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Senolytics Discussion

Discussions about senolytics for the removal of senescent cells.

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Sources of dasatinib
Hello everyone, We’ve received reports from Age Reversal Network members about lower-cost sources of dasatinib. This post is intended to aggregate this information into a single forum post for easy…
- Maximus Peto
- Researcher, website & forum admin
- Maximus
- updated 5 yrs ago
- 136replies
- 3368
- 5
- Last replyCurtis Smith1 yr ago
- Senolytics Discussion
Introduction to senolytics
Hi everyone, The term "senolytics" refers to compounds that selectively induce cell death in senescent cells. Senescent cells are cells whose metabolism has gone awry for one reason or another,…
- Maximus Peto
- Researcher, website & forum admin
- Maximus
- updated 7 yrs ago
- 33replies
- 1528
- 2
- Last replyJuan Daw2 yrs ago
- Senolytics Discussion
is pevonedistat an unknown novel anti-aging drug?
Targeting Protein Neddylation for Cancer Therapy. https://www.ncbi.nlm.nih.gov/pubmed/31898235 I recently participated in a phase 1 dosage safety cancer clinical trial combining this investigation…
- chad cooper
- chad_cooper
- 5 yrs ago
- 8replies
- 230
- 7
- Last replyFred Cloud2 mths ago
- Senolytics Discussion
Updates to 2018 "Age Reversal Protocol" Step 3?
Six years is a long time. Has anyone read of any updates/refinements to the 2018 proposed doses and frequency of Dasatinib-Quercetin cocktail (found here: https://age-reversal.net/senolytics/ )?
- Jeff Jones
- Jeff_Jones
- 5 mths ago
- 1reply
- 36
- 1
- Last replyBrian Valerie5 mths ago
- Senolytics Discussion
Fisetin ( + quercitin)
Among flavonoids, fisetin appears to be an effective senolytic: https://www.fightaging.org/archives/2018/10/animal-data-shows-fisetin-to-be-a-surprisingly-effective-senolytic/ "Fisetin appears about…
- cacarr
- cacarr
- 6 yrs ago
- 63replies
- 3282
- 5
- Last replyAllen DeLaney11 mths ago
- Senolytics Discussion
Fisetin experimentation one year (reposted as topic for info purposes)
Hello everyone I wanted to make my first post here as I have been doing a fisetin routine for a year now just about and I have results that are not placebo and very profound.…
- David C
- David_C
- 5 yrs ago
- 535replies
- 7999
- 17
- Last replygarland1 yr ago
- Senolytics Discussion
Senolytics and Female Fertility
Does anyone know how senolytic therapy could impact female fertility? While the theory that women start with a finite amount of eggs which simply dwindle over time until fertility is depleted has…
- Phoenix
- phoenix
- 5 yrs ago
- 21replies
- 881
- 2
- Last replyStaffan Olsson1 yr ago
- Senolytics Discussion
Azrithomycin dose for senolytic
- are we there yet
- are_we_there_yet
- 1 yr ago
- 6replies
- 123
- Last replyBruce B1 yr ago
- Senolytics Discussion
Trametinib - is it still just theoretical?
Hi Everyone, I just watched Bill Faloon at RAADfest 2023 (https://www.youtube.com/watch?v=nfaZ_0Rajdc) and saw he mentioned trametinib. Is it still theoretical at this point or have studies been…
- ROB KRAFT
- ROB_KRAFT
- 1 yr ago
- 21
- Senolytics Discussion
Senolytic Effects of FOXO4-DRI
I found this research on target specific effects of FOXO4-DRI to be interesting. Please add your thoughts and links to any other research. Could this be a viable experimental therapy? https://www.…
- Dorian Gray
- Dorian_gray
- 5 yrs ago
- 12replies
- 555
- Last replyJohn Mcgough1 yr ago
- Senolytics Discussion
Qualia Senolytic product
Having booked a lot of success with improving my NAD+ levels by taking resveratrol and a NAD precursor ( which I've described in another forum ) I decided to take the next logical step and tackle…
- David Young
- David_Young
- 1 yr ago
- 9replies
- 96
- 1
- Last replyBrian Valerie1 yr ago
- Senolytics Discussion
Has anyone tried taking fietin as a suppository?
I would think that, by bypassing the GI tract, this would guarantee 100% absorption into the blood.
- Robert Uomini
- Robert_Uomini
- 3 yrs ago
- 5replies
- 303
