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Self-Experimentation

Share your story of trying or designing a promising age-reversal protocol.

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Hello everyone, Many of us are self-experimenting in an effort to prolong our good health. In this sub-forum, we encourage you to share your own stories of what seems to be working for you.…
- Max Petomoderator
- Researcher, website & forum admin
- Maximus
- 1 yr ago
- 628
- 12
- Self-Experimentation
Metformin: worth it? and what to expect
Hello all. I got my Doctor to give me a prescription for Metformin. I have read about its possible age-reversing effects, but I have also read about some possible significant side effects,…
- Jeff Bennion
- Jeff_Bennion
- 9 mths ago
- 35 replies
- 510
- 1
- Cherith16 min ago
- Self-Experimentation
Rapamycin Cost
Let me clear some things up for people considering rapamycin (generic sirolimus). I am taking it and so are my dogs!! (I have a very open-minded vet who trusts my judgement.) Dr.…
- Rob8311
- Rob8311
- 1 yr ago
- 142 replies
- 3,764
- 7
- Paul Beauchemin14 hrs ago
- Self-Experimentation
Senolytics
I've just finished my third Senolytic cycle. Fisetin 1500 mgs on 2 consecutihve days repeated one month later Dasatinab 180 mgs on 2 consecutive days + Quercitn 2250 mgs on the same days I also take…
- Charles Grashow
- Charles_Grashow
- 2 mths ago
- 11 replies
- 535
- 3
- Mark Thimineur3 days ago
- Self-Experimentation
Paul's self experimentation
I inadvertently started on this 5 years ago when I started taking Metformin. Was diagnosed with a Gleason 6 prostate cancer. Docs didn't want to treat just monitor.…
- Paul Beauchemin
- Paul_Beauchemin
- 1 mth ago
- 4 replies
- 127
- 1
- Paul Beauchemin3 days ago
- Self-Experimentation
Kaufmann Protocol Analysis
Dr. Sandra Kaufman, an MD anesthesiologist with an interest in aging, wrote a 2017 book entitled The Kaufmann Protocol: Why We Age and How to Stop It ,…
- JGC
- JGC
- 11 days ago
- 9 replies
- 122
- 1
- Danmoderator4 days ago
- Self-Experimentation
Should you get a micronutrient test?
Imagine my excitement as the moment finally arrived - the comprehensive results from my 15 vials of blood and four detailed blood tests that I completed at NextHealth arrived in my inbox.…
- Dr Nick Engerer
- The Longevity Blog
- Dr_Nick_Engerer
- 8 days ago
- 1 reply
- 45
- Karl8 days ago
- Self-Experimentation
Relaxin (RLX)
Hi Everyone, Has anyone looked at sourcing & using RLX? I've had an AVR operation 8 months ago & my EF has gone from 67 (12 months pre-op) to 55 (pre-op) to 35 (post-op).…
- Trevor Bingley
- Trevor_Bingley
- 9 days ago
- 22
- Self-Experimentation
Green tea and green tea extracts
Green tea benefits (and how to get them).
- Staffan Olsson
- Staffan_Olsson
- 4 mths ago
- 40 replies
- 416
- 1
- Larry11 days ago
- Self-Experimentation
Lisinopril and Self Experimentation.
Has anyone had any problems with metformin whilst on Lisinopril drug ? Possible interactions are mentioned on advice sites. Dasatinib and Lisinopril also get a mention in this regard.…
- Seaside
- Seaside
- 12 days ago
- 2 replies
- 29
- Seaside12 days ago
- Self-Experimentation
How to increase the bioavailability of Fisetin
I'm preparing to do a Fisetin senolytic experiment, but I've read on the article from Mayo Clinic ( https://linkinghub.elsevier.com/retrieve/pii/S2352396418303736 ) that the administration mode was…
- JPA
- JPA
- 1 yr ago
- 76 replies
- 2,158
- 2
- Paul Beauchemin2 wk ago
- Self-Experimentation
Resveratrol -- value, dose, source?
There is controversy over resveratrol, and its advocates. What is the value of resveratrol as part of an age reversal supplement program? One highly visible individual recommends Resveratrol that is:…
- JohnnyAdamsmoderator
- Mission: Slow and Ultimately Reverse Biological Aging and Age Related Decline for More Years of Healthy Living
- JohnnyAdams
- 3 wk ago
- 15 replies
- 179
- Staffan Olsson2 wk ago
- Self-Experimentation
Rapamycin self-experimentation
