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Re: How to increase the bioavailability of Fisetin @JGC I have checked out nature's essentials line of products. I hesitate to try them until they have been tested by a third party. I sometimes check what https://www.consumerlab.…
- Staffan Olsson
- Staffan_Olsson
- 4 yrs ago
- Self-Experimentation
- Reported - view
Re: How to increase the bioavailability of Fisetin @JGC The cell metabolism in the human body is very complex and the complexity makes it , as we all know, difficult to create specific and effective interventions.…
- Staffan Olsson
- Staffan_Olsson
- 4 yrs ago
- Self-Experimentation
- Reported - view
Re: Rapamycin Cost @BobM There is a listed company in Bangladesh called Beacon Pharmaceuticals Limited. They claim to distribute dasatinib to all corners of the world, (through direct selling).…
- Staffan Olsson
- Staffan_Olsson
- 4 yrs ago
- Self-Experimentation
- Reported - view
Re: How to increase the bioavailability of Fisetin @JGC Regarding your discussion regarding about the bioavailability of polyphenols. (In the resveratrol thread). I have done two experiments with fisetin using homemade rectal suppositories.…
- Staffan Olsson
- Staffan_Olsson
- 4 yrs ago
- Self-Experimentation
- Reported - view
Re: Resveratrol -- value, dose, source? @JGC Thank you for bringing many attention to this. So obvious that it is deceptive. Now when I look at the pictures, non of them show the full label.
- Staffan Olsson
- Staffan_Olsson
- 4 yrs ago
- Self-Experimentation
- Reported - view
Ursolic acid
I am curious about this substance - Ursolic acid. I wonder if there are people in here that have first hand experience from the use of Ursolic acid. I post a link to a review from 2018.…
- Staffan Olsson
- Staffan_Olsson
- 4 yrs ago
- 64
- Self-Experimentation
Re: Resveratrol -- value, dose, source? @David Hanson This company is also selling Fisetin in 500 mg capsules. I have never bought any of their products but I am glad that someone is bringing 500 mg capsules of Fisetin to market.…
- Staffan Olsson
- Staffan_Olsson
- 4 yrs ago
- Self-Experimentation
- Reported - view
Re: Newbie here! @EVH EVH Hi! May I ask what dose you plan to take? There are people taking 250 mg quercetin phytosome daily. Which might be the equivalent of up to 5000 mg regular quercetin.…
- Staffan Olsson
- Staffan_Olsson
- 4 yrs ago
- General Discussion
- Reported - view
Re: The "Reprogramming" of Aging Cells @Robert Reny Here is another comment on this interesting research. https://www.leafscience.org/blood-proteins-can-show-how-old-you-really-are/
- Staffan Olsson
- Staffan_Olsson
- 4 yrs ago
- General Discussion
- Reported - view
Re: AMPK activation - RAADFest 2019 slide Hi, Gynostemma Pentaphyllum leaves for tea is easily bought online. I think you will find it in the parmacies as well. I have only bought gynostemma tea online.…
- Staffan Olsson
- Staffan_Olsson
- 4 yrs ago
- AMPK Activation
- Reported - view
Re: A different point of view @Karl yes right now we focus a lot of attention to senolytics, AMPK activationn NAD replacement. I guess that is because we have got resaech from those fields that seam rather easy to translate into…
- Staffan Olsson
- Staffan_Olsson
- 4 yrs ago
- Senolytics Discussion
- Reported - view
Re: Sulfuraphane Interesting question. I don't think there is a clear answer to it. I can say that some senolytic substances and the apoptosis they generate is depending on ROS (reactive oxidant species).…
- Staffan Olsson
- Staffan_Olsson
- 4 yrs ago
- 1
- Senolytics Discussion
- Reported - view
Re: How to increase the bioavailability of Fisetin I found this report from 2016. Some are obviously trying to increase bioavailability through nanoencapsulation. I hope someone soon has an efficient route for placing fisetin in the bloodstream.…
