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Re: Fisetin to Clear Senescent Cells
@Staffan Olsson @chuck_stanley OK, to summarize, it would appear that the short-duration (~15 minute) bio-enhancement effect of taking Bioperine is that it stimulates gut cells to release…
- Retired Professor of Physics
- JGC
- 4 yrs ago
- 1
- Self-Experimentation
- Reported - view
Re: Fisetin to Clear Senescent Cells
@Dan Nave I don't know enough anatomy, but it is my understanding that the Perine has to get into the bloodstream to interfere with the production of the digestive enzymes.
- Retired Professor of Physics
- JGC
- 4 yrs ago
- 1
- Self-Experimentation
- Reported - view
Re: Fisetin to Clear Senescent Cells
@chuck stanley I looked up the Piperine half life on the web and found this: "Serial blood samples were collected and plasma piperine concentrations were determined using HPLC.…
- Retired Professor of Physics
- JGC
- 4 yrs ago
- Self-Experimentation
- Reported - view
Re: Can snorting fisetin improve bioavailability and is it safe?
@Robert Uomini I meant "Kirkland". Have a look at the interview that Dr. James Kirkland did for the Foresight Institute at this LINK. He discusses the virtue of "burst" doses of D+Q and/or Fisetin…
- Retired Professor of Physics
- JGC
- 4 yrs ago
- Senolytics Discussion
- Reported - view
Re: Can snorting fisetin improve bioavailability and is it safe?
@Robert Uomini Our routine is based on the work of the Kirkwood Group at the Mayo Clinic, with the BioPerine added.
- Retired Professor of Physics
- JGC
- 4 yrs ago
- Senolytics Discussion
- Reported - view
Senolytics with DGLA and GLA?

In a comment posted on Fight Aging!, Robert Read says: "There is a specific fatty acid made in small amounts in the body called dihomo-gamma-linoleic acid or DGLA.…
- Retired Professor of Physics
- JGC
- 4 yrs ago
- 3replies
- 142
- 2
- Self-Experimentation
Re: Can snorting fisetin improve bioavailability and is it safe?
@Robert Uomini Do you mean that you take 500 mg of Fisetin every day? Senolytics with Fisetin is supposed to be done in 3-day burst doses of a few grams about every 3-6 months.…
- Retired Professor of Physics
- JGC
- 4 yrs ago
- 1
- Senolytics Discussion
- Reported - view
Re: Can snorting fisetin improve bioavailability and is it safe?
@Robert Uomini No. My assumption is that all flavenoids are chemically similar and react in about the same way to digestive enzymes. Therefore, if taking Piperine enhances the bioavailability of…
- Retired Professor of Physics
- JGC
- 4 yrs ago
- Senolytics Discussion
- Reported - view
Re: Can snorting fisetin improve bioavailability and is it safe?
@Robert Uomini Flavenoids like Fisetin have a very low solubility in water and are disassembled by enzymes in the digestive system. This makes for a low (but NOT zero) bioavailability.…
- Retired Professor of Physics
- JGC
- 4 yrs ago
- 2
- Senolytics Discussion
- Reported - view
Re: Fisetin to Clear Senescent Cells
@Sebastian The answer to your question about F+Q is not completely clear. However, it's likely that F and Q, both of which are similar flavenoids, play essentially the same role in senolytics,…
- Retired Professor of Physics
- JGC
- 4 yrs ago
- Self-Experimentation
- Reported - view
Re: Fisetin to Clear Senescent Cells
@Sebastian Shure, start with a few grams of Fisetin preceded by 10 mg of BioPerine an hour earlier. Do that for three days and you should achieve some senolytics.…
- Retired Professor of Physics
- JGC
- 4 yrs ago
- 1
- Self-Experimentation
- Reported - view
Re: Spermidine: a physiological autophagy inducer acting as an anti-aging vitamin inhumans?
@aribadabar OK, I looked at the thread. While it's good that the adventurous guy who was taking 100 mg/day didn't suffer any bad side effects, he also "didn't notice anything" in the way of benefits.…
- Retired Professor of Physics
- JGC
- 4 yrs ago
- General Discussion
- Reported - view
Re: Spermidine: a physiological autophagy inducer acting as an anti-aging vitamin inhumans?
