Senolytics and Female Fertility

Does anyone know how senolytic therapy could impact female fertility? While the theory that women start with a finite amount of eggs which simply dwindle over time until fertility is depleted has been longstanding, newer research points to the possibility that stem cells nests in the ovaries might be able to produce new eggs.  Has anyone read anything about his or have you seen changes in your fertlity after senolytic (or other anti-aging) therapy?

Might a senolytic therapy boost stem cell nests in the ovary by eliminating general SASP or senescent cells in the ovary itself.

I wonder if currently available senolytics could impact the senolytic ovary cells, as in do senescent ovary cells undergo apoptosis by the mechanisms of currently available drugs and supplements?

Thank you!

8replies Oldest first
  • Oldest first
  • Newest first
  • Active threads
  • Popular
  • About a month ago I began taking 3 day doses of senolytic combination every other week; three total treatments so far for possible protection from early dementia (Fisetin, myrecetin and quercetin).  I'm menopausal and have been taking HRT for almost 2 years.  If I miss any HRT doses, I start having severe menopausal symptoms.  I can't be sure it is the treatment that did this, but I haven't changed anything else in my routine.  I chart temps and LH surges.  My body has been aggressively trying to ovulate with all the symptomology of a young lady, except that ovulation has not yet occured according to LH strips and thermal surge.  I have not touched any HRT since I started noticing these symptoms a few days after the first dosage.  If I'd tried something like this in the past, the lack of estrogen from patches would cause severe menopausal symptomolgy, but nothing.  Because if this dramatic shift, I believe that one or more of these particular supplements may have caused senescent ovarian cells to die, which may have resulted in fresh new eggs being produced from ovarian stem cells.  I should also note, that in between the treatments, I take nicotinimid riboside as rejuvenation therapy, though unlike the senolytics, this is not new.  I've taken this on and off for 3 years.  Due to these physiological changes, I'll be combing the scientific literature for information on how these may affect reproduction.  On cursory glance, there isn't a lot of work...all with other mammals, and some is a bit conflicting, indicating species specific effects that may not translate to people. But it seems  like one or more of these may affect reproductive hormones in both women and men.  Personally, I believe this could be an area that could use immediate and prompt interest from reproductive aging researchers doing work on oogonial stem cells and general aging of the female reproductive system.

    Reply Like
    • Self Hacker Lynn 

       

      Now you made me curious. I think you are the first person in here to add myricetin to a senolytic Fisetin and quercetin combination.

       

      May I ask you about why you have myricetin as a key component in you senolytic combination? We have talked about myricetin in here but so far I think you are the first person to use it in a self experiment aiming at reducing senescent cells. I am very happy to hear more about this way of using myrecitin and learn about this approach. 

      Reply Like
    • Staffan Olsson 

      Hi, so originally I added the myricetin because I was taking these for cognitive protection against dementia as I mentioned above, and myricetin protects from glutamates negative effects on brain senescence.  I'm not certain it is an effective senolytic though.  I saw one research report where it wasn't and another that said it had some effect.  Here are some papers:  Iyer SC, Gopal A, Halagowder D. Myricetin induces apoptosis by inhibiting P21 activated kinase 1 (PAK1) signaling cascade in hepatocellular carcinoma. Mol Cell Biochem. 2015;407(1-2):223-37.  

      1. Huang H, Chen AY, Ye X, et al. Myricetin inhibits proliferation of cisplatin-resistant cancer cells through a p53-dependent apoptotic pathway. Int J Oncol. 2015;47(4):1494-502.
      2. Huang H, Chen AY, Rojanasakul Y, et al. Dietary compounds galangin and myricetin suppress ovarian cancer cell angiogenesis. J Funct Foods. 2015;15:464-75.
      3. Life extension article that mentions effects of myricetin in more detail https://www.lifeextension.com/magazine/2017/4/geroprotectors 
      Reply Like
    • Self Hacker Lynn BTW, there are many scientific papers that show myricetin induces cancer cell apoptosis, probably through negative affects on mitochondria and various other pathways like blocking angiogensis in several kinds of cancer cells... bladder, gastric, hepatocellular, cervical, esophageal, colon,  thyroid, osteoblastic, pancreatic, skin, and liver.  Whether this translates to scenescent cells is far less certain.  The effects seem cell type specific with an emphasis on cancer cells.

      Reply Like
    • Self Hacker Lynn 

       

      Thank you for sharing your thinking about myricetin. Myricetin is something I will add to my regim later. it seams to be a promising geroprotector. Actually I should have incorporated it already but decided to start with ferulic acid first. 

      Reply Like
    • Self Hacker Lynn 

       

      Hi again.

       

      I wonder if you can share how much fisetin, quercetin and myricetin you take. And also what the  brands are. I ask this question just beacuase there are a few different formulas of the substances you use.  Best regards 

      Reply Like
    • Staffan Olsson 500mg Fisetin -Novusetin,  200mg myrecetin- source naturals, Activated quercetin source naturals 1g.  All are taken one time per day at night for three days every other week for 3 months.  Currently on 4th treatment. 

      Reply Like
    • Self Hacker Lynn Hi Lynn.  Since female sex drive tends to increase during ovulation, one wonders if senolytics might be a possible treatment for menopausal loss of libido.

      Reply Like
Like Follow
  • 2 wk agoLast active
  • 8Replies
  • 89Views
  • 4 Following