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Re: Rapamycin Cost
@Chris Los That is extremely disappointing! From a 6mg dose I would have expected at least 24ng/ml. Thanks for sharing that information. In retrospect I believe the reps at Zhejiang Multinpharma…
chuck stanley
chuck_stanley
2 yrs ago
2
Self-Experimentation
Reported - view
Re: Stopping Metformin
Yes, for that reason I've cut back, but although I'm not prediabetic my glucose is consistently high. I've ordered some empagliflozin in hopes that will bring it into normal range so I can reduce it…
chuck stanley
chuck_stanley
2 yrs ago
AMPK Activation
Reported - view
Re: Dr Green new Rapamycin high dose
@Peter H. Howe Interesting. There might be an association with my exercise related nocturnal leg cramps. Although I take minimal dose statin, plus I do take CoQ10,…
chuck stanley
chuck_stanley
2 yrs ago
Rapamycin Discussion
Reported - view
Re: Dr Green new Rapamycin high dose
@Chris Los I'm glad you mentioned that. Since I take an evening statin, I cant take Grapefruit in the evening. My doc says occasional grapefruit in the morning would be okay.…
chuck stanley
chuck_stanley
2 yrs ago
Rapamycin Discussion
Reported - view
Re: Spermidine: a physiological autophagy inducer acting as an anti-aging vitamin inhumans?
@Hello World , I diluted with lactose 100:1 and add a little scoop of the mix (~12 mg spermidine) to my smoothie. It has no taste and if it sits in the smoothie for hours it still has no taste…
chuck stanley
chuck_stanley
2 yrs ago
General Discussion
Reported - view
Re: Spermidine: a physiological autophagy inducer acting as an anti-aging vitamin inhumans?
@chuck stanley Botany.bio
chuck stanley
chuck_stanley
2 yrs ago
General Discussion
Reported - view
Re: Spermidine: a physiological autophagy inducer acting as an anti-aging vitamin inhumans?
Has anyone else had trouble with Botany.com orders? I bought 2 jars of spermidine, supposed to contain 500 mg each. One jar contained 492 mg, the other jar contained only 438 mg.…
chuck stanley
chuck_stanley
2 yrs ago
General Discussion
Reported - view
Re: Interactions with rapamycin
I took another look at the curcumin study. If one does the actual animal to human dose conversion, the human equivalent dose would be about 500mg. (Divide rat dose of 50 mg/kg by 6.…
chuck stanley
chuck_stanley
2 yrs ago
Rapamycin Discussion
Reported - view
Re: Interactions with rapamycin
Thanks for bringing perspective to the issue, Mac!
chuck stanley
chuck_stanley
2 yrs ago
Rapamycin Discussion
Reported - view
Interactions with rapamycin
The enzyme CYP3A4, located primarily in the liver and intestines, metabolizes rapamycin. It is well known that grapefruit juice inhibits the enzyme. So taking grapefruit juice with rapamycin…
chuck stanley
chuck_stanley
2 yrs ago
4
replies
188
Rapamycin Discussion
Re: How To Freeze Rapamycin Powder?
I packaged mine in small ziplock bags along with color changing gel pack dessicants in larger ziplock bags. I'm thinking of placing the bags in a rigid container so they dont get squashed by freezer…
chuck stanley
chuck_stanley
2 yrs ago
1
General Discussion
Reported - view
Re: Are members here having real results with rapamycin?
@chuck stanley I think they use Quest to draw the sample.
chuck stanley
chuck_stanley
2 yrs ago
Rapamycin Discussion
Reported - view
Re: Are members here having real results with rapamycin?
@C B Ulta Lab said I could self order the test. Lab Corps said my doctor had to order.
chuck stanley
chuck_stanley
2 yrs ago
Rapamycin Discussion
Reported - view
Re: Anyone actually experience marked increased energy from NMN?
In the absence of published studies, I personally am inclined to be wary of the higher doses. But based on these encouraging individual reports I think its worth experimenting with very modest…
chuck stanley
chuck_stanley
2 yrs ago
Self-Experimentation
Reported - view
Re: Anyone actually experience marked increased energy from NMN?
@Paul Beauchemin that is fascinating. So 60 mg (not er I assume) before bed, and another 60mg when you wake up, as many of us do for a bathroom call. And that doesnt adversely affect your circadian…
chuck stanley
chuck_stanley
2 yrs ago
1
Self-Experimentation
Reported - view
Re: Spermidine: a physiological autophagy inducer acting as an anti-aging vitamin inhumans?
@Fred Cloud I think the point about redundancy in multiple approaches toward the same result is an often overlooked but very important concept since redundancy can potentially be detrimental.…
chuck stanley
chuck_stanley
2 yrs ago
General Discussion
Reported - view
Re: Spermidine: a physiological autophagy inducer acting as an anti-aging vitamin inhumans?
@Fred Cloud I see what you are saying. If we aren’t careful we could be over inducing general autophagy which could have detrimental effects. Or we could be combining compounds that target the same…
chuck stanley
chuck_stanley
2 yrs ago
1
General Discussion
Reported - view
Re: Spermidine: a physiological autophagy inducer acting as an anti-aging vitamin inhumans?
@Fred Cloud Yes, redundant in the sense that they both show longevity effect and cognitive protection effect. Is the mechanism for spermidine benefits attributable to mTOR inhibition or is there…
chuck stanley
chuck_stanley
2 yrs ago
1
General Discussion
Reported - view
Re: Spermidine: a physiological autophagy inducer acting as an anti-aging vitamin inhumans?
@Bobby thanks for the information from Viobin. Good point about its water solubility. It does look like they sell their defatted product, maybe just for commercial use?
chuck stanley
chuck_stanley
2 yrs ago
General Discussion
Reported - view
Re: Spermidine: a physiological autophagy inducer acting as an anti-aging vitamin inhumans?
@Hello World thanks for noting that. I decided I better go ahead and order the spermidine powder, and also ordered some EGCG powder while I was at it. I wonder why they are going out of business...…
chuck stanley
chuck_stanley
2 yrs ago
General Discussion
Reported - view
Re: Spermidine: a physiological autophagy inducer acting as an anti-aging vitamin inhumans?
@Staffan Olsson 2.4 mg per 10g.
chuck stanley
chuck_stanley
2 yrs ago
General Discussion
Reported - view
Re: Spermidine: a physiological autophagy inducer acting as an anti-aging vitamin inhumans?
@Donald Slowik I tried the raw wheat germ with apple, banana, nuts and raisins and I agree it tasted pretty good.
chuck stanley
chuck_stanley
2 yrs ago
1
General Discussion
Reported - view
Re: Spermidine: a physiological autophagy inducer acting as an anti-aging vitamin inhumans?
@Paul Beauchemin that looks like a great find. Please post a review once you try it!
chuck stanley
chuck_stanley
2 yrs ago
General Discussion
Reported - view
Re: Spermidine: a physiological autophagy inducer acting as an anti-aging vitamin inhumans?
@Fred Cloud how would one go about making that into a consumable product?
chuck stanley
chuck_stanley
2 yrs ago
1
General Discussion
Reported - view
Re: Spermidine: a physiological autophagy inducer acting as an anti-aging vitamin inhumans?
I think you may be overestimating the amount of spermidine you are actually getting. It is reported that heating spermidine above 100 Celsius will reduce/degrade it,…
chuck stanley
chuck_stanley
2 yrs ago
General Discussion
Reported - view
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chuck stanley
chuck_stanley
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