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Self-Experimentation

Share your story of trying or designing a promising age-reversal protocol.

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Hello everyone, Many of us are self-experimenting in an effort to prolong our good health. In this sub-forum, we encourage you to share your own stories of what seems to be working for you.…
- Max Petomoderator
- Researcher, website & forum admin
- Maximus
- 3 yrs ago
- 844
- 15
- Self-Experimentation
How to increase the bioavailability of Fisetin
I'm preparing to do a Fisetin senolytic experiment, but I've read on the article from Mayo Clinic ( https://linkinghub.elsevier.com/retrieve/pii/S2352396418303736 ) that the administration mode was…
- JPA
- JPA
- 2 yrs ago
- 92 replies
- 3,444
- 3
- Dorian Grayyesterday
- Self-Experimentation
Rapamycin Cost
Let me clear some things up for people considering rapamycin (generic sirolimus). I am taking it and so are my dogs!! (I have a very open-minded vet who trusts my judgement.) Dr.…
- Rob8311
- Rob8311
- 2 yrs ago
- 319 replies
- 6,927
- 10
- Paul Beauchemin2 days ago
- Self-Experimentation
Preparations for self-treating COVID-19
The mortality rate of the aged population from COVID-19 is very high, around 20% for the over-80 group of which I and my wife are members. Further, if medical facilities are limited and physicians…
- JGC
- JGC
- 10 mths ago
- 85 replies
- 913
- 3
- albedo3 days ago
- Self-Experimentation
Quantifying Biological Age With Aging.ai: 24 Blood Tests Since 2009
The maximal reduction for biological age when using the biological age calculator, Phenotypic Age, is ~20 years. In other words, if I'm 80 years old and my biomarkers are all reflective of youth,…
- michael lustgarten
- michael_lustgarten
- 4 days ago
- 12
- Self-Experimentation
"Senolytic Activator" and Extended Fasting …
Gentlefolk, Our fine friends at Life Extension have released a new product, Senolytic Activator. It is a combination of Quercertin and Theaflavins. They intend us to use it weekly as a…
- adonoho
- adonoho
- 2 yrs ago
- 35 replies
- 1,423
- 5
- Henry milton8 days ago
- Self-Experimentation
High dose nicotinic acid with acetyl-carnitine restores hair color?
I found out that high dose nicotinic acid (3+ grams) with high dose acetyl-carnitine (1+ grams) seems to be able to at least partially restore hair color in my father in his 70s,…
- Big Guy
- Big_Guy
- 1 mth ago
- 5 replies
- 164
- 1
- Ludovic Debels8 days ago
- Self-Experimentation
Dasatinib update
Just finished a 3 day course of D & Q. The Dasatinib was purchased from Taylor Made Compounding. Dosage was 100 mg D &1000 mg Q. Cost for 6 @50 mg capsules, including shipping was USD $33.…
- Charles Grashow
- Charles_Grashow
- 4 mths ago
- 17 replies
- 328
- 1
- Stephen Lewis8 days ago
- Self-Experimentation
Is it me or is Apigenin not so hot in this forum
Treatment of cells with apigenin or quercetin inhibits CD38 and promotes an increase in intracellular NAD+ levels. An increased NAD+ level decreases protein acetylation through sirtuin activation. ..…
- Andrew P K Yap
- Andrew_P_K_Yap
- 7 mths ago
- 21 replies
- 426
- Michael9 days ago
- Self-Experimentation
Epithalon
Anyone inject Epithalon? 1) Any suggestions on both reformulating 50mg Epithalon and daily dose? 2) Anyone have experience mixing in a facial cream? (ALA Mark's rapamycin cream as found all over…
- Michael
- Michael.1
- 2 wk ago
- 4 replies
- 44
- Michael9 days ago
- Self-Experimentation
wrinkle reduction
has anyone noticed wrinkle reduction in systemic use of sirolimus?
- curious
- curious
- 4 mths ago
- 82 replies
- 776
- 3
- garland11 days ago
- Self-Experimentation
sirolimus vehicle
Does anyone have any sources for formulating aqueous solutions of rapamycin? I got my hands on 10g pure powder, and I would like to start the 5mg/week regimen.…
- Anna Marie
- Anna_Marie
- 3 wk ago
- 1 reply
- 26
- Michael13 days ago
- Self-Experimentation
Quantifying Biological Age: Blood Test #6 in 2020
Discussed in the video : What's my biological age on blood test #6 in 2020? What's my average biological age for 2020, and how does it compare with 2019? Are there links between calorie intake,…
