Fisetin to Clear Senescent Cells
Following studies with mice that showed significant senolytic clearance of senescent cells following large doses of the readily available flavenoid supplement Fisetin, my wife and I (ages 79 and 84) decided to try it. We have just completed two sets of massive Fisetin doses.
We had Life Extension blood-work done in October before the start, and we will have more again next week to observe any changes. The first set of Fisetin doses was on October 22-25 with 800 mg/day for three days followed by 600 mg on the fourth day, for a total of 4 g. I didn't notice much in the way of effects. Perhaps some reduction of small aches and pains and some increase in energy and mental acuity.
For the second set of doses done November 22-26, since we experienced no negative side effects in the first set we decided to increase the dosage a bit and to add 10 mg of BioPerine, a supplement that is reputed to magnify the effects and potency of flavenoids. For five days starting on Thanksgiving we took 500 mg of Fisetin and 10 mg of BioPerine twice per day, for a total of 5 g of Fisetin.
This time. I did experience one negative side effect. A few months ago, about 2 AM in the morning I awoke from a deep sleep and experienced a severe episode of vertigo. I turned over in bed, and the the whole room seemed to tilt. Suddenly, I didn't know which way was up. I staggered to the bathroom and vomited. The symptoms tapered off and disappeared in a few days, but it was a very distributing experience.
On the 2nd day of our 2nd Fisetin series, I experience a recurrence of that vertigo in the middle of the night, not as bad as my initial experience but still rather disturbing. I tolerated this mild vertigo and continued the treatment. My wife had no similar symptoms, and after my last dose I experienced no further vertigo symptoms.
On the positive side, following the second set of dosages I did feel very well, and very sharp and alert. This past weekend I ran my Shetland Sheepdog Taliesin in an AKC Canine Agility Trial in Mt. Vernon, WA, and we did very well, qualifying in 7 runs out of 15 and getting various colored placement ribbons. I was feeling quite sharp, and I even invented a new dog-handling technique that fixed an ongoing problem we were having.
Next week we will do the blood-work again, and I'll report any changes.
Hi Everyone! I just stumbled across this thread and find it very informative. I would like to ask the group their opinion of what I should do next. I am 65 and have had chronic pain for 10 years: knee pain, L4-5 issues, nerve pain in butt (probably die to L4/5), neck pain (severe OA there) and more recently should/arm pain. It just keeps expanding to new areas. I work with an Anti-Aging institute and they can find little to work with as my blood work is, in their words, impressive: lipid panel 30 yr olds would love to have (their words), C reactive protein WNL, nutrients all good, liver enzymes low, etc...I feel like I have tried everything with no symptom relief. Here is what I've done over the last couple years: a variety of Peptides ( one combination worked on my knees but we couldn't replicate it), PPS, EGCG, high doses of Melatonin, bioidentical hormone replacement, intermittent fasting, Spermidine, and a stint of D+Q about a year ago; all of this they recommended to me to reduce inflammation (which hasn't worked). I thought maybe I was focusing on the wrong thing so I took a blood test that measures cytokines and I'm waiting for the results. After reading much of this thread, I decided that my D+Q protocol was under-dosed, so just yesterday I started a more aggressive protocol of 200 mg D+ 1250mg of Quercetin which I will do for 4 days. Does anyone have any other ideas of what else I can try? I would really appreciate your suggestions. Thank you in advance.
Thanks Peter! Yes, my PA at the longevity institute has recommended this and I did it for as long as I could stand it (I think it was until the bottle was gone). Since I take so many supplements, those horse pills were hard to get down every day and I had little faith because nothing else worked. Have you had a good experience with fish oil? I will do it again if you think it'll work.