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Re: Fisetin experimentation one year (reposted as topic for info purposes) @John Mcgough That really is intriguing, John, and similar to Steffan Olsson's report. By the way, Stefan is the one who reported "a minor" euphoria, not me.…
- Brian Valerie
- Semi-Retired Health Education Teacher
- Brian_Valerie
- 10 days ago
- 1
- Senolytics Discussion
- Reported - view
Re: Fisetin experimentation one year (reposted as topic for info purposes) @Staffan Olsson That really is intriguing, Staffan. It does seem that there is a real effect there, but unlike some skeptics, my big question with anecdotal evidence is not the well documented…
- Brian Valerie
- Semi-Retired Health Education Teacher
- Brian_Valerie
- 2 wk ago
- 1
- Senolytics Discussion
- Reported - view
Re: Fisetin experimentation one year (reposted as topic for info purposes) @John Mcgough Keep us posted. My resting heart rate has gradually been going down (to about 55-65), but I expect that's due to my daily exercise rather than senolytics.…
- Brian Valerie
- Semi-Retired Health Education Teacher
- Brian_Valerie
- 2 wk ago
- 1
- Senolytics Discussion
- Reported - view
Re: Fisetin experimentation one year (reposted as topic for info purposes) @John Mcgough Thanks for sharing your results, John. I likewise don't notice any difference in how I feel after my monthly fisetin (along with quercetin and theaflavins) protocols,…
- Brian Valerie
- Semi-Retired Health Education Teacher
- Brian_Valerie
- 2 wk ago
- 1
- Senolytics Discussion
- Reported - view
Re: Polling your opinion - longevity themed forums, the best ones And I thank you, Agingdoc! No membership price offsets, but that's fine since the membership fee is quite modest. Welcome to another longevity minded community!
- Brian Valerie
- Semi-Retired Health Education Teacher
- Brian_Valerie
- 3 wk ago
- 2
- General Discussion
- Reported - view
Re: Polling your opinion - longevity themed forums, the best ones HI there, David, I'm a member of LongeCity (longecity.org), which is an open public forum for information and discussion, a repository for relevant information,…
- Brian Valerie
- Semi-Retired Health Education Teacher
- Brian_Valerie
- 3 wk ago
- 1
- General Discussion
- Reported - view
Re: Azrithomycin dose for senolytic This sounds more than intriguing if such results are replicated! This must be a very recently published study. Would you be able to give us a reference to the original study please?
- Brian Valerie
- Semi-Retired Health Education Teacher
- Brian_Valerie
- 2 mths ago
- 1
- Senolytics Discussion
- Reported - view
Re: Qualia Senolytic product Great! Nice chatting with you, David.
- Brian Valerie
- Semi-Retired Health Education Teacher
- Brian_Valerie
- 2 mths ago
- Senolytics Discussion
- Reported - view
Re: Qualia Senolytic product I'm happy for your feeling so much energy, David, and will try not to be envious! I was only referring to the fact that our bodies "adjust" to many of the supplements and drugs that we take,…
- Brian Valerie
- Semi-Retired Health Education Teacher
- Brian_Valerie
- 2 mths ago
- 1
- Senolytics Discussion
- Reported - view
Re: Qualia Senolytic product Sounds good. On Life Extension website's Senolytic Activator (which contains 56mg of Bio-Fisetin) Product Details "Convenient, once-weekly formula" sub-section, they write,…
- Brian Valerie
- Semi-Retired Health Education Teacher
- Brian_Valerie
- 2 mths ago
- 1
- Senolytics Discussion
- Reported - view
Re: Qualia Senolytic product Sorry for the nine day delay in replying, David, but only yesterday was I notified of your post. Well, I do feel some (quite mild) anxiety about choosing the optimal dosing protocols for some…
- Brian Valerie
- Semi-Retired Health Education Teacher
- Brian_Valerie
- 2 mths ago
- 1
- Senolytics Discussion
- Reported - view
Re: Qualia Senolytic product Hi David, and welcome to the Senolytics Fan Club! I haven't noticed any effects from taking Life Extension's Senolytic Activator (nor from resveratrol, pterostilbene, NMN, NR, etc.…
- Brian Valerie
- Semi-Retired Health Education Teacher
- Brian_Valerie
- 3 mths ago
- 1
- Senolytics Discussion
- Reported - view
Re: GlyNAC @martino lorenzon Anhedonia has not been a widely reported side effect of GlyNAC supplementation. I think that we should consider some other confounding variable(s) as the possible cause(s).
- Brian Valerie
- Semi-Retired Health Education Teacher
- Brian_Valerie
