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TERT and its Activator TAC
Shim, et al published a recent (6/21/2024) paper in Cell entitled "TERT activation targets DNA methylation and multiple aging hallmarks," in which they present some very interesting results on aging…
- JGC
- Retired Professor of Physics
- JGC
- 2 mths ago
- 1reply
- 78
- 2
- Self-Experimentation
Re: Fisetin experimentation one year (reposted as topic for info purposes) @Dean W. As I recall, the Mayo Clinic work identified Fisetin and D+Q as senolytics, i.e., senescent cell killers, in part by observing cultures of human cells that had been made senescent by X-rays…
- JGC
- Retired Professor of Physics
- JGC
- 6 mths ago
- 2
- Senolytics Discussion
- Reported - view
Re: Azrithomycin dose for senolytic Correction: Azithromycin, not Axithromycin. I note that Azithromycin has a bioavailability of about 37% and Roxithromycin has an exceptionally high bioavailability (72–85%).…
- JGC
- Retired Professor of Physics
- JGC
- 1 yr ago
- 2
- Senolytics Discussion
- Reported - view
Re: Azrithomycin dose for senolytic Here's a LINK to the human cell in vitro study. They showed that an Axithromycin dose level of 50 micromoles administered to a human cell culture had no effect,…
- JGC
- Retired Professor of Physics
- JGC
- 1 yr ago
- 2
- Senolytics Discussion
- Reported - view
Re: A Spreadsheet for Calculating Your Levine Phenotypic Age Here's the Levine Phenotypic Age spreadsheet (again) People have been having trouble downloading the spreadsheet from various locations in the Cloud. Therefore,…
Attachment
- JGC
- Retired Professor of Physics
- JGC
- 1 yr ago
- 1
- Assessing Biological Age
- Reported - view
Re: Hair regrowth using topical resveratrol and fisetin? Both Fisetin and Resveratrol are relatively insoluble in water, so dissolving a mix in water and rubbing it on your scalp probably wouldn't work. However, both are rather soluble in ethyl alcohol,…
- JGC
- Retired Professor of Physics
- JGC
- 1 yr ago
- Self-Experimentation
- Reported - view
Re: Menin, D-serine, and Neurological Age Reversal Followup on D-serine I just looked 3 hours after the above post, and Relentless Improvement is now sold out of D-serine. I guess I triggered a stampede. Maybe others (Life Extension, Swanson, ...…
- JGC
- Retired Professor of Physics
- JGC
- 1 yr ago
- 1
- Self-Experimentation
- Reported - view
Menin, D-serine, and Neurological Age Reversal
There is a new report published in PLOS Biology by a Chinese group led by Lige Leng that provides evidence of a correlation between decline in the protein Menin secreted by the hypothalamus and a…
- JGC
- Retired Professor of Physics
- JGC
- 1 yr ago
- 3replies
- 138
- 3
- Self-Experimentation
Re: Fisetin to Clear Senescent Cells @Dan Nave In a Q&A session that I viewed, Kirkland said that he did not personally do courses of senolytics because they had not been sufficiently tested on humans.…
- JGC
- Retired Professor of Physics
- JGC
- 1 yr ago
- 2
- Self-Experimentation
- Reported - view
Re: Introduction to senolytics @RobH Ordering prescription-only meds from BonHoa and other suppliers in India is a bit of a crapshoot. I had a ~$200 order of Dasatinib from the AntiAging Store that was comfiscated at JFK customs…
- JGC
- Retired Professor of Physics
- JGC
- 1 yr ago
- Senolytics Discussion
- Reported - view
Re: My 80 year old father's proposed regimen. What do you think? @chuck stanley Here's the translation: "Metformin lowers cholesterol levels. Lower cholesterol can be brought to a lower level for some hormones. Tosi effect is weak and not intersecting with a lot…
- JGC
- Retired Professor of Physics
- JGC
- 2 yrs ago
- Self-Experimentation
- Reported - view
Re: My 80 year old father's proposed regimen. What do you think? To what metformin side effects are you referring? I just did a web search, and the NIH lists the possible side effects as: nausea, diarrhoea, stomach ache, loss of appetite,…
- JGC
- Retired Professor of Physics
- JGC
- 2 yrs ago
- Self-Experimentation
- Reported - view
Re: My 80 year old father's proposed regimen. What do you think? IMHO as an 86-year-old who is attempting to stay in good health, the items that is missing from your father's regimen are: (1) weekly doses of rapamycin, (2) daily doses of metformin,…
