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Self-Experimentation

Share your story of trying or designing a promising age-reversal protocol.

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Hello everyone, Many of us are self-experimenting in an effort to prolong our good health. In this sub-forum, we encourage you to share your own stories of what seems to be working for you.…
- Max Petomoderator
- Researcher, website & forum admin
- Maximus
- 3 yrs ago
- 915
- 15
- Self-Experimentation
Fisetin to Clear Senescent Cells
Following studies with mice that showed significant senolytic clearance of senescent cells following large doses of the readily available flavenoid supplement Fisetin ,…
- JGC
- JGC
- 11 mths ago
- 550 replies
- 10,357
- 17
- Fairy8i816 hrs ago
- Self-Experimentation
Autophagy / fasting
I've recently become aware of the importance of autophagy in the cells and the ability to promote or trigger this through fasting. Just started a 3 day fast yesterday (I'm doing the apple fast,…
- Phoebe Saffold
- Phoebe_Saffold
- 4 wk ago
- 2 replies
- 84
- James Cyesterday
- Self-Experimentation
NAD+ then Rapamycin?
I have read on this forum that NAD+ and Rapamycin counteract eachother. But it seems NAD+ shows affects in 2 weeks while Rapa takes 10 weeks. My plan is to do a 2 week cycle of SubQ NAD+ then…
- Arizona Kid
- Arizona_Kid
- yesterday
- 15
- Self-Experimentation
Do doctors prescribe rapamycin to people in their 20s?
I'm looking to experiment with Rapamycin. Does anyone have experience with getting it in their 20s?
- rapalogical
- rapalogical
- 4 mths ago
- 6 replies
- 185
- Arizona Kidyesterday
- Self-Experimentation
Rapamycin Cost
Let me clear some things up for people considering rapamycin (generic sirolimus). I am taking it and so are my dogs!! (I have a very open-minded vet who trusts my judgement.) Dr.…
- Rob8311
- Rob8311
- 3 yrs ago
- 398 replies
- 8,635
- 11
- Staffan Olsson2 days ago
- Self-Experimentation
Calorie Restriction, Eat Once Every Other Day (EOD Diet)
I'm thinking about doing this. I'm not sure if I will have the will power to do so. The EOD Diet will reduce my calorie intake by more than 50%. My goal is to reduce my epigenetic age.…
- Jimmy
- Jim_N
- 2 mths ago
- 8 replies
- 131
- Lynne1 mth ago
- Self-Experimentation
Mechanism for Immortality
OK guys, here goes. This is controversial so I apologize beforehand. All you need is NMN because it repairs DNA damage and it boots energy via the mitochondria.…
- Chan
- Chan
- 1 yr ago
- 23 replies
- 811
- Chan13 days ago
- Self-Experimentation
Canagliflozin - A One Month Report, Its Good
I've been using Canagliflozin for the past month and really like it. It moderates blood glucose levels and makes it really easy to lose weight. I've lost about 10 lbs in 3 weeks,…
- Brin Chikovski
- Brin_Chikovski
- 5 days ago
- 43
- 2
- Self-Experimentation
Red Blood Cells Decline During Aging, But Can Be Increased Through Diet
https://www.youtube.com/watch?v=3JpyDiNxNeE&feature=youtu.be
- michael lustgarten
- michael_lustgarten
- 4 mths ago
- 5 replies
- 124
- Michael9 days ago
- Self-Experimentation
Biohackers Perform First Plasma Dilution Experiment on Humans This technique is a human modification of the Conboys' mouse experiments.
https://www.lifespan.io/news/biohackers-perform-first-plasma-dilution-experiment-on-humans/
- Larry
- Larry.1
- 6 mths ago
- 6 replies
- 141
- aribadabar11 days ago
- Self-Experimentation
Gamma-Linolenic Acid (GLA), Blood Autophagy, and Phenotypic Age
A recent study published in Nature indicates that as mice age, the autophagy mechanism that clears old and damaged red blood cells falters, reducing the effectiveness of their blood circulation.…
- JGC
- JGC
- 2 mths ago
- 22 replies
- 288
- 3
- aribadabar11 days ago
- Self-Experimentation
GlyNAC
Has anyone tried Glycine/N-acetylcysteine? It appears to have amazing effects on age reversal. Glycine and N‐acetylcysteine (GlyNAC) supplementation in older adults improves glutathione deficiency,…
- Qimin You
- Qimin_You
- 2 mths ago
- 32 replies
- 380
- 2
- aribadabar11 days ago