- Last replyStaffan Olsson2 yrs ago
- Senolytics Discussion
Someone tried to contact me in chat...
Someone tried to contact me in chat..., I had to update windows and lost the chat. Thanks
- John Ramos
- John_Ramos
- 2 yrs ago
- 3replies
- 57
- Last replyChris2 yrs ago
- Senolytics Discussion
Senolytics- How many different ones do you take and why
I am assuming that a given Senolytic may not cause senolysis in all cell types and therefore it is probably better to rotate through different senolytics.…
- Karl
- Karl.1
- updated 3 yrs ago
- 4replies
- 268
- 1
- Last replyBrian Valerie3 yrs ago
- Senolytics Discussion
A hypothesis about Senescent Cells
My hypothesis is that a large proportion of Senescent Cells are in fact Stem Cells which have not differentiated properly. What happens is they cause inflammation which causes a reduction in NF-κb…
- John Hemming
- John_Hemming
- 3 yrs ago
- 7replies
- 191
- Last replyUB3 yrs ago
- Senolytics Discussion
PCC1 is senolytic and senomorphic
Procyanidin C1 (PCC1 or PC-C1), which is found in grape seed extract (GSE), is senolytic, senomorphic, and has been proven to increase the lifespan of mice.…
- Florin
- Florin
- updated 3 yrs ago
- 3replies
- 307
- 2
- Last replyKarl3 yrs ago
- Senolytics Discussion
Azithromycin (Zithromax) as senolytic; a note of caution
This is the problem with "cell studies." The authors who found this result decided to look at what they called a "low dose" of azithromycin (AZM) on cells.…
- Steve Harris
- Steve_Harris
- updated 6 yrs ago
- 14replies
- 1546
- 5
- Last replyVan3 yrs ago
- Senolytics Discussion
Alternative mechanism for senolytics
Do senolytics only work because the affect mTor? Interesting article. What do you think? https://www.oncotarget.com/article/28049/text/
- Karl
- Karl.1
- 3 yrs ago
- 69
- 1
- Senolytics Discussion
A different point of view
Interesting article that argues for telomere therapy and against senolytics. https://www.leafscience.org/are-senolytics-potentially-damaging-for-longevity/
- Karl
- Karl.1
- 5 yrs ago
- 8replies
- 305
- Last replyJGC3 yrs ago
- Senolytics Discussion
Can snorting fisetin improve bioavailability and is it safe?
Title says it all. I suspect that since fisetin is hydrophobic, it won't dissolve in the body and would only serve to irritate the lungs, but I'm not a pulmonary expert.
- Robert Uomini
- Robert_Uomini
- 4 yrs ago
- 16replies
- 249
- Last replyRobert Uomini3 yrs ago
- Senolytics Discussion
Inexexpensive Rapamycin and Datatinib from India
Just received my shipment of 200 1mg rapamycin pills and 120 20 mg datsatinib pills from Varun Medicals at https://www.varunmedicals.com. The rapa pills were from Swiss Garnier Biotech marketed…
- Bernie
- Bernie_Singer
- 4 yrs ago
- 218
- 2
- Senolytics Discussion
Senolytic guru Dr De Keizer says quercetin is useless?
"As for quercetin and dasatinib, I’m absolutely not a fan of those. We’ve tried a couple of experiments; we’ve never seen a good result. Campisi’s lab has tried it extensively,…
- Fred Cloud
- Fred_Cloud
- 4 yrs ago
- 2replies
- 449
- Last replyGleb Merkurev4 yrs ago
- Senolytics Discussion
Levels of senescent cells correlates with death?
Interesting study https://www.nature.com/articles/s41467-019-13192-4
- Paul Beauchemin
- Paul_Beauchemin
- 5 yrs ago
- 1reply
- 188
- Last replyJoe smith5 yrs ago
- Senolytics Discussion
Just got my dasatinib capsules
I live in S.CA and went to Las Vegas to Dr Garcia who prescribed the dasatinib dosage promoted by Faloon. A few months passed while COVID-19 disrupted supply chains.…
- Brook Norton
- Brook_Norton
- 5 yrs ago
- 3replies
- 217
- Last replyBrook Norton5 yrs ago
- Senolytics Discussion
Senolytics and Covid-19
https://youtu.be/2DvJwthiMPk great discussion on why senolytics could be major help in combating Covid-19. talks about Rapamycin and Dasatinib too. Glad I didn’t stop Rapamycin
- Paul Beauchemin
- Paul_Beauchemin
- 5 yrs ago
- 4replies
- 169
- 3
- Last replyEdward Meininger5 yrs ago
- Senolytics Discussion

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