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  • New Dasatinib Sources
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    • AMPK Activation
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  • Fruit with Anti-Aging Power

    Finger lime an Australian fruit carries an anti-aging strength of ‘citrus caviar.” It is actually the small pearls that are found in the flesh of finger limes that have become the most trending and…
    • Robert Reny
    • Robert_Reny
    • 5 yrs ago
    • 2replies
    • 88
    • 1
    • Last replyDr. Ava Shamban2 wk ago
    • General Discussion
  • Sleep Quality DSIP

    For those struggling with sleep quality, particularly waking up around midnight and being unable to return to deep sleep until early morning, I'd like to share my experience.…
    • Bruce B
    • Bruce_123
    • 10 mths ago
    • 20replies
    • 382
    • 2
    • Last replyMoonlitnight1 mth ago
    • Self-Experimentation
  • HPE (Human Placental Extract) hydrolysate Laennec/Melsmon

    Curious if anyone has tried either of these HPE products, which were originally targeted for cosmetic and skin rejuvenation, but have been broadened somewhat for claims of positive systemic effects…
    • Mitnoxid
    • Mitnoxid
    • 2 mths ago
    • 12
    • Self-Experimentation
  • Human Placental Extract (Laennec or JBP)

    Has anyone experimented personally with these human placental hydrolysate products--if so can you share your experience and results? Traditionally used primarily in cosmetic applications,…
    • Mitnoxid
    • Mitnoxid
    • 2 mths ago
    • 18
    • Self-Experimentation
  • Has anyone tried exosomes?

    I just tried 3 days ago, still don't feel different *yet*
    • Alex K. Chen
    • Alex_K_Chen
    • 1 yr ago
    • 3replies
    • 93
    • Last replyAlerk Kross2 mths ago
    • Mesenchymal Stem Cells
  • A Spreadsheet for Calculating Your Levine Phenotypic Age

    An excellent paper by M. E. Levine, et al, entitled "An epigenetic biomarker of aging for lifespan and healthspan" describes a technique for combining nine blood-work values with calendar age to…
    • JGC
    • Retired Professor of Physics
    • JGC
    • 6 yrs ago
    • 113replies
    • 5420
    • 15
    • Last replyOmar Hernández López3 mths ago
    • Assessing Biological Age
  • Towermeds.com

    Jeffrey Kaufman is the visionary founder behind TowerMeds, a cutting-edge telemedicine platform committed to delivering safe, effective, and convenient wellness solutions.…
    • Jeffrey Kaufman
    • Towermeds.com
    • Jeffrey_Kaufman
    • 4 mths ago
    • 3replies
    • 37
    • 1
    • Last replyJeffrey Kaufman4 mths ago
    • NAD+ Restoration
  • is pevonedistat an unknown novel anti-aging drug?

    Targeting Protein Neddylation for Cancer Therapy. https://www.ncbi.nlm.nih.gov/pubmed/31898235 I recently participated in a phase 1 dosage safety cancer clinical trial combining this investigation…
    • chad cooper
    • chad_cooper
    • 5 yrs ago
    • 8replies
    • 239
    • 7
    • Last replyFred Cloud5 mths ago
    • Senolytics Discussion
  • Small molecule/chemical reprogramming

    Who is working on or considering self-experimentation in small molecule/chemical reprogramming. There is great potential for us to work together to advance.…
    • JohnnyAdamsmoderator
    • Mission: Slow and Ultimately Reverse Biological Aging and Age Related Decline for More Years of Healthy Living
    • JohnnyAdams
    • 6 mths ago
    • 3replies
    • 64
    • Last replyVan5 mths ago
    • Self-Experimentation
  • What happened to crsociety.org

    It's been down for a few days
    • Alex K. Chen
    • Alex_K_Chen
    • 1 yr ago
    • 2replies
    • 82
    • Last replyOld Pete6 mths ago
    • General Discussion
  • NAD+ Experience

    I’ve gotten NAD+ injections from JoinEzra for a few months, and I feel really great. My energy is coming back, my focus is improving, and most nights, I can finally sleep through without waking up.…
    • Isabel Hart
    • Isabel_Hart
    • 6 mths ago
    • 1reply
    • 71
    • 2
    • Last replyBrian Valerie6 mths ago
    • General Discussion
  • Introduction to NAD+

    NAD+ is an acronym for nicotinamide adenine dinucleotide (quite a mouthful). It is a cofactor in the body, used by multiple enzymes and processes, including energy production and DNA repair.…
    • Maximus Peto
    • Researcher, website & forum admin
    • Maximus
    • 7 yrs ago
    • 34replies
    • 2196
    • 2
    • Last replyJay Orman6 mths ago
    • NAD+ Restoration
  • TERT and its Activator TAC

    Shim, et al published a recent (6/21/2024) paper in Cell entitled "TERT activation targets DNA methylation and multiple aging hallmarks," in which they present some very interesting results on aging…
    • JGC
    • Retired Professor of Physics
    • JGC
    • 1 yr ago
    • 3replies
    • 237
    • 2
    • Last replyBruce B7 mths ago
    • Self-Experimentation
  • Updates to 2018 "Age Reversal Protocol" Step 3?

