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Senolytics Discussion
Discussions about senolytics for the removal of senescent cells.
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Introduction to senolytics
Hi everyone, The term " senolytics " refers to compounds that selectively induce cell death in senescent cells. Senescent cells are cells whose metabolism has gone awry for one reason or another,…
Maximus Peto
Researcher, website & forum admin
Maximus
5 yrs ago
33
replies
1,254
2
Juan Daw
7 mths ago
Senolytics Discussion
Sources of dasatinib
Hello everyone, We’ve received reports from Age Reversal Network members about lower-cost sources of dasatinib. This post is intended to aggregate this information into a single forum post for easy…
Maximus Peto
Researcher, website & forum admin
Maximus
3 yrs ago
134
replies
3,007
5
Stephen Lewis
1 yr ago
Senolytics Discussion
Has anyone tried taking fietin as a suppository?
I would think that, by bypassing the GI tract, this would guarantee 100% absorption into the blood.
Robert Uomini
Robert_Uomini
1 yr ago
5
replies
224
Staffan Olsson
3 mths ago
Senolytics Discussion
Fisetin experimentation one year (reposted as topic for info purposes)
Hello everyone I wanted to make my first post here as I have been doing a fisetin routine for a year now just about and I have results that are not placebo and very profound.…
David C
David_C
3 yrs ago
455
replies
6,513
16
John Ramos
6 mths ago
Senolytics Discussion
Someone tried to contact me in chat...
Someone tried to contact me in chat..., I had to update windows and lost the chat. Thanks
John Ramos
John_Ramos
8 mths ago
3
replies
45
Chris
8 mths ago
Senolytics Discussion
Senolytic Effects of FOXO4-DRI
I found this research on target specific effects of FOXO4-DRI to be interesting. Please add your thoughts and links to any other research. Could this be a viable experimental therapy? https://www.…
Dorian Gray
Dorian_gray
3 yrs ago
11
replies
292
JGC
10 mths ago
Senolytics Discussion
Senolytics- How many different ones do you take and why
I am assuming that a given Senolytic may not cause senolysis in all cell types and therefore it is probably better to rotate through different senolytics.…
Karl
Karl.1
1 yr ago
4
replies
222
1
Brian Valerie
1 yr ago
Senolytics Discussion
A hypothesis about Senescent Cells
My hypothesis is that a large proportion of Senescent Cells are in fact Stem Cells which have not differentiated properly. What happens is they cause inflammation which causes a reduction in NF-κb…
John Hemming
John_Hemming
1 yr ago
7
replies
161
UB
1 yr ago
Senolytics Discussion
PCC1 is senolytic and senomorphic
Procyanidin C1 (PCC1 or PC-C1), which is found in grape seed extract (GSE), is senolytic, senomorphic, and has been proven to increase the lifespan of mice.…
Florin
Florin
1 yr ago
3
replies
275
2
Karl
1 yr ago
Senolytics Discussion
is pevonedistat an unknown novel anti-aging drug?
Targeting Protein Neddylation for Cancer Therapy. https://www.ncbi.nlm.nih.gov/pubmed/31898235 I recently participated in a phase 1 dosage safety cancer clinical trial combining this investigation…
chad cooper
chad_cooper
3 yrs ago
6
replies
190
7
Erik A Aronesty
1 yr ago
Senolytics Discussion
Fisetin ( + quercitin)
Among flavonoids, fisetin appears to be an effective senolytic: https://www.fightaging.org/archives/2018/10/animal-data-shows-fisetin-to-be-a-surprisingly-effective-senolytic/ "Fisetin appears about…
cacarr
cacarr
4 yrs ago
59
replies
2,913
5
Hello World
1 yr ago
Senolytics Discussion
Azithromycin (Zithromax) as senolytic; a note of caution
This is the problem with "cell studies." The authors who found this result decided to look at what they called a "low dose" of azithromycin (AZM) on cells.…
Steve Harris
Steve_Harris
4 yrs ago
14
replies
1,388
5
Van
1 yr ago
Senolytics Discussion
Alternative mechanism for senolytics
Do senolytics only work because the affect mTor? Interesting article. What do you think? https://www.oncotarget.com/article/28049/text/
Karl
Karl.1
1 yr ago
60
1
Senolytics Discussion
Senolytics and Female Fertility
Does anyone know how senolytic therapy could impact female fertility? While the theory that women start with a finite amount of eggs which simply dwindle over time until fertility is depleted has…
Phoenix
phoenix
3 yrs ago
20
replies
628
1
Jane
1 yr ago
Senolytics Discussion
A different point of view
Interesting article that argues for telomere therapy and against senolytics. https://www.leafscience.org/are-senolytics-potentially-damaging-for-longevity/
Karl
Karl.1
3 yrs ago
8
replies
288
JGC
1 yr ago
Senolytics Discussion
Can snorting fisetin improve bioavailability and is it safe?
