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Self-Experimentation

Share your story of trying or designing a promising age-reversal protocol.

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Hello everyone, Many of us are self-experimenting in an effort to prolong our good health. In this sub-forum, we encourage you to share your own stories of what seems to be working for you.…
- Max Petomoderator
- Researcher, website & forum admin
- Maximus
- 2 yrs ago
- 762
- 14
- Self-Experimentation
Is it me or is Apigenin not so hot in this forum
Treatment of cells with apigenin or quercetin inhibits CD38 and promotes an increase in intracellular NAD+ levels. An increased NAD+ level decreases protein acetylation through sirtuin activation. ..…
- Andrew P K Yap
- Andrew_P_K_Yap
- 2 mths ago
- 17 replies
- 232
- Andrew P K Yap2 days ago
- Self-Experimentation
Biological Age Test #4 in 2020: Getting Better or Getting Worse?
- michael lustgarten
- michael_lustgarten
- 6 days ago
- 4 replies
- 62
- JGC4 days ago
- Self-Experimentation
Paul's self experimentation
I inadvertently started on this 5 years ago when I started taking Metformin. Was diagnosed with a Gleason 6 prostate cancer. Docs didn't want to treat just monitor.…
- Paul Beauchemin
- Paul_Beauchemin
- 7 mths ago
- 15 replies
- 473
- 2
- Paul Beauchemin9 days ago
- Self-Experimentation
Rapamycin Cost
Let me clear some things up for people considering rapamycin (generic sirolimus). I am taking it and so are my dogs!! (I have a very open-minded vet who trusts my judgement.) Dr.…
- Rob8311
- Rob8311
- 2 yrs ago
- 242 replies
- 5,447
- 8
- Fred Cloud9 days ago
- Self-Experimentation
Can Senolytic drug cure Chronic kidney disease ?
Could you help to advise about senolytic drug and CKD ?
- PuRi
- PuRi
- 11 days ago
- 2 replies
- 40
- hellscreamer11 days ago
- Self-Experimentation
Resveratrol -- value, dose, source?
There is controversy over resveratrol, and its advocates. What is the value of resveratrol as part of an age reversal supplement program? One highly visible individual recommends Resveratrol that is:…
- JohnnyAdamsmoderator
- Mission: Slow and Ultimately Reverse Biological Aging and Age Related Decline for More Years of Healthy Living
- JohnnyAdams
- 7 mths ago
- 18 replies
- 399
- Endless3 wk ago
- Self-Experimentation
liposomal Fisetin
Wondering if anyone has heard of this? Supposedly much better absorption, but I would have no idea how to dose it... https://alivebynature.com/product/lsg-fisetin-liposomal-sublingual-gel/
- Robin Maisel
- Robin_Maisel
- 3 wk ago
- 2 replies
- 91
- Endless3 wk ago
- Self-Experimentation
Phosphatidylcholine IV
Ray Kurzweil is a fan of Phosphatidylcholine, and seems to be alone in this. Bill and others don't make much truck with it AFAIK. Ray has said he does both IV's and oral supplementation.…
- Danmoderator
- skipping my funeral
- dantheman
- 1 yr ago
- 19 replies
- 405
- 1
- garland4 wk ago
- Self-Experimentation
EPIGENETIC MUTATIONS, REVERSAL TO NORMAL
Does anybody know of any studies that suggest ways to revert epigenetic mutations back to normal? Direct or indirect methods. Thanks
- Andrew P K Yap
- Andrew_P_K_Yap
- 2 mths ago
- 11 replies
- 183
- Rhett Barret4 wk ago
- Self-Experimentation
Fisetin to Clear Senescent Cells
Following studies with mice that showed significant senolytic clearance of senescent cells following large doses of the readily available flavenoid supplement Fisetin ,…
- JGC
- JGC
- 1 mth ago
- 395 replies
- 6,463
- 12
- Peter H. Howe1 mth ago
- Self-Experimentation
Physician in the UK
Hello guys, I hope this is the good section for this. I am hoping to find a medical doctor in the UK that would be open to self experimentation for longevity purpose.…
- Raphael Nicolle
- Raphael_Nicolle
- 1 mth ago
- 17
- Self-Experimentation
Quantifying Phenotypic Age: Blood Test Measurement #3 in 2020
- michael lustgarten
- michael_lustgarten
- 1 mth ago
- 33
- Self-Experimentation
Biological Age = 32.75y, Chronological Age = 47y: First 2020 measurement