- JGC
- Retired Professor of Physics
- JGC
- 2 yrs ago
- 3
- Self-Experimentation
- Reported - view
NaNots: Targeted Removal of Pathogenic Molecules
Last Thursday morning I was a virtual attendee at the ARDD 2022 Meeting held in Copenhagen this week. At 11:22 AM Seattle time a very interesting 20-minute talk was given by Lou Hawthorne of…
- JGC
- Retired Professor of Physics
- JGC
- updated 2 yrs ago
- 1reply
- 51
- 2
- General Discussion
Principal Component Analysis of Epigenetic Age (Morgan Levine)
In one of today's ARDD 2022 Meeting presentations (8/31/2022), Morgan Levine mentioned that her group at Yale had developed a new method of eliminating the "noise" in using CpG methylation of DNA to…
- JGC
- Retired Professor of Physics
- JGC
- 2 yrs ago
- 2replies
- 62
- 2
- Assessing Biological Age
Deprenyl (Selegiline) as a Longevity Drug?
Prompted by UW Professor Matt Kaeberlein's participation in a panel discussion on ARDD 2022 this morning, I listened to the audio of Kaeberlein's long podcast interview with Tim Ferriss.…
- JGC
- Retired Professor of Physics
- JGC
- 2 yrs ago
- 3replies
- 176
- 1
- Self-Experimentation
Low-Dose Oral Minoxidil for Hair Regrowth
There is an interesting article in today's New York Times describing an accidental discovery by an Australian MD. He found that Minoxidil (trade name Rogaine) when taken orally at very low dose…
- JGC
- Retired Professor of Physics
- JGC
- 2 yrs ago
- 9replies
- 345
- 3
- Self-Experimentation
Low-Dose Oral Minoxidil for Hair Regrowth
There's an interesting article in today's New York Times. It describes the accidental discovery that taking a low dose of Minoxidil (i.e., Rogaine) orally instead of rubbing a high dose on your…
- JGC
- Retired Professor of Physics
- JGC
- updated 2 yrs ago
- 5replies
- 236
- 1
- Self-Experimentation
Re: Are these issues related to rapamycin It seems clear that it would be a very good idea to get vaccinated against singles before undertaking regular doses of Rapamycin due to its effect on the immune system.…
- JGC
- Retired Professor of Physics
- JGC
- 2 yrs ago
- 4
- Self-Experimentation
- Reported - view
Re: Are these issues related to rapamycin Question: Have any of you who report shingles after taking rapamycin had the shingles vaccine?
- JGC
- Retired Professor of Physics
- JGC
- 2 yrs ago
- Self-Experimentation
- Reported - view
The DIM Supplement and Wound Healing
Forgive me for introducing a topic to this Forum that is slightly off the topic on anti-aging. The supplement DIM (3, 3,-diindolylmethane) sold by Swanson ($8.…
- JGC
- Retired Professor of Physics
- JGC
- updated 2 yrs ago
- 6replies
- 198
- 3
- Self-Experimentation
Re: Senolytic Effects of FOXO4-DRI FOXO4-DRI and the Blood-Brain Barrier Darren Moore mentions that in injecting the peptide FOXO4-DRI, he did not experience the hangover-like symptoms (mild headache, nausea, ...…
- JGC
- Retired Professor of Physics
- JGC
- 2 yrs ago
- 1
- Senolytics Discussion
- Reported - view
Re: Senolytic Effects of FOXO4-DRI What Happened to Senolytics with FOXO4-DRI? This topic discussion was started several years ago, when the big news in senolytics was that a new treatment, FOXO4-DRI,…
- JGC
- Retired Professor of Physics
- JGC
- 2 yrs ago
- 4
- Senolytics Discussion
- Reported - view
Re: Spermidine: a physiological autophagy inducer acting as an anti-aging vitamin inhumans? @Fred Cloud Actually, it's $0.06 per mg, because the caps only contain 5 mg of spermidine hydrochloride, with a "serving size" of two caps. I really object to the serving-size games these supplement…
- JGC
- Retired Professor of Physics
- JGC
- 2 yrs ago
- General Discussion
- Reported - view
Re: Spermidine: a physiological autophagy inducer acting as an anti-aging vitamin inhumans? @Fred Cloud Good suggestion! The price comes to $0.03/mg of spermidine trihydrochloride. This was not available when I made the table that is on this thread. Anyhow, I just ordered two bottles.
- JGC
- Retired Professor of Physics
- JGC
- 2 yrs ago
- General Discussion
- Reported - view

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JGC

JGC

Retired Professor of Physics

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Joined: 13 Aug 2018

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