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Re: Sleep Quality DSIP Thanks for sharing this, Bruce. DSIP (Delta sleep-inducing peptide) has been studied for more than 40 years and is not commonly prescribed, but if your doctor approves and it works for you,…
- Brian Valerie
- Semi-Retired Health Education Teacher
- Brian_Valerie
- 2 mths ago
- 1
- Self-Experimentation
- Reported - view
Re: D+Q+F+P+L+G+GLA: A New Senolytic Cocktail @Jay Orman Thank you. I did reply.
- Brian Valerie
- Semi-Retired Health Education Teacher
- Brian_Valerie
- 2 mths ago
- Self-Experimentation
- Reported - view
Re: D+Q+F+P+L+G+GLA: A New Senolytic Cocktail @Jay Orman I've always taken my senolytics stack with food, as I believe that at least one of its ingredients may be fat soluble. I was just wondering, Jay,…
- Brian Valerie
- Semi-Retired Health Education Teacher
- Brian_Valerie
- 2 mths ago
- 1
- Self-Experimentation
- Reported - view
Re: D+Q+F+P+L+G+GLA: A New Senolytic Cocktail @Moonlitnight I've added piperlongumine (fermented long pepper extract standardized to 1% piperlongumine from CellFend) to my episodic senolytic stack, which also includes fisetin, quercetin,…
- Brian Valerie
- Semi-Retired Health Education Teacher
- Brian_Valerie
- 2 mths ago
- 2
- Self-Experimentation
- Reported - view
Re: Fisetin experimentation one year (reposted as topic for info purposes) @Staffan Olsson Thanks for sharing this truly fascinating info, Staffan. My best guess is that PL will also prove to have fewer side effects than dasatinib.
- Brian Valerie
- Semi-Retired Health Education Teacher
- Brian_Valerie
- 8 mths ago
- 1
- Senolytics Discussion
- Reported - view
Re: Fisetin experimentation one year (reposted as topic for info purposes) @Dean W. Thanks for sharing that, Dean. Another alternative on Amazon is CellFend brand fermented (to increase bioavailability) long pepper extract capsules,…
- Brian Valerie
- Semi-Retired Health Education Teacher
- Brian_Valerie
- 8 mths ago
- 1
- Senolytics Discussion
- Reported - view
Re: Fisetin experimentation one year (reposted as topic for info purposes) IMPORTANT DASATINIB SUBSTITUTES UPDATE! Just published: Meiners, et al., "Computational identification of natural senotherapeutic compounds that mimic dasatinib based on gene expression data",…
- Brian Valerie
- Semi-Retired Health Education Teacher
- Brian_Valerie
- 8 mths ago
- 1
- Senolytics Discussion
- Reported - view
Re: Fisetin experimentation one year (reposted as topic for info purposes) @Dean W. In defense of your doctor, very, very few doctors will prescribe off-label dasatinib (or rapamycin). It's not because they're necessarily unaware of the research either,…
- Brian Valerie
- Semi-Retired Health Education Teacher
- Brian_Valerie
- 8 mths ago
- 1
- Senolytics Discussion
- Reported - view
Re: Fisetin experimentation one year (reposted as topic for info purposes) @garland Yes, as part of my senolytic protocol I use the Life Extension Senolytic Activator, which they say contains "ultra-absorbable" forms of quercetin and fisetin, along with apigenin,…
- Brian Valerie
- Semi-Retired Health Education Teacher
- Brian_Valerie
- 8 mths ago
- 1
- Senolytics Discussion
- Reported - view
Re: Fisetin experimentation one year (reposted as topic for info purposes) @Fred Cloud Thanks for sharing your anecdotal evidence, Fred. I should share mine as well, so here goes. My own anecdote is different in that I haven't yet been able to clearly correlate (without…
- Brian Valerie
- Semi-Retired Health Education Teacher
- Brian_Valerie
- 9 mths ago
- 1
- Senolytics Discussion
- Reported - view
Re: Fisetin experimentation one year (reposted as topic for info purposes) Thank you for sharing, Allen DeLaney. It is the hard science and objective self experimentation reports such as yours that keep me on my episodic fisetin/senolytic protocol,…
- Brian Valerie
- Semi-Retired Health Education Teacher
- Brian_Valerie
- 10 mths ago
- 1
- Senolytics Discussion
- Reported - view
Re: Green Tea Is Associated With Reduced All-Cause Mortality Risk Thanks for the pesticide tip. Some organic foods are probably worth the extra price, while others are probably not.
- Brian Valerie
- Semi-Retired Health Education Teacher
- Brian_Valerie
- 11 mths ago
- 1
- General Discussion
- Reported - view
Re: Thymus aging mitigation strategies @Moonlitnight I share your caution regarding rapamycin, Moonlitnight. There is so much current research on rapamycin, and perhaps more importantly, on the probably superior rapamycin analogs…
- Brian Valerie
