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Self-Experimentation

Share your story of trying or designing a promising age-reversal protocol.

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Hello everyone, Many of us are self-experimenting in an effort to prolong our good health. In this sub-forum, we encourage you to share your own stories of what seems to be working for you.…
- Max Petomoderator
- Researcher, website & forum admin
- Maximus
- 3 yrs ago
- 880
- 15
- Self-Experimentation
Gamma-Linolenic Acid (GLA), Blood Autophagy, and Phenotypic Age
A recent study published in Nature indicates that as mice age, the autophagy mechanism that clears old and damaged red blood cells falters, reducing the effectiveness of their blood circulation.…
- JGC
- JGC
- 7 days ago
- 11 replies
- 100
- 3
- Jimmy4 hrs ago
- Self-Experimentation
Resveratrol -- value, dose, source?
There is controversy over resveratrol, and its advocates. What is the value of resveratrol as part of an age reversal supplement program? One highly visible individual recommends Resveratrol that is:…
- JohnnyAdamsmoderator
- Mission: Slow and Ultimately Reverse Biological Aging and Age Related Decline for More Years of Healthy Living
- JohnnyAdams
- 1 yr ago
- 21 replies
- 577
- Michael A19 hrs ago
- Self-Experimentation
Do doctors prescribe rapamycin to people in their 20s?
I'm looking to experiment with Rapamycin. Does anyone have experience with getting it in their 20s?
- rapalogical
- rapalogical
- 1 mth ago
- 2 replies
- 75
- Vnova23 hrs ago
- Self-Experimentation
Dasatinib update
Just finished a 3 day course of D & Q. The Dasatinib was purchased from Taylor Made Compounding. Dosage was 100 mg D &1000 mg Q. Cost for 6 @50 mg capsules, including shipping was USD $33.…
- Charles Grashow
- Charles_Grashow
- 6 mths ago
- 18 replies
- 401
- 1
- Andrewyesterday
- Self-Experimentation
Fisetin to Clear Senescent Cells
Following studies with mice that showed significant senolytic clearance of senescent cells following large doses of the readily available flavenoid supplement Fisetin ,…
- JGC
- JGC
- 9 mths ago
- 516 replies
- 9,343
- 15
- Vanyesterday
- Self-Experimentation
Calorie Restriction, Eat Once Every Other Day (EOD Diet)
I'm thinking about doing this. I'm not sure if I will have the will power to do so. The EOD Diet will reduce my calorie intake by more than 50%. My goal is to reduce my epigenetic age.…
- Jimmy
- Jim_N
- 2 days ago
- 14
- Self-Experimentation
Rapamycin and Blood Pressure Pills
Is anyone here taking Rapamycin along with high blood-pressure pills (Ace Inhibitors and amLODIPine)? I’m curious, as I’ve been doing a lot of research and the combo doesn’t seem all that positive.…
- Paula Marie
- Paula_Marie
- 3 mths ago
- 3 replies
- 68
- 1
- Paula Marie6 days ago
- Self-Experimentation
Anti-Aging Self-Experiment with Epitalon (AEDG)
There is a body of evidence, coming primarily from the publications of Vladimir Kh. Khavinson and his group at the Institute of Bioregulation and Gerontology (IB&G) in Moscow,…
- JGC
- JGC
- 2 wk ago
- 4 replies
- 129
- 4
- JOHN8 days ago
- Self-Experimentation
sirolimus vehicle
Does anyone have any sources for formulating aqueous solutions of rapamycin? I got my hands on 10g pure powder, and I would like to start the 5mg/week regimen.…
- Anna Marie
- Anna_Marie
- 3 mths ago
- 6 replies
- 128
- Van8 days ago
- Self-Experimentation
Has anyone tried urolithin A?
Urolithin A is a bacterial metabolite that enhances mitophagy, which declines as we age and allows dysfunctional mitochondria to accumulate. I just wanted to see if anyone has experimented with…
- Will Hunter
- Will_Hunter
- 1 mth ago
- 9 replies
- 162
- 1
- Brin Chikovski11 days ago
- Self-Experimentation
linda
has anyone purchased 1 rapacan --sirolimus manufactured by bicon from varun medicals?? trying to find out if this is a reliable source
- linda little
- linda 32963
- linda_little
- 1 mth ago
- 6 replies
- 79
- Unmesh Basu2 wk ago
- Self-Experimentation
Are we using WAY to low dose of fisetin? 10% vs 50% vs 98%
Hey guys. I just came to the conclusion that we might are using a way to low dose of fisetin. Alot of the sellers use 10% fisetin. This last year ive bought a 98% extract.…