- Staffan Olsson
- Staffan_Olsson
- 4 yrs ago
- 1
- Self-Experimentation
- Reported - view
Re: A different point of view Yes, I agree . These are opposing views. But this is how science move forward. Senolytics and elimination of senescent cells or rejuvenation through moving old cells into a more youthful state. “Dr.…
- Staffan Olsson
- Staffan_Olsson
- 4 yrs ago
- 1
- Senolytics Discussion
- Reported - view
Re: Berberine @Karl I do not know if they can be taken together. But here is a comparison between metformin and berberine. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5839379/
- Staffan Olsson
- Staffan_Olsson
- 4 yrs ago
- AMPK Activation
- Reported - view
Re: Berberine I would like to mention that I each day take curcumin, quercetin, and green tea (drinking it as well as capsules). Those might contribute to weightloss.
- Staffan Olsson
- Staffan_Olsson
- 4 yrs ago
- 2
- AMPK Activation
- Reported - view
Re: Introduction to senolytics @Karl To get the senolytic effect you need to reach a threshold. if under that threshold level you might have other positive effects but not very much of the senolytic effect.…
- Staffan Olsson
- Staffan_Olsson
- 4 yrs ago
- 2
- Senolytics Discussion
- Reported - view
Re: Berberine I have used AMPK activator (life extension) one pill per day for two months and then I have used Berberine 500 mg once or twice a day (thorne product) for two months. Now I am back on AMPK activator.…
- Staffan Olsson
- Staffan_Olsson
- 4 yrs ago
- 4
- AMPK Activation
- Reported - view
Re: Fisetin to Clear Senescent Cells @John W When using fisetin as a geroneuroprotector, most humans would need to take at least 150 - 200 mg fisetin daily. this based on to the above posted link and according to a basic dose…
- Staffan Olsson
- Staffan_Olsson
- 4 yrs ago
- Self-Experimentation
- Reported - view
Re: Fisetin to Clear Senescent Cells @John W When it comes to translate the animal doses that is used in experiments it is a science of itself. Difference in size as well as differences in metabolism.…
- Staffan Olsson
- Staffan_Olsson
- 4 yrs ago
- 1
- Self-Experimentation
- Reported - view
Re: Fisetin to Clear Senescent Cells @John W When I translate the doses used on mice it quals a daily dose for humans of 2 mg/kg.
- Staffan Olsson
- Staffan_Olsson
- 4 yrs ago
- 1
- Self-Experimentation
- Reported - view
Re: Antioxidants and Dasatinib regimen There is research showing that some senolytic substances works through ROS activated apoptosis. But here are also pathways to senolysis that are ROS independent.…
- Staffan Olsson
- Staffan_Olsson
- 4 yrs ago
- 1
- Questions & Answers
- Reported - view
Re: Fisetin to Clear Senescent Cells For those interested in dosing of chlorogenic acid. They studied the metabolism of chlorogenic acid by giving 2000 mg to the participants. So that (2000 mg) is defintely a tolerable dose.…
- Staffan Olsson
- Staffan_Olsson
- 5 yrs ago
- 1
- Self-Experimentation
- Reported - view
Re: Senolytics and Female Fertility @Self Hacker Lynn Hi again. I wonder if you can share how much fisetin, quercetin and myricetin you take. And also what the brands are. I ask this question just beacuase there are a few different…
- Staffan Olsson
- Staffan_Olsson
- 5 yrs ago
- Senolytics Discussion
- Reported - view
Re: Senolytics and Female Fertility @Self Hacker Lynn Thank you for sharing your thinking about myricetin. Myricetin is something I will add to my regim later. it seams to be a promising geroprotector.…
- Staffan Olsson
- Staffan_Olsson
- 5 yrs ago
- Senolytics Discussion
- Reported - view

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Staffan Olsson

Staffan_Olsson

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Joined: Sat May 04 15:54:07 UTC 2019

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