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Re: Fisetin to Clear Senescent Cells
@Michael Fast sometimes anyway. Everything I find about our metabolism seems to scream that we're highly adapted to survive famines. Fast and feast seems very agreeable to the human body.…
- Jack_Black
- 3 yrs ago
- 2
- Self-Experimentation
- Reported - view
Re: Fisetin to Clear Senescent Cells
@Robert Olin I find a nice approach to fasting is to eat my last meal on the afternoon of a Friday (2-3pm as work allows). Go through Saturday on green tea or black coffee -> add a little salt for…
- Jack_Black
- 3 yrs ago
- 1
- Self-Experimentation
- Reported - view
Re: GlyNAC
I've been taking glycine (4000mg), serine (900mg) and NAC (1200mg) daily for about six months. I'm 50 so the lower dose is intended as a top-up that I might scale as I get older.…
- Jack_Black
- 3 yrs ago
- 2
- Self-Experimentation
- Reported - view
Re: wrinkle reduction
The comments above about skin elasticity caught my attention. I haven't used the sirolimus lotion yet. I have completed about 4 months of daily collagen peptides (in a morning coffee) plus daily…
- Jack_Black
- 3 yrs ago
- 6
- Self-Experimentation
- Reported - view
Re: Anyone actually experience marked increased energy from NMN?
@John Hemming yes inflammation is raising CD38 levels which is destroying NAD+. The science isn't clear why but it could even be a defense mechanism by the body;…
- Jack_Black
- 3 yrs ago
- Self-Experimentation
- Reported - view
Re: Anyone actually experience marked increased energy from NMN?
@Jared I notice Ca-AKG when I exercise. You call for the energy and it's there. In domestic life where I'm not needing the energy boost I don't notice much.…
- Jack_Black
- 3 yrs ago
- Self-Experimentation
- Reported - view
Re: Anyone actually experience marked increased energy from NMN?
Sublingual NMN doesn't seem to do anything for me. I could fool myself into thinking the 1g daily of oral capsules this past year have had some effect.…
- Jack_Black
- 3 yrs ago
- 2
- Self-Experimentation
- Reported - view
Re: Spermidine: a physiological autophagy inducer acting as an anti-aging vitamin inhumans?
@MAC. I have an easily accessible Japanese supermarket in town and get Natto there for Spermidine and Vitamin K. Not saying I love it, but then it isn't so bad either.…
- Jack_Black
- 3 yrs ago
- General Discussion
- Reported - view
Re: Spermidine: a physiological autophagy inducer acting as an anti-aging vitamin inhumans?
JFYI today I ordered some 3mg caps from these guys; spermidinepro.com . Reason being the prior vendor I was using only had about 0.3 per cap for 2/3 the price!…
- Jack_Black
- 3 yrs ago
- 1
- General Discussion
- Reported - view
Re: Regulation of the one carbon folate cycle as a shared metabolic signature of longevity
Thanks for posting. That looks like the basis to significant future advances.
- Jack_Black
- 4 yrs ago
- Ideas
- Reported - view
Re: Thymus aging mitigation strategies
On the subject of enhancing T cells, I read an article the other year that people who slept in a room with Hinoki Cypress oil in the air had enhanced killer T cell count for a week afterwards.…
- Jack_Black
- 4 yrs ago
- Thymus Regeneration
- Reported - view
Re: Fisetin experimentation one year (reposted as topic for info purposes)
@Andrew P K Yap Fisetin (and Quercetin) inhibit the expression and activation of the PI3K/Akt/mTOR signaling pathway in some types of cells which enhances apoptosis.…
- Jack_Black
- 4 yrs ago
- 2
- Senolytics Discussion
- Reported - view
Re: Fisetin to Clear Senescent Cells
@karl kuffner I've only just seen this post but the mention of black tea is interesting. As I mention elsewhere I took 500mg of fisetin but after drinking a large cup of black & green tea with…
- Jack_Black
- 4 yrs ago
- Self-Experimentation
- Reported - view
Re: Exercise Mimetics
I've been thinking about this topic and think exercise mimetics like GW1516 are probably a bad idea unless you absolutely can't do real exercise. The stuff sounds like anti-rapamycin in a way.…
- Jack_Black
- 4 yrs ago
- Self-Experimentation
- Reported - view
Re: I don't know why this great supplement is not talked about: alpha-ketoglutarate
@Gokhan I was tempted until I saw the price. Eye watering! Normal AKG is cheap as chips!
- Jack_Black
- 4 yrs ago
- General Discussion
- Reported - view
Re: Inexpensive Datsatinib and Rapamycin from India
I've also received a similar care package from Pravin. No hassle at all. How are you feeling after 5 months of taking it? Notice anything?
- Jack_Black
- 4 yrs ago
- Rapamycin Discussion
- Reported - view
Re: Intro to rapamycin
@chuck stanley studies seem OK... https://pubmed.ncbi.nlm.nih.gov/25948162/
- Jack_Black
- 4 yrs ago
- 1
- Rapamycin Discussion
- Reported - view
Re: Exercise Mimetics
@Brin Chikovski I saw that article, but there are more recent ones where more research was done in 2018. That's why New Scientist mentioned it. There's many ways to boost irisin naturally,…
- Jack_Black
- 4 yrs ago
- Self-Experimentation
- Reported - view
Re: Fisetin to Clear Senescent Cells
@JGC Sheeky Science show did a piece on that marker this week, did you also see that?
- Jack_Black
- 4 yrs ago
- Self-Experimentation
- Reported - view
Exercise Mimetics

[Not medical advice or a recommendation. Sharing for information only.] Exercise being something of an anti-aging aid, the idea of exercise mimetics comes up.…
- Jack_Black
- 4 yrs ago
- 5replies
- 176
- 1
- Self-Experimentation
Re: Fisetin to Clear Senescent Cells
Elsewhere on the forum someone states "some senolytic substances works through ROS activated apoptosis....stay away from antioxidant supplements before a senolytic treatment" This led me to thinking…
- Jack_Black
- 4 yrs ago
- Self-Experimentation
- Reported - view
Re: Metformin
@Jack Black I keep thinking about this so will finally post the thought; If the metformin toxicity from worms translates to humans the TAME study is going to fall flat,…
- Jack_Black
- 4 yrs ago
- AMPK Activation
- Reported - view
Re: Fisetin to Clear Senescent Cells
@Fred Cloud I wonder if you or others might want to try the same approach. Reason being I had just 100mg of Fisetin yesterday with the big pot of black tea, green tea,…
- Jack_Black
- 4 yrs ago
- Self-Experimentation
- Reported - view
Re: Glutathione Restoration Improves Hallmarks Of Aging in Older Adults
I take 1g of glycine 3 times a week so I'm probably missing a trick. :) Led to this by the Sheeky Science show which pointed me to an Interventions Testing Program study that found it genuinely…
- Jack_Black
- 4 yrs ago
- General Discussion
- Reported - view
Re: Metformin
Some evidence I was reading today that Metformin was toxic to [non insulin resistant] worms when administered in later life. It extended life if given when young,…
- Jack_Black
- 4 yrs ago
- 1
- AMPK Activation
- Reported - view

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