Azrithomycin dose for senolytic

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  • A single axithromycin dose study is said to remove 97% of senescent cells while causing no harm to others. 
    question: what dose is recommended for humans?

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    • Brian Valerie
    • Semi-Retired Health Education Teacher
    • Brian_Valerie
    • 9 mths ago
    • Reported - view

    This sounds more than intriguing if such results are replicated!  This must be a very recently published study.  Would you be able to give us a reference to the original study please?

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  • I believe that study was done in mice and that the applicability to human cells was based on an in vitro study. 

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    • JGC
    • Retired Professor of Physics
    • JGC
    • 9 mths ago
    • Reported - view

        Here's a LINK to the human cell in vitro study.  They showed that an Axithromycin dose level of 50 micromoles administered to a human cell culture had no effect, while a dose level of 100 micromoles cleared about 44% of the human senescent cells.  Roxithromycin at the same dosage did even better, clearing about 69%.

        Does anyone know how to translate that dose level as applied to a cell culture to a self-experiment oral dosage in mg?  The molar mass of Axithromycin is 748.996 g/mol.

    Like 2
      • JGC
      • Retired Professor of Physics
      • JGC
      • 9 mths ago
      • Reported - view

          Correction:  Azithromycin, not Axithromycin.

          I note that Azithromycin has a  bioavailability of about 37% and Roxithromycin has an exceptionally high bioavailability (72–85%).  "Following a single oral 500 mg dose of Azithromycin, peak plasma concentrations of about 0.35-0.45 mg/l were attained within approximately 2 hours."

          The trouble with these drugs is that they are antibiotics that kill benign gut bacteria and may send your digestive system for a loop.

      Like 2
    • Bruce B
    • Bruce_123
    • 7 mths ago
    • Reported - view

    Over the past three years, my wife and I have committed to annual 5-day fast, extending almost six days. During this period, we incorporate a senolytics regimen. This year, my wife took Zithromax for the first three days, followed by a three-day course of Dasatinib Quercetin. Similarly, I used Roxithromycin for the initial three days and then switched to Dasatinib Quercetin for the remaining period.

    Reflecting on this practice, I've observed that combining fasting with senolytics heightens the overall discomfort, particularly in the final stages. This discomfort is physically and mentally challenging.

    I initially started this routine three years ago while dealing with mild arthritis in my left hand. After a 5-day fast, complemented by a Dasatinib/Quercetin combo in the last three days, the arthritis remarkably disappeared. However, the symptoms returned before this year's fast. I felt continuous sensations in the joints of my left hand and developed a painful joint with a developing Heberden's node on my right pointer finger.

    To address these symptoms, I experimented with Dasatinib Quercetin outside of fasting but didn't observe any noticeable effects. Additionally, I used Pentosan, intended for a knee cartilage injury, which provided some relief for the joint discomfort and reduced inflammation in the Heberden's node, though it didn't completely eliminate the symptoms.

    As we commenced our annual fast, I tested Roxithromycin during the first three days, curious about its impact on my few grey hairs, but there were no significant changes. The Dasatinib/Quercetin regimen, started on the third day, had a remarkable and immediate effect on my arthritis. By the end of the fast, the discomfort in my left hand had vanished, and the condition of my right pointer finger, including the Heberden's node, had significantly improved becoming unnoticeable.

    My wife, diagnosed with MGUS, a precursor to Multiple Myeloma, experienced substantial discomfort from Zithromax, particularly bone pain in her legs. However, she found the Dasatinib Quercetin in the last three days of the fast more bearable.

    Neither of us had any stomach issues related to the antibiotics. Following the fast, we both felt revitalized. We continue to conduct yearly epigenetic tests as part of our health management, tracking our progress.
     

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