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Self-Experimentation

Share your story of trying or designing a promising age-reversal protocol.

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Hello everyone, Many of us are self-experimenting in an effort to prolong our good health. In this sub-forum, we encourage you to share your own stories of what seems to be working for you.…
- Maximus Peto
- Researcher, website & forum admin
- Maximus
- 7 yrs ago
- 1284
- 15
- Self-Experimentation
HPE (Human Placental Extract) hydrolysate Laennec/Melsmon
Curious if anyone has tried either of these HPE products, which were originally targeted for cosmetic and skin rejuvenation, but have been broadened somewhat for claims of positive systemic effects…
- Mitnoxid
- Mitnoxid
- 3 wk ago
- 6
- Self-Experimentation
Human Placental Extract (Laennec or JBP)
Has anyone experimented personally with these human placental hydrolysate products--if so can you share your experience and results? Traditionally used primarily in cosmetic applications,…
- Mitnoxid
- Mitnoxid
- 2 wk ago
- 5
- Self-Experimentation
Sleep Quality DSIP
For those struggling with sleep quality, particularly waking up around midnight and being unable to return to deep sleep until early morning, I'd like to share my experience.…
- Bruce B
- Bruce_123
- 8 mths ago
- 19replies
- 310
- 2
- Last replyripeideas3 mths ago
- Self-Experimentation
Small molecule/chemical reprogramming
Who is working on or considering self-experimentation in small molecule/chemical reprogramming. There is great potential for us to work together to advance.…
- JohnnyAdamsmoderator
- Mission: Slow and Ultimately Reverse Biological Aging and Age Related Decline for More Years of Healthy Living
- JohnnyAdams
- 5 mths ago
- 3replies
- 59
- Last replyVan4 mths ago
- Self-Experimentation
TERT and its Activator TAC
Shim, et al published a recent (6/21/2024) paper in Cell entitled "TERT activation targets DNA methylation and multiple aging hallmarks," in which they present some very interesting results on aging…
- JGC
- Retired Professor of Physics
- JGC
- 1 yr ago
- 3replies
- 222
- 2
- Last replyBruce B6 mths ago
- Self-Experimentation
Honokiol for age retardation
Every year in September, I research what products to investigate for pro-youthening next year. It seems to me that honokiol is worth a try. I am getting the TruAge test done soon (bought the four…
- Moonlitnight
- Medical Writer working on age reversal for over 20 yrs
- Moonlitnight
- updated 9 mths ago
- 7replies
- 111
- 2
- Last replyCurtis Smith9 mths ago
- Self-Experimentation
D+Q+F+P+L+G+GLA: A New Senolytic Cocktail
For my May 15-18 senolytic session I tried something new. In a recent Foresight Institute talk available on YouTube, James Kirkland identified the flavonoid Luteolin as a senolytic.…
- JGC
- Retired Professor of Physics
- JGC
- updated 3 yrs ago
- 40replies
- 885
- 4
- Last replyBrian Valerie9 mths ago
- Self-Experimentation
GlyNAC
Has anyone tried Glycine/N-acetylcysteine? It appears to have amazing effects on age reversal. Glycine and N‐acetylcysteine (GlyNAC) supplementation in older adults improves glutathione deficiency,…
- Qimin You
- Qimin_You
- 4 yrs ago
- 104replies
- 6172
- 3
- Last replyJay Orman10 mths ago
- Self-Experimentation
Help: Drastic results on DNA biological age test
Hi I’m a long time reader and first time poster. Advice needed please. I just received my results from myDNAGE which shows my biological age as 69 when my chrono age is 47.…
- Vega Rejuvinated
- Vega_Rejuvinated
- 3 yrs ago
- 23replies
- 688
- 1
- Last replyMoonlitnight10 mths ago
- Self-Experimentation
Cell Death Mechanisms Behind D+Q and Fisetin Senolytics
After having done about 9 months of self-experimentation with the effects of D+Q and Fisetin senolytic burst-treatments, I and others in my family have noticed that senolytics with D+Q tends to…
- JGC
- Retired Professor of Physics
- JGC
- 5 yrs ago
- 45replies
- 1057
- 2
- Last replyVijay10 mths ago
- Self-Experimentation
Immunosenescence anyone?
