Can snorting fisetin improve bioavailability and is it safe?
Title says it all. I suspect that since fisetin is hydrophobic, it won't dissolve in the body and would only serve to irritate the lungs, but I'm not a pulmonary expert.
16 replies
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Probably snorting Fisetin would improve its bioavailabilty, but it would take a lot of such snorts to reach the level needed for senolytics. Let's say (as a guess) that putting Fisetin powder in contact with the rich blood vessel network back in the nose would increase bioavilability by a factor of 5. Still, to get to the equivalent of swallowing 2 g of Fisetin powder, you would need to snort about 400 mg, which is a lot. However, if snorting is your thing, give it a try. It should be safe (except for all the yellow snot).
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I get great results from oral fisetin and so do many others in this group. You are trying to solve a problem that doesnt exist.
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I had researched the bioavailability of fisetin when used with Piperine, but I found nothing, although I did see that bioavailability of certain other flavenoids, especially curcumin, was increased. Do you know of any peer-reviewed articles that support the improved bioavailability of fisetin using Piperine?
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My capsules of Fisetin 100mg are filled with up to 500mg of material. So if you are snorting fisetin, you are also snorting 3 or 4 times as much filler material. You should probably not do that...