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Self-Experimentation

Share your story of trying or designing a promising age-reversal protocol.

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Hello everyone, Many of us are self-experimenting in an effort to prolong our good health. In this sub-forum, we encourage you to share your own stories of what seems to be working for you.…
- Max Petomoderator
- Researcher, website & forum admin
- Maximus
- 2 yrs ago
- 720
- 13
- Self-Experimentation
Fiestin to Clear Senescent Cells
Following studies with mice that showed significant senolytic clearance of senescent cells following large doses of the readily available flavenoid supplement Fisetin ,…
- JGC
- JGC
- 1 yr ago
- 288 replies
- 5,380
- 11
- Staffan Olsson6 hrs ago
- Self-Experimentation
Is it me or is Apigenin not so hot in this forum
Treatment of cells with apigenin or quercetin inhibits CD38 and promotes an increase in intracellular NAD+ levels. An increased NAD+ level decreases protein acetylation through sirtuin activation. ..…
- Andrew P K Yap
- Andrew_P_K_Yap
- 8 hrs ago
- 12
- Self-Experimentation
Dasatinib
Hi Brian, On the website "SocietyforAgeReversal.org which is the same as rescueelders.org I think. You mentioned in the blog, "I'm taking a very quick break from the engaging presentations to report…
- Snowbird
- Snowbird
- 1 yr ago
- 105 replies
- 1,686
- William Parker19 hrs ago
- Self-Experimentation
Self Experimenting: Rapamycin & NAD+ Boosters
How many people are taking sirolimus and NAD+ Boosters (NR and/or NMN)? Do you notice different effects from either? Also, do you cycle the NAD+ Boosters or take them daily?
- Thomas G
- Thomas_G
- yesterday
- 12
- Self-Experimentation
Paul's Anti-Aging Efforts
Preparing for a LONG FUTURE, here are the prescriptions and supplements I take to STOP or REVERSE AGING, with the blessings of my doctors. After each one are the number of Web sites mentioning them,…
- Paul Mason
- Paul_Mason
- 1 yr ago
- 12 replies
- 942
- 4
- Simon Lee4 days ago
- Self-Experimentation
Senolytics
I've just finished my third Senolytic cycle. Fisetin 1500 mgs on 2 consecutihve days repeated one month later Dasatinab 180 mgs on 2 consecutive days + Quercitn 2250 mgs on the same days I also take…
- Charles Grashow
- Charles_Grashow
- 7 mths ago
- 87 replies
- 1,858
- 4
- Van9 days ago
- Self-Experimentation
Rapamycin Cost
Let me clear some things up for people considering rapamycin (generic sirolimus). I am taking it and so are my dogs!! (I have a very open-minded vet who trusts my judgement.) Dr.…
- Rob8311
- Rob8311
- 2 yrs ago
- 241 replies
- 5,118
- 8
- Patient 13913 days ago
- Self-Experimentation
Preparations for self-treating COVID-19
The mortality rate of the aged population from COVID-19 is very high, around 20% for the over-80 group of which I and my wife are members. Further, if medical facilities are limited and physicians…
- JGC
- JGC
- 2 mths ago
- 84 replies
- 788
- 3
- Florin13 days ago
- Self-Experimentation
EPIGENETIC MUTATIONS, REVERSAL TO NORMAL
Does anybody know of any studies that suggest ways to revert epigenetic mutations back to normal? Direct or indirect methods. Thanks
- Andrew P K Yap
- Andrew_P_K_Yap
- 2 wk ago
- 9 replies
- 121
- Joe smith2 wk ago
- Self-Experimentation
Rapamycin self-experimentation
I've just begun a 10 week self-experimentation with RapaPro rapamycin. I'll be taking 5 mg once a week, which is roughly the dose that Dr. Alan Green recommends on the high side and seems to be…
- Tam
- Tam
- 1 yr ago
- 70 replies
- 1,807
- 2
- GEdwards2 wk ago
- Self-Experimentation
32 years old. Is self-experimentation right for me?
So, as the title says, I'm 32 years old. I'm very interested in longevity research and I would like to try some of these methods to help slow my aging.…
- Sara V
- Sara_V
- 6 mths ago
- 6 replies
- 212
- Fairy8i82 wk ago
- Self-Experimentation
Senolytic Self-experiments and COVID-19
There is evidence that the TOP2 receptor that the COVID-19 virus uses to enter cells is more prevalent in senescent cells. Also, clearing accumulated senescent cells from the immune system probably…
- JGC
- JGC
- 3 wk ago
- 10 replies
- 172
- 1
- Andrew P K Yap2 wk ago
- Self-Experimentation
Resveratrol -- value, dose, source?
