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Re: Rapamycin vs Metformin @Karl Withaferin is usually not sold pure. It is usually sold as ashwagandha extracts. KSM-66 and sensoril are well known standardized extracts.
- Staffan Olsson
- Staffan_Olsson
- 7 days ago
- AMPK Activation
- Reported - view
Re: Rapamycin vs Metformin @Christine @Dan Hi! Since this thread is about metformin and rapamycin I decided to post this link here. https://www.aging-us.com/article/101319/text#fulltext It is a link to research based on AI.…
- Staffan Olsson
- Staffan_Olsson
- 7 days ago
- 1
- AMPK Activation
- Reported - view
Re: Bill Faloon's Recent Blood Test Results @laryk5 @Self Hacker Lynn @David C I have read Bill Faloon’s mail about the positive changes he see in his recent labtests and I notice his experience of feeling rejuvenated after treatments with…
- Staffan Olsson
- Staffan_Olsson
- 8 days ago
- 1
- Test Results Discussions
- Reported - view
Re: Green tea and green tea extracts @Larry Hi Larry! I read this report from MIT and I think that maybe it also can be interesting to you. The report is about TGF signalling and how it can effect senescense and aging.…
- Staffan Olsson
- Staffan_Olsson
- 12 days ago
- 1
- Self-Experimentation
- Reported - view
Re: How to increase the bioavailability of Fisetin @David Hanson I agree they only test a fraction of what is available. But when learning about a new brand selling products in new formulations, then one want to have some proof of their concept.…
- Staffan Olsson
- Staffan_Olsson
- 2 wk ago
- Self-Experimentation
- Reported - view
Re: How to increase the bioavailability of Fisetin @JGC I have checked out nature's essentials line of products. I hesitate to try them until they have been tested by a third party. I sometimes check what https://www.consumerlab.…
- Staffan Olsson
- Staffan_Olsson
- 2 wk ago
- Self-Experimentation
- Reported - view
Re: How to increase the bioavailability of Fisetin @JGC The cell metabolism in the human body is very complex and the complexity makes it , as we all know, difficult to create specific and effective interventions.…
- Staffan Olsson
- Staffan_Olsson
- 2 wk ago
- Self-Experimentation
- Reported - view
Re: Rapamycin Cost @BobM There is a listed company in Bangladesh called Beacon Pharmaceuticals Limited. They claim to distribute dasatinib to all corners of the world, (through direct selling).…
- Staffan Olsson
- Staffan_Olsson
- 2 wk ago
- Self-Experimentation
- Reported - view
Re: How to increase the bioavailability of Fisetin @JGC Regarding your discussion regarding about the bioavailability of polyphenols. (In the resveratrol thread). I have done two experiments with fisetin using homemade rectal suppositories.…
- Staffan Olsson
- Staffan_Olsson
- 2 wk ago
- Self-Experimentation
- Reported - view
Re: Resveratrol -- value, dose, source? @JGC Thank you for bringing many attention to this. So obvious that it is deceptive. Now when I look at the pictures, non of them show the full label.
- Staffan Olsson
- Staffan_Olsson
- 2 wk ago
- Self-Experimentation
- Reported - view
Ursolic acid
I am curious about this substance - Ursolic acid. I wonder if there are people in here that have first hand experience from the use of Ursolic acid. I post a link to a review from 2018.…
- Staffan Olsson
- Staffan_Olsson
- 2 wk ago
- 29
- Self-Experimentation
Re: Resveratrol -- value, dose, source? @David Hanson This company is also selling Fisetin in 500 mg capsules. I have never bought any of their products but I am glad that someone is bringing 500 mg capsules of Fisetin to market.…
- Staffan Olsson
- Staffan_Olsson
- 3 wk ago
- Self-Experimentation
- Reported - view
Re: Newbie here! @EVH EVH Hi! May I ask what dose you plan to take? There are people taking 250 mg quercetin phytosome daily. Which might be the equivalent of up to 5000 mg regular quercetin.…
- Staffan Olsson
- Staffan_Olsson
- 1 mth ago
- General Discussion
- Reported - view
Re: The "Reprogramming" of Aging Cells @Robert Reny Here is another comment on this interesting research. https://www.leafscience.org/blood-proteins-can-show-how-old-you-really-are/
- Staffan Olsson
- Staffan_Olsson
- 1 mth ago
- General Discussion
- Reported - view
Re: AMPK activation - RAADFest 2019 slide Hi, Gynostemma Pentaphyllum leaves for tea is easily bought online. I think you will find it in the parmacies as well. I have only bought gynostemma tea online.…
- Staffan Olsson
- Staffan_Olsson
- 1 mth ago
- AMPK Activation
- Reported - view
Re: A different point of view @Karl yes right now we focus a lot of attention to senolytics, AMPK activationn NAD replacement. I guess that is because we have got resaech from those fields that seam rather easy to translate into…
- Staffan Olsson
- Staffan_Olsson
- 1 mth ago
- Senolytics Discussion
- Reported - view
Re: Sulfuraphane Interesting question. I don't think there is a clear answer to it. I can say that some senolytic substances and the apoptosis they generate is depending on ROS (reactive oxidant species).…
- Staffan Olsson
- Staffan_Olsson
- 1 mth ago
- Senolytics Discussion
- Reported - view
Re: How to increase the bioavailability of Fisetin I found this report from 2016. Some are obviously trying to increase bioavailability through nanoencapsulation. I hope someone soon has an efficient route for placing fisetin in the bloodstream.…
- Staffan Olsson
- Staffan_Olsson
- 1 mth ago
- 1
- Self-Experimentation
- Reported - view
Re: A different point of view Yes, I agree . These are opposing views. But this is how science move forward. Senolytics and elimination of senescent cells or rejuvenation through moving old cells into a more youthful state. “Dr.…
- Staffan Olsson
- Staffan_Olsson
- 1 mth ago
- 1
- Senolytics Discussion
- Reported - view
Re: Berberine @Karl I do not know if they can be taken together. But here is a comparison between metformin and berberine. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5839379/
- Staffan Olsson
- Staffan_Olsson
- 1 mth ago
- AMPK Activation
- Reported - view
Re: Berberine I would like to mention that I each day take curcumin, quercetin, and green tea (drinking it as well as capsules). Those might contribute to weightloss.
- Staffan Olsson
- Staffan_Olsson
- 1 mth ago
- 2
- AMPK Activation
- Reported - view
Re: Introduction to senolytics @Karl To get the senolytic effect you need to reach a threshold. if under that threshold level you might have other positive effects but not very much of the senolytic effect.…
- Staffan Olsson
- Staffan_Olsson
- 1 mth ago
- 2
- Senolytics Discussion
- Reported - view
Re: Berberine I have used AMPK activator (life extension) one pill per day for two months and then I have used Berberine 500 mg once or twice a day (thorne product) for two months. Now I am back on AMPK activator.…
- Staffan Olsson
- Staffan_Olsson
- 1 mth ago
- 3
- AMPK Activation
- Reported - view
Re: Fiestin to Clear Senescent Cells @John W When using fisetin as a geroneuroprotector, most humans would need to take at least 150 - 200 mg fisetin daily. this based on to the above posted link and according to a basic dose…
- Staffan Olsson
- Staffan_Olsson
- 1 mth ago
- Self-Experimentation
- Reported - view
Re: Fiestin to Clear Senescent Cells @John W When it comes to translate the animal doses that is used in experiments it is a science of itself. Difference in size as well as differences in metabolism.…
- Staffan Olsson
- Staffan_Olsson
- 1 mth ago
- 1
- Self-Experimentation
- Reported - view

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