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Self-Experimentation
Share your story of trying or designing a promising age-reversal protocol.
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About this forum topic
Hello everyone, Many of us are self-experimenting in an effort to prolong our good health. In this sub-forum, we encourage you to share your own stories of what seems to be working for you.…
Max Peto
moderator
Researcher, website & forum admin
Maximus
3 yrs ago
844
15
Self-Experimentation
How to increase the bioavailability of Fisetin
I'm preparing to do a Fisetin senolytic experiment, but I've read on the article from Mayo Clinic ( https://linkinghub.elsevier.com/retrieve/pii/S2352396418303736 ) that the administration mode was…
JPA
JPA
2 yrs ago
92
replies
3,444
3
Dorian Gray
yesterday
Self-Experimentation
Rapamycin Cost
Let me clear some things up for people considering rapamycin (generic sirolimus). I am taking it and so are my dogs!! (I have a very open-minded vet who trusts my judgement.) Dr.…
Rob8311
Rob8311
2 yrs ago
319
replies
6,927
10
Paul Beauchemin
2 days ago
Self-Experimentation
Preparations for self-treating COVID-19
The mortality rate of the aged population from COVID-19 is very high, around 20% for the over-80 group of which I and my wife are members. Further, if medical facilities are limited and physicians…
JGC
JGC
10 mths ago
85
replies
913
3
albedo
3 days ago
Self-Experimentation
Quantifying Biological Age With Aging.ai: 24 Blood Tests Since 2009
The maximal reduction for biological age when using the biological age calculator, Phenotypic Age, is ~20 years. In other words, if I'm 80 years old and my biomarkers are all reflective of youth,…
michael lustgarten
michael_lustgarten
4 days ago
12
Self-Experimentation
"Senolytic Activator" and Extended Fasting …
Gentlefolk, Our fine friends at Life Extension have released a new product, Senolytic Activator. It is a combination of Quercertin and Theaflavins. They intend us to use it weekly as a…
adonoho
adonoho
2 yrs ago
35
replies
1,423
5
Henry milton
8 days ago
Self-Experimentation
High dose nicotinic acid with acetyl-carnitine restores hair color?
I found out that high dose nicotinic acid (3+ grams) with high dose acetyl-carnitine (1+ grams) seems to be able to at least partially restore hair color in my father in his 70s,…
Big Guy
Big_Guy
1 mth ago
5
replies
164
1
Ludovic Debels
8 days ago
Self-Experimentation
Dasatinib update
Just finished a 3 day course of D & Q. The Dasatinib was purchased from Taylor Made Compounding. Dosage was 100 mg D &1000 mg Q. Cost for 6 @50 mg capsules, including shipping was USD $33.…
Charles Grashow
Charles_Grashow
4 mths ago
17
replies
328
1
Stephen Lewis
8 days ago
Self-Experimentation
Is it me or is Apigenin not so hot in this forum
Treatment of cells with apigenin or quercetin inhibits CD38 and promotes an increase in intracellular NAD+ levels. An increased NAD+ level decreases protein acetylation through sirtuin activation. ..…
Andrew P K Yap
Andrew_P_K_Yap
7 mths ago
21
replies
426
Michael
9 days ago
Self-Experimentation
Epithalon
Anyone inject Epithalon? 1) Any suggestions on both reformulating 50mg Epithalon and daily dose? 2) Anyone have experience mixing in a facial cream? (ALA Mark's rapamycin cream as found all over…
Michael
Michael.1
2 wk ago
4
replies
44
Michael
9 days ago
Self-Experimentation
wrinkle reduction
has anyone noticed wrinkle reduction in systemic use of sirolimus?
curious
curious
4 mths ago
82
replies
776
3
garland
11 days ago
Self-Experimentation
sirolimus vehicle
Does anyone have any sources for formulating aqueous solutions of rapamycin? I got my hands on 10g pure powder, and I would like to start the 5mg/week regimen.…
Anna Marie
Anna_Marie
3 wk ago
1
reply
26
Michael
13 days ago
Self-Experimentation
Quantifying Biological Age: Blood Test #6 in 2020
Discussed in the video : What's my biological age on blood test #6 in 2020? What's my average biological age for 2020, and how does it compare with 2019? Are there links between calorie intake,…
michael lustgarten
michael_lustgarten
2 wk ago
19
Self-Experimentation
Possible negative response to oral NAD+
Hello, My wife and I (~50) have started a NAD+ regime in addition to rest of the other life long regime (vegan, exercise, other suppls). We started with 250mg (sourced from Life Extension),…
Dan
moderator
skipping my funeral
dantheman
2 yrs ago
17
replies
882
2
katie larking
3 wk ago
Self-Experimentation
Biohackers Perform First Plasma Dilution Experiment on Humans This technique is a human modification of the Conboys' mouse experiments.