Hi all! Just dropping by to ask if anyone has been diagnosed with immunosenescence. During some tests to check for auto-immune conditions (I suddenly developed extremely mild peripheral neuropathy…
- Moonlitnight
- Medical Writer working on age reversal for over 20 yrs
- Moonlitnight
- updated 1 yr ago
- 6replies
- 167
- Last replyMoonlitnight11 mths ago
- Self-Experimentation
Looking for a physician
I am looking for a physician (must be an M. D.) who can supervise my taking of supplements. Over the years I have bought supplements from Life Extension, Dr. Al Sears, Dr. David Williams, Peak Co.…
- Birgit Thorwald
- Birgit_Thorwald
- 11 mths ago
- 39
- Self-Experimentation
2023 State of lifespan in mouse models
Just going to place this here https://www.youtube.com/watch?v=sZ-krUa6VH0 Highlights - Unsuccessful drugs studied by the ITP: resveratrol, metformin, and nicotinamide riboside - https://www.youtube.…
- Michael
- Michael.1
- 1 yr ago
- 1reply
- 110
- 1
- Last replyBruce B1 yr ago
- Self-Experimentation
Hair regrowth using topical resveratrol and fisetin?
Anyone combine the two into a topical for hair regrowth? https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7593534/
- Michael
- Michael.1
- 2 yrs ago
- 4replies
- 372
- Last replyMichael1 yr ago
- Self-Experimentation
Photo evidence that the experiment is working
Correct me if I'm wrong. I figured that this deserves it's own discussion topic. More than 5 years ago I started doing age-reversal. Couple of years back when I realized that it was working I…
- Andrew P K Yap
- Andrew_P_K_Yap
- 3 yrs ago
- 109replies
- 2453
- 3
- Last replyAndrew P K Yap1 yr ago
- Self-Experimentation
Biomarkers Of Kidney Function: Creatinine, Cystatin C, What's Optimal?
https://www.youtube.com/watch?v=RM-dQZj3h6U
- michael lustgarten
- michael_lustgarten
- 1 yr ago
- 31
- Self-Experimentation
Is spontaneous hair colour restoration normal?
So, I am a 44yo male with a speckling of grey hair, and I have been taking a mix of compounds that are often discussed in the forums. I started in about mid-January this year.…
- David Ng
- David_Ng
- updated 3 yrs ago
- 17replies
- 1923
- 2
- Last replyAllen DeLaney1 yr ago
- Self-Experimentation
Preparations for self-treating COVID-19
The mortality rate of the aged population from COVID-19 is very high, around 20% for the over-80 group of which I and my wife are members. Further, if medical facilities are limited and physicians…
- JGC
- Retired Professor of Physics
- JGC
- 5 yrs ago
- 88replies
- 1156
- 3
- Last replyVic Emmay1 yr ago
- Self-Experimentation
Virgin Olive Oil Study
Anyone see this? It's from 2019. Recommended dose? A LITRE a WEEK! https://youtu.be/Uklt4zVVtS0?t=2976
- Michael
- Michael.1
- 2 yrs ago
- 1reply
- 152
- Last replyAllen DeLaney1 yr ago
- Self-Experimentation
Longer Telomere Length In 2023 vs 2022 (Also, Correlations With Diet)
https://youtu.be/zndKB2yi1Z8
- michael lustgarten
- michael_lustgarten
- 1 yr ago
- 1reply
- 86
- Last replymichael lustgarten1 yr ago
- Self-Experimentation
First post!.... Introducing myself!
Hi everyone!!! Just call me Lucky So, I'm currently 61 years old and I've been a lifetime exercise and diet enthusiast. In my late teens and early 20's I was a competitive powerlifter and…
- Donkey Hotie
- Donkey_Hotie
- 2 yrs ago
- 4replies
- 117
- 2
- Last replyMoonlitnight1 yr ago
- Self-Experimentation
2024 Best Rapa Protocols
Greetings my fellow forum age reversalites. Well, I haven't gotten any younger. Admittedly, my journey into rapa was short lived having experienced some chest fluid junk which at that time,…
- Michael
- Michael.1
- 1 yr ago
- 131
- Self-Experimentation
Successful treatment of diabetic neuropathy.
The method consists in precise control of blood glucose in the range of 70 to 80 mg/dL. Medicines used: 1. Glucophage XR in doses of 1.5 to 2.5 grams. 2. Ozempic 0.5 milligrams per week. 3.…
- Spasov
- Spasov
- 2 yrs ago
- 1reply
- 92
- Last replyBruce B1 yr ago
- Self-Experimentation
Epigenetic Test #9: Finally, A Younger Horvath Age Than the Chronological
https://www.youtube.com/watch?v=Kcc2QtasjGg
- michael lustgarten
- michael_lustgarten
- 1 yr ago
- 34
- Self-Experimentation

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