    Six years is a long time. Has anyone read of any updates/refinements to the 2018 proposed doses and frequency of Dasatinib-Quercetin cocktail (found here: https://age-reversal.net/senolytics/ )?
    • Jeff Jones
    • Jeff_Jones
    • 8 mths ago
    • 1reply
    • 43
    • 1
    • Last replyBrian Valerie7 mths ago
    • Senolytics Discussion
  • Royal jelly life extension

    Bee royal jelly is said to extend the lives of several animal studies but I can not find official studies on humans. Only many antidotal positive comments.…
    • are we there yet
    • are_we_there_yet
    • 9 mths ago
    • 36
    • General Discussion
  • Beware of Cipro and other Quinolone Antibiotics

    The broad-spectrum antibiotic Cipro and similar quinolones kill bacteria by destroying the bacterium's little ring of DNA, and they are very effective.…
    • JGC
    • Retired Professor of Physics
    • JGC
    • 9 mths ago
    • 1reply
    • 33
    • Last replyJay Orman9 mths ago
    • General Discussion
  • Modeling the TRIIM Study

    I was wondering if anyone has tried trying the protocol used in the TRIIM study. It seems like much of the info is public. They dosed HGH 4 days per week and continued to tweak the dosing (starting…
    • Mel
    • Mel
    • 1 yr ago
    • 12replies
    • 135
    • Last replyCurtis Smith10 mths ago
    • Thymus Regeneration
  • Honokiol for age retardation

    Every year in September, I research what products to investigate for pro-youthening next year. It seems to me that honokiol is worth a try. I am getting the TruAge test done soon (bought the four…
    • Moonlitnight
    • Medical Writer working on age reversal for over 20 yrs
    • Moonlitnight
    • updated 11 mths ago
    • 7replies
    • 120
    • 2
    • Last replyCurtis Smith11 mths ago
    • Self-Experimentation
  • D+Q+F+P+L+G+GLA: A New Senolytic Cocktail

    For my May 15-18 senolytic session I tried something new. In a recent Foresight Institute talk available on YouTube, James Kirkland identified the flavonoid Luteolin as a senolytic.…
    • JGC
    • Retired Professor of Physics
    • JGC
    • updated 3 yrs ago
    • 40replies
    • 893
    • 4
    • Last replyBrian Valerie11 mths ago
    • Self-Experimentation
  • Testing

    Hello, just beginning my educational journey and I'm looking for a suggestion on a comprehensive male related blood test that will help me determine what I deficient in?
    • Robert M Basmajian
    • Robert_M_Basmajian
    • 2 yrs ago
    • 1reply
    • 28
    • Last replyVijay1 yr ago
    • Questions & Answers
  • GlyNAC

    Has anyone tried Glycine/N-acetylcysteine? It appears to have amazing effects on age reversal. Glycine and N‐acetylcysteine (GlyNAC) supplementation in older adults improves glutathione deficiency,…
    • Qimin You
    • Qimin_You
    • 4 yrs ago
    • 104replies
    • 6237
    • 3
    • Last replyJay Orman11 mths ago
    • Self-Experimentation
  • Metformin v. B12

    I have heard that Metformin kills vit. B12 or at least diminishes it in our bodies. Is this true ? If it is true, then what can we do about it ? Get extra heavy injections of B 12 ? Birgit.
    • Birgit Thorwald
    • Birgit_Thorwald
    • 6 yrs ago
    • 9replies
    • 337
    • 1
    • Last replyJay Orman11 mths ago
    • Questions & Answers
  • 19.5y Younger Biological Age: My Best Data Yet (31 Tests Since 2018)

    YT Link: https://www.youtube.com/watch?v=mUEGbBEPzgo
    • michael lustgarten
    • michael_lustgarten
    • updated 1 yr ago
    • 3replies
    • 178
    • Last replyMoonlitnight1 yr ago
    • Assessing Biological Age
  • Clomid to raise Testosterone?

    Anyone try use Clomid to raise T? Seems to stimulate the body to produce its own testosterone. Testes don’t shrink and can still produce sperm. Seems like a better idea than the gels
    • Paul Beauchemin
    • Paul_Beauchemin
    • 5 yrs ago
    • 13replies
    • 404
    • 1
    • Last replyVijay1 yr ago
    • Questions & Answers
  • Help: Drastic results on DNA biological age test

    Hi I’m a long time reader and first time poster. Advice needed please. I just received my results from myDNAGE which shows my biological age as 69 when my chrono age is 47.…
    • Vega Rejuvinated
    • Vega_Rejuvinated
    • 3 yrs ago
    • 23replies
    • 694
    • 1
    • Last replyMoonlitnight1 yr ago
    • Self-Experimentation
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    • Mesenchymal Stem Cells
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  • New Dasatinib Sources
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  • Assessing Biological Age
  • Human Age Reversal Discussions
    • AMPK Activation
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