Skip to main content

Age Reversal Forum

Latest Posts

Re: Fisetin to Clear Senescent Cells
@karl kuffner Karl, The clinical trial that is directed by James Kirkland at the Mayo Clinic uses 20 mg/kg on two consecutive days. That brings us to 2000 mg for a 100 kg person.…
- Staffan_Olsson
- 6 yrs ago
- Self-Experimentation
- Reported - view
Re: Fisetin to Clear Senescent Cells
@JGC No, I have not taken CRP test before the senolytic experiments.
- Staffan_Olsson
- 6 yrs ago
- Self-Experimentation
- Reported - view
Re: Fisetin to Clear Senescent Cells
@JGC that is a reasonable theory. For now my reasoning is that high doses of quercetin reduces whole body inflammation or reduce organspecific inflammation.…
- Staffan_Olsson
- 6 yrs ago
- 2
- Self-Experimentation
- Reported - view
Re: Fisetin to Clear Senescent Cells
@BobM I like to give this link to you. it explains the issues surrounding green tea research. And it explains why I put more value on forwardlooking research done by tracking real people over time,…
- Staffan_Olsson
- 6 yrs ago
- Self-Experimentation
- Reported - view
Re: Fisetin to Clear Senescent Cells
@BobM Yes this kind of articles are tough reads, Indeed very tough. regarding human dosing of EGCG and cancerprevention/treatment I have found this article. https://www.ncbi.nlm.nih.…
- Staffan_Olsson
- 6 yrs ago
- Self-Experimentation
- Reported - view
Re: Fisetin to Clear Senescent Cells
@Dan Nave So far I have learned that I get a rather strong feel good effect from senolytic activator. Especially when I take it with extra quercetin. An effect that lasts 2-3 days.…
- Staffan_Olsson
- 6 yrs ago
- 1
- Self-Experimentation
- Reported - view
Re: How to increase the bioavailability of Fisetin
@Dan Nave @Dan Nave Today I had my first dose of fisetin. To enhance bioavailability I made my own PHOSAL (I mixed 50% phosphatidylcholine with 50% propylene glycol) and then I added Polyethylene…
- Staffan_Olsson
- 6 yrs ago
- 1
- Self-Experimentation
- Reported - view
Re: Fisetin to Clear Senescent Cells
@Dan Nave I have to correct myself. The study that I had in mind before is not about tissue concentrations. It is about synergies, it's about how quercetin synergizes with epigallocathechin gallate…
- Staffan_Olsson
- 6 yrs ago
- 1
- Self-Experimentation
- Reported - view
Re: Fisetin to Clear Senescent Cells
@Dan Nave I am also a bit reluctant to use PG, PEG. But will go for it when I start my fisetin experiment. By the way I want to inform you about a research I read the other day.…
- Staffan_Olsson
- 6 yrs ago
- Self-Experimentation
- Reported - view
Re: Fisetin to Clear Senescent Cells
@BobM Hi Bob! My body weight is 77-78 kg. I have gradually incresed the dosing and along the way I have added more substances. (curcumin, tocotrienols and piperlongum) During my most recent…
- Staffan_Olsson
- 6 yrs ago
- 1
- Self-Experimentation
- Reported - view
Re: Fisetin to Clear Senescent Cells
@karl kuffner I used avocado oil. When I take senolytic doses of fisetin I will use the same mix as in the original research. " 100 mg/kg of fisetin in 60% Phosal 50 PG:30% PEG400:10% ethanol".…
- Staffan_Olsson
- 6 yrs ago
- Self-Experimentation
- Reported - view
Re: Fisetin to Clear Senescent Cells
@Dan Nave Hi Dave! I am doing this step by step. First, I took senility activator double dose on two consecutive days. I felt good during those two days and I also felt good a few days after.…
- Staffan_Olsson
- 6 yrs ago
- 3
- Self-Experimentation
- Reported - view
Re: Fisetin ( + quercitin)
@HD @Rob8311 This is a late response but I find this "simple practice guide for dose conversion between animals and human"educational and useful. https://www.ncbi.nlm.nih.…
- Staffan_Olsson
- 6 yrs ago
- Senolytics Discussion
- Reported - view
Re: 'Increased NAD+ metabolism may enhance secretory activity of senescent cells in a way that promotes tumor progression'
the first logical step is to fokus on removing senescent cells before starting NAD+ therapy. it is senescent cell that "may" promote cancer proliferation. (At least in in vivo mouse models).…
- Staffan_Olsson
- 6 yrs ago
- 2
- NAD+ Restoration
- Reported - view
Re: How to increase the bioavailability of Fisetin
@Paul Tozour @JGC @Jesper de Meeuw I am also trying to find ways to increase bioavailability of Fisetin besides spculative use of oil and piperine. I am thinking of ordering liquid…
- Staffan_Olsson
- 6 yrs ago
- 2
- Self-Experimentation
- Reported - view
Re: Fisetin to Clear Senescent Cells
@Dan Nave Hi Dan! How are you doing? Regarding curcumin and its role as anti-ageing agent. Senolytic or not? I read this article and I like to share it.…
- Staffan_Olsson
- 6 yrs ago
- 1
- Self-Experimentation
- Reported - view
Re: Fisetin to Clear Senescent Cells
@Antonia Gauer @Iðunn Tocotrienols show, like many other substances, potential for reducing risk for various diseases. I look forward to see what the future will hold for tocotrienols. https://www.…
- Staffan_Olsson
- 6 yrs ago
- 1
- Self-Experimentation
- Reported - view
Re: Fisetin to Clear Senescent Cells
@Antonia Gauer Maybe these links can help you to find useful references about tocotrienols? https://www.ncbi.nlm.nih.gov/pubmed/26343116 https://www.ncbi.nlm.nih.gov/pubmed/30479579
- Staffan_Olsson
- 6 yrs ago
- 2
- Self-Experimentation
- Reported - view
Re: Fisetin to Clear Senescent Cells
@Iðunn if, like its said in this thread, the structure of fisetin and quercetin is very close to each other they might just as well end up competing for transporters.…
- Staffan_Olsson
- 6 yrs ago
- 1
- Self-Experimentation
- Reported - view
Ferulic acid

