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Self-Experimentation

Share your story of trying or designing a promising age-reversal protocol.

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Hello everyone, Many of us are self-experimenting in an effort to prolong our good health. In this sub-forum, we encourage you to share your own stories of what seems to be working for you.…
- Max Peto
- Researcher, website & forum admin
- Maximus
- 3 yrs ago
- 1,014
- 15
- Self-Experimentation
Feeling pretty sick after taking Fisetin. Thoughts?
So, I recently acquired a bottle of life extension's bio-fisetin. I took 10 pills a day for 3 days straight, seeking senotherapeutic effects. On the first day, everything was more or less fine.…
- John
- John.6
- 5 mths ago
- 4
- Self-Experimentation
Just Ordered Rapamycin w/ No Prescription
When I was at Raadfest18, it was announced that there was a vendor in the Exhibition Hall from whom Rapamycin could be ordered at a good price. Later I found out exactly what vendor from someone…
- Mermaid
- Mermaid
- 3 yrs ago
- 67 replies
- 3,385
- 5
- Chuck Frasher1 mth ago
- Self-Experimentation
Fisetin to Clear Senescent Cells
Following studies with mice that showed significant senolytic clearance of senescent cells following large doses of the readily available flavenoid supplement Fisetin ,…
- JGC
- JGC
- 1 yr ago
- 643 replies
- 13,220
- 18
- Christopher Bennett13 days ago
- Self-Experimentation
Rapamycin Cost
Let me clear some things up for people considering rapamycin (generic sirolimus). I am taking it and so are my dogs!! (I have a very open-minded vet who trusts my judgement.) Dr.…
- Rob8311
- Rob8311
- 3 yrs ago
- 555 replies
- 10,881
- 14
- Jay Orman7 hrs ago
- Self-Experimentation
Photo evidence that the experiment is working
Correct me if I'm wrong. I figured that this deserves it's own discussion topic. More than 5 years ago I started doing age-reversal. Couple of years back when I realized that it was working I…
- Andrew P K Yap
- Andrew_P_K_Yap
- 4 mths ago
- 50 replies
- 732
- 3
- Andrew P K Yap19 hrs ago
- Self-Experimentation
Berberine and Melatonin - can this reverse aging of cells?
I am using an unusual mix of Melatonin (taken in the middle of the night,early morning really) and Berberine. This video explains the reasons why this has the potential to demethylate the epigenome…
- John Hemming
- John_Hemming
- 1 mth ago
- 5 replies
- 196
- 1
- John Hemming4 days ago
- Self-Experimentation
cell metabolism article--that says metformin, resveratrol and rapaymcin dampen the response from good nutrients--Would love to hear thoughts
- linda
- linda
- linda_
- 12 days ago
- 2 replies
- 70
- linda4 days ago
- Self-Experimentation
Rapamycin and muscle mass
I often hear rapamycin touted as a way of preserving muscle mass but mTOR is vital for muscle hypertrophy? Can anyone explain this apparent contradiction?…
- DAVID W
- DAVID_WOODHOUSE
- 2 wk ago
- 2 replies
- 95
- Brin Chikovski8 days ago
- Self-Experimentation
A Safe, Low-cost Alternative to Rapamycin Powder from China
I see people on here discussing the idea of importing rapamycin powder from China from some unknown middleman, so as to save a little money over buying tablets from India.…
- Brin Chikovski
- Brin_Chikovski
- 11 days ago
- 2 replies
- 78
- 1
- Brin Chikovski8 days ago
- Self-Experimentation
Using chelation for cardiovascular health
I wasn't sure if this was an appropriate topic for a longevity discussion. But, with further thought, I figured any process that helps extend my life is appropriate.…
- Jay Galambos
- Jay_Galambos
- 2 yrs ago
- 6 replies
- 141
- 2
- James9 days ago
- Self-Experimentation
Rapamycin - progress so far
Hi all, About me: I'm 46 y.o. medical doctor based in Europe and started taking weekly rapamycin 4 months ago. I go to the gym regularly and am in average physical condition for a guy of my age.…
- George McMillan
- MD in Europe self-testing rapamycin
- George_Malcolm
- 3 mths ago
- 52 replies
- 1,076
- 6
- Fred Cloud2 wk ago
- Self-Experimentation
Apigenin: An Alternative Way of Boosting NAD+
At the recent Ending Age-Related Diseases 2021 online conference, Dr. Eric Verdin of the Buck Institute gave a talk in which he described the mechanism behind the well-known drop in NAD+ with age,…