- Semi-Retired Health Education Teacher
- Brian_Valerie
- 11 mths ago
- 2
- Thymus Regeneration
- Reported - view
Re: Fisetin experimentation one year (reposted as topic for info purposes) @John Mcgough That really is intriguing, John, and similar to Steffan Olsson's report. By the way, Stefan is the one who reported "a minor" euphoria, not me.…
- Brian Valerie
- Semi-Retired Health Education Teacher
- Brian_Valerie
- 1 yr ago
- 1
- Senolytics Discussion
- Reported - view
Re: Fisetin experimentation one year (reposted as topic for info purposes) @Staffan Olsson That really is intriguing, Staffan. It does seem that there is a real effect there, but unlike some skeptics, my big question with anecdotal evidence is not the well documented…
- Brian Valerie
- Semi-Retired Health Education Teacher
- Brian_Valerie
- 1 yr ago
- 1
- Senolytics Discussion
- Reported - view
Re: Fisetin experimentation one year (reposted as topic for info purposes) @John Mcgough Keep us posted. My resting heart rate has gradually been going down (to about 55-65), but I expect that's due to my daily exercise rather than senolytics.…
- Brian Valerie
- Semi-Retired Health Education Teacher
- Brian_Valerie
- 1 yr ago
- 1
- Senolytics Discussion
- Reported - view
Re: Fisetin experimentation one year (reposted as topic for info purposes) @John Mcgough Thanks for sharing your results, John. I likewise don't notice any difference in how I feel after my monthly fisetin (along with quercetin and theaflavins) protocols,…
- Brian Valerie
- Semi-Retired Health Education Teacher
- Brian_Valerie
- 1 yr ago
- 1
- Senolytics Discussion
- Reported - view
Re: Polling your opinion - longevity themed forums, the best ones And I thank you, Agingdoc! No membership price offsets, but that's fine since the membership fee is quite modest. Welcome to another longevity minded community!
- Brian Valerie
- Semi-Retired Health Education Teacher
- Brian_Valerie
- 1 yr ago
- 2
- General Discussion
- Reported - view
Re: Polling your opinion - longevity themed forums, the best ones HI there, David, I'm a member of LongeCity (longecity.org), which is an open public forum for information and discussion, a repository for relevant information,…
- Brian Valerie
- Semi-Retired Health Education Teacher
- Brian_Valerie
- 1 yr ago
- 1
- General Discussion
- Reported - view
Re: Azrithomycin dose for senolytic This sounds more than intriguing if such results are replicated! This must be a very recently published study. Would you be able to give us a reference to the original study please?
- Brian Valerie
- Semi-Retired Health Education Teacher
- Brian_Valerie
- 1 yr ago
- 1
- Senolytics Discussion
- Reported - view
Re: Qualia Senolytic product Great! Nice chatting with you, David.
- Brian Valerie
- Semi-Retired Health Education Teacher
- Brian_Valerie
- 1 yr ago
- Senolytics Discussion
- Reported - view
Re: Qualia Senolytic product I'm happy for your feeling so much energy, David, and will try not to be envious! I was only referring to the fact that our bodies "adjust" to many of the supplements and drugs that we take,…
- Brian Valerie
- Semi-Retired Health Education Teacher
- Brian_Valerie
- 1 yr ago
- 1
- Senolytics Discussion
- Reported - view
Re: Qualia Senolytic product Sounds good. On Life Extension website's Senolytic Activator (which contains 56mg of Bio-Fisetin) Product Details "Convenient, once-weekly formula" sub-section, they write,…
- Brian Valerie
- Semi-Retired Health Education Teacher
- Brian_Valerie
- 1 yr ago
- 1
- Senolytics Discussion
- Reported - view
Re: Qualia Senolytic product Sorry for the nine day delay in replying, David, but only yesterday was I notified of your post. Well, I do feel some (quite mild) anxiety about choosing the optimal dosing protocols for some…
- Brian Valerie
- Semi-Retired Health Education Teacher
- Brian_Valerie
- 1 yr ago
- 1
- Senolytics Discussion
- Reported - view
Re: Qualia Senolytic product Hi David, and welcome to the Senolytics Fan Club! I haven't noticed any effects from taking Life Extension's Senolytic Activator (nor from resveratrol, pterostilbene, NMN, NR, etc.…
- Brian Valerie
- Semi-Retired Health Education Teacher
- Brian_Valerie
- 1 yr ago
- 1
- Senolytics Discussion
- Reported - view

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Brian Valerie

Brian_Valerie

Semi-Retired Health Education Teacher

Dana Point, California, USA

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Joined: 16 Jan 2021

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Member at LongeCity.org;
Health Topics Writer at Quora.com