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Self-Experimentation

Share your story of trying or designing a promising age-reversal protocol.

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Hello everyone, Many of us are self-experimenting in an effort to prolong our good health. In this sub-forum, we encourage you to share your own stories of what seems to be working for you.…
- Max Petomoderator
- Researcher, website & forum admin
- Maximus
- 3 yrs ago
- 972
- 15
- Self-Experimentation
Photo evidence that the experiment is working
Correct me if I'm wrong. I figured that this deserves it's own discussion topic. More than 5 years ago I started doing age-reversal. Couple of years back when I realized that it was working I…
- Andrew P K Yap
- Andrew_P_K_Yap
- 2 mths ago
- 37 replies
- 486
- 2
- Andrew P K Yap1 hr ago
- Self-Experimentation
Current longevity protocol: Should I add rapamycin?
This is my first post here, and I’m hoping to get some insights from people with similar protocols. In particular, I’m curious to hear people’s perspective on rapamycin given my current regimen.…
- Simon Smith
- Simon_Smith
- 5 days ago
- 17 replies
- 108
- 1
- SCOTT WEANER2 hrs ago
- Self-Experimentation
Rapamycin Cost
Let me clear some things up for people considering rapamycin (generic sirolimus). I am taking it and so are my dogs!! (I have a very open-minded vet who trusts my judgement.) Dr.…
- Rob8311
- Rob8311
- 3 yrs ago
- 414 replies
- 9,550
- 11
- Van21 hrs ago
- Self-Experimentation
Canagliflozin - A One Month Report, Its Good
I've been using Canagliflozin for the past month and really like it. It moderates blood glucose levels and makes it really easy to lose weight. I've lost about 10 lbs in 3 weeks,…
- Brin Chikovski
- Brin_Chikovski
- 3 mths ago
- 2 replies
- 158
- 4
- Davidyesterday
- Self-Experimentation
Fisetin to Clear Senescent Cells
Following studies with mice that showed significant senolytic clearance of senescent cells following large doses of the readily available flavenoid supplement Fisetin ,…
- JGC
- JGC
- 1 yr ago
- 618 replies
- 12,218
- 17
- Arizona Kid3 days ago
- Self-Experimentation
Rapamycin - progress so far
Hi all, About me: I'm 46 y.o. medical doctor based in Europe and started taking weekly rapamycin 4 months ago. I go to the gym regularly and am in average physical condition for a guy of my age.…
- George McMillan
- MD in Europe self-testing rapamycin
- George_Malcolm
- 1 mth ago
- 45 replies
- 612
- 2
- George McMillan4 days ago
- Self-Experimentation
Replacing Hormones to Optimal Levels
I’ve been experimenting with exogenous testosterone for over 15 years. At almost 73 I have been able to build and keep muscle. I eat a diet high in protein, lower in carbs and healthy fats.…
- Sharon Smith
- Sharon_Smith
- 2 mths ago
- 27 replies
- 421
- 4
- Arizona Kid5 days ago
- Self-Experimentation
NAD+ then Rapamycin?
I have read on this forum that NAD+ and Rapamycin counteract eachother. But it seems NAD+ shows affects in 2 weeks while Rapa takes 10 weeks. My plan is to do a 2 week cycle of SubQ NAD+ then…
- Arizona Kid
- Arizona_Kid
- 3 mths ago
- 2 replies
- 125
- Arizona Kid9 days ago
- Self-Experimentation
Anyone actually experience marked increased energy from NMN?
It's been 2 years now - sublingual. Nothing. I'm ready to throw it in the box with the resveratrol and rapamycin. Please leave your experiences and types/doses as well as how you can differentiate…
- Michael
- Michael.1
- 2 mths ago
- 6 replies
- 255
- Staffan Olsson9 days ago
- Self-Experimentation
Cosmetic Peptides
Anyone have experience with any of the (cosmetic) peptides on this site or equivalent? Tried the rapa cream formula suggested on the forum here with zero benefit.…
- Michael
- Michael.1
- 9 mths ago
- 2 replies
- 84
- Michael10 days ago
- Self-Experimentation
Help: Drastic results on DNA biological age test
Hi I’m a long time reader and first time poster. Advice needed please. I just received my results from myDNAGE which shows my biological age as 69 when my chrono age is 47.…
- Vega Rejuvinated
- Vega_Rejuvinated
- 2 wk ago
- 10 replies
- 161
- Jimmy212 days ago
- Self-Experimentation
Bio-Fisetin, a x25 Boost in Bioavailability?
