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Re: How to increase the bioavailability of Fisetin
@Dan Nave @JGC When it comes to bioavailability there is research going on with a nanoemulsion. It works fine with mice. If it is well tolerated by humans and is as effective in humans as in mice it…
- Staffan_Olsson
- 6 yrs ago
- Self-Experimentation
- Reported - view
Re: D.I.Y. patches for supplement delivery
Hi! Very interesting approach. I am considering alternative ways to get molecules into the bloodstream. My first thought has been to make my own Suppositories.…
- Staffan_Olsson
- 6 yrs ago
- Self-Experimentation
- Reported - view
Re: Fisetin to Clear Senescent Cells
@BobM Hi! Since I have written a bit about green tea extracts poor availability I would like to share this link to Life extensions new product. Claiming to be 10 – 12 times mora bioavailable than…
- Staffan_Olsson
- 6 yrs ago
- Self-Experimentation
- Reported - view
Re: An EU meet up? Where and what purpose will the meet up have?
Purpose and potential benefits of a EU meet up? And were would a meet up take place? As I see it - some of us live in countries that are very conservative when it comes to rejuvenating interventions…
- Staffan_Olsson
- 6 yrs ago
- Europe Meetups
- Reported - view
An EU meet up? Where and what purpose will the meet up have?
- Staffan_Olsson
- 6 yrs ago
- 12replies
- 278
- Europe Meetups
Re: Quercetin recomendations
@Michael Avenoso https://link.springer.com/article/10.1007%2Fs13318-018-0517-3 This is research done by Indena http://www.indena.com/ Even though its done for building the scientific foundation for…
- Staffan_Olsson
- 6 yrs ago
- Self-Experimentation
- Reported - view
Re: Kaufmannprotocol
@Dan I like to mention that I get a good night’s sleep from 300-400 mg standard folic acid that is taken before I lay down in bed. I take it alone or with different kinds of magnesium.…
- Staffan_Olsson
- 6 yrs ago
- General Discussion
- Reported - view
Re: Cell Death Mechanisms Behind D+Q and Fisetin Senolytics
I have not tried D+Q yet. When I do Fisetin as single treatment I don’t feel any negative effects. But when I have tried Fisetin in combination with other substances I have felt unwell and had…
- Staffan_Olsson
- 6 yrs ago
- 1
- Self-Experimentation
- Reported - view
Re: Fisetin to Clear Senescent Cells
@JGC Thank you for sharing. I speculate that dasatinib + alcohol can put to much stress on the liver. but a recommendation to avoid alcohol when doing senolytic treatments seems like good advice.
- Staffan_Olsson
- 6 yrs ago
- Self-Experimentation
- Reported - view
Re: Quercetin recomendations
@Michael Avenoso Hi! 1. Life extension's capsules Bio-Quercetin phytosome 29mg delivers 10 mg quercetin. 2. The thorne product used in the last human trial ( idiopatic lungfibrosis) at the el mayo…
- Staffan_Olsson
- 6 yrs ago
- 1
- Self-Experimentation
- Reported - view
Re: KLOTHO and GABA for Brain Enhancement
@JGC I have not tired it myself but if you want GABA to reach the brain and increase gaba levels and therefore get increase klotho? then maybe picamilone can be interesting.…
- Staffan_Olsson
- 6 yrs ago
- 1
- General Discussion
- Reported - view
Re: Kaufmannprotocol
@Dan Thanks Dan. I did not know that there is a specific substance in green tea that can effect stomach in that way. I can have gotten used to it. I drink plenty of green tea and quite strong.…
- Staffan_Olsson
- 6 yrs ago
- 1
- General Discussion
- Reported - view
Re: Kaufmannprotocol
@Jennifer Klein Hi! I have also experienced an upset stomach when I took Green tea extracts (EGCG mega extract) on empty stomach. I could reduce the discomfort in a few ways.…
- Staffan_Olsson
- 6 yrs ago
- 1
- General Discussion
- Reported - view
Re: Fisetin to Clear Senescent Cells
@JGC I can show you who it looked like. Your question made me curious so today I used two oils. Olive oil and avocado oil. In the picture the avocado oil is to the right and olive oil is to the left.…
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- Staffan_Olsson
- 6 yrs ago
- 3
- Self-Experimentation
- Reported - view
Re: Fisetin to Clear Senescent Cells
@JGC Four weeks ago I did my first experiment with a fisetin combination. For two days I did 20 mg/kg Fisetin. Today I did a 30 mg/kg fisetin combination. (Using Dr’s best brand).…
- Staffan_Olsson
- 6 yrs ago
- 2
- Self-Experimentation
- Reported - view
Re: Add a category for local meetups
@Flavio Ferlitz Hi! We can start right away with a EU group here on the Forum. Before local meetup we can see if there are enough members here that are interested in sharing EU related issues as…
- Staffan_Olsson
- 6 yrs ago
- Ideas
- Reported - view
Re: Exercise and AMPK activation.
I have communicated with persons who don't think it's a good idea to work out when the body is in a fasting state. But when it comes to AMPK activation it is best done when the body is not in a fed…
- Staffan_Olsson
- 6 yrs ago
- 2
- AMPK Activation
- Reported - view
Exercise and AMPK activation.

How to exercise to achieve the greatest health benefits. And what experiences do we have. Exercise promotes AMPK activation. Exercise is such a powerful factor for creating health promoting and…
- Staffan_Olsson
- 6 yrs ago
- 2replies
- 325
- 1
- AMPK Activation
Re: Quercetin recomendations
in the first human study on idiopatic lung fibrosis they used this kind of Quercetin. https://www.thorne.com/products/dp/quercetin-phytosome
- Staffan_Olsson
- 6 yrs ago
- 1
- Self-Experimentation
- Reported - view
Re: Fisetin to Clear Senescent Cells
@JGC For your information and also to adress the issue of bioavailability I want to mention that, in their human study on idiopatic lungfibrosis, the El Mayo group used a Quercetinproduct from…
- Staffan_Olsson
- 6 yrs ago
- Self-Experimentation
- Reported - view
Re: Fisetin to Clear Senescent Cells
@JGC Thank you for your report. How do you feel now? It has now been two weeks since I had my fisetin experiment. In two weeks time I will have two more days of fisetin treatment.…
- Staffan_Olsson
- 6 yrs ago
- Self-Experimentation
- Reported - view
Re: Possible negative response to oral NAD+
@William Sarill Thank you for your interesting and insightful contribution. I wonder if you have other experiences you would like to share. Experiences related to supplements that are supposed to…
- Staffan_Olsson
- 6 yrs ago
- 2
- Self-Experimentation
- Reported - view
Re: Fisetin to Clear Senescent Cells
@karl kuffner The dosing regimen regarding fisetin is in its infancy. There have been research done using fisetin on two consecetuive days. And then the same treatment was repeated again after 4…
- Staffan_Olsson
- 6 yrs ago
- Self-Experimentation
- Reported - view
Re: Mitochondrial health
I have not been able to find out what protocoll they used in the original study. What I have found out is that they used ”reiterated doses (1.7 mg/kg of body weight)”.…
- Staffan_Olsson
- 6 yrs ago
- 1
- General Discussion
- Reported - view
Re: Mitochondrial health
Hi Barry! May I ask how you have used C60? Regarding dose and program? And have you any specific effects and experiences that you can relate to C60? In one study on rats they used 4 mg/kg every day…
- Staffan_Olsson
- 6 yrs ago
- 1
- General Discussion
- Reported - view

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