There is controversy over resveratrol, and its advocates. What is the value of resveratrol as part of an age reversal supplement program? One highly visible individual recommends Resveratrol that is:…
- JohnnyAdamsmoderator
- Mission: Slow and Ultimately Reverse Biological Aging and Age Related Decline for More Years of Healthy Living
- JohnnyAdams
- 5 mths ago
- 16 replies
- 280
- Fairy8i82 wk ago
- Self-Experimentation
Life is an experiment
I've been working on "me" for years and lately I've started to look beyond diet, exercise, lifestyle, sleep etc. Until now I've only been supplementing with creatine, fish oil,…
- Dave C
- David_Clubine
- 5 mths ago
- 2 replies
- 115
- 2
- Fairy8i82 wk ago
- Self-Experimentation
Did anyone experience acute inflammation after senolytics?
Hello, I have Myalgic Encephalomyelitis/Chronic Fatigue Syndrome. It is a condition that involves chronic inflammation. I tried 3 days of high dose Fisetin the last 3 days (1000mg/day).…
- Phoenix
- phoenix
- 1 yr ago
- 7 replies
- 362
- 1
- Andrew P K Yap2 wk ago
- Self-Experimentation
Trehalose
Has anybody researched or tried trehalose to kill senescent cells? I have just come across it in the literature, apparently it stimulates AMPK like Metformin does,…
- Koo
- Koo
- 6 mths ago
- 1 reply
- 59
- Andrew P K Yap3 wk ago
- Self-Experimentation
D.I.Y. patches for supplement delivery
Is anyone else interested in making your own patches for supplement delivery? Patches are not strictly about age-reversal. They can be used for other vitamins & supplements, too.…
- Mike Almerjanski
- Mike_Almerjanski
- 8 mths ago
- 4 replies
- 98
- 2
- Chan1 mth ago
- Self-Experimentation
Mechanism for Immortality
OK guys, here goes. This is controversial so I apologize beforehand. All you need is NMN because it repairs DNA damage and it boots energy via the mitochondria.…
- Chan
- Chan
- 10 mths ago
- 20 replies
- 599
- Steven Jacobs1 mth ago
- Self-Experimentation
7 months taking rapamune
I have lived in Mexico for 9 years. After catching an article about rapamycin I found that I could get it here, without a prescription. Farmalisto in Mexico City to be exact but they do not ship to…
- Dale Duke
- Dale_Duke
- 2 mths ago
- 1 reply
- 92
- 2
- uzoma iwuagwu1 mth ago
- Self-Experimentation
Lisinopril and Self Experimentation.
Has anyone had any problems with metformin whilst on Lisinopril drug ? Possible interactions are mentioned on advice sites. Dasatinib and Lisinopril also get a mention in this regard.…
- Seaside
- Seaside
- 4 mths ago
- 10 replies
- 101
- MSS1 mth ago
- Self-Experimentation
Hyperbaric oxygen therapy
Hi, What is hyperbaric oxygen therapy and how it will helpful for patient? Researcher Shai Efrati share complete information regarding such question. Hope this will help many patients.
- Cherith
- Cherith
- 1 mth ago
- 1 reply
- 50
- Mark Thimineur1 mth ago
- Self-Experimentation
Here is another Doctor Who prescribes rapamycin in Las Vegas.
I thought I would provide the name of my Doctor who does prescribes rapamycin but his practice is different from Dr. Green in New York. I have found him to be very knowledgeable and extremely…
- John Mcgough
- John_Mcgough
- 2 mths ago
- 42
- 1
- Self-Experimentation
LDL-C reduction with diet and supplements (no statins)
Hi everyone, I recently came across some interesting videos about the optimal levels of LDL-C at the website, http://plantpositive.com/ . The author of the videos includes screenshots of the…
- Max Petomoderator
- Researcher, website & forum admin
- Maximus
- 1 yr ago
- 14 replies
- 427
- 2
- Ajax2 mths ago
- Self-Experimentation
Paul's self experimentation
I inadvertently started on this 5 years ago when I started taking Metformin. Was diagnosed with a Gleason 6 prostate cancer. Docs didn't want to treat just monitor.…
- Paul Beauchemin
- Paul_Beauchemin
- 5 mths ago
- 6 replies
- 256
- 2
- Karl2 mths ago
- Self-Experimentation
Which Dasatinib and Quercetin dosing regimen for longevity?
I have read about two different dosing regimens: 3 consecutive daily doses a week repeated for three weeks based on weight at a 1 to 10 ration based on weight (IE: for a 165lb person,…
- Randall James
- Randall_James
- 2 mths ago
- 8 replies
- 157
- 1
- Florin2 mths ago
- Self-Experimentation

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