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Re: TERT and its Activator TAC
Nowadays, the activity in this forum is low. That is an interesting find. I am afraid the chance of finding someone here who can provide the information you ask for is rather slim.…
- Staffan_Olsson
- 1 yr ago
- 1
- Self-Experimentation
- Reported - view
Re: Fisetin experimentation one year (reposted as topic for info purposes)
@Brian Valerie Piperlongumine is fascinating. Piperlongumine promotes autophagy via inhibition of Akt/mTOR signalling and mediates cancer cell death - PMC (nih.…
- Staffan_Olsson
- 1 yr ago
- 2
- Senolytics Discussion
- Reported - view
Re: Senolytics and Female Fertility
@Self Hacker Lynn are you still here? There has been quite a bit of research (mostly in vitro) that shows that myricetin, Quercetin and Fisetin can inhibit mTOR.…
- Staffan_Olsson
- 1 yr ago
- Senolytics Discussion
- Reported - view
Re: Thymus aging mitigation strategies
@Moonlitnight A very long interview, but full of the most up-to-date information about rapamycin. At 1.26.40 they talk about the rejuvenation of the immune system.…
- Staffan_Olsson
- 1 yr ago
- 1
- Thymus Regeneration
- Reported - view
Re: Thymus aging mitigation strategies
@Moonlitnight . Most research indicate that mTOR inhibition is a way to improve the function of the immune system in older persons. that is done by taking low dose once a week. (5 mg) https://www.…
- Staffan_Olsson
- 1 yr ago
- 1
- Thymus Regeneration
- Reported - view
Re: Thymus aging mitigation strategies
@Moonlitnight Have you considered Rapamycin for immune senescence?
- Staffan_Olsson
- 1 yr ago
- Thymus Regeneration
- Reported - view
Re: Fisetin experimentation one year (reposted as topic for info purposes)
@Dean W. I mix the fisetin in a shot, 3-4 cl, of oil (Olive or canola). I get the Pfizer's rapamune prescribed by a doctor. ( if you live in Europe, that is a potential option in a few countries).…
- Staffan_Olsson
- 1 yr ago
- Senolytics Discussion
- Reported - view
Re: Fisetin experimentation one year (reposted as topic for info purposes)
@Dean W. I take the fisetin, the very first I do in the morning, on empty an stomach.
- Staffan_Olsson
- 1 yr ago
- Senolytics Discussion
- Reported - view
Re: Fisetin experimentation one year (reposted as topic for info purposes)
@Brian Valerie The effects I got the two years before rapamycin were remarkable. I still get effects from intermittent treatment with large doses of fisetin, but not as pronounced as before .…
- Staffan_Olsson
- 1 yr ago
- 1
- Senolytics Discussion
- Reported - view
Re: Fisetin experimentation one year (reposted as topic for info purposes)
@Dean W. Yes, I open up every capsule and mix the fisetin with oil. I think the effect might depend on each person's individual burden of senescent cells.
- Staffan_Olsson
- 1 yr ago
- Senolytics Discussion
- Reported - view
Re: Fisetin experimentation one year (reposted as topic for info purposes)
@Brian Valerie I get different effects from different brands of Fisetin supplements. I get a strong effect when I use Dr's best fisetin 30mg/Kg body weight mixed with oliveoil and taken 1 hour after…
- Staffan_Olsson
- 1 yr ago
- 1
- Senolytics Discussion
- Reported - view
Re: Fisetin and Sleep
@Moonlitnight If I wake up in the middle of the night I take 1 - 3 gr taurine. It does not provaide an immidate effect. It is like I am slowly drifting back to sleep, during 30 min or so.
- Staffan_Olsson
- 1 yr ago
- 1
- Self-Experimentation
- Reported - view
Re: Has anyone tried taking fietin as a suppository?
@Michael_123 I am sorry but I can only speculate about how the anal route differs from the oral route. When it comes to using suppositories to aid substances to reach reach the prostate, colon, etc.…
- Staffan_Olsson
- 2 yrs ago
- Senolytics Discussion
- Reported - view
Re: Intermittent dosing
You raise an important aspect on supplementation. When we take pharmaceuticals we know that the risk of negative interactions (side effects) go up with the number of medicines we take.…
- Staffan_Olsson
- 2 yrs ago
- General Discussion
- Reported - view
Re: Glycine + N-Acetyl Cysteine Supplementation Increases Lifespan
Is there a treshold effect when using NAC on compromised levels of glutathione and for inhibition of mTOR? Since some persons (like Dr brad Stanfield) promote the view that the amount of NAC-Glycine…
- Staffan_Olsson
- 2 yrs ago
- 1
- General Discussion
- Reported - view
Re: Norvaline
@chuck stanley Norvaline has several interesting effects that is related to antiaging and to disease prevention. And yes I have also seen what is written in medical express.…
- Staffan_Olsson
- 2 yrs ago
- 1
- Questions & Answers
- Reported - view
Norvaline

Does anybody here have experience from the use of Norvaline? in that case did you notice any cognitive effects? https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6557086/
- Staffan_Olsson
- 2 yrs ago
- 2replies
- 108
- Questions & Answers
- Answered
- Answered
Re: Webinars - Lifespan - Healthpan etc
Here is a link to his fascinating presentation, quite short but comprehensive about the ongoing ITP research. Drugs that slow ageing in mice | Prof Richard A.…
- Staffan_Olsson
- 2 yrs ago
- 1
- General Discussion
- Reported - view
Webinars - Lifespan - Healthpan etc

You can register here to participate on webinars from Singapore. Next up is Prof Richard MIller, Leader of the ITP lab. The host of the week is Brian Kennedy.…
- Staffan_Olsson
- 2 yrs ago
- 1reply
- 38
- General Discussion
Re: Taurine in general health as well as in mitochondrial health
@Staffan Olsson @michael lustgarten Taurine is used in many PWO products. In my self-experimentation with taurine I have evaluated its effect on exercise capacity.…
- Staffan_Olsson
- 2 yrs ago
- 2
- Ideas
- Reported - view
Re: Photo evidence that the experiment is working
@Andrew P K Yap Thank you for publicly documenting your journey with pictures. I wonder how you would describe your experience with words? What are the biological and psychological differences you…
- Staffan_Olsson
- 2 yrs ago
- Self-Experimentation
- Reported - view
Re: Taurine in general health as well as in mitochondrial health
Three papers focusing on Taurine and its potential effects on health and longevity. The Role of Taurine in Mitochondria Health: More Than Just an Antioxidant - PMC (nih.…
- Staffan_Olsson
- 2 yrs ago
- 1
- Ideas
- Reported - view
Taurine in general health as well as in mitochondrial health

Taurine is a supplement that deserve more attention from the antiaging community, and I wish the ITP program could test Taurine’s effects on aging. Taurine has many interesting effects.…
- Staffan_Olsson
- 2 yrs ago
- 4replies
- 146
- Ideas
2022 ARDD videos now available

The videos from this years (2022) "Aging research and drug discovery meeting" is now available. Some really good ones. https://www.youtube.com/channel/UClOnplI2mzpJlwdX3vlOMJA/videos
- Staffan_Olsson
- 2 yrs ago
- 33
- 1
- General Discussion
Re: Introduction to senolytics
First link: Here is is a very informative update about senescence and the potential of senolytic therapies. By Prof James Kirkland. He starts his talk at 45 min and 50 sec.…
- Staffan_Olsson
- 2 yrs ago
- Senolytics Discussion
- Reported - view

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