https://michaellustgarten.com/2020/02/14/biological-age-32-75y-chronological-age-47y-first-2020-measurement/
- michael lustgarten
- michael_lustgarten
- 5 mths ago
- 1 reply
- 182
- michael lustgarten1 mth ago
- Self-Experimentation
Dasatinib
Hi Brian, On the website "SocietyforAgeReversal.org which is the same as rescueelders.org I think. You mentioned in the blog, "I'm taking a very quick break from the engaging presentations to report…
- Snowbird
- Snowbird
- 1 yr ago
- 106 replies
- 1,835
- ssny. sotero1 mth ago
- Self-Experimentation
Senolytics
I've just finished my third Senolytic cycle. Fisetin 1500 mgs on 2 consecutihve days repeated one month later Dasatinab 180 mgs on 2 consecutive days + Quercitn 2250 mgs on the same days I also take…
- Charles Grashow
- Charles_Grashow
- 9 mths ago
- 91 replies
- 2,162
- 4
- Van1 mth ago
- Self-Experimentation
Rapamycin thanks to Dr.Garcia, Significantly improves Lymphocytes
In January I went to see Dr. Garcia in Las Vegas who I regularly see for PRP. I explain to him how my lymphocytes including cd4 which had dropped to 325 way below normal and asked about taking…
- John Mcgough
- John_Mcgough
- 2 mths ago
- 66
- 1
- Self-Experimentation
Self Experimenting: Rapamycin & NAD+ Boosters
How many people are taking sirolimus and NAD+ Boosters (NR and/or NMN)? Do you notice different effects from either? Also, do you cycle the NAD+ Boosters or take them daily?
- Thomas G
- Thomas_G
- 2 mths ago
- 80
- Self-Experimentation
Paul's Anti-Aging Efforts
Preparing for a LONG FUTURE, here are the prescriptions and supplements I take to STOP or REVERSE AGING, with the blessings of my doctors. After each one are the number of Web sites mentioning them,…
- Paul Mason
- Paul_Mason
- 1 yr ago
- 12 replies
- 1,054
- 4
- Simon Lee2 mths ago
- Self-Experimentation
Preparations for self-treating COVID-19
The mortality rate of the aged population from COVID-19 is very high, around 20% for the over-80 group of which I and my wife are members. Further, if medical facilities are limited and physicians…
- JGC
- JGC
- 4 mths ago
- 84 replies
- 841
- 3
- Florin2 mths ago
- Self-Experimentation
Rapamycin self-experimentation
I've just begun a 10 week self-experimentation with RapaPro rapamycin. I'll be taking 5 mg once a week, which is roughly the dose that Dr. Alan Green recommends on the high side and seems to be…
- Tam
- Tam
- 1 yr ago
- 70 replies
- 1,937
- 2
- GEdwards2 mths ago
- Self-Experimentation
32 years old. Is self-experimentation right for me?
So, as the title says, I'm 32 years old. I'm very interested in longevity research and I would like to try some of these methods to help slow my aging.…
- Sara V
- Sara_V
- 9 mths ago
- 6 replies
- 243
- Fairy8i82 mths ago
- Self-Experimentation
Senolytic Self-experiments and COVID-19
There is evidence that the TOP2 receptor that the COVID-19 virus uses to enter cells is more prevalent in senescent cells. Also, clearing accumulated senescent cells from the immune system probably…
- JGC
- JGC
- 3 mths ago
- 10 replies
- 192
- 1
- Andrew P K Yap2 mths ago
- Self-Experimentation
Life is an experiment
I've been working on "me" for years and lately I've started to look beyond diet, exercise, lifestyle, sleep etc. Until now I've only been supplementing with creatine, fish oil,…
- Dave C
- David_Clubine
- 8 mths ago
- 2 replies
- 128
- 2
- Fairy8i82 mths ago
- Self-Experimentation
Did anyone experience acute inflammation after senolytics?
Hello, I have Myalgic Encephalomyelitis/Chronic Fatigue Syndrome. It is a condition that involves chronic inflammation. I tried 3 days of high dose Fisetin the last 3 days (1000mg/day).…
- Phoenix
- phoenix
- 1 yr ago
- 7 replies
- 391
- 1
- Andrew P K Yap2 mths ago
- Self-Experimentation
Trehalose
Has anybody researched or tried trehalose to kill senescent cells? I have just come across it in the literature, apparently it stimulates AMPK like Metformin does,…
- Koo
- Koo
- 8 mths ago
- 1 reply
- 69
- Andrew P K Yap3 mths ago
- Self-Experimentation

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