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Senolytics Discussion

Discussions about senolytics for the removal of senescent cells.

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Introduction to senolytics
Hi everyone, The term " senolytics " refers to compounds that selectively induce cell death in senescent cells. Senescent cells are cells whose metabolism has gone awry for one reason or another,…
- Maximus Peto
- Researcher, website & forum admin
- Maximus
- 5 yrs ago
- 33 replies
- 1,254
- 2
- Juan Daw7 mths ago
- Senolytics Discussion
Sources of dasatinib
Hello everyone, We’ve received reports from Age Reversal Network members about lower-cost sources of dasatinib. This post is intended to aggregate this information into a single forum post for easy…
- Maximus Peto
- Researcher, website & forum admin
- Maximus
- 3 yrs ago
- 134 replies
- 3,007
- 5
- Stephen Lewis1 yr ago
- Senolytics Discussion
Has anyone tried taking fietin as a suppository?
I would think that, by bypassing the GI tract, this would guarantee 100% absorption into the blood.
- Robert Uomini
- Robert_Uomini
- 1 yr ago
- 5 replies
- 224
- Staffan Olsson3 mths ago
- Senolytics Discussion
Fisetin experimentation one year (reposted as topic for info purposes)
Hello everyone I wanted to make my first post here as I have been doing a fisetin routine for a year now just about and I have results that are not placebo and very profound.…
- David C
- David_C
- 3 yrs ago
- 455 replies
- 6,513
- 16
- John Ramos6 mths ago
- Senolytics Discussion
Someone tried to contact me in chat...
Someone tried to contact me in chat..., I had to update windows and lost the chat. Thanks
- John Ramos
- John_Ramos
- 8 mths ago
- 3 replies
- 45
- Chris8 mths ago
- Senolytics Discussion
Senolytic Effects of FOXO4-DRI
I found this research on target specific effects of FOXO4-DRI to be interesting. Please add your thoughts and links to any other research. Could this be a viable experimental therapy? https://www.…
- Dorian Gray
- Dorian_gray
- 3 yrs ago
- 11 replies
- 292
- JGC10 mths ago
- Senolytics Discussion
Senolytics- How many different ones do you take and why
I am assuming that a given Senolytic may not cause senolysis in all cell types and therefore it is probably better to rotate through different senolytics.…
- Karl
- Karl.1
- 1 yr ago
- 4 replies
- 222
- 1
- Brian Valerie1 yr ago
- Senolytics Discussion
A hypothesis about Senescent Cells
My hypothesis is that a large proportion of Senescent Cells are in fact Stem Cells which have not differentiated properly. What happens is they cause inflammation which causes a reduction in NF-κb…
- John Hemming
- John_Hemming
- 1 yr ago
- 7 replies
- 161
- UB1 yr ago
- Senolytics Discussion
PCC1 is senolytic and senomorphic
Procyanidin C1 (PCC1 or PC-C1), which is found in grape seed extract (GSE), is senolytic, senomorphic, and has been proven to increase the lifespan of mice.…
- Florin
- Florin
- 1 yr ago
- 3 replies
- 275
- 2
- Karl1 yr ago
- Senolytics Discussion
is pevonedistat an unknown novel anti-aging drug?
Targeting Protein Neddylation for Cancer Therapy. https://www.ncbi.nlm.nih.gov/pubmed/31898235 I recently participated in a phase 1 dosage safety cancer clinical trial combining this investigation…
- chad cooper
- chad_cooper
- 3 yrs ago
- 6 replies
- 190
- 7
- Erik A Aronesty1 yr ago
- Senolytics Discussion
Fisetin ( + quercitin)
Among flavonoids, fisetin appears to be an effective senolytic: https://www.fightaging.org/archives/2018/10/animal-data-shows-fisetin-to-be-a-surprisingly-effective-senolytic/ "Fisetin appears about…
- cacarr
- cacarr
- 4 yrs ago
- 59 replies
- 2,913
- 5
- Hello World1 yr ago
- Senolytics Discussion
Azithromycin (Zithromax) as senolytic; a note of caution
This is the problem with "cell studies." The authors who found this result decided to look at what they called a "low dose" of azithromycin (AZM) on cells.…
- Steve Harris
- Steve_Harris
- 4 yrs ago
- 14 replies
- 1,388
- 5
