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Variability Among Horvath-type DNA Methylation Age Tests

I have had four Horvath-type DNA methylation age tests done, three by Zymo and one by EpiAging. The results disagree radically. The result earlier thus year from EpiAging is that my DNAm age is 63.…
- Retired Professor of Physics
- JGC
- 5 yrs ago
- 14replies
- 361
- Assessing Biological Age
Re: The Conboy Plasma-Dilution Treatment is Available Now
@Fred Cloud I remember discussing the amount of plasma replaced per session with Dr. Kiprov, and as I recall it was about a liter. However, this was to be done on three successive days,…
- Retired Professor of Physics
- JGC
- 5 yrs ago
- 1
- General Discussion
- Reported - view
Re: The Conboy Plasma-Dilution Treatment is Available Now
@Fred Cloud Problem: The plasma donation folks will not accept donations from a potential donor over 65 or so. Therefore, plasma donation is not an option for my wife and I.
- Retired Professor of Physics
- JGC
- 5 yrs ago
- 1
- General Discussion
- Reported - view
Re: Is there still any reason to bank your own stem cells when Brent Nally can use stem cells from someone else in mexico?
You may need to wear diapers for a while afterwards ... 🙂
- Retired Professor of Physics
- JGC
- 5 yrs ago
- General Discussion
- Reported - view
Re: Is there still any reason to bank your own stem cells when Brent Nally can use stem cells from someone else in mexico?
Wouldn't you want stem cells that had your own DNA?
- Retired Professor of Physics
- JGC
- 5 yrs ago
- General Discussion
- Reported - view
Re: Longevity Achieved
@Richard Brook I looked at the SpectraCell website. They do not say how much they charge for a simple test of telomere length, and they seem to want you to involve an MD when you place an order.…
- Retired Professor of Physics
- JGC
- 5 yrs ago
- 1
- Self-Experimentation
- Reported - view
Re: Longevity Achieved
@Richard Brook I have a question for you, Richard. What lab did your telomere length testing, how was it arranged, and how much did they charge? When we planned our ongoing self-test with Epitalon…
- Retired Professor of Physics
- JGC
- 5 yrs ago
- 1
- Self-Experimentation
- Reported - view
Re: Fisetin to Clear Senescent Cells
@Allen Papers in the literature indicate that BioPerine greatly enhances the bioavailability of the flavonoid Curcumin (which is contained in turmeric).…
- Retired Professor of Physics
- JGC
- 5 yrs ago
- 1
- Self-Experimentation
- Reported - view
Re: Longevity Achieved
@Richard Brook Congratulations, Richard! And ignore those guys. Computer-based messaging is a "hot" medium and offensive stuff easily creeps in by accident.…
- Retired Professor of Physics
- JGC
- 5 yrs ago
- 2
- Self-Experimentation
- Reported - view
HGLA and GLA as Senolytics

