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Re: GlyNAC @martino lorenzon Anhedonia has not been a widely reported side effect of GlyNAC supplementation. I think that we should consider some other confounding variable(s) as the possible cause(s).
- Brian Valerie
- Semi-Retired Health Education Teacher
- Brian_Valerie
- 1 yr ago
- 1
- Self-Experimentation
- Reported - view
Re: GlyNAC Hi Martino, My taking glycine and NAC evidently hasn't raised my rather consistently low blood pressure (about 110/65). I'm skeptical that either of them have the negative interactions that you…
- Brian Valerie
- Semi-Retired Health Education Teacher
- Brian_Valerie
- 1 yr ago
- Self-Experimentation
- Reported - view
Re: GlyNAC @martino lorenzon I take 2 g each of NAC and glycine at bedtime and another 1 g of NAC and 1.5 g of glycine when I get up to use the restroom about 4 or 5 hours later.…
- Brian Valerie
- Semi-Retired Health Education Teacher
- Brian_Valerie
- 1 yr ago
- 1
- Self-Experimentation
- Reported - view
Re: Fisetin experimentation one year (reposted as topic for info purposes) @David C Thanks for sharing, David. May I ask your (or other readers') opinion of Life Extension Foundation's recommendation of the equivalent (of their bioavailable fisetin,…
- Brian Valerie
- Semi-Retired Health Education Teacher
- Brian_Valerie
- 2 yrs ago
- Senolytics Discussion
- Reported - view
Re: Cure for Cancer? 18 participants with a 100% success rate is certainly not too small a trial to take seriously. Let's hope "beyond hope" that this immunotherapy is likewise applicable to cancers other than rectal!
- Brian Valerie
- Semi-Retired Health Education Teacher
- Brian_Valerie
- 2 yrs ago
- 2
- General Discussion
- Reported - view
Re: Senolytics- How many different ones do you take and why @Karl You may already know this, but there is recent evidence that curcumin has some senolytic effect, so along with my daily dose I've added an extra dose of bioavailable curcumin to my weekly…
- Brian Valerie
- Semi-Retired Health Education Teacher
- Brian_Valerie
- 2 yrs ago
- 1
- Senolytics Discussion
- Reported - view
Re: Senolytics- How many different ones do you take and why @Karl My wife thinks the same thing and takes less the half the supplements that I do. I admit that many of them are only speculatively health or life extending,…
- Brian Valerie
- Semi-Retired Health Education Teacher
- Brian_Valerie
- 2 yrs ago
- 1
- Senolytics Discussion
- Reported - view
Re: Senolytics- How many different ones do you take and why Our friends at Life Extension (and I) add theaflavins and apigenin to their bioavailable quercetin and bioavailable fisetin Senolytic Activator. I also take ginger, grape seed extract, luteolin,…
- Brian Valerie
- Semi-Retired Health Education Teacher
- Brian_Valerie
- 2 yrs ago
- 1
- Senolytics Discussion
- Reported - view
Re: GlyNAC @Jack Black I'm guessing you meant to write 9 grams rather than 9mg (?). As noted above, I'm taking four grams qod, and admit to being shy about taking more chronically until we have more human…
- Brian Valerie
- Semi-Retired Health Education Teacher
- Brian_Valerie
- 2 yrs ago
- 1
- Self-Experimentation
- Reported - view
Re: GlyNAC @Jack Black I take 4200mg of NAC along with 4000mg of the reportedly somnorific glycine every other day (alternating with 3000mg of the somnorific anti-inflammatory ashwagandha in the perhaps vain…
- Brian Valerie
- Semi-Retired Health Education Teacher
- Brian_Valerie
- 2 yrs ago
- 2
- Self-Experimentation
- Reported - view
Re: Fisetin experimentation one year (reposted as topic for info purposes) @John Ramos One can get what may be a reasonable amount of spermidine from raw wheat germ.
- Brian Valerie
- Semi-Retired Health Education Teacher
- Brian_Valerie
- 2 yrs ago
- 1
- Senolytics Discussion
- Reported - view
Re: Stopping Metformin @Karl I haven't read any endocrinologists (not that I've read them all by any means!) who would be opposed to your decision, assuming you obtained the metformin by prescription.
