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Re: Fisetin to Clear Senescent Cells @JGC I agree with you. Their proscription of senolytic use seems a bit craven.
- Dan Nave
- Dan_Nave
- 3 mths ago
- Self-Experimentation
- Reported - view
Re: Fisetin to Clear Senescent Cells @Chris M The Professor looks like he could use a senolytic course...
- Dan Nave
- Dan_Nave
- 3 mths ago
- Self-Experimentation
- Reported - view
Re: Are these issues related to rapamycin @Michael_B I believe you have misread the information about Shingles and Alzheimer's Disease. It is not the people who had the vaccine who had more AD, but the people who had Shingles...…
- Dan Nave
- Dan_Nave
- 5 mths ago
- 1
- Self-Experimentation
- Reported - view
Re: Fisetin to Clear Senescent Cells @JGC Isn't the action of Bioperine in the intestines, rather than in the blood?
- Dan Nave
- Dan_Nave
- 5 mths ago
- Self-Experimentation
- Reported - view
Re: Are these issues related to rapamycin @Karl Either check out the link a few posts above or search the quotes provided there, or see this link: https://content.iospress.com/articles/journal-of-alzheimers-disease/jad220287 This seems to…
- Dan Nave
- Dan_Nave
- 7 mths ago
- Self-Experimentation
- Reported - view
Re: Low-Dose Oral Minoxidil for Hair Regrowth Keep us updated.
- Dan Nave
- Dan_Nave
- 7 mths ago
- Self-Experimentation
- Reported - view
Re: Are these issues related to rapamycin @JGC A bit off topic, but... I'm not taking Rapa, but several years ago I had an outbreak of shingles so later I decided to get the Shingrix vaccine. I got the first shot,…
- Dan Nave
- Dan_Nave
- 7 mths ago
- Self-Experimentation
- Reported - view
Re: Fisetin to Clear Senescent Cells @Denise Shugerman This may be a bit of a different approach from what you have tried, but you mention OA which I assume is osteoarthritis, and joint pain.…
- Dan Nave
- Dan_Nave
- 1 yr ago
- 1
- Self-Experimentation
- Reported - view
Re: Anyone actually experience marked increased energy from NMN? @John Hemming Excuse me? Natto....Nattokinase???... "Nattokinase (NK), the most active ingredient of natto, possesses a variety of favourable cardiovascular effects and the consumption of Natto has…
- Dan Nave
- Dan_Nave
- 1 yr ago
- Self-Experimentation
- Reported - view
Re: Anyone actually experience marked increased energy from NMN? @John Hemming Reading your comments here about K2, which is extracted from natto, also the source of nattokinase (nattokinase decreases plasma levels of fibrinogen),…
- Dan Nave
- Dan_Nave
- 1 yr ago
- 1
- Self-Experimentation
- Reported - view
Re: Feeling pretty sick after taking Fisetin. Thoughts? Even though you are young you may have a lot of damage due to your lifestyle, as you mention. I expect that the first time you take a large senolytic dose of Fisetin you would have a strong reaction,…
- Dan Nave
- Dan_Nave
- 1 yr ago
- 1
- Self-Experimentation
- Reported - view
Re: metformin negative study Towards the end of the article it says: "Rapamycin alleviates metformin toxicity "Using proteome and lipid metabolism analysis, the team showed that metformin treatment initiated at an advanced age…
- Dan Nave
- Dan_Nave
- 1 yr ago
- General Discussion
- Reported - view
Re: Targeted clearance of senescent cells using an antibody-drug conjugate against a specific membrane marker Targeted clearance of senescent cells using an antibody-drug conjugate against a specific membrane marker https://www.nature.com/articles/s41598-021-99852-2
- Dan Nave
- Dan_Nave
- 1 yr ago
- 1
- Self-Experimentation
- Reported - view
Targeted clearance of senescent cells using an antibody-drug conjugate against a specific membrane marker
https://phys.org/news/2021-10-antibodies-cells-aging.html?fbclid=IwAR0VjejnoL7OXThHjznaImnlmyL-KTrRcSk3AZqlp_Fn5-cEOBXDJ7iQHww No one knows why some people age worse than others and develop diseases…
- Dan Nave
- Dan_Nave
- 1 yr ago
- 2 replies
- 50
- Self-Experimentation
Re: 'Mandated Gov Vax or get fired' I'm one of them. Which one is the least toxic in the long run to our longevity path..? Thanks @Karl That sounds like balderdash...
