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Self-Experimentation

Share your story of trying or designing a promising age-reversal protocol.

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Hello everyone, Many of us are self-experimenting in an effort to prolong our good health. In this sub-forum, we encourage you to share your own stories of what seems to be working for you.…
- Max Peto
- Researcher, website & forum admin
- Maximus
- 3 yrs ago
- 993
- 15
- Self-Experimentation
Melatonin - some thoughts
I find melatonin quite interesting not just for its sleep effects, but also for its other effects in terms of cellular health. Hence I have done a video about that.
- John Hemming
- John_Hemming
- 2 days ago
- 2 replies
- 35
- 2
- John Hemming21 hrs ago
- Self-Experimentation
Targeted clearance of senescent cells using an antibody-drug conjugate against a specific membrane marker
https://phys.org/news/2021-10-antibodies-cells-aging.html?fbclid=IwAR0VjejnoL7OXThHjznaImnlmyL-KTrRcSk3AZqlp_Fn5-cEOBXDJ7iQHww No one knows why some people age worse than others and develop diseases…
- Dan Nave
- Dan_Nave
- 5 days ago
- 2 replies
- 40
- Paul D Wolf3 days ago
- Self-Experimentation
Source of pyridoxamine?
Anybody have a source of pyridoxamine for anti-glycation self-experimentation? It is still sold in Europe as a supplement, but was banned in USA since it's being developed as a drug. Thanks
- David
- M.S. Nutrition
- Davin8r
- 12 days ago
- 14
- Self-Experimentation
Epidemiological Studies vs n=1: What's Optimal For Dietary Cholesterol?
https://www.youtube.com/watch?v=eQmPZiW72Yc
- michael lustgarten
- michael_lustgarten
- 2 wk ago
- 15
- Self-Experimentation
Improving Cellular Health and specifically Vitamin D
I have been doing quite a bit of self-experimentation with a view to improving my cellular health and trying to undo some of the damage that has been done to my cells over the years.…
- John Hemming
- John_Hemming
- 2 wk ago
- 31
- Self-Experimentation
My Rapamycin Experiment: Male / Early 30s / Non-US Based
Hi, So I'm currently at the early stages of experimenting with Rapamycin, and thought, if I'm going to take an experimental drug, I might as well document the process and see if it can benefit the…
- rapa_experimenter
- rapa_experimenter
- 2 wk ago
- 2 replies
- 67
- 1
- rapa_experimenter2 wk ago
- Self-Experimentation
Making sirolimus cream---Tried to grind a 2mg rapamune pill with a grinder and then dissolve in DMSO to put in cream.
My pill was not ground to a powder. DMSO did not seem to dissolve it but instead made it stick to container so I had little left to put in cream. I f you get a capsule of sirolimus to open will it…
- linda
- linda
- linda_
- 3 wk ago
- 3 replies
- 60
- Fred Cloud2 wk ago
- Self-Experimentation
Apigenin: An Alternative Way of Boosting NAD+
At the recent Ending Age-Related Diseases 2021 online conference, Dr. Eric Verdin of the Buck Institute gave a talk in which he described the mechanism behind the well-known drop in NAD+ with age,…
- JGC
- JGC
- 3 wk ago
- 15 replies
- 131
- 4
- Staffan Olsson2 wk ago
- Self-Experimentation
Attempting To Further Reduce Biological Age: hs-CRP
https://www.youtube.com/watch?v=0sUYtkiJEMs
- michael lustgarten
- michael_lustgarten
- 4 wk ago
- 29
- Self-Experimentation
Current longevity protocol: Should I add rapamycin?
This is my first post here, and I’m hoping to get some insights from people with similar protocols. In particular, I’m curious to hear people’s perspective on rapamycin given my current regimen.…
- Simon Smith
- Simon_Smith
- 1 mth ago
- 20 replies
- 204
- 2
- Ludovic Debels7 hrs ago
- Self-Experimentation
Help: Drastic results on DNA biological age test
Hi I’m a long time reader and first time poster. Advice needed please. I just received my results from myDNAGE which shows my biological age as 69 when my chrono age is 47.…
- Vega Rejuvinated
- Vega_Rejuvinated
- 1 mth ago
- 11 replies
- 226
- Adam Gibson3 wk ago
- Self-Experimentation
Rapamycin - progress so far