https://www.lifespan.io/news/biohackers-perform-first-plasma-dilution-experiment-on-humans/
Larry
Larry.1
1 mth ago
5
replies
76
CK
3 wk ago
Self-Experimentation
Fisetin to Clear Senescent Cells
Following studies with mice that showed significant senolytic clearance of senescent cells following large doses of the readily available flavenoid supplement Fisetin ,…
JGC
JGC
6 mths ago
489
replies
8,595
15
Fred Cloud
3 wk ago
Self-Experimentation
Rapamycin and Blood Pressure Pills
Is anyone here taking Rapamycin along with high blood-pressure pills (Ace Inhibitors and amLODIPine)? I’m curious, as I’ve been doing a lot of research and the combo doesn’t seem all that positive.…
Paula Marie
Paula_Marie
4 wk ago
24
1
Self-Experimentation
Dogs and cats and people
I am learning something new every day. https://www.purinainstitute.com/can-summit/can-2018/new-insights-into-getting-older This has helped me understand what I read here better.
Jennifer Smith
We are all responsible for our own health, wealth, and happiness
Jennifer_Smith
4 wk ago
25
Self-Experimentation
mark t
I was wondering how you made your cream the 2mg in 4oz? 4oz of what? Thank you.
curious
curious
4 mths ago
6
replies
115
chuck stanley
4 wk ago
Self-Experimentation
Paul's self experiment II
My original thread was hi-jacked so starting another Still taking rapamycin. Experimented with GDF11 and will take blood tests in Jan to see if it has had an effect Looking into peptides.…
Paul Beauchemin
Paul_Beauchemin
1 mth ago
79
1
Self-Experimentation
Cosmetic Peptides
Anyone have experience with any of the (cosmetic) peptides on this site or equivalent? Tried the rapa cream formula suggested on the forum here with zero benefit.…
Michael
Michael.1
1 mth ago
32
Self-Experimentation
Neutrophils, Lymphocytes, Monocytes: What’s Optimal For Health And Longevity?
For those who track their WBC differentials, here's my latest video about what's optimal for neutrophils, lymphocytes, and monocytes in terms of health and longevity: https://www.youtube.…
michael lustgarten
michael_lustgarten
1 mth ago
30
1
Self-Experimentation
Can any meaningful conclusions of efficacy/harm ever be drawn form individual experience/"self experimentation"?
Hi. This post might irritate, but I mean well. It's prompted by a useful article I read this morning...about the nocebo effect with statin's. https://www.nejm.org/doi/full/10.…
Steve Roedde
Steve_Roedde
2 mths ago
22
replies
164
John Mcgough
1 mth ago
Self-Experimentation
Finished the First 3 Protocol Steps
I an 72 and have been taking metformin (twice a day but recently increased to 3 times a day) for 5 years. I recently completed 6 patches of NAD+. I also have just taken 2 doses of quercetin and…
Bernie
Bernie_Singer
2 yrs ago
8
replies
356
4
Ross Barker
1 mth ago
Self-Experimentation
HDL: What's Optimal For Minimizing Disease Risk And Maximizing Longevity?
Meta-analysis for the association between HDL with all-cause mortality risk has identified HDL levels 55 - 60 mg/dL range as optimal. However, that data includes subjects up to 85y-in the video,…
michael lustgarten
michael_lustgarten
2 mths ago
47
2
Self-Experimentation
Tracking progress of my experiment
Hi everyone, I wanted to try a self experiment to see if diet and exercise had an effect on my biological age. It has been a while and I wanted to check my progress,…
Dave A
Dave_A
2 mths ago
5
replies
95
Michael
2 mths ago
Self-Experimentation
1
2
3
4
5
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