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Re: Fisetin to Clear Senescent Cells
@JGC Correct me if I am wrong, but isn't the enzyme in question, and the action we are looking for, in the intestine? How are we testing this if it is given intravenously?
Dan Nave
Dan_Nave
3 yrs ago
Self-Experimentation
Reported - view
Re: Fisetin to Clear Senescent Cells
@JGC did you see chuck stanley's comment about the timing of Bioperine ingestion?
Dan Nave
Dan_Nave
3 yrs ago
1
Self-Experimentation
Reported - view
Re: Senolytics with DGLA and GLA?
There is not a lot of specifics in that article, but if it works like other senolytics it may be advisable to use it like other senolytics in intermittent bursts.…
Dan Nave
Dan_Nave
3 yrs ago
Self-Experimentation
Reported - view
Re: Can snorting fisetin improve bioavailability and is it safe?
My capsules of Fisetin 100mg are filled with up to 500mg of material. So if you are snorting fisetin, you are also snorting 3 or 4 times as much filler material. You should probably not do that...
Dan Nave
Dan_Nave
3 yrs ago
Senolytics Discussion
Reported - view
Re: Fisetin to Clear Senescent Cells
@JGC and Sebastian, If you would want to take 1gm of Fisetin and 1 gm of Quercetin, I suspect you could leave off the Quercetin if you increase the Fisetin to 2gm.…
Dan Nave
Dan_Nave
3 yrs ago
1
Self-Experimentation
Reported - view
Re: Fisetin to Clear Senescent Cells
@Florin Because that would cost me $6,745 a year...
Dan Nave
Dan_Nave
4 yrs ago
Self-Experimentation
Reported - view
Re: Fisetin to Clear Senescent Cells
@garland The question here was whether to take Curcumin and Quercetin together. My feeling is *no* for C + Q, or C + F. I would take Quercetin together with Fisetin though.
Dan Nave
Dan_Nave
4 yrs ago
Self-Experimentation
Reported - view
Re: Fisetin to Clear Senescent Cells
@garland The clinical studies I saw for D+Q used from 50 to 100 mg of Dasatinib with about 1000 mg of Quercetin a day. One of the studies divided up the Quercetin into 2 doses per day.…
Dan Nave
Dan_Nave
4 yrs ago
1
Self-Experimentation
Reported - view
Re: Fisetin to Clear Senescent Cells
@JGC Thanks JGC!
Dan Nave
Dan_Nave
4 yrs ago
Self-Experimentation
Reported - view
Re: Fisetin to Clear Senescent Cells
@JGC What do you think about mixing regular fisetin with, say, Guar Gum which is a galactomannan containing gum to simulate the Bio-Fisetin? Or are they doing some special process to combine them?
Dan Nave
Dan_Nave
4 yrs ago
Self-Experimentation
Reported - view
Re: Fisetin to Clear Senescent Cells
@garland Anything that is in quotes is quoted. You can take a unique portion of the quote or all of it and do a Google search to get the source. I have stopped including urls as it is easy enough…
Dan Nave
Dan_Nave
4 yrs ago
Self-Experimentation
Reported - view
Re: Fisetin to Clear Senescent Cells
@garland I'd be more concerned with the Dasatinib. Anything you do that increases the bioavailability of the polyphenols, including taking more of them, increases the bioavailability of Dasatinib,…
Dan Nave
Dan_Nave
4 yrs ago
1
Self-Experimentation
Reported - view
Re: Fisetin to Clear Senescent Cells
Supplement Facts Serving Size 1 vegetarian capsule Amount Per Serving Proprietary Blend: 44.5 mg Providing 18% fisetin (8 mg) [from wax tree extract (stem)],…
Dan Nave
Dan_Nave
4 yrs ago
Self-Experimentation
Reported - view
Re: Fisetin to Clear Senescent Cells
@garland said: Today I just tried my first dose of Bio-Fisetin which is many times greater potency then the regular one. I wonder if we couldn't do this ourselves by mixing regular fisetin with, say,…
Dan Nave
Dan_Nave
4 yrs ago
1
Self-Experimentation
Reported - view
Re: Fisetin to Clear Senescent Cells
Has anyone seen any information that Curcumin and Fisetin counteract each other when used as a senolytic, or their different modalities of actions nullify each other?…
Dan Nave
Dan_Nave
4 yrs ago
Self-Experimentation
Reported - view
Re: Fisetin to Clear Senescent Cells
@Dan Nave I have decided to not add curcumin to the Quercetin/Fisetin senolytic protocol. I no longer recommend adding curcumin to the mix. My feeling is to take Curcumin separately, if you wish,…
Dan Nave
Dan_Nave
4 yrs ago
1
Self-Experimentation
Reported - view
Re: Introduction to Young Plasma Infusions
@JGC What do you think of this article "Diluting blood plasma rejuvenates tissue, reverses aging in mice" which seemed to achieve similar outcomes without any young plasma fraction?…
Dan Nave
Dan_Nave
4 yrs ago
Young Plasma Infusions
Reported - view
Re: I don't want to live longer. I want to live better. Wanna help a young guy taking his life back?
You can reuse the flannel and oil, just replenish the oil a bit. Just make sure not to get it contaminated. I put the pack in a plastic bag and store in the refrigerator.…
Dan Nave
Dan_Nave
4 yrs ago
General Discussion
Reported - view
Re: I don't want to live longer. I want to live better. Wanna help a young guy taking his life back?
You might want to try Castor Oil packs along with your DMSO routine. DMSO is going to dry out your skin by itself. Castor oil will also soften scar tissue and cause it to be reabsorbed,…
Dan Nave
Dan_Nave
4 yrs ago
General Discussion
Reported - view
Re: Regenerative medicine from the future
Science: Making the world safe for rats and mice...
Dan Nave
Dan_Nave
4 yrs ago
General Discussion
Reported - view
Re: Senolytics
@Edward Meininger Do you normally have joint problems, arthritis, rheumatism, etc?
Dan Nave
Dan_Nave
4 yrs ago
1
Self-Experimentation
Reported - view
Re: Senolytics
@Karl We can only hope for a reasonable price. Who wouldn't want to use it.
Dan Nave
Dan_Nave
4 yrs ago
1
Self-Experimentation
Reported - view
Re: Senolytics
A new wide spectrum senolytic SSK1 in development. They imply that it works on all senescent cell types and works better than Dasatinib, Fisetin, and Quercetin. https://www.nature.c...…
Dan Nave
Dan_Nave
4 yrs ago
2
Self-Experimentation
Reported - view
Re: Preparations for self-treating COVID-19
@Florin Along these lines, it is being bandied about that Quercetin is also an iontophor like Hydroxychloroquine and might be able to be used in its place. https://www.ncbi.nlm.nih.…
Dan Nave
Dan_Nave
4 yrs ago
Self-Experimentation
Reported - view
Re: Fisetin to Clear Senescent Cells
@Philip V. Anstett https://www.hindawi.com/journals/omcl/2015/854015/ Interactions between CYP3A4 and Dietary Polyphenols https://www.ncbi.nlm.nih.gov/pubmed/12130727 Piperine,…
Dan Nave
Dan_Nave
4 yrs ago
1
Self-Experimentation
Reported - view
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