Title says it all. I suspect that since fisetin is hydrophobic, it won't dissolve in the body and would only serve to irritate the lungs, but I'm not a pulmonary expert.
Robert Uomini
Robert_Uomini
2 yrs ago
16
replies
230
Robert Uomini
1 yr ago
Senolytics Discussion
Inexexpensive Rapamycin and Datatinib from India
Just received my shipment of 200 1mg rapamycin pills and 120 20 mg datsatinib pills from Varun Medicals at https://www.varunmedicals.com . The rapa pills were from Swiss Garnier Biotech marketed…
Bernie
Bernie_Singer
2 yrs ago
196
2
Senolytics Discussion
Senolytic guru Dr De Keizer says quercetin is useless?
"As for quercetin and dasatinib, I’m absolutely not a fan of those. We’ve tried a couple of experiments; we’ve never seen a good result. Campisi’s lab has tried it extensively,…
Fred Cloud
Fred_Cloud
2 yrs ago
2
replies
411
Gleb Merkurev
2 yrs ago
Senolytics Discussion
Levels of senescent cells correlates with death?
Interesting study https://www.nature.com/articles/s41467-019-13192-4
Paul Beauchemin
Paul_Beauchemin
3 yrs ago
1
reply
176
Joe smith
3 yrs ago
Senolytics Discussion
Just got my dasatinib capsules
I live in S.CA and went to Las Vegas to Dr Garcia who prescribed the dasatinib dosage promoted by Faloon. A few months passed while COVID-19 disrupted supply chains.…
Brook Norton
Brook_Norton
3 yrs ago
3
replies
183
Brook Norton
3 yrs ago
Senolytics Discussion
Senolytics and Covid-19
https://youtu.be/2DvJwthiMPk great discussion on why senolytics could be major help in combating Covid-19. talks about Rapamycin and Dasatinib too. Glad I didn’t stop Rapamycin
Paul Beauchemin
Paul_Beauchemin
3 yrs ago
4
replies
158
3
Edward Meininger
3 yrs ago
Senolytics Discussion
Details of dasatinib + quercetin study
What were the dosages of dasatinib and quercetin used for this study? What kind of quercetin was used? Any issues or side effects noted so far?
Ozone8
Ozone8
5 yrs ago
78
replies
2,030
3
Mel
3 yrs ago
Senolytics Discussion
New Anti-Aging clinic in Georgia.
I noticed a new clinic has opened in the state of Georgia that prescribes metformin, rapamycin, and dasatinib. Mikhail Blagosklonney tweeted the link this morning.…
Larry
Larry.1
3 yrs ago
107
Senolytics Discussion
Sulfuraphane
On Dr Kaufmann’s website, it states that sulfuraphane protects cells from apoptosis and senescence. This would seem to work against senolytics. Does anyone take sulfuraphane and if so do you stop…
Karl
Karl.1
3 yrs ago
1
reply
200
1
Staffan Olsson
3 yrs ago
Senolytics Discussion
Blocking negative effects of senescence in human skin fibroblasts with a plant extract
I find this very interesting. And people that focus on preventing senescence and the aging of their skin might be extra interested in how we can interpretate the research above.…
Staffan Olsson
Staffan_Olsson
3 yrs ago
2
replies
191
1
BobM
3 yrs ago
Senolytics Discussion
1
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