@aribadabar Can you provide a link to the experiment that describes those doses? I've had a lot of trouble finding such information, and the paper I did find (see above) used much smaller doses.…
- Retired Professor of Physics
- JGC
- 4 yrs ago
- General Discussion
- Reported - view
Re: Spermidine: a physiological autophagy inducer acting as an anti-aging vitamin inhumans?
@Staffan Olsson Interesting writeup, but perhaps self-serving. The person I contacted in Swanson Customer Support did warn me that Swanson had never assayed the Spermidine content of their wheat…
- Retired Professor of Physics
- JGC
- 4 yrs ago
- 1
- General Discussion
- Reported - view
Re: Spermidine: a physiological autophagy inducer acting as an anti-aging vitamin inhumans?
@Fred Cloud I improved my spreadsheet with more suppliers, links to them, and an extra column giving the price per mg that each one is selling their Spermidine for, sorted from highest to lowest.…
- Retired Professor of Physics
- JGC
- 4 yrs ago
- 2
- General Discussion
- Reported - view
Re: Rejuvant?
@Jimmy2 Interesting point. I suppose "cancelled each other out" means that something is up-regulated by one and down-regulated by the other. I doubt that the "cancellation" applies to all of the…
- Retired Professor of Physics
- JGC
- 4 yrs ago
- General Discussion
- Reported - view
Re: Spermidine: a physiological autophagy inducer acting as an anti-aging vitamin inhumans?
@Fred Cloud I looked at an article in Nature Medicine on the effects of Spermidine on heart health and longevity in mice and also at the Supplementary Information that is linked to the paper.…
- Retired Professor of Physics
- JGC
- 4 yrs ago
- General Discussion
- Reported - view
Re: Spermidine: a physiological autophagy inducer acting as an anti-aging vitamin inhumans?
I've been looking into obtaining a Spermidine supplement on the Internet. (I had previously bought a rather expensive one that doesn't actually state how much Spermidine is in it.…
- Retired Professor of Physics
- JGC
- 4 yrs ago
- 2
- General Discussion
- Reported - view
Re: Introduction to Young Plasma Infusions
@Fred Cloud I just read two of his YOUNGING1.0 blog posts. I would have thought that if his age-reversal assertions about dementhylating histones are correct,…
- Retired Professor of Physics
- JGC
- 4 yrs ago
- Young Plasma Infusions
- Reported - view
Re: Rapamycin dosage at age 34
I don't think the Rapamycin dosage depends on age, but it probably does depend on body weight. My wife and I, both weighing around 70 kg, take 3 mg every Sunday.…
- Retired Professor of Physics
- JGC
- 4 yrs ago
- 2
- Rapamycin Discussion
- Reported - view
Re: Introduction to Young Plasma Infusions
@Fred Cloud KMD4A is pretty big, around 130,000 Da, and I think it would be difficult to synthesize (which Katcher claims he can do). Therefore, I doubt that it is a component of Elixir.…
- Retired Professor of Physics
- JGC
- 4 yrs ago
- 1
- Young Plasma Infusions
- Reported - view
Re: Are epigenetic tests accurate?
@aribadabar I've had two Zymo tests (one still in progress), but both were arranged for me by Johnny Adams. I'm under the impression that you can set up a Zymo test by making an inquiry,…
- Retired Professor of Physics
- JGC
- 4 yrs ago
- Assessing Biological Age
- Reported - view
Re: Are epigenetic tests accurate?
@aribadabar Zymo and myDNAge do have the same cost, and both offer blood and urine versions. Also, I believe myDNAge was started by a former Zymo person.…
- Retired Professor of Physics
- JGC
- 4 yrs ago
- Assessing Biological Age
- Reported - view
Re: TRIIM study results are in
@Jimmy After having taken Metformin daily for a couple of years, in 2019 I had my DNAm age checked by Zymo Research (which uses the CpGs for the 2nd version of Steve Horvath's methylation age test).…
- Retired Professor of Physics
- JGC
- 4 yrs ago
- 4
- Thymus Regeneration
- Reported - view
Re: Are epigenetic tests accurate?
I've put together a 1st-try spreadsheet summarizing the commercial DNAm Age testers. They vary wildly in cost and site count. I think Zymo is the standard 2nd gen Horvath DNAm Age test,…
- Retired Professor of Physics
- JGC
- 4 yrs ago
- 3
- Assessing Biological Age
- Reported - view

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