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Re: SGLT2
@Paul Beauchemin FYI my antivirus goes crazy on that URL.
- Jack_Black
- 3 yrs ago
- General Discussion
- Reported - view
Re: Is spontaneous hair colour restoration normal?
@Staffan Olsson Same here, some darker hairs after taking spermidine.
- Jack_Black
- 3 yrs ago
- 1
- Self-Experimentation
- Reported - view
Re: Fisetin to Clear Senescent Cells
Small update, I noticed today that I didn't have the minor ache in my injured hip joint that I've had since the Fisetin. Maybe that's a sign there has been some clear up this week.
- Jack_Black
- 3 yrs ago
- Self-Experimentation
- Reported - view
Re: Fisetin to Clear Senescent Cells
@Chris M That's the strange thing, I had the opposite reaction of it being too strong. I was dosing 2600mg per day plus Q on top, and had had a 10mg BioPerine 20 minutes before the Fisetin.…
- Jack_Black
- 3 yrs ago
- 1
- Self-Experimentation
- Reported - view
Re: Fisetin to Clear Senescent Cells
@Staffan Olsson I was using the Dr's Best Fisetin with novusetin. Cut the capsules open to mix into the oil. Going to try again in a month and I might employ some D at the same time.
- Jack_Black
- 3 yrs ago
- Self-Experimentation
- Reported - view
Re: Fisetin to Clear Senescent Cells
50 year old guy here. Finally tried the fisetin hit and run regimen. Aimed for 30mg per kg dissolved in warm olive oil. Threw in 400mg of Q on top by taking a bio-available 250mg cap plus 2x the…
- Jack_Black
- 3 yrs ago
- 1
- Self-Experimentation
- Reported - view
Re: GlyNAC
@Karl I take a constellation of substances targeting glutathione production, support of the mitochondria, brain health, folate cycle, skin and joints health, bone strength, and of course Rapa.…
- Jack_Black
- 3 yrs ago
- 1
- Self-Experimentation
- Reported - view
Re: GlyNAC
@Stevan Lieberman Another thought; It's been shown that human glutathione levels tend to start declining dramatically around age 45. Correlation does not mean causation but it is interesting how…
- Jack_Black
- 3 yrs ago
- Self-Experimentation
- Reported - view
Re: GlyNAC
@Stevan Lieberman Sounds like a good case for senolytics?
- Jack_Black
- 3 yrs ago
- Self-Experimentation
- Reported - view
Re: GlyNAC
@Brian Valerie Absolutely! Grams not mg. :) I'd say taking a week off the supplements every month sounds like a good move for most of these substances.
- Jack_Black
- 3 yrs ago
- 1
- Self-Experimentation
- Reported - view
Re: Testosterone Trials
I recently found that drinking Ashwagandha tea raised Testosterone levels. I'm 50 and hadn't really noticed I had lower levels, but the evidence is when you wake up in the morning,…
- Jack_Black
- 3 yrs ago
- 1
- Self-Experimentation
- Reported - view
Re: Recent constellation has had an effect... again
One further bit of evidence; I've had a Garmin Fenix watch for 6 months or so. It does a Body Battery measure based on heart rate variability, stress etc.…
- Jack_Black
- 3 yrs ago
- Self-Experimentation
- Reported - view
Re: Any results from D & Q course?
I'm interested to see your anecdotal evidence that D&Q is better than D&F. A lot of the coverage last year was Fisetin being better. I had read that we shouldn't do Rapamycin at the same time as…
- Jack_Black
- 3 yrs ago
- Self-Experimentation
- Reported - view
Re: GlyNAC
@Stevan Lieberman I can't derive an equivalent human dose from the paper, but these are usually way higher than people would take. I would imagine some ROS action in humans would indeed be…
- Jack_Black
- 3 yrs ago
- 2
- Self-Experimentation
- Reported - view
Re: Any results from D & Q course?
@JGC I appreciate your posts. Have Fisetin and D stockpiled but want to complete a 4 month Rapa course before I go for a proper D & F protocol, but I've got a lot from your posts to this forum.…
- Jack_Black
- 3 yrs ago
- Self-Experimentation
- Reported - view
Recent constellation has had an effect... again

I wish I had more scientific data to bring, but in messy real life we end up trying various things and it muddies the waters. I've got existing benefits from a heap of stuff already,…
- Jack_Black
- 3 yrs ago
- 1reply
- 131
- 1
- Self-Experimentation
Re: Autophagy / fasting
Saw an interesting article today which seems to be discussing targeted programmed autophagy in order to target specific proteins and stop cancer; https://www.theguardian.…
- Jack_Black
- 3 yrs ago
- Self-Experimentation
- Reported - view
Rapamycin & Covid

Recently the new Omicron BA2 variant busted through the triple vaxed fortress my family had built. I was ill for a few days, but never felt in danger. When the illness subsided I suffered from…
- Jack_Black
- 3 yrs ago
- 1reply
- 76
- 1
- Self-Experimentation
Re: GlyNAC
@Jack Black For info I've noticed something else recently. Based on discussions on this forum I decided to raise my daily dose of AKG from 300mg a day to 1200mg.…
- Jack_Black
- 3 yrs ago
- 2
- Self-Experimentation
- Reported - view
Re: Anyone actually experience marked increased energy from NMN?
@John Ramos https://en.wikipedia.org/wiki/Herpesviridae Chickenpox is a herpes virus, not a private matter at all. You're clearly asking me if I have the genital version, which I can happily deny.…
- Jack_Black
- 3 yrs ago
- Self-Experimentation
- Reported - view
Re: Anyone actually experience marked increased energy from NMN?
@chuck stanley My Creatine AKG came from Vitafy.ch https://www.vitafy.ch/creatin-akg-180-kapseln.html?utm_source=parcellab&utm_medium=email&utm_content=any&utm_campaign=any&utm_term=any
- Jack_Black
- 3 yrs ago
- 1
- Self-Experimentation
- Reported - view
Re: Anyone actually experience marked increased energy from NMN?
@Michael When I boosted my creatine [akg] dose to what they said on the bottle, 2g before and 2g after I noticed some exercise benefit. It's nice rushing up the hill past noticeably younger people…
- Jack_Black
- 3 yrs ago
- 1
- Self-Experimentation
- Reported - view
Re: Anyone actually experience marked increased energy from NMN?
@John Ramos Hey John, I got my Rapa from Indiamart and also theantiaging.store So far so good. Too early to spot any differences. AKG seems to be the thing that gave me extra energy when I'm…
- Jack_Black
- 3 yrs ago
- Self-Experimentation
- Reported - view
Re: Anyone actually experience marked increased energy from NMN?
@John Ramos I'm 50. Thanks for the link above, I am a fan of Eleanor. 80 bucks a kilo sounds like a great price.
- Jack_Black
- 3 yrs ago
- Self-Experimentation
- Reported - view
Re: Anyone actually experience marked increased energy from NMN?
@John Ramos Hi, where do you get the 20% figure for AKG life extension? The info I've seen was 5% for male mice. Also, where do you source your Ca-AKG from?…
- Jack_Black
- 3 yrs ago
- Self-Experimentation
- Reported - view

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