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Senolytics Discussion

Discussions about senolytics for the removal of senescent cells.

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Sources of dasatinib
Hello everyone, We’ve received reports from Age Reversal Network members about lower-cost sources of dasatinib. This post is intended to aggregate this information into a single forum post for easy…
- Max Petomoderator
- Researcher, website & forum admin
- Maximus
- 9 mths ago
- 44 replies
- 1,033
- 4
- angie4life2 wk ago
- Senolytics Discussion
Introduction to senolytics
Hi everyone, The term " senolytics " refers to compounds that selectively induce cell death in senescent cells. Senescent cells are cells whose metabolism has gone awry for one reason or another,…
- Max Petomoderator
- Researcher, website & forum admin
- Maximus
- 1 yr ago
- 29 replies
- 814
- 2
- Staffan Olsson3 mths ago
- Senolytics Discussion
Fisetin experimentation one year (reposted as topic for info purposes)
Hello everyone I wanted to make my first post here as I have been doing a fisetin routine for a year now just about and I have results that are not placebo and very profound.…
- David C
- David_C
- 3 mths ago
- 42 replies
- 606
- 6
- Robert Olin2 days ago
- Senolytics Discussion
Senolytics and Covid-19
https://youtu.be/2DvJwthiMPk great discussion on why senolytics could be major help in combating Covid-19. talks about Rapamycin and Dasatinib too. Glad I didn’t stop Rapamycin
- Paul Beauchemin
- Paul_Beauchemin
- 2 days ago
- 4 replies
- 62
- 2
- Edward Meiningeryesterday
- Senolytics Discussion
Senolytic Effects of FOXO4-DRI
I found this research on target specific effects of FOXO4-DRI to be interesting. Please add your thoughts and links to any other research. Could this be a viable experimental therapy? https://www.…
- Dorian Gray
- Dorian_gray
- 1 mth ago
- 6 replies
- 78
- Dorian Gray1 mth ago
- Senolytics Discussion
Levels of senescent cells correlates with death?
Interesting study https://www.nature.com/articles/s41467-019-13192-4
- Paul Beauchemin
- Paul_Beauchemin
- 1 mth ago
- 40
- Senolytics Discussion
Details of dasatinib + quercetin study
What were the dosages of dasatinib and quercetin used for this study? What kind of quercetin was used? Any issues or side effects noted so far?
- Ozone8
- Ozone8
- 2 yrs ago
- 78 replies
- 1,657
- 3
- Mel1 mth ago
- Senolytics Discussion
is pevonedistat an unknown novel anti-aging drug?
Targeting Protein Neddylation for Cancer Therapy. https://www.ncbi.nlm.nih.gov/pubmed/31898235 I recently participated in a phase 1 dosage safety cancer clinical trial combining this investigation…
- chad cooper
- chad_cooper
- 2 mths ago
- 19
- 2
- Senolytics Discussion
New Anti-Aging clinic in Georgia.
I noticed a new clinic has opened in the state of Georgia that prescribes metformin, rapamycin, and dasatinib. Mikhail Blagosklonney tweeted the link this morning.…
- Larry
- Larry.1
- 2 mths ago
- 32
- Senolytics Discussion
A different point of view
Interesting article that argues for telomere therapy and against senolytics. https://www.leafscience.org/are-senolytics-potentially-damaging-for-longevity/
- Karl
- Karl.1
- 3 mths ago
- 5 replies
- 130
- David C3 mths ago
- Senolytics Discussion
Fisetin ( + quercitin)
Among flavonoids, fisetin appears to be an effective senolytic: https://www.fightaging.org/archives/2018/10/animal-data-shows-fisetin-to-be-a-surprisingly-effective-senolytic/ "Fisetin appears about…
- cacarr
- cacarr
- 1 yr ago
- 46 replies
- 1,672
- 4
- David C3 mths ago
- Senolytics Discussion
Sulfuraphane
On Dr Kaufmann’s website, it states that sulfuraphane protects cells from apoptosis and senescence. This would seem to work against senolytics. Does anyone take sulfuraphane and if so do you stop…
- Karl
- Karl.1
- 3 mths ago
- 1 reply
- 71
- Staffan Olsson3 mths ago
- Senolytics Discussion
Azithromycin (Zithromax) as senolytic; a note of caution
This is the problem with "cell studies." The authors who found this result decided to look at what they called a "low dose" of azithromycin (AZM) on cells.…
- Steve Harris
- Steve_Harris
- 1 yr ago
- 7 replies
- 660
- 4
- Danmoderator3 mths ago
- Senolytics Discussion
Senolytics and Female Fertility
Does anyone know how senolytic therapy could impact female fertility? While the theory that women start with a finite amount of eggs which simply dwindle over time until fertility is depleted has…
- Phoenix
- phoenix
- 6 mths ago
- 9 replies
- 126
- Self Hacker Lynn3 mths ago
- Senolytics Discussion
Blocking negative effects of senescence in human skin fibroblasts with a plant extract
I find this very interesting. And people that focus on preventing senescence and the aging of their skin might be extra interested in how we can interpretate the research above.…
- Staffan Olsson
- Staffan_Olsson
- 4 mths ago
- 2 replies
- 88
- 1
- BobM4 mths ago
- Senolytics Discussion
Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin
https://www.ebiomedicine.com/article/S2352-3964(19)30591-2/fulltext
- Larry
- Larry.1
- 6 mths ago
- 2 replies
- 106
- Larry6 mths ago
- Senolytics Discussion
fisetin phytosome preparation
curcumin phytosome was prepared from curcumin , phosphatidylcholine in methylene chlride,acta pharm v65 (2015) P 285- 297. May be fisetin phytosome could be prepared likewise?
- leon golabou
- leon_golabou
- 7 mths ago
- 98
- Senolytics Discussion
AB263 Navitoclax
This is very interesting https://www.adooq.com/abt-263-navitoclax.html The 10ml dosing is in 1ml of DMSO, taken orally. We need to look at this further!
- BobM
- BobM
- 9 mths ago
- 2 replies
- 68
- cacarr8 mths ago
- Senolytics Discussion
Fisetin Dosage Calculations
Hi everyone! I'm new to this forum, but I've been observing from the sidelines and learning a lot from your posts, so thank you! I found this forum after becoming interested in fisetin as a…
- Ash P
- Ash_P
- 9 mths ago
- 1 reply
- 306
- Steve Harris8 mths ago
- Senolytics Discussion
The Initial D+Q Study
I became curious as to just how it was determined that the combination of Dasatinib and Quercetin in a 1:10 combination was an effective senolytic treatment.…
- JGC
- JGC
- 1 yr ago
- 235
- 5
- Senolytics Discussion

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