I've just begun a 10 week self-experimentation with RapaPro rapamycin. I'll be taking 5 mg once a week, which is roughly the dose that Dr. Alan Green recommends on the high side and seems to be…
- Tam
- Tam
- 8 mths ago
- 32 replies
- 907
- 1
- DRGL2 wk ago
- Self-Experimentation
Ursolic acid
I am curious about this substance - Ursolic acid. I wonder if there are people in here that have first hand experience from the use of Ursolic acid. I post a link to a review from 2018.…
- Staffan Olsson
- Staffan_Olsson
- 2 wk ago
- 29
- Self-Experimentation
enhancing NAD precursor effectiveness
Therapeutic doses of NR and NMN in studies are usually much larger than the suggested amount on the label. Chromadex NR studies usually use a gram or more of the stuff,…
- Ajax
- Ajax
- 3 wk ago
- 6 replies
- 134
- 1
- Dorian Gray3 wk ago
- Self-Experimentation
Mechanism for Immortality
OK guys, here goes. This is controversial so I apologize beforehand. All you need is NMN because it repairs DNA damage and it boots energy via the mitochondria.…
- Chan
- Chan
- 6 mths ago
- 9 replies
- 424
- Karl3 wk ago
- Self-Experimentation
Paul's Anti-Aging Efforts
Preparing for a LONG FUTURE, here are the prescriptions and supplements I take to STOP or REVERSE AGING, with the blessings of my doctors. After each one are the number of Web sites mentioning them,…
- Paul Mason
- Paul_Mason
- 1 yr ago
- 11 replies
- 811
- 3
- Cherith3 wk ago
- Self-Experimentation
Late life metformin treatment limits cell survival and shortens lifespan by triggering an aging-associated failure of energy metabolism
Not sure how to take this. Anyone more knowledgeable care to comment? https://www.biorxiv.org/content/10.1101/863357v1
- Patrick McHargue
- Patrick_McHargue
- 1 mth ago
- 3 replies
- 85
- David Hanson1 mth ago
- Self-Experimentation
Life is an experiment
I've been working on "me" for years and lately I've started to look beyond diet, exercise, lifestyle, sleep etc. Until now I've only been supplementing with creatine, fish oil,…
- Dave C
- David_Clubine
- 1 mth ago
- 1 reply
- 83
- 2
- Dave C1 mth ago
- Self-Experimentation
32 years old. Is self-experimentation right for me?
So, as the title says, I'm 32 years old. I'm very interested in longevity research and I would like to try some of these methods to help slow my aging.…
- Sara V
- Sara_V
- 2 mths ago
- 3 replies
- 134
- Karl1 mth ago
- Self-Experimentation
Fiestin to Clear Senescent Cells
Following studies with mice that showed significant senolytic clearance of senescent cells following large doses of the readily available flavenoid supplement Fisetin ,…
- JGC
- JGC
- 1 yr ago
- 196 replies
- 3,815
- 10
- GEdwards1 mth ago
- Self-Experimentation
Telomerase Activators
I couldn’t find discussions about the available telomerase activators such as Isegenesis, TA-65, and Defytime Aging Care Capsules (previously named TAM-818,…
- David Hanson
- David_Hanson
- 1 mth ago
- 2 replies
- 93
- Karl1 mth ago
- Self-Experimentation
Serrapeptase headaches
Serrapeptase and proteolytic enzymes cause headaches over a very long period of time. I think the headaches may be caused primariy by the brain's attempts to get rid of the debris left behind after…
- Paul B
- Paul_B
- 2 mths ago
- 1 reply
- 30
- DIANE B1 mth ago
- Self-Experimentation
GDF11 rejuvenation
Has anybody here participated with GDF11 Rejuvenation ? Results, experience?
- Danmoderator
- skipping my funeral
- dantheman
- 1 yr ago
- 4 replies
- 187
- 1
- Danmoderator1 mth ago
- Self-Experimentation
Trehalose
Has anybody researched or tried trehalose to kill senescent cells? I have just come across it in the literature, apparently it stimulates AMPK like Metformin does,…
- Koo
- Koo
- 1 mth ago
- 33
- Self-Experimentation
Sources for Metformin?
Suggestions? The best source is via your GP. I have script for Metformin due to an undiscovered elevated glucose (check yours first thing in the morning,…
- Danmoderator
- skipping my funeral
- dantheman
- 4 mths ago
- 27 replies
- 761
- 2
- Mermaid2 mths ago
- Self-Experimentation

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