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Re: How to increase the bioavailability of Fisetin
@JGC I have checked out nature's essentials line of products. I hesitate to try them until they have been tested by a third party. I sometimes check what https://www.consumerlab.…
- Staffan_Olsson
- 5 yrs ago
- Self-Experimentation
- Reported - view
Re: How to increase the bioavailability of Fisetin
@JGC The cell metabolism in the human body is very complex and the complexity makes it , as we all know, difficult to create specific and effective interventions.…
- Staffan_Olsson
- 5 yrs ago
- Self-Experimentation
- Reported - view
Re: Rapamycin Cost
@BobM There is a listed company in Bangladesh called Beacon Pharmaceuticals Limited. They claim to distribute dasatinib to all corners of the world, (through direct selling).…
- Staffan_Olsson
- 5 yrs ago
- Self-Experimentation
- Reported - view
Re: How to increase the bioavailability of Fisetin
@JGC Regarding your discussion regarding about the bioavailability of polyphenols. (In the resveratrol thread). I have done two experiments with fisetin using homemade rectal suppositories.…
- Staffan_Olsson
- 5 yrs ago
- Self-Experimentation
- Reported - view
Re: Resveratrol -- value, dose, source?
@JGC Thank you for bringing many attention to this. So obvious that it is deceptive. Now when I look at the pictures, non of them show the full label.
- Staffan_Olsson
- 5 yrs ago
- Self-Experimentation
- Reported - view
Ursolic acid

I am curious about this substance - Ursolic acid. I wonder if there are people in here that have first hand experience from the use of Ursolic acid. I post a link to a review from 2018.…
- Staffan_Olsson
- 5 yrs ago
- 65
- Self-Experimentation
Re: Resveratrol -- value, dose, source?
@David Hanson This company is also selling Fisetin in 500 mg capsules. I have never bought any of their products but I am glad that someone is bringing 500 mg capsules of Fisetin to market.…
- Staffan_Olsson
- 5 yrs ago
- Self-Experimentation
- Reported - view
Re: Newbie here!
@EVH EVH Hi! May I ask what dose you plan to take? There are people taking 250 mg quercetin phytosome daily. Which might be the equivalent of up to 5000 mg regular quercetin.…
- Staffan_Olsson
- 5 yrs ago
- General Discussion
- Reported - view
Re: The "Reprogramming" of Aging Cells
@Robert Reny Here is another comment on this interesting research. https://www.leafscience.org/blood-proteins-can-show-how-old-you-really-are/
- Staffan_Olsson
- 5 yrs ago
- General Discussion
- Reported - view
Re: AMPK activation - RAADFest 2019 slide
Hi, Gynostemma Pentaphyllum leaves for tea is easily bought online. I think you will find it in the parmacies as well. I have only bought gynostemma tea online.…
- Staffan_Olsson
- 5 yrs ago
- AMPK Activation
- Reported - view
Re: A different point of view
@Karl yes right now we focus a lot of attention to senolytics, AMPK activationn NAD replacement. I guess that is because we have got resaech from those fields that seam rather easy to translate into…
- Staffan_Olsson
- 5 yrs ago
- Senolytics Discussion
- Reported - view
Re: Sulfuraphane
Interesting question. I don't think there is a clear answer to it. I can say that some senolytic substances and the apoptosis they generate is depending on ROS (reactive oxidant species).…
- Staffan_Olsson
- 5 yrs ago
- 1
- Senolytics Discussion
- Reported - view
Re: How to increase the bioavailability of Fisetin
I found this report from 2016. Some are obviously trying to increase bioavailability through nanoencapsulation. I hope someone soon has an efficient route for placing fisetin in the bloodstream.…
- Staffan_Olsson
- 5 yrs ago
- 1
- Self-Experimentation
- Reported - view
Re: A different point of view
Yes, I agree . These are opposing views. But this is how science move forward. Senolytics and elimination of senescent cells or rejuvenation through moving old cells into a more youthful state. “Dr.…
- Staffan_Olsson
- 5 yrs ago
- 1
- Senolytics Discussion
- Reported - view
Re: Berberine
@Karl I do not know if they can be taken together. But here is a comparison between metformin and berberine. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5839379/
- Staffan_Olsson
- 5 yrs ago
- AMPK Activation
- Reported - view
Re: Berberine
I would like to mention that I each day take curcumin, quercetin, and green tea (drinking it as well as capsules). Those might contribute to weightloss.
- Staffan_Olsson
- 5 yrs ago
- 2
- AMPK Activation
- Reported - view
Re: Introduction to senolytics
@Karl To get the senolytic effect you need to reach a threshold. if under that threshold level you might have other positive effects but not very much of the senolytic effect.…
- Staffan_Olsson
- 5 yrs ago
- 2
- Senolytics Discussion
- Reported - view
Re: Berberine
I have used AMPK activator (life extension) one pill per day for two months and then I have used Berberine 500 mg once or twice a day (thorne product) for two months. Now I am back on AMPK activator.…
- Staffan_Olsson
- 5 yrs ago
- 4
- AMPK Activation
- Reported - view
Re: Fisetin to Clear Senescent Cells
@John W When using fisetin as a geroneuroprotector, most humans would need to take at least 150 - 200 mg fisetin daily. this based on to the above posted link and according to a basic dose…
- Staffan_Olsson
- 5 yrs ago
- Self-Experimentation
- Reported - view
Re: Fisetin to Clear Senescent Cells
@John W When it comes to translate the animal doses that is used in experiments it is a science of itself. Difference in size as well as differences in metabolism.…
- Staffan_Olsson
- 5 yrs ago
- 1
- Self-Experimentation
- Reported - view
Re: Fisetin to Clear Senescent Cells
@John W When I translate the doses used on mice it quals a daily dose for humans of 2 mg/kg.
- Staffan_Olsson
- 5 yrs ago
- 1
- Self-Experimentation
- Reported - view
Re: Antioxidants and Dasatinib regimen
There is research showing that some senolytic substances works through ROS activated apoptosis. But here are also pathways to senolysis that are ROS independent.…
- Staffan_Olsson
- 5 yrs ago
- 1
- Questions & Answers
- Reported - view
Re: Fisetin to Clear Senescent Cells
For those interested in dosing of chlorogenic acid. They studied the metabolism of chlorogenic acid by giving 2000 mg to the participants. So that (2000 mg) is defintely a tolerable dose.…
- Staffan_Olsson
- 5 yrs ago
- 1
- Self-Experimentation
- Reported - view
Re: Senolytics and Female Fertility
@Self Hacker Lynn Hi again. I wonder if you can share how much fisetin, quercetin and myricetin you take. And also what the brands are. I ask this question just beacuase there are a few different…
- Staffan_Olsson
- 5 yrs ago
- Senolytics Discussion
- Reported - view
Re: Senolytics and Female Fertility
@Self Hacker Lynn Thank you for sharing your thinking about myricetin. Myricetin is something I will add to my regim later. it seams to be a promising geroprotector.…
- Staffan_Olsson
- 5 yrs ago
- Senolytics Discussion
- Reported - view

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