- 5 mths ago
- 1
- Self-Experimentation
- Reported - view
Re: GlyNAC Hi Martino, My taking glycine and NAC evidently hasn't raised my rather consistently low blood pressure (about 110/65). I'm skeptical that either of them have the negative interactions that you…
- Brian Valerie
- Semi-Retired Health Education Teacher
- Brian_Valerie
- 6 mths ago
- Self-Experimentation
- Reported - view
Re: GlyNAC @martino lorenzon I take 2 g each of NAC and glycine at bedtime and another 1 g of NAC and 1.5 g of glycine when I get up to use the restroom about 4 or 5 hours later.…
- Brian Valerie
- Semi-Retired Health Education Teacher
- Brian_Valerie
- 6 mths ago
- 1
- Self-Experimentation
- Reported - view
Re: Fisetin experimentation one year (reposted as topic for info purposes) @David C Thanks for sharing, David. May I ask your (or other readers') opinion of Life Extension Foundation's recommendation of the equivalent (of their bioavailable fisetin,…
- Brian Valerie
- Semi-Retired Health Education Teacher
- Brian_Valerie
- 1 yr ago
- Senolytics Discussion
- Reported - view
Re: Cure for Cancer? 18 participants with a 100% success rate is certainly not too small a trial to take seriously. Let's hope "beyond hope" that this immunotherapy is likewise applicable to cancers other than rectal!
- Brian Valerie
- Semi-Retired Health Education Teacher
- Brian_Valerie
- 1 yr ago
- 2
- General Discussion
- Reported - view
Re: Senolytics- How many different ones do you take and why @Karl You may already know this, but there is recent evidence that curcumin has some senolytic effect, so along with my daily dose I've added an extra dose of bioavailable curcumin to my weekly…
- Brian Valerie
- Semi-Retired Health Education Teacher
- Brian_Valerie
- 1 yr ago
- 1
- Senolytics Discussion
- Reported - view
Re: Senolytics- How many different ones do you take and why @Karl My wife thinks the same thing and takes less the half the supplements that I do. I admit that many of them are only speculatively health or life extending,…
- Brian Valerie
- Semi-Retired Health Education Teacher
- Brian_Valerie
- 1 yr ago
- 1
- Senolytics Discussion
- Reported - view
Re: Senolytics- How many different ones do you take and why Our friends at Life Extension (and I) add theaflavins and apigenin to their bioavailable quercetin and bioavailable fisetin Senolytic Activator. I also take ginger, grape seed extract, luteolin,…
- Brian Valerie
- Semi-Retired Health Education Teacher
- Brian_Valerie
- 1 yr ago
- 1
- Senolytics Discussion
- Reported - view
Re: GlyNAC @Jack Black I'm guessing you meant to write 9 grams rather than 9mg (?). As noted above, I'm taking four grams qod, and admit to being shy about taking more chronically until we have more human…
- Brian Valerie
- Semi-Retired Health Education Teacher
- Brian_Valerie
- 1 yr ago
- 1
- Self-Experimentation
- Reported - view
Re: GlyNAC @Jack Black I take 4200mg of NAC along with 4000mg of the reportedly somnorific glycine every other day (alternating with 3000mg of the somnorific anti-inflammatory ashwagandha in the perhaps vain…
- Brian Valerie
- Semi-Retired Health Education Teacher
- Brian_Valerie
- 1 yr ago
- 2
- Self-Experimentation
- Reported - view
Re: Fisetin experimentation one year (reposted as topic for info purposes) @John Ramos One can get what may be a reasonable amount of spermidine from raw wheat germ.
- Brian Valerie
- Semi-Retired Health Education Teacher
- Brian_Valerie
- 1 yr ago
- 1
- Senolytics Discussion
- Reported - view
Re: Stopping Metformin @Karl I haven't read any endocrinologists (not that I've read them all by any means!) who would be opposed to your decision, assuming you obtained the metformin by prescription.
- Brian Valerie
- Semi-Retired Health Education Teacher
- Brian_Valerie
- 1 yr ago
- 1
- AMPK Activation
- Reported - view
Re: Fisetin to Clear Senescent Cells @Robert Olin I'd just like to clarify that autophagy does NOT "start" at the 17 hour mark, which is by no means a definitive dividing line in any case.…
- Brian Valerie
- Semi-Retired Health Education Teacher
- Brian_Valerie
- 1 yr ago
- 1
- Self-Experimentation
- Reported - view

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Brian Valerie

Brian_Valerie

Semi-Retired Health Education Teacher

Dana Point, California, USA

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Joined: 16 Jan 2021

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Member at LongeCity.org;
Health Topics Writer at Quora.com