- Self-Experimentation
Rapamycin cost
Well-studied results show a huge increase in lifespan across the board among mammals with rapamycin (sirolimus CAS 53123-88-9) dosing. Why is not everyone taking it?…
- Bart Bear
- Bart_Bear
- 2 wk ago
- 2 replies
- 81
- 1
- Bart Bear2 wk ago
- Self-Experimentation
An alternative criterion for evaluating a senolytic.
I apologize in advance for my bad English! Quantifying the effectiveness of senolytics is a task for which methodologies are still being developed. Throughout the years,…
- Spasov
- Spasov
- 2 wk ago
- 4 replies
- 91
- 2
- Spasov2 wk ago
- Self-Experimentation
Anti-Aging Self-Experiment with Epitalon (AEDG)
There is a body of evidence, coming primarily from the publications of Vladimir Kh. Khavinson and his group at the Institute of Bioregulation and Gerontology (IB&G) in Moscow,…
- JGC
- JGC
- 3 mths ago
- 9 replies
- 367
- 5
- JGC3 wk ago
- Self-Experimentation
Exercise Mimetics
[Not medical advice or a recommendation. Sharing for information only.] Exercise being something of an anti-aging aid, the idea of exercise mimetics comes up.…
- Jack Black
- Jack_Black
- 1 mth ago
- 5 replies
- 115
- 1
- Vasiliy1 mth ago
- Self-Experimentation
Started my D+Q+F Protocol
I was able to purchase dasatinib from this source: https://teamtlr.com/anti-aginglongevity-research/118-senolytix-an-optimized-anti-aging-research-agent.…
- SCOTT WEANER
- SCOTT_WEANER
- 1 mth ago
- 86
- Self-Experimentation
VLDL Increases During Aging, And Is Associated With Adverse Cardiovascular Outcomes
Including 40 blood test measurements for VLDL: https://www.youtube.com/watch?v=NBzWUsfmBc8
- michael lustgarten
- michael_lustgarten
- 1 mth ago
- 29
- Self-Experimentation
Has anyone tried urolithin A?
Urolithin A is a bacterial metabolite that enhances mitophagy, which declines as we age and allows dysfunctional mitochondria to accumulate. I just wanted to see if anyone has experimented with…
- Will Hunter
- Will_Hunter
- 4 mths ago
- 11 replies
- 247
- 1
- Staffan Olsson1 mth ago
- Self-Experimentation
Dasatinib
Hi Brian, On the website "SocietyforAgeReversal.org which is the same as rescueelders.org I think. You mentioned in the blog, "I'm taking a very quick break from the engaging presentations to report…
- Snowbird
- Snowbird
- 2 yrs ago
- 110 replies
- 2,155
- 2
- Chuck Frasher1 mth ago
- Self-Experimentation
How to increase the bioavailability of Fisetin
I'm preparing to do a Fisetin senolytic experiment, but I've read on the article from Mayo Clinic ( https://linkinghub.elsevier.com/retrieve/pii/S2352396418303736 ) that the administration mode was…
- JPA
- JPA
- 2 yrs ago
- 104 replies
- 4,361
- 3
- Joe F2 mths ago
- Self-Experimentation
New Spermidine Paper: Dietary spermidine improves cognitive function
Full Paper Here: https://www.cell.com/cell-reports/fulltext/S2211-1247(21)00299-0 Highlights Elevated spermidine intake improves cognitive function in flies and mice Dietary spermidine intake…
- Brin Chikovski
- Brin_Chikovski
- 2 mths ago
- 1 reply
- 94
- Brin Chikovski2 mths ago
- Self-Experimentation
mark t
I was wondering how you made your cream the 2mg in 4oz? 4oz of what? Thank you.
- curious
- curious
- 9 mths ago
- 9 replies
- 175
- Andrew2 mths ago
- Self-Experimentation
Resveratrol -- value, dose, source?
There is controversy over resveratrol, and its advocates. What is the value of resveratrol as part of an age reversal supplement program? One highly visible individual recommends Resveratrol that is:…
- JohnnyAdamsmoderator
- Mission: Slow and Ultimately Reverse Biological Aging and Age Related Decline for More Years of Healthy Living
- JohnnyAdams
- 1 yr ago
- 21 replies
- 654
- Michael A2 mths ago
- Self-Experimentation
Dasatinib update
Just finished a 3 day course of D & Q. The Dasatinib was purchased from Taylor Made Compounding. Dosage was 100 mg D &1000 mg Q. Cost for 6 @50 mg capsules, including shipping was USD $33.…
- Charles Grashow
- Charles_Grashow
- 9 mths ago
- 18 replies
- 468
- 1
- Andrew2 mths ago
- Self-Experimentation

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