree
Diamond_Tree
updated
2 yrs ago
86
replies
3119
7
Last reply
Jonas Huberman
8 mths ago
Self-Experimentation
Just Ordered Rapamycin w/ No Prescription
When I was at Raadfest18, it was announced that there was a vendor in the Exhibition Hall from whom Rapamycin could be ordered at a good price. Later I found out exactly what vendor from someone…
Mermaid
Mermaid
5 yrs ago
80
replies
6704
5
Last reply
Steve Roedde
1 yr ago
Self-Experimentation
Rapamycin self-experimentation
I've just begun a 10 week self-experimentation with RapaPro rapamycin. I'll be taking 5 mg once a week, which is roughly the dose that Dr. Alan Green recommends on the high side and seems to be…
Tam
Tam
4 yrs ago
74
replies
3599
5
Last reply
Ludovic Debels
3 yrs ago
Self-Experimentation
Rapamycin Side Effect
Just read a recent addition to Dr. Green's site. I'll just post part of what he says. I don't get the impression he thinks it is a reason to stop treating, but important to be aware of.…
Rob8311
Rob8311
5 yrs ago
67
replies
1358
3
Last reply
Vincent Stona
4 yrs ago
Self-Experimentation
Paul's self experimentation
I inadvertently started on this 5 years ago when I started taking Metformin. Was diagnosed with a Gleason 6 prostate cancer. Docs didn't want to treat just monitor.…
Paul Beauchemin
Paul_Beauchemin
4 yrs ago
66
replies
1287
3
Last reply
Alex
11 mths ago
Self-Experimentation
Green tea and green tea extracts
Green tea benefits (and how to get them).
Staffan Olsson
Staffan_Olsson
4 yrs ago
43
replies
749
1
Last reply
Karl
4 yrs ago
Self-Experimentation
Rapamycin in humans
I'm cautious on pharmaceuticals but am considering Rapamycin. Downsides are cost, difficulty to source and potential side effects (some people suffer from stomach issues IIRC).…
Dan
moderator
skipping my funeral
dantheman
5 yrs ago
41
replies
943
1
Last reply
Alex
11 mths ago
Self-Experimentation
Cell Death Mechanisms Behind D+Q and Fisetin Senolytics
After having done about 9 months of self-experimentation with the effects of D+Q and Fisetin senolytic burst-treatments, I and others in my family have noticed that senolytics with D+Q tends to…
JGC
Retired Professor of Physics
JGC
4 yrs ago
40
replies
876
2
Last reply
Dan Nave
2 yrs ago
Self-Experimentation
Longevity Achieved
Recently received my results on my biological age. To my surprise, my biological age is 15. The process to get to this point was difficult. My formula has proven itself over and over.…
Richard Brook
Richard_Brook
2 yrs ago
38
replies
1008
1
Last reply
Spasov
2 yrs ago
Self-Experimentation
"Senolytic Activator" and Extended Fasting …
Gentlefolk, Our fine friends at Life Extension have released a new product, Senolytic Activator. It is a combination of Quercertin and Theaflavins. They intend us to use it weekly as a…
adonoho
adonoho
5 yrs ago
36
replies
1920
6
Last reply
Marc Bauchet
2 yrs ago
Self-Experimentation
Metformin: worth it? and what to expect
Hello all. I got my Doctor to give me a prescription for Metformin. I have read about its possible age-reversing effects, but I have also read about some possible significant side effects,…
Jeff Bennion
Jeff_Bennion
updated
5 yrs ago
35
replies
1339
1
Last reply
Cherith
4 yrs ago
Self-Experimentation
D+Q+F+P+L+G+GLA: A New Senolytic Cocktail
For my May 15-18 senolytic session I tried something new. In a recent Foresight Institute talk available on YouTube, James Kirkland identified the flavonoid Luteolin as a senolytic.…
JGC
Retired Professor of Physics
JGC
updated
1 yr ago
33
replies
706
4
Last reply
Michael_123
1 yr ago
Self-Experimentation
Has anyone tried urolithin A?
Urolithin A is a bacterial metabolite that enhances mitophagy, which declines as we age and allows dysfunctional mitochondria to accumulate. I just wanted to see if anyone has experimented with…
Will Hunter
Will_Hunter
3 yrs ago
31
replies
1445
2
Last reply
Karl
1 yr ago
Self-Experimentation
Are these issues related to rapamycin
Hello there and thank you to all on the forum, I am finding it enormously helpful directing my self experimentation. I am 53 with a string family history of dementia I am trying to stave off.…
Dr Sian Klerk
Doctor and self experimenter
Dr_Sian_McIver
1 yr ago
30
replies
464
Last reply
Michael_123
1 yr ago
Self-Experimentation
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