Exercise and AMPK activation.

How to exercise to achieve the greatest health benefits. And what experiences do we have. Exercise promotes AMPK activation. Exercise is such a powerful factor for creating health promoting and disease preventing adaptations in the human physiology. Regular physical activity reduces the risk for cardiovascular diseases, type 2 diabetes, multiple cancers, depression, obesity, and musculoskeletal diseases.

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  • I have communicated with persons who don't think it's a good idea to work out when the body is in a fasting state. But when it comes to AMPK activation it is best done when the body is not in a fed state.

    ” commencing endurance exercise with low muscle glycogen stores (so-called “train low”) results in a greater transcriptional activation of enzymes involved in carbohydrate metabolism, including the adenosine 5′-monophosphate-activated protein kinase (AMPK), GLUT4, and the pyruvate dehydrogenase (PDH) complex, compared with when glycogen content is normal”




    My point is that if maximal AMPK activation is a goal, then it is preferable to exercise when the body is not in a fed state. And also to avoid eating carbohydrates after the workout. So when doing intermittent fasting it is great to exercise when one is at the end of the fast.


    I usually work out in the morning when I am in a fasting state and after having a cup of coffee.  That makes me more alert for many hours, compared to when I work out in the morning and have my coffee after the workout. Strange but a fact for me.

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