One of the big problems with senolytic flavenoids like Fisetin and Quercetin is that they have a very low solubility in water and poor survival in the digestive tract,…
- JGC
- JGC
- 11 mths ago
- 12 replies
- 607
- 4
- Ernie Cohen13 days ago
- Self-Experimentation
GlyNAC
Has anyone tried Glycine/N-acetylcysteine? It appears to have amazing effects on age reversal. Glycine and N‐acetylcysteine (GlyNAC) supplementation in older adults improves glutathione deficiency,…
- Qimin You
- Qimin_You
- 5 mths ago
- 40 replies
- 696
- 2
- Geoff Welch2 wk ago
- Self-Experimentation
Anti-Aging Self-Experiment with Epitalon (AEDG)
There is a body of evidence, coming primarily from the publications of Vladimir Kh. Khavinson and his group at the Institute of Bioregulation and Gerontology (IB&G) in Moscow,…
- JGC
- JGC
- 6 mths ago
- 22 replies
- 547
- 5
- John Mcgough2 wk ago
- Self-Experimentation
Paul's self experiment II
My original thread was hi-jacked so starting another Still taking rapamycin. Experimented with GDF11 and will take blood tests in Jan to see if it has had an effect Looking into peptides.…
- Paul Beauchemin
- Paul_Beauchemin
- 9 mths ago
- 1 reply
- 175
- 1
- John Mcgough2 wk ago
- Self-Experimentation
wrinkle reduction
has anyone noticed wrinkle reduction in systemic use of sirolimus?
- curious
- curious
- 1 yr ago
- 98 replies
- 1,301
- 3
- Dorian Gray1 mth ago
- Self-Experimentation
Longevity Achieved
Recently received my results on my biological age. To my surprise, my biological age is 15. The process to get to this point was difficult. My formula has proven itself over and over.…
- Richard Brook
- Richard_Brook
- 2 mths ago
- 34 replies
- 580
- 1
- chuck stanley1 mth ago
- Self-Experimentation
Scenescent fibroblasts
Hi - first post/new here. I've read with great interest about senolytics and I'm specifically looking for something that could target fibroblasts. I'd found extract of milk thistle flowers that is…
- Suzannah White
- Suzannah_White
- 1 mth ago
- 48
- Self-Experimentation
Interested in Self-experimentation Protocol
Hi Everyone, I'm new to this forum and would like to ask some questions. I apologise if these questions have been asked before, I did a search through the forum but could not find the answers.…
- Basil_dev
- Sonia_Devine
- 1 mth ago
- 78
- Self-Experimentation
Dietary CD38 Inhibitors: Are They Correlated With Biological Age?
https://www.youtube.com/watch?v=ESCIfQp7z-U
- michael lustgarten
- michael_lustgarten
- 1 mth ago
- 31
- Self-Experimentation
How to increase the bioavailability of Fisetin
I'm preparing to do a Fisetin senolytic experiment, but I've read on the article from Mayo Clinic ( https://linkinghub.elsevier.com/retrieve/pii/S2352396418303736 ) that the administration mode was…
- JPA
- JPA
- 2 yrs ago
- 110 replies
- 4,852
- 3
- Robert Uomini2 mths ago
- Self-Experimentation
Cell Death Mechanisms Behind D+Q and Fisetin Senolytics
After having done about 9 months of self-experimentation with the effects of D+Q and Fisetin senolytic burst-treatments, I and others in my family have noticed that senolytics with D+Q tends to…
- JGC
- JGC
- 2 yrs ago
- 40 replies
- 732
- 2
- Dan Nave2 mths ago
- Self-Experimentation
My story (your suggestions) Dr Arvind Poswal
Hi. I am new here. Would like to know your thoughts. I begin by detailing my major life health points. I think I am a good candidate for knowing the effects of many of the anti-ageing medicines.…
- Arvind Poswal
- Arvind_Poswal
- 2 mths ago
- 58
- 2
- Self-Experimentation
Self Experimenting: Rapamycin & NAD+ Boosters
How many people are taking sirolimus and NAD+ Boosters (NR and/or NMN)? Do you notice different effects from either? Also, do you cycle the NAD+ Boosters or take them daily?
- Thomas G
- Thomas_G
- 1 yr ago
- 1 reply
- 191
- Mark Rittman2 mths ago
- Self-Experimentation
HGLA and GLA as Senolytics
In an interview posted online by Tufts Now , Dr. Christopher Wiley of Tufts University describes his discovery that dihomo-gamma-linoleic acid (DGLA) is a powerful senolytic.…
- JGC
- JGC
- 2 mths ago
- 1 reply
- 89
- chuck stanley2 mths ago
- Self-Experimentation

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