is pevonedistat an unknown novel anti-aging drug?

Targeting Protein Neddylation for Cancer Therapy. https://www.ncbi.nlm.nih.gov/pubmed/31898235 I recently participated in a phase 1 dosage safety cancer clinical trial combining this investigation…

Updates to 2018 "Age Reversal Protocol" Step 3?

Six years is a long time. Has anyone read of any updates/refinements to the 2018 proposed doses and frequency of Dasatinib-Quercetin cocktail (found here: https://age-reversal.net/senolytics/ )?

Fisetin ( + quercitin)

Among flavonoids, fisetin appears to be an effective senolytic: https://www.fightaging.org/archives/2018/10/animal-data-shows-fisetin-to-be-a-surprisingly-effective-senolytic/ "Fisetin appears about…

Fisetin experimentation one year (reposted as topic for info purposes)

Hello everyone I wanted to make my first post here as I have been doing a fisetin routine for a year now just about and I have results that are not placebo and very profound.…

Senolytics and Female Fertility

Does anyone know how senolytic therapy could impact female fertility? While the theory that women start with a finite amount of eggs which simply dwindle over time until fertility is depleted has…

Azrithomycin dose for senolytic

Trametinib - is it still just theoretical?

Hi Everyone, I just watched Bill Faloon at RAADfest 2023 (https://www.youtube.com/watch?v=nfaZ_0Rajdc) and saw he mentioned trametinib. Is it still theoretical at this point or have studies been…

Senolytic Effects of FOXO4-DRI

I found this research on target specific effects of FOXO4-DRI to be interesting. Please add your thoughts and links to any other research. Could this be a viable experimental therapy? https://www.…

Qualia Senolytic product

Having booked a lot of success with improving my NAD+ levels by taking resveratrol and a NAD precursor ( which I've described in another forum ) I decided to take the next logical step and tackle…

Has anyone tried taking fietin as a suppository?

I would think that, by bypassing the GI tract, this would guarantee 100% absorption into the blood.

Someone tried to contact me in chat...

Someone tried to contact me in chat..., I had to update windows and lost the chat. Thanks

Senolytics- How many different ones do you take and why

I am assuming that a given Senolytic may not cause senolysis in all cell types and therefore it is probably better to rotate through different senolytics.…

A hypothesis about Senescent Cells

My hypothesis is that a large proportion of Senescent Cells are in fact Stem Cells which have not differentiated properly. What happens is they cause inflammation which causes a reduction in NF-κb…

PCC1 is senolytic and senomorphic

Procyanidin C1 (PCC1 or PC-C1), which is found in grape seed extract (GSE), is senolytic, senomorphic, and has been proven to increase the lifespan of mice.…

Azithromycin (Zithromax) as senolytic; a note of caution

This is the problem with "cell studies." The authors who found this result decided to look at what they called a "low dose" of azithromycin (AZM) on cells.…

Alternative mechanism for senolytics

Do senolytics only work because the affect mTor? Interesting article. What do you think? https://www.oncotarget.com/article/28049/text/

A different point of view

Interesting article that argues for telomere therapy and against senolytics. https://www.leafscience.org/are-senolytics-potentially-damaging-for-longevity/

Can snorting fisetin improve bioavailability and is it safe?

Title says it all. I suspect that since fisetin is hydrophobic, it won't dissolve in the body and would only serve to irritate the lungs, but I'm not a pulmonary expert.

Inexexpensive Rapamycin and Datatinib from India

Just received my shipment of 200 1mg rapamycin pills and 120 20 mg datsatinib pills from Varun Medicals at https://www.varunmedicals.com. The rapa pills were from Swiss Garnier Biotech marketed…

Senolytic guru Dr De Keizer says quercetin is useless?

"As for quercetin and dasatinib, I’m absolutely not a fan of those. We’ve tried a couple of experiments; we’ve never seen a good result. Campisi’s lab has tried it extensively,…

Levels of senescent cells correlates with death?

Interesting study https://www.nature.com/articles/s41467-019-13192-4

Just got my dasatinib capsules

I live in S.CA and went to Las Vegas to Dr Garcia who prescribed the dasatinib dosage promoted by Faloon. A few months passed while COVID-19 disrupted supply chains.…

Senolytics and Covid-19

https://youtu.be/2DvJwthiMPk great discussion on why senolytics could be major help in combating Covid-19. talks about Rapamycin and Dasatinib too. Glad I didn’t stop Rapamycin