Senolytics and Female Fertility
Does anyone know how senolytic therapy could impact female fertility? While the theory that women start with a finite amount of eggs which simply dwindle over time until fertility is depleted has been longstanding, newer research points to the possibility that stem cells nests in the ovaries might be able to produce new eggs. Has anyone read anything about his or have you seen changes in your fertlity after senolytic (or other anti-aging) therapy?
Might a senolytic therapy boost stem cell nests in the ovary by eliminating general SASP or senescent cells in the ovary itself.
I wonder if currently available senolytics could impact the senolytic ovary cells, as in do senescent ovary cells undergo apoptosis by the mechanisms of currently available drugs and supplements?
About a month ago I began taking 3 day doses of senolytic combination every other week; three total treatments so far for possible protection from early dementia (Fisetin, myrecetin and quercetin). I'm menopausal and have been taking HRT for almost 2 years. If I miss any HRT doses, I start having severe menopausal symptoms. I can't be sure it is the treatment that did this, but I haven't changed anything else in my routine. I chart temps and LH surges. My body has been aggressively trying to ovulate with all the symptomology of a young lady, except that ovulation has not yet occured according to LH strips and thermal surge. I have not touched any HRT since I started noticing these symptoms a few days after the first dosage. If I'd tried something like this in the past, the lack of estrogen from patches would cause severe menopausal symptomolgy, but nothing. Because if this dramatic shift, I believe that one or more of these particular supplements may have caused senescent ovarian cells to die, which may have resulted in fresh new eggs being produced from ovarian stem cells. I should also note, that in between the treatments, I take nicotinimid riboside as rejuvenation therapy, though unlike the senolytics, this is not new. I've taken this on and off for 3 years. Due to these physiological changes, I'll be combing the scientific literature for information on how these may affect reproduction. On cursory glance, there isn't a lot of work...all with other mammals, and some is a bit conflicting, indicating species specific effects that may not translate to people. But it seems like one or more of these may affect reproductive hormones in both women and men. Personally, I believe this could be an area that could use immediate and prompt interest from reproductive aging researchers doing work on oogonial stem cells and general aging of the female reproductive system.