- JGC
- JGC
- 1 mth ago
- 22 replies
- 246
- 5
- Staffan Olsson2 wk ago
- Self-Experimentation
Help: Drastic results on DNA biological age test
Hi I’m a long time reader and first time poster. Advice needed please. I just received my results from myDNAGE which shows my biological age as 69 when my chrono age is 47.…
- Vega Rejuvinated
- Vega_Rejuvinated
- 2 mths ago
- 16 replies
- 310
- 1
- Vega Rejuvinated2 wk ago
- Self-Experimentation
Anyone actually experience marked increased energy from NMN?
It's been 2 years now - sublingual. Nothing. I'm ready to throw it in the box with the resveratrol and rapamycin. Please leave your experiences and types/doses as well as how you can differentiate…
- Michael
- Michael.1
- 5 mths ago
- 11 replies
- 424
- DAVID W2 wk ago
- Self-Experimentation
Where to buy rapamycin?
Hey everyone, I’m new to the group. Really cool to see everyone’s experience with Rapamycin. I’m looking to get some myself. I’m actually more interested in it for my cat’s heart condition.…
- Stefan Pougatchev
- Stefan_Pougatchev
- 1 mth ago
- 2 replies
- 122
- Brin Chikovski3 wk ago
- Self-Experimentation
Physician in the UK
Hello guys, I hope this is the good section for this. I am hoping to find a medical doctor in the UK that would be open to self experimentation for longevity purpose.…
- Raphael Nicolle
- Raphael_Nicolle
- 1 yr ago
- 2 replies
- 55
- Raphael Nicolle3 wk ago
- Self-Experimentation
stem cells---Does anyone have experience with prp + stem cells for bone on bone knee pain? I an considering it but very expensive
- linda
- linda
- linda_
- 3 wk ago
- 17
- Self-Experimentation
D.I.Y. patches for supplement delivery
Is anyone else interested in making your own patches for supplement delivery? Patches are not strictly about age-reversal. They can be used for other vitamins & supplements, too.…
- Mike Almerjanski
- Mike_Almerjanski
- 2 yrs ago
- 6 replies
- 244
- 2
- hadse rub3 wk ago
- Self-Experimentation
Preparations for self-treating COVID-19
The mortality rate of the aged population from COVID-19 is very high, around 20% for the over-80 group of which I and my wife are members. Further, if medical facilities are limited and physicians…
- JGC
- JGC
- 1 yr ago
- 87 replies
- 1,038
- 3
- Kohag Man4 wk ago
- Self-Experimentation
Senolytics
I've just finished my third Senolytic cycle. Fisetin 1500 mgs on 2 consecutihve days repeated one month later Dasatinab 180 mgs on 2 consecutive days + Quercitn 2250 mgs on the same days I also take…
- Charles Grashow
- Charles_Grashow
- 2 yrs ago
- 128 replies
- 3,344
- 7
- Wil4 wk ago
- Self-Experimentation
My Rapamycin Experiment: Male / Early 30s / Non-US Based
Hi, So I'm currently at the early stages of experimenting with Rapamycin, and thought, if I'm going to take an experimental drug, I might as well document the process and see if it can benefit the…
- rapa_experimenter
- rapa_experimenter
- 1 mth ago
- 8 replies
- 173
- 2
- rapa_experimenter1 mth ago
- Self-Experimentation
Current longevity protocol: Should I add rapamycin?
This is my first post here, and I’m hoping to get some insights from people with similar protocols. In particular, I’m curious to hear people’s perspective on rapamycin given my current regimen.…
- Simon Smith
- Simon_Smith
- 2 mths ago
- 24 replies
- 296
- 2
- Ludovic Debels1 mth ago
- Self-Experimentation
Just waiting for the forum Nazi moderators to remove my comments - again
- Michael
- Michael.1
- 1 mth ago
- 48
- Self-Experimentation
Canagliflozin - A One Month Report, Its Good
I've been using Canagliflozin for the past month and really like it. It moderates blood glucose levels and makes it really easy to lose weight. I've lost about 10 lbs in 3 weeks,…
- Brin Chikovski
- Brin_Chikovski
- 5 mths ago
- 6 replies
- 295
- 5
- David1 mth ago
- Self-Experimentation
Biohackers Perform First Plasma Dilution Experiment on Humans This technique is a human modification of the Conboys' mouse experiments.
https://www.lifespan.io/news/biohackers-perform-first-plasma-dilution-experiment-on-humans/
- Larry
- Larry.1
- 11 mths ago
- 8 replies
- 214
- Spasov1 mth ago
- Self-Experimentation

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