- Mr. Joules
- Mr_Joules
- 3 wk ago
- 61
- Self-Experimentation
how to get rid of depression and anxiety through medication
Anxiety and depression are two different things but you can get rid of them by taking a single pills. Anxiety and depression is so common now a days. a large num of crowd is facing the same issue on…
- elvinchard
- elvinchard
- 1 mth ago
- 1 reply
- 78
- James4 wk ago
- Self-Experimentation
How to increase the bioavailability of Fisetin
I'm preparing to do a Fisetin senolytic experiment, but I've read on the article from Mayo Clinic ( https://linkinghub.elsevier.com/retrieve/pii/S2352396418303736 ) that the administration mode was…
- JPA
- JPA
- 2 yrs ago
- 99 replies
- 3,989
- 3
- Joe F1 mth ago
- Self-Experimentation
Quantifying Biological Age: Blood Test #1 in 2021
https://www.youtube.com/watch?v=U0nTtDmCwSQ
- michael lustgarten
- michael_lustgarten
- 1 mth ago
- 28
- Self-Experimentation
Rapamycin Cost
Let me clear some things up for people considering rapamycin (generic sirolimus). I am taking it and so are my dogs!! (I have a very open-minded vet who trusts my judgement.) Dr.…
- Rob8311
- Rob8311
- 2 yrs ago
- 342 replies
- 7,677
- 11
- David H1 mth ago
- Self-Experimentation
Dasatinib
Hi Brian, On the website "SocietyforAgeReversal.org which is the same as rescueelders.org I think. You mentioned in the blog, "I'm taking a very quick break from the engaging presentations to report…
- Snowbird
- Snowbird
- 2 yrs ago
- 109 replies
- 2,078
- 2
- ssny. sotero1 mth ago
- Self-Experimentation
Kidney Function Declines During Aging-Can It Be Reversed?
In the video : Data for changes in kidney function during aging, kidney function values that are associated with an increased risk of death for all causes What's my data for kidney function,…
- michael lustgarten
- michael_lustgarten
- 2 mths ago
- 10 replies
- 179
- Edward Meininger1 mth ago
- Self-Experimentation
Red Blood Cells Decline During Aging, But Can Be Increased Through Diet
https://www.youtube.com/watch?v=3JpyDiNxNeE&feature=youtu.be
- michael lustgarten
- michael_lustgarten
- 1 mth ago
- 35
- Self-Experimentation
Micro-Dosing Lithium for Life Extension - How to Divide 300mg Tablet?
I've been reading the research on how low-dose lithium looks to be helpful in age mitigation as outlined in links below. I want to try it at the level of 5mg to 10mg a day.…
- Brin Chikovski
- Brin_Chikovski
- 2 mths ago
- 28 replies
- 268
- aribadabar2 mths ago
- Self-Experimentation
Who Else taking Acarbose for longevity?
I started taking Acarbose about 6 months ago after reading the ITP studies that showed a that it and rapamycin are the only two drugs approved for human use that have been shown to significantly…
- Brin Chikovski
- Brin_Chikovski
- 2 mths ago
- 1 reply
- 97
- Brin Chikovski2 mths ago
- Self-Experimentation
Epithalon
Anyone inject Epithalon? 1) Any suggestions on both reformulating 50mg Epithalon and daily dose? 2) Anyone have experience mixing in a facial cream? (ALA Mark's rapamycin cream as found all over…
- Michael
- Michael.1
- 3 mths ago
- 5 replies
- 100
- Michael2 mths ago
- Self-Experimentation
Preparations for self-treating COVID-19
The mortality rate of the aged population from COVID-19 is very high, around 20% for the over-80 group of which I and my wife are members. Further, if medical facilities are limited and physicians…
- JGC
- JGC
- 1 yr ago
- 85 replies
- 945
- 3
- albedo2 mths ago
- Self-Experimentation
Quantifying Biological Age With Aging.ai: 24 Blood Tests Since 2009
The maximal reduction for biological age when using the biological age calculator, Phenotypic Age, is ~20 years. In other words, if I'm 80 years old and my biomarkers are all reflective of youth,…
- michael lustgarten
- michael_lustgarten
- 2 mths ago
- 45
- Self-Experimentation
"Senolytic Activator" and Extended Fasting …
Gentlefolk, Our fine friends at Life Extension have released a new product, Senolytic Activator. It is a combination of Quercertin and Theaflavins. They intend us to use it weekly as a…
- adonoho
- adonoho
- 2 yrs ago
- 35 replies
- 1,501
- 5
- Henry milton2 mths ago
- Self-Experimentation

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