How to use ferulic acid and where to buy ferulic acid as supplement for oral use? My plan is to try Ferulic acid and EGCG (Green tea). My aim for this experiment is to see if this combo can clear…
- Staffan_Olsson
- 6 yrs ago
- 1reply
- 99
- Self-Experimentation
Re: Fisetin to Clear Senescent Cells
@Iðunn Thank you for the reminder. We are in uncharterd territory here, but that the territorry where selfexperimentation usually is.
- Staffan_Olsson
- 6 yrs ago
- Self-Experimentation
- Reported - view
Re: Fisetin to Clear Senescent Cells
@Don I plan to dissolve it with oil. Avaocado oil is my first choice. I try to incorporate more avacado oil in my lifestyle (mostly on salads) so it might just as well be used as a dissolvent to.…
- Staffan_Olsson
- 6 yrs ago
- Self-Experimentation
- Reported - view
Re: Fisetin to Clear Senescent Cells
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6197652/ The original study bring forward some ideas. The reserchers show that curcumin is one of the few substances (besides fisetin) that have a proven…
- Staffan_Olsson
- 6 yrs ago
- 1
- Self-Experimentation
- Reported - view
Re: Peripheral neuropathy?
@Staffan Olsson I forgot the most important word. Google " Periferal neuropathy and benafotiamine".
- Staffan_Olsson
- 6 yrs ago
- General Discussion
- Reported - view
Re: Peripheral neuropathy?
I can recommend to google "Periferal Neurpathy" and then make an informed choice if that is something for you try.
- Staffan_Olsson
- 6 yrs ago
- General Discussion
- Reported - view

1 6 7 8 9 10 11 12

Back to top

Forum Home

- Questions & Answers
- Ideas

View all topics