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Senolytics Discussion
Discussions about senolytics for the removal of senescent cells.
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Sources of dasatinib
Hello everyone, We’ve received reports from Age Reversal Network members about lower-cost sources of dasatinib. This post is intended to aggregate this information into a single forum post for easy…
Max Peto
moderator
Researcher, website & forum admin
Maximus
1 yr ago
117
replies
1,994
4
Lavinia Jones
5 mths ago
Senolytics Discussion
Introduction to senolytics
Hi everyone, The term " senolytics " refers to compounds that selectively induce cell death in senescent cells. Senescent cells are cells whose metabolism has gone awry for one reason or another,…
Max Peto
moderator
Researcher, website & forum admin
Maximus
2 yrs ago
29
replies
931
2
Staffan Olsson
1 yr ago
Senolytics Discussion
Fisetin experimentation one year (reposted as topic for info purposes)
Hello everyone I wanted to make my first post here as I have been doing a fisetin routine for a year now just about and I have results that are not placebo and very profound.…
David C
David_C
1 yr ago
196
replies
2,164
8
aribadabar
3 wk ago
Senolytics Discussion
Inexexpensive Rapamycin and Datatinib from India
Just received my shipment of 200 1mg rapamycin pills and 120 20 mg datsatinib pills from Varun Medicals at https://www.varunmedicals.com . The rapa pills were from Swiss Garnier Biotech marketed…
Bernie
Bernie_Singer
2 mths ago
44
1
Senolytics Discussion
Azithromycin (Zithromax) as senolytic; a note of caution
This is the problem with "cell studies." The authors who found this result decided to look at what they called a "low dose" of azithromycin (AZM) on cells.…
Steve Harris
Steve_Harris
2 yrs ago
11
replies
955
5
Aristotle Bancale
2 mths ago
Senolytics Discussion
Senolytic guru Dr De Keizer says quercetin is useless?
"As for quercetin and dasatinib, I’m absolutely not a fan of those. We’ve tried a couple of experiments; we’ve never seen a good result. Campisi’s lab has tried it extensively,…
Fred Cloud
Fred_Cloud
6 mths ago
2
replies
201
Gleb Merkurev
2 mths ago
Senolytics Discussion
Senolytics and Female Fertility
Does anyone know how senolytic therapy could impact female fertility? While the theory that women start with a finite amount of eggs which simply dwindle over time until fertility is depleted has…
Phoenix
phoenix
1 yr ago
19
replies
344
1
Aka Loo
3 mths ago
Senolytics Discussion
is pevonedistat an unknown novel anti-aging drug?
Targeting Protein Neddylation for Cancer Therapy. https://www.ncbi.nlm.nih.gov/pubmed/31898235 I recently participated in a phase 1 dosage safety cancer clinical trial combining this investigation…
chad cooper
chad_cooper
1 yr ago
1
reply
64
2
Savannah Luis
4 mths ago
Senolytics Discussion
Fisetin ( + quercitin)
Among flavonoids, fisetin appears to be an effective senolytic: https://www.fightaging.org/archives/2018/10/animal-data-shows-fisetin-to-be-a-surprisingly-effective-senolytic/ "Fisetin appears about…
cacarr
cacarr
2 yrs ago
50
replies
2,128
4
Rob8311
6 mths ago
Senolytics Discussion
Levels of senescent cells correlates with death?
Interesting study https://www.nature.com/articles/s41467-019-13192-4
Paul Beauchemin
Paul_Beauchemin
11 mths ago
1
reply
108
Joe smith
7 mths ago
Senolytics Discussion
Just got my dasatinib capsules
I live in S.CA and went to Las Vegas to Dr Garcia who prescribed the dasatinib dosage promoted by Faloon. A few months passed while COVID-19 disrupted supply chains.…
Brook Norton
Brook_Norton
7 mths ago
3
replies
85
Brook Norton
7 mths ago
Senolytics Discussion
Senolytics and Covid-19
https://youtu.be/2DvJwthiMPk great discussion on why senolytics could be major help in combating Covid-19. talks about Rapamycin and Dasatinib too. Glad I didn’t stop Rapamycin
Paul Beauchemin
Paul_Beauchemin
9 mths ago
4
replies
120
3
Edward Meininger
9 mths ago
Senolytics Discussion
Senolytic Effects of FOXO4-DRI
I found this research on target specific effects of FOXO4-DRI to be interesting. Please add your thoughts and links to any other research. Could this be a viable experimental therapy? https://www.…
Dorian Gray
Dorian_gray
11 mths ago
6
replies
135
Dorian Gray
11 mths ago
Senolytics Discussion
Details of dasatinib + quercetin study
What were the dosages of dasatinib and quercetin used for this study? What kind of quercetin was used? Any issues or side effects noted so far?
Ozone8
Ozone8
3 yrs ago
78
replies
1,825
3
Mel
11 mths ago
Senolytics Discussion
New Anti-Aging clinic in Georgia.
I noticed a new clinic has opened in the state of Georgia that prescribes metformin, rapamycin, and dasatinib. Mikhail Blagosklonney tweeted the link this morning.…
Larry
Larry.1
1 yr ago
57
Senolytics Discussion
A different point of view
Interesting article that argues for telomere therapy and against senolytics. https://www.leafscience.org/are-senolytics-potentially-damaging-for-longevity/
Karl
Karl.1
1 yr ago
5
replies
169
David C
1 yr ago
Senolytics Discussion
Sulfuraphane
On Dr Kaufmann’s website, it states that sulfuraphane protects cells from apoptosis and senescence. This would seem to work against senolytics. Does anyone take sulfuraphane and if so do you stop…
Karl
Karl.1
1 yr ago
1
reply
120
Staffan Olsson
1 yr ago
Senolytics Discussion
Blocking negative effects of senescence in human skin fibroblasts with a plant extract
I find this very interesting. And people that focus on preventing senescence and the aging of their skin might be extra interested in how we can interpretate the research above.…
Staffan Olsson
Staffan_Olsson
1 yr ago
2
replies
131
1
BobM
1 yr ago
Senolytics Discussion
Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin
https://www.ebiomedicine.com/article/S2352-3964(19)30591-2/fulltext
Larry
Larry.1
1 yr ago
2
replies
128
Larry
1 yr ago
Senolytics Discussion
fisetin phytosome preparation
curcumin phytosome was prepared from curcumin , phosphatidylcholine in methylene chlride,acta pharm v65 (2015) P 285- 297. May be fisetin phytosome could be prepared likewise?
leon golabou
leon_golabou
1 yr ago
133
Senolytics Discussion
AB263 Navitoclax
This is very interesting https://www.adooq.com/abt-263-navitoclax.html The 10ml dosing is in 1ml of DMSO, taken orally. We need to look at this further!
BobM
BobM
1 yr ago
2
replies
78
cacarr
1 yr ago
Senolytics Discussion
Fisetin Dosage Calculations
Hi everyone! I'm new to this forum, but I've been observing from the sidelines and learning a lot from your posts, so thank you! I found this forum after becoming interested in fisetin as a…
Ash P
Ash_P
1 yr ago
1
reply
454
Steve Harris
1 yr ago
Senolytics Discussion
The Initial D+Q Study
I became curious as to just how it was determined that the combination of Dasatinib and Quercetin in a 1:10 combination was an effective senolytic treatment.…
JGC
JGC
2 yrs ago
274
5
Senolytics Discussion
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Discussions about senolytics for the removal of senescent cells.
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