- Brian Valerie
- Semi-Retired Health Education Teacher
- Brian_Valerie
- 2 yrs ago
- 1
- AMPK Activation
- Reported - view
Re: Fisetin to Clear Senescent Cells @Robert Olin I'd just like to clarify that autophagy does NOT "start" at the 17 hour mark, which is by no means a definitive dividing line in any case.…
- Brian Valerie
- Semi-Retired Health Education Teacher
- Brian_Valerie
- 2 yrs ago
- 1
- Self-Experimentation
- Reported - view
Re: Stopping Metformin I was about to start metformin, but decided that berberine (along with milk thistle extract) was a better alternative. I agree with you that the evidence thus far does not justify use of metformin…
- Brian Valerie
- Semi-Retired Health Education Teacher
- Brian_Valerie
- 2 yrs ago
- 1
- AMPK Activation
- Reported - view
Re: Fisetin to Clear Senescent Cells @ripeideas The truth is that the researchers at the Mayo Clinic are guessing! The two consecutive days is based on limited murine studies, but in a longer lived mammal like humans,…
- Brian Valerie
- Semi-Retired Health Education Teacher
- Brian_Valerie
- 3 yrs ago
- 3
- Self-Experimentation
- Reported - view
Re: Selenium: How Much Is Optimal For Health? I'd just like to add a note of caution regarding selenium and fans of Brazil nuts. Brazil nuts typically contain from 68 to 91 mcg of selenium each, but the tolerable upper intake level of selenium…
- Brian Valerie
- Semi-Retired Health Education Teacher
- Brian_Valerie
- 3 yrs ago
- 1
- General Discussion
- Reported - view
Re: GlyNAC @Andrew Glad you found some NAC that agrees with you. No, I haven't taken more than 3g. Since more human trials are no doubt soon forthcoming, I'd rather be cautious about the higher doses.…
- Brian Valerie
- Semi-Retired Health Education Teacher
- Brian_Valerie
- 3 yrs ago
- 2
- Self-Experimentation
- Reported - view
Re: GlyNAC @Andrew Excellent questions! I'm surprised that you felt a surge of energy, since glycine is a known somnorific. The devil must be either in the high NAC dosage or some confounding variable.…
- Brian Valerie
- Semi-Retired Health Education Teacher
- Brian_Valerie
- 3 yrs ago
- 1
- Self-Experimentation
- Reported - view
Re: Fisetin to Clear Senescent Cells @Fairy8i8 Thanks so much for sharing your experience and wise reflections with me, Fairy. I do agree with you that we shouldn't assume that experiencing negative side effects is an indication that…
- Brian Valerie
- Semi-Retired Health Education Teacher
- Brian_Valerie
- 3 yrs ago
- 1
- Self-Experimentation
- Reported - view
Re: Fisetin to Clear Senescent Cells @karl kuffner Thank you very much for sharing your experience with me, Karl. I reread your post in which you related positive effects, even including euphoria! Since I'm dosing weekly,…
- Brian Valerie
- Semi-Retired Health Education Teacher
- Brian_Valerie
- 3 yrs ago
- 1
- Self-Experimentation
- Reported - view
Re: Fisetin to Clear Senescent Cells @Michael Avenoso Yep! Maybe we shouldn't expect to feel any improvements from what could simply be a diminishing of the rate of aging. Before and after biomarker tests of some sort might be more…
- Brian Valerie
- Semi-Retired Health Education Teacher
- Brian_Valerie
- 3 yrs ago
- 2
- Self-Experimentation
- Reported - view
Re: Fisetin to Clear Senescent Cells I don't have high regard for anecdotal evidence, even my own, due to its great susceptibility to variations, confounding variables, placebo effect, etc.…
- Brian Valerie
- Semi-Retired Health Education Teacher
- Brian_Valerie
- 3 yrs ago
- 2
- Self-Experimentation
- Reported - view

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Brian Valerie

Brian_Valerie

Semi-Retired Health Education Teacher

Dana Point, California, USA

47
53
1

Joined: Sat Jan 16 23:25:27 UTC 2021

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Member at LongeCity.org;
Health Topics Writer at Quora.com