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Re: Azrithomycin dose for senolytic I believe that study was done in mice and that the applicability to human cells was based on an in vitro study.
- chuck stanley
- chuck_stanley
- 2 days ago
- 1
- Senolytics Discussion
- Reported - view
Re: Rapamycin - progress so far @Michael I’ve never noticed any particular benefits from rapamycin. In general my bloodwork tends to be improving but I attribute that more to the other supplements and drugs that specifically…
- chuck stanley
- chuck_stanley
- 3 mths ago
- 1
- Self-Experimentation
- Reported - view
Re: Anyone actually experience marked increased energy from NMN? @Ben Hoffman Correction: I misread "even counterfeit brands are sold as legitimate brands, like ProHealth, DoNotAge and Renue by Science" to mean that those brands were counterfeit.
- chuck stanley
- chuck_stanley
- 3 mths ago
- Self-Experimentation
- Reported - view
Re: Anyone actually experience marked increased energy from NMN? @Ben Hoffman interesting results. Any blood test improvements that you can share? I didnt know about the counterfeit brands. What is the source of that information? What brand have you been using?
- chuck stanley
- chuck_stanley
- 3 mths ago
- Self-Experimentation
- Reported - view
Re: Warning for those considering Rapamycin.news @Michael_666 Why not use your previous handle, Hypochondriac Michael Berger? As you know, I voiced my opinion on Rapamycin news that I thought your views were worth considering. And I still do.…
- chuck stanley
- chuck_stanley
- 7 mths ago
- 1
- General Discussion
- Reported - view
Re: The DIM Supplement and Wound Healing I dont remember the half life of DIM, probably will be fine as long as they are a few days apart would be my guess. And of course it also interacts with statins.
- chuck stanley
- chuck_stanley
- 9 mths ago
- Self-Experimentation
- Reported - view
Re: Norvaline I couldnt understand why research on such a promising supplement seemed to show no follow up. I found this on Medical Express: "People taking the protein supplement L-norvaline should be aware of…
- chuck stanley
- chuck_stanley
- 9 mths ago
- Questions & Answers
- Reported - view
Re: Deleted posts I see plenty of mentions that weren't deleted. So probably not.
- chuck stanley
- chuck_stanley
- 11 mths ago
- Questions & Answers
- Reported - view
Re: Fisetin to Clear Senescent Cells @Moonlitnight I have bought from Hansen, they are very good. Their spermidine tastes fine, very neutral, and can easily be mixed into a smoothie. I didnt realize they had fisetin...I need some.
- chuck stanley
- chuck_stanley
- 1 yr ago
- 1
- Self-Experimentation
- Reported - view
Re: Fisetin experimentation one year (reposted as topic for info purposes) @Michael_B By spinal decompression, did that include use of an inversion table? Did you find that the increased disc height was reflected in your overall height?
- chuck stanley
- chuck_stanley
- 1 yr ago
- Senolytics Discussion
- Reported - view
Re: My 80 year old father's proposed regimen. What do you think? @JGC Yeh, that looks like the google translation I saw. 😊
- chuck stanley
- chuck_stanley
- 1 yr ago
- Self-Experimentation
- Reported - view
Re: My 80 year old father's proposed regimen. What do you think? Can you please repost in English. My Google translation didnt make sense.
- chuck stanley
- chuck_stanley
- 1 yr ago
- Self-Experimentation
- Reported - view
Re: My 80 year old father's proposed regimen. What do you think? @Peter H. Howe "There is no question that metformin significantly inhibits hormone production based on a number of publications". I wasnt aware of that. Do you have a link to some in vivo studies?
- chuck stanley
- chuck_stanley
- 1 yr ago
- Self-Experimentation
- Reported - view
Re: My 80 year old father's proposed regimen. What do you think? If you compare the side effects of metformin with the benefits, its not much of a contest, as reflected in the following recent article. https://academic.oup.…
- chuck stanley
- chuck_stanley
- 1 yr ago
- Self-Experimentation
- Reported - view
Re: The DIM Supplement and Wound Healing @Jay Orman No problem, I'm not either. We're all here to learn from what others have learned. CYP3A4 is an important enzyme found mainly in the intestine and liver.…
- chuck stanley
- chuck_stanley
- 1 yr ago
- Self-Experimentation
- Reported - view
Re: The DIM Supplement and Wound Healing Great find! I have a lot of DIM leftover after I stopped taking it for prostate health due to its inducing CYP3A4. https://pubmed.ncbi.nlm.nih.gov/25542144/ "Together,…
- chuck stanley
- chuck_stanley
- 1 yr ago
- 1
- Self-Experimentation
- Reported - view
Re: Rapamycin - progress so far @Ulf Rasmusson Yes, 2 per day, but since it contains silymarin I only take 1/d. I've found in the past that too much silymarin gives me diarrhea.
- chuck stanley
- chuck_stanley
- 1 yr ago
- Self-Experimentation
- Reported - view
Re: Rapamycin - progress so far @Ulf Rasmusson This is the blend he recommended, Mushroom Synergy: https://www.amazon.com/gp/product/B081QKG76Q/ref=ppx_yo_dt_b_search_asin_image?ie=UTF8&psc=1
- chuck stanley
- chuck_stanley
- 1 yr ago
- Self-Experimentation
- Reported - view
Re: Rapamycin - progress so far @Ulf Rasmusson My neutraphil % went up but my lymph% came down, dropping below normal range with rapa so my doctor recommended a mushroom formula. It will be some months before I know if it worked.
- chuck stanley
- chuck_stanley
- 1 yr ago
- Self-Experimentation
- Reported - view
Re: Spermidine: a physiological autophagy inducer acting as an anti-aging vitamin inhumans? @Staffan Olsson thanks for the link. Since cellulose doesnt readily dissolve, what have you found to be a convenient way to take the spermidine? How about the apigenin?
- chuck stanley
- chuck_stanley
- 1 yr ago
- General Discussion
- Reported - view
Re: Spermidine: a physiological autophagy inducer acting as an anti-aging vitamin inhumans? @brad Since the wheat germ didnt work out for me as a smoothie additive, I still have it hanging around. I've never had cacao nibs. Its described as bitter... makes it sound sort of unappetizing.…
- chuck stanley
- chuck_stanley
- 1 yr ago
- General Discussion
- Reported - view
Re: SGLT2 @Fred Cloud @Peter H. Howe is this it? https://youtu.be/VHs_2Dv8MkU
- chuck stanley
- chuck_stanley
- 1 yr ago
- 1
- General Discussion
- Reported - view
Re: Spermidine: a physiological autophagy inducer acting as an anti-aging vitamin inhumans? @joseph mikhael Yes, its not extract. Just be aware of the fact that it is not 10mg of spermidine. Its 10mg of spermidine trihydrochloride, which as I recall is about 60% spermidine.
- chuck stanley
- chuck_stanley
- 1 yr ago
- General Discussion
- Reported - view
Re: Rapamycin Cost @Chris Los you may have found, as I recently have, that sirolimus powder is degraded in the stomach. Sirolimus must make it to the small intestine in order to be absorbed.…
- chuck stanley
- chuck_stanley
- 1 yr ago
- Self-Experimentation
- Reported - view
Re: D+Q+F+P+L+G+GLA: A New Senolytic Cocktail @JGC I'm not sure. I am confused by the following publications I found: Piperine, a major constituent of black pepper, inhibits human ... https://pubmed.ncbi.nlm.nih.gov › ...…
- chuck stanley
- chuck_stanley
- 1 yr ago
- Self-Experimentation
- Reported - view

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