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Senolytics Discussion

Discussions about senolytics for the removal of senescent cells.

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Sources of dasatinib
Hello everyone, We’ve received reports from Age Reversal Network members about lower-cost sources of dasatinib. This post is intended to aggregate this information into a single forum post for easy…
- Max Peto
- Researcher, website & forum admin
- Maximus
- 2 yrs ago
- 134 replies
- 2,667
- 5
- Stephen Lewis6 mths ago
- Senolytics Discussion
Introduction to senolytics
Hi everyone, The term " senolytics " refers to compounds that selectively induce cell death in senescent cells. Senescent cells are cells whose metabolism has gone awry for one reason or another,…
- Max Peto
- Researcher, website & forum admin
- Maximus
- 3 yrs ago
- 29 replies
- 1,056
- 2
- Staffan Olsson2 yrs ago
- Senolytics Discussion
Fisetin ( + quercitin)
Among flavonoids, fisetin appears to be an effective senolytic: https://www.fightaging.org/archives/2018/10/animal-data-shows-fisetin-to-be-a-surprisingly-effective-senolytic/ "Fisetin appears about…
- cacarr
- cacarr
- 3 yrs ago
- 59 replies
- 2,564
- 5
- Hello World3 days ago
- Senolytics Discussion
PCC1 is senolytic and senomorphic
Procyanidin C1 (PCC1 or PC-C1), which is found in grape seed extract (GSE), is senolytic, senomorphic, and has been proven to increase the lifespan of mice.…
- Florin
- Florin
- 6 mths ago
- 2 replies
- 135
- 2
- Karl3 wk ago
- Senolytics Discussion
Fisetin experimentation one year (reposted as topic for info purposes)
Hello everyone I wanted to make my first post here as I have been doing a fisetin routine for a year now just about and I have results that are not placebo and very profound.…
- David C
- David_C
- 2 yrs ago
- 329 replies
- 4,608
- 15
- Michael1 mth ago
- Senolytics Discussion
Azithromycin (Zithromax) as senolytic; a note of caution
This is the problem with "cell studies." The authors who found this result decided to look at what they called a "low dose" of azithromycin (AZM) on cells.…
- Steve Harris
- Steve_Harris
- 3 yrs ago
- 14 replies
- 1,228
- 5
- Van3 mths ago
- Senolytics Discussion
Alternative mechanism for senolytics
Do senolytics only work because the affect mTor? Interesting article. What do you think? https://www.oncotarget.com/article/28049/text/
- Karl
- Karl.1
- 3 mths ago
- 35
- 1
- Senolytics Discussion
Senolytics and Female Fertility
Does anyone know how senolytic therapy could impact female fertility? While the theory that women start with a finite amount of eggs which simply dwindle over time until fertility is depleted has…
- Phoenix
- phoenix
- 2 yrs ago
- 20 replies
- 509
- 1
- Jane4 mths ago
- Senolytics Discussion
A different point of view
Interesting article that argues for telomere therapy and against senolytics. https://www.leafscience.org/are-senolytics-potentially-damaging-for-longevity/
- Karl
- Karl.1
- 2 yrs ago
- 8 replies
- 263
- JGC4 mths ago
- Senolytics Discussion
is pevonedistat an unknown novel anti-aging drug?
Targeting Protein Neddylation for Cancer Therapy. https://www.ncbi.nlm.nih.gov/pubmed/31898235 I recently participated in a phase 1 dosage safety cancer clinical trial combining this investigation…
- chad cooper
- chad_cooper
- 2 yrs ago
- 5 replies
- 150
- 7
- Spasov5 mths ago
- Senolytics Discussion
Has anyone tried taking fietin as a suppository?
I would think that, by bypassing the GI tract, this would guarantee 100% absorption into the blood.
- Robert Uomini
- Robert_Uomini
- 7 mths ago
- 3 replies
- 96
- Staffan Olsson6 mths ago
- Senolytics Discussion
Can snorting fisetin improve bioavailability and is it safe?
Title says it all. I suspect that since fisetin is hydrophobic, it won't dissolve in the body and would only serve to irritate the lungs, but I'm not a pulmonary expert.
- Robert Uomini
- Robert_Uomini
- 8 mths ago