In an interview posted online by Tufts Now, Dr. Christopher Wiley of Tufts University describes his discovery that dihomo-gamma-linoleic acid (DGLA) is a powerful senolytic.…
- Retired Professor of Physics
- JGC
- updated 5 yrs ago
- 3replies
- 249
- Self-Experimentation
Re: Fisetin to Clear Senescent Cells
There is a paper to be presented at the upcoming meeting of the American Aging Association (July 20-23) in which the researchers do one single dose of D+Q senolytics (D: 5 mg/kg + Q:…
- Retired Professor of Physics
- JGC
- 5 yrs ago
- 3
- Self-Experimentation
- Reported - view
Re: Fisetin experimentation one year (reposted as topic for info purposes)
@Fred Cloud Interesting question. I would think that once beta-gal is present, it would not easily go away, even if the SASP was temporarily stopped. I note that in a recent Foresight Institute…
- Retired Professor of Physics
- JGC
- 5 yrs ago
- Senolytics Discussion
- Reported - view
Re: Fisetin experimentation one year (reposted as topic for info purposes)
@Fred Cloud You wrote: "I am simply saying it is quieting the cells temporarily rather than killing them off." Research either published or presented at ARDD 2020 shows that,…
- Retired Professor of Physics
- JGC
- 5 yrs ago
- 1
- Senolytics Discussion
- Reported - view
Re: Replacing Hormones to Optimal Levels
@Sharon Smith I hesitate to venture into the waters of optimal female hormone levels, but I would like to point out that Life Extension offers comprehensive female hormone tests for about $225.
- Retired Professor of Physics
- JGC
- 5 yrs ago
- Self-Experimentation
- Reported - view
Re: The Conboy Plasma-Dilution Treatment is Available Now
@Fred Cloud Katcher was talking about initially using E-5 on pets, particularly dogs, to extend their regrettably short lives. I recommended a like-minded vet in Southern California to him for this…
- Retired Professor of Physics
- JGC
- 5 yrs ago
- 1
- General Discussion
- Reported - view
Re: The Conboy Plasma-Dilution Treatment is Available Now
@Burgundy Summer Until last week I had five items on my list of potential ways of obtaining a significant epigenetic reset to a younger DNAm age. They were:…
- Retired Professor of Physics
- JGC
- 5 yrs ago
- 2
- General Discussion
- Reported - view
Re: The Conboy Plasma-Dilution Treatment is Available Now
@Winslow James Foster True, but in their publication on plasma dilution in mice, they did not even bother to measure the effect on DNAm age. I "make assumptions without data review" because that data…
- Retired Professor of Physics
- JGC
- 5 yrs ago
- General Discussion
- Reported - view
Re: The Conboy Plasma-Dilution Treatment is Available Now
@Winslow James Foster The plasma dilution treatment may be at an early stage, but I think two things are pretty clear: The Conboy plasma dilution treatment provides only minimal epigenetic…
- Retired Professor of Physics
- JGC
- 5 yrs ago
- 3
- General Discussion
- Reported - view
Re: Fisetin to Clear Senescent Cells
@garland You wrote: "I also read several studies that questioned whether it is a good idea to get rid of all our senescent cells? It seems the have some useful purpose." I recently watched Dr.…
- Retired Professor of Physics
- JGC
- 5 yrs ago
- 3
- Self-Experimentation
- Reported - view
Re: Fisetin to Clear Senescent Cells
@garland On Monday and Tuesday (July 5 & 6, 2021) we did another session of D+F+P senolytics (now taking 10 mg of BioPerine 5 minutes before the Dasatinib and BioFisetin).…
- Retired Professor of Physics
- JGC
- 5 yrs ago
- Self-Experimentation
- Reported - view
Re: Fisetin to Clear Senescent Cells
@Aneil You have identified a real problem for those of us doing senolytic self-experiments, i.e., that there is not presently a good way of measuring the senolytic cell population before/after the…
- Retired Professor of Physics
- JGC
- 5 yrs ago
- 3
- Self-Experimentation
- Reported - view
Re: Fisetin to Clear Senescent Cells
@Aneil In the blood lab tests we did, I wanted to provide inputs for my Levine PhenoAge spreadsheet calculation, so we used Life Extension's Complete Blood Count (CBC) / Chemistry / Lipids Panel…
- Retired Professor of Physics
- JGC
- 5 yrs ago
- Self-Experimentation
- Reported - view
Re: A Spreadsheet for Calculating Your Levine Phenotypic Age
New Spreadsheet Link There have been problems accessing this spreadsheet from DropBox, and also from MS Cloud, where someone named Karen recently replaced it with a blank file!…
- Retired Professor of Physics
- JGC
- 5 yrs ago
- Assessing Biological Age
- Reported - view
Re: The Conboy Plasma-Dilution Treatment is Available Now
@Winslow James Foster You said: "While I did achieve my lowest methylation age reduction of all experimental treatments tried, the Conboys and Kiprov discount this measurement.".…
- Retired Professor of Physics
- JGC
- 5 yrs ago
- 1
- General Discussion
- Reported - view
Re: The Conboy Plasma-Dilution Treatment is Available Now
@Burgundy Summer As I understand it from my conversation with Dr. Kiprov, one would come to San Francisco and have 2 plasma dilution sessions spaced with an off-day in bethween.…
- Retired Professor of Physics
- JGC
- 5 yrs ago
- 1
- General Discussion
- Reported - view

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