Hi all, About me: I'm 46 y.o. medical doctor based in Europe and started taking weekly rapamycin 4 months ago. I go to the gym regularly and am in average physical condition for a guy of my age.…
- George McMillan
- MD in Europe self-testing rapamycin
- George_Malcolm
- 2 mths ago
- 49 replies
- 878
- 2
- Spasov7 days ago
- Self-Experimentation
Scenescent fibroblasts
Hi - first post/new here. I've read with great interest about senolytics and I'm specifically looking for something that could target fibroblasts. I'd found extract of milk thistle flowers that is…
- Suzannah White
- Suzannah_White
- 2 mths ago
- 50
- Self-Experimentation
Interested in Self-experimentation Protocol
Hi Everyone, I'm new to this forum and would like to ask some questions. I apologise if these questions have been asked before, I did a search through the forum but could not find the answers.…
- Basil_dev
- Sonia_Devine
- 2 mths ago
- 84
- Self-Experimentation
Dietary CD38 Inhibitors: Are They Correlated With Biological Age?
https://www.youtube.com/watch?v=ESCIfQp7z-U
- michael lustgarten
- michael_lustgarten
- 2 mths ago
- 34
- Self-Experimentation
My story (your suggestions) Dr Arvind Poswal
Hi. I am new here. Would like to know your thoughts. I begin by detailing my major life health points. I think I am a good candidate for knowing the effects of many of the anti-ageing medicines.…
- Arvind Poswal
- Arvind_Poswal
- 3 mths ago
- 68
- 2
- Self-Experimentation
Photo evidence that the experiment is working
Correct me if I'm wrong. I figured that this deserves it's own discussion topic. More than 5 years ago I started doing age-reversal. Couple of years back when I realized that it was working I…
- Andrew P K Yap
- Andrew_P_K_Yap
- 3 mths ago
- 47 replies
- 636
- 3
- Andrew P K Yap10 hrs ago
- Self-Experimentation
Inflammation and time to change
I've often expressed skepticism at folks who take a supplement and are immediately convinced of its efficacy. I've been on a two year journey to reduce inflammation by reducing Omega 6 and…
- Paul Beauchemin
- Paul_Beauchemin
- 3 mths ago
- 94
- 1
- Self-Experimentation
HGLA and GLA as Senolytics
In an interview posted online by Tufts Now , Dr. Christopher Wiley of Tufts University describes his discovery that dihomo-gamma-linoleic acid (DGLA) is a powerful senolytic.…
- JGC
- JGC
- 3 mths ago
- 3 replies
- 128
- chuck stanley6 days ago
- Self-Experimentation
Ziconotide sources?
Thank you
- Michael
- Michael.1
- 3 mths ago
- 28
- Self-Experimentation
Longevity Achieved
Recently received my results on my biological age. To my surprise, my biological age is 15. The process to get to this point was difficult. My formula has proven itself over and over.…
- Richard Brook
- Richard_Brook
- 3 mths ago
- 36 replies
- 662
- 1
- chuck stanley4 wk ago
- Self-Experimentation
Replacing Hormones to Optimal Levels
I’ve been experimenting with exogenous testosterone for over 15 years. At almost 73 I have been able to build and keep muscle. I eat a diet high in protein, lower in carbs and healthy fats.…
- Sharon Smith
- Sharon_Smith
- 3 mths ago
- 27 replies
- 455
- 4
- Arizona Kid1 mth ago
- Self-Experimentation
Aspartate Aminotransferase: What's Optimal, And Can It Be Improved?
https://www.youtube.com/watch?v=EO-dB0Hhg20 Papers referenced in the video : Loss of Life Expectancy by 10 Years or More From Elevated Aspartate Aminotransferase:…
- michael lustgarten
- michael_lustgarten
- 3 mths ago
- 14
- Self-Experimentation
Anyone actually experience marked increased energy from NMN?
It's been 2 years now - sublingual. Nothing. I'm ready to throw it in the box with the resveratrol and rapamycin. Please leave your experiences and types/doses as well as how you can differentiate…
- Michael
- Michael.1
- 3 mths ago
- 10 replies
- 374
- Michael3 wk ago
- Self-Experimentation
Wynn Protocol
Hi everyone, here is a link to my protocol, the "Wynn Protocol". I've 42 years old. My last phenotypic age was -16 years. I'm 5'10" 156 pounds. I've taken a lot of supplements and I've also stopped…
- Jimmy2
- Jimmy2
- 4 mths ago
- 7 replies
- 198
- 2
- Jimmy211 days ago
- Self-Experimentation

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