- michael lustgarten
- michael_lustgarten
- 2 wk ago
- 19
- Self-Experimentation
Possible negative response to oral NAD+
Hello, My wife and I (~50) have started a NAD+ regime in addition to rest of the other life long regime (vegan, exercise, other suppls). We started with 250mg (sourced from Life Extension),…
- Danmoderator
- skipping my funeral
- dantheman
- 2 yrs ago
- 17 replies
- 882
- 2
- katie larking3 wk ago
- Self-Experimentation
Biohackers Perform First Plasma Dilution Experiment on Humans This technique is a human modification of the Conboys' mouse experiments.
https://www.lifespan.io/news/biohackers-perform-first-plasma-dilution-experiment-on-humans/
- Larry
- Larry.1
- 1 mth ago
- 5 replies
- 76
- CK3 wk ago
- Self-Experimentation
Fisetin to Clear Senescent Cells
Following studies with mice that showed significant senolytic clearance of senescent cells following large doses of the readily available flavenoid supplement Fisetin ,…
- JGC
- JGC
- 6 mths ago
- 489 replies
- 8,595
- 15
- Fred Cloud3 wk ago
- Self-Experimentation
Rapamycin and Blood Pressure Pills
Is anyone here taking Rapamycin along with high blood-pressure pills (Ace Inhibitors and amLODIPine)? I’m curious, as I’ve been doing a lot of research and the combo doesn’t seem all that positive.…
- Paula Marie
- Paula_Marie
- 4 wk ago
- 24
- 1
- Self-Experimentation
Dogs and cats and people
I am learning something new every day. https://www.purinainstitute.com/can-summit/can-2018/new-insights-into-getting-older This has helped me understand what I read here better.
- Jennifer Smith
- We are all responsible for our own health, wealth, and happiness
- Jennifer_Smith
- 4 wk ago
- 25
- Self-Experimentation
mark t
I was wondering how you made your cream the 2mg in 4oz? 4oz of what? Thank you.
- curious
- curious
- 4 mths ago
- 6 replies
- 115
- chuck stanley4 wk ago
- Self-Experimentation
Paul's self experiment II
My original thread was hi-jacked so starting another Still taking rapamycin. Experimented with GDF11 and will take blood tests in Jan to see if it has had an effect Looking into peptides.…
- Paul Beauchemin
- Paul_Beauchemin
- 1 mth ago
- 79
- 1
- Self-Experimentation
Cosmetic Peptides
Anyone have experience with any of the (cosmetic) peptides on this site or equivalent? Tried the rapa cream formula suggested on the forum here with zero benefit.…
- Michael
- Michael.1
- 1 mth ago
- 32
- Self-Experimentation
Neutrophils, Lymphocytes, Monocytes: What’s Optimal For Health And Longevity?
For those who track their WBC differentials, here's my latest video about what's optimal for neutrophils, lymphocytes, and monocytes in terms of health and longevity: https://www.youtube.…
- michael lustgarten
- michael_lustgarten
- 1 mth ago
- 30
- 1
- Self-Experimentation
Can any meaningful conclusions of efficacy/harm ever be drawn form individual experience/"self experimentation"?
Hi. This post might irritate, but I mean well. It's prompted by a useful article I read this morning...about the nocebo effect with statin's. https://www.nejm.org/doi/full/10.…
- Steve Roedde
- Steve_Roedde
- 2 mths ago
- 22 replies
- 164
- John Mcgough1 mth ago
- Self-Experimentation
Finished the First 3 Protocol Steps
I an 72 and have been taking metformin (twice a day but recently increased to 3 times a day) for 5 years. I recently completed 6 patches of NAD+. I also have just taken 2 doses of quercetin and…
- Bernie
- Bernie_Singer
- 2 yrs ago
- 8 replies
- 356
- 4
- Ross Barker1 mth ago
- Self-Experimentation
HDL: What's Optimal For Minimizing Disease Risk And Maximizing Longevity?
Meta-analysis for the association between HDL with all-cause mortality risk has identified HDL levels 55 - 60 mg/dL range as optimal. However, that data includes subjects up to 85y-in the video,…
- michael lustgarten
- michael_lustgarten
- 2 mths ago
- 47
- 2
- Self-Experimentation
Tracking progress of my experiment
Hi everyone, I wanted to try a self experiment to see if diet and exercise had an effect on my biological age. It has been a while and I wanted to check my progress,…
- Dave A
- Dave_A
- 2 mths ago
- 5 replies
- 95
- Michael2 mths ago
- Self-Experimentation

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