- Van1 yr ago
- Senolytics Discussion
Alternative mechanism for senolytics
Do senolytics only work because the affect mTor? Interesting article. What do you think? https://www.oncotarget.com/article/28049/text/
- Karl
- Karl.1
- 1 yr ago
- 60
- 1
- Senolytics Discussion
Senolytics and Female Fertility
Does anyone know how senolytic therapy could impact female fertility? While the theory that women start with a finite amount of eggs which simply dwindle over time until fertility is depleted has…
- Phoenix
- phoenix
- 3 yrs ago
- 20 replies
- 628
- 1
- Jane1 yr ago
- Senolytics Discussion
A different point of view
Interesting article that argues for telomere therapy and against senolytics. https://www.leafscience.org/are-senolytics-potentially-damaging-for-longevity/
- Karl
- Karl.1
- 3 yrs ago
- 8 replies
- 288
- JGC1 yr ago
- Senolytics Discussion
Can snorting fisetin improve bioavailability and is it safe?
Title says it all. I suspect that since fisetin is hydrophobic, it won't dissolve in the body and would only serve to irritate the lungs, but I'm not a pulmonary expert.
- Robert Uomini
- Robert_Uomini
- 2 yrs ago
- 16 replies
- 230
- Robert Uomini1 yr ago
- Senolytics Discussion
Inexexpensive Rapamycin and Datatinib from India
Just received my shipment of 200 1mg rapamycin pills and 120 20 mg datsatinib pills from Varun Medicals at https://www.varunmedicals.com . The rapa pills were from Swiss Garnier Biotech marketed…
- Bernie
- Bernie_Singer
- 2 yrs ago
- 196
- 2
- Senolytics Discussion
Senolytic guru Dr De Keizer says quercetin is useless?
"As for quercetin and dasatinib, I’m absolutely not a fan of those. We’ve tried a couple of experiments; we’ve never seen a good result. Campisi’s lab has tried it extensively,…
- Fred Cloud
- Fred_Cloud
- 2 yrs ago
- 2 replies
- 411
- Gleb Merkurev2 yrs ago
- Senolytics Discussion
Levels of senescent cells correlates with death?
Interesting study https://www.nature.com/articles/s41467-019-13192-4
- Paul Beauchemin
- Paul_Beauchemin
- 3 yrs ago
- 1 reply
- 176
- Joe smith3 yrs ago
- Senolytics Discussion
Just got my dasatinib capsules
I live in S.CA and went to Las Vegas to Dr Garcia who prescribed the dasatinib dosage promoted by Faloon. A few months passed while COVID-19 disrupted supply chains.…
- Brook Norton
- Brook_Norton
- 3 yrs ago
- 3 replies
- 183
- Brook Norton3 yrs ago
- Senolytics Discussion
Senolytics and Covid-19
https://youtu.be/2DvJwthiMPk great discussion on why senolytics could be major help in combating Covid-19. talks about Rapamycin and Dasatinib too. Glad I didn’t stop Rapamycin
- Paul Beauchemin
- Paul_Beauchemin
- 3 yrs ago
- 4 replies
- 158
- 3
- Edward Meininger3 yrs ago
- Senolytics Discussion
Details of dasatinib + quercetin study
What were the dosages of dasatinib and quercetin used for this study? What kind of quercetin was used? Any issues or side effects noted so far?
- Ozone8
- Ozone8
- 5 yrs ago
- 78 replies
- 2,030
- 3
- Mel3 yrs ago
- Senolytics Discussion
New Anti-Aging clinic in Georgia.
I noticed a new clinic has opened in the state of Georgia that prescribes metformin, rapamycin, and dasatinib. Mikhail Blagosklonney tweeted the link this morning.…
- Larry
- Larry.1
- 3 yrs ago
- 107
- Senolytics Discussion
Sulfuraphane
On Dr Kaufmann’s website, it states that sulfuraphane protects cells from apoptosis and senescence. This would seem to work against senolytics. Does anyone take sulfuraphane and if so do you stop…
- Karl
- Karl.1
- 3 yrs ago
- 1 reply
- 200
- 1
- Staffan Olsson3 yrs ago
- Senolytics Discussion
Blocking negative effects of senescence in human skin fibroblasts with a plant extract
I find this very interesting. And people that focus on preventing senescence and the aging of their skin might be extra interested in how we can interpretate the research above.…
- Staffan Olsson
- Staffan_Olsson
- 3 yrs ago
- 2 replies
- 191
- 1
- BobM3 yrs ago
- Senolytics Discussion

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