- Dan Nave
- Dan_Nave
- 1 yr ago
- General Discussion
- Reported - view
Re: 'Mandated Gov Vax or get fired' I'm one of them. Which one is the least toxic in the long run to our longevity path..? Thanks @Jimmy2 To put this in perspective: "HEART inflammation triggered by some covid-19 vaccines has been a concern, especially in younger people, but a preliminary study suggests that in those most…
- Dan Nave
- Dan_Nave
- 1 yr ago
- 1
- General Discussion
- Reported - view
Re: 'Mandated Gov Vax or get fired' I'm one of them. Which one is the least toxic in the long run to our longevity path..? Thanks How does this compare to actually getting infected with Covid-19?
- Dan Nave
- Dan_Nave
- 1 yr ago
- General Discussion
- Reported - view
Re: 'Mandated Gov Vax or get fired' I'm one of them. Which one is the least toxic in the long run to our longevity path..? Thanks For how long after vaccination? And how does this compare to response after infection with Covid-19 which we will all be eventually exposed to?...
- Dan Nave
- Dan_Nave
- 1 yr ago
- 1
- General Discussion
- Reported - view
Re: 'Mandated Gov Vax or get fired' I'm one of them. Which one is the least toxic in the long run to our longevity path..? Thanks Here's a good reason to get vaccinated rather than chance immunization from infection by Covid-19. https://medicalxpress.com/news/2021-09-links-severe-covid-self-attacking-antibodies.html
- Dan Nave
- Dan_Nave
- 1 yr ago
- 2
- General Discussion
- Reported - view
Re: Fisetin to Clear Senescent Cells @JGC I am considering the possibility that using 1/2 tsp of freshly ground black pepper may be superior to using Bioperine. Previous discussion indicated that the effect bioperine may last for 15…
- Dan Nave
- Dan_Nave
- 1 yr ago
- 1
- Self-Experimentation
- Reported - view
Re: Cell Death Mechanisms Behind D+Q and Fisetin Senolytics @Katy Weston The first time I took the protocol I had a much more noticeable reaction than with subsequent doses. If you initially have a high number of senescent cells you might expect that.
- Dan Nave
- Dan_Nave
- 1 yr ago
- 1
- Self-Experimentation
- Reported - view
Re: Fisetin to Clear Senescent Cells @Sebastian I like to take it on an empty stomach, but I add 1 Tablespoon of oil and mix the fisetin into it. I don't have data to say taking it on an empty stomach is better,…
- Dan Nave
- Dan_Nave
- 1 yr ago
- Self-Experimentation
- Reported - view
Re: Fisetin to Clear Senescent Cells @Allen I'm glad they don't add it. If they added 10mg of Bioperine to each 100mg capsule of fisetin you would be getting way to much since you would use 10 or more capsules at a time.…
- Dan Nave
- Dan_Nave
- 1 yr ago
- Self-Experimentation
- Reported - view
Re: Fisetin to Clear Senescent Cells I just wanted to post this again separately as I think it is a good compromise for incorporating a protocol of dasatinib, quercetin, fisetin and bioperine.…
- Dan Nave
- Dan_Nave
- 1 yr ago
- Self-Experimentation
- Reported - view
Re: Fisetin to Clear Senescent Cells @karl kuffner My feeling is that it is good to take Fisetin on an empty stomach so that it isn't mixed in with a mass of other food material, but that it should be taken with a bit of oil since it…
- Dan Nave
- Dan_Nave
- 1 yr ago
- Self-Experimentation
- Reported - view

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