- 16 replies
- 189
- Robert Uomini6 mths ago
- Senolytics Discussion
Inexexpensive Rapamycin and Datatinib from India
Just received my shipment of 200 1mg rapamycin pills and 120 20 mg datsatinib pills from Varun Medicals at https://www.varunmedicals.com . The rapa pills were from Swiss Garnier Biotech marketed…
- Bernie
- Bernie_Singer
- 1 yr ago
- 156
- 2
- Senolytics Discussion
Senolytic guru Dr De Keizer says quercetin is useless?
"As for quercetin and dasatinib, I’m absolutely not a fan of those. We’ve tried a couple of experiments; we’ve never seen a good result. Campisi’s lab has tried it extensively,…
- Fred Cloud
- Fred_Cloud
- 1 yr ago
- 2 replies
- 337
- Gleb Merkurev1 yr ago
- Senolytics Discussion
Levels of senescent cells correlates with death?
Interesting study https://www.nature.com/articles/s41467-019-13192-4
- Paul Beauchemin
- Paul_Beauchemin
- 1 yr ago
- 1 reply
- 157
- Joe smith1 yr ago
- Senolytics Discussion
Just got my dasatinib capsules
I live in S.CA and went to Las Vegas to Dr Garcia who prescribed the dasatinib dosage promoted by Faloon. A few months passed while COVID-19 disrupted supply chains.…
- Brook Norton
- Brook_Norton
- 1 yr ago
- 3 replies
- 147
- Brook Norton1 yr ago
- Senolytics Discussion
Senolytics and Covid-19
https://youtu.be/2DvJwthiMPk great discussion on why senolytics could be major help in combating Covid-19. talks about Rapamycin and Dasatinib too. Glad I didn’t stop Rapamycin
- Paul Beauchemin
- Paul_Beauchemin
- 1 yr ago
- 4 replies
- 143
- 3
- Edward Meininger1 yr ago
- Senolytics Discussion
Senolytic Effects of FOXO4-DRI
I found this research on target specific effects of FOXO4-DRI to be interesting. Please add your thoughts and links to any other research. Could this be a viable experimental therapy? https://www.…
- Dorian Gray
- Dorian_gray
- 1 yr ago
- 6 replies
- 172
- Dorian Gray1 yr ago
- Senolytics Discussion
Details of dasatinib + quercetin study
What were the dosages of dasatinib and quercetin used for this study? What kind of quercetin was used? Any issues or side effects noted so far?
- Ozone8
- Ozone8
- 4 yrs ago
- 78 replies
- 1,952
- 3
- Mel1 yr ago
- Senolytics Discussion
New Anti-Aging clinic in Georgia.
I noticed a new clinic has opened in the state of Georgia that prescribes metformin, rapamycin, and dasatinib. Mikhail Blagosklonney tweeted the link this morning.…
- Larry
- Larry.1
- 2 yrs ago
- 82
- Senolytics Discussion
Sulfuraphane
On Dr Kaufmann’s website, it states that sulfuraphane protects cells from apoptosis and senescence. This would seem to work against senolytics. Does anyone take sulfuraphane and if so do you stop…
- Karl
- Karl.1
- 2 yrs ago
- 1 reply
- 167
- 1
- Staffan Olsson2 yrs ago
- Senolytics Discussion
Blocking negative effects of senescence in human skin fibroblasts with a plant extract
I find this very interesting. And people that focus on preventing senescence and the aging of their skin might be extra interested in how we can interpretate the research above.…
- Staffan Olsson
- Staffan_Olsson
- 2 yrs ago
- 2 replies
- 168
- 1
- BobM2 yrs ago
- Senolytics Discussion
Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin
https://www.ebiomedicine.com/article/S2352-3964(19)30591-2/fulltext
- Larry
- Larry.1
- 2 yrs ago
- 2 replies
- 142
- Larry2 yrs ago
- Senolytics Discussion
fisetin phytosome preparation
curcumin phytosome was prepared from curcumin , phosphatidylcholine in methylene chlride,acta pharm v65 (2015) P 285- 297. May be fisetin phytosome could be prepared likewise?
- leon golabou
- leon_golabou
- 2 yrs ago
- 157
- Senolytics Discussion
AB263 Navitoclax
This is very interesting https://www.adooq.com/abt-263-navitoclax.html The 10ml dosing is in 1ml of DMSO, taken orally. We need to look at this further!
- BobM
- BobM
- 2 yrs ago
- 2 replies
- 103
- cacarr2 yrs ago
- Senolytics Discussion

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