PCC1 is senolytic and senomorphic

Procyanidin C1 (PCC1 or PC-C1), which is found in grape seed extract (GSE), is senolytic, senomorphic, and has been proven to increase the lifespan of mice. PCC1 is also claimed to be a better senolytic in certain ways than even fisetin and D + Q.

Cons: PCC1 is only readily available in GSE; it's mixed in with other proanthocyanidins, and so, the dose can't be standardized.

Pros: GSE is probably safer and may have less side effects than D + Q. It also has less of a chance of being contaminated compared to fisetin.

GSE, when combined with resveratrol (RSV), may have the additional benefit of lowering the risk of cancer. GSE-RSV has been should to kill human colon cancer cells in vitro and suppresses tumor formation in mice without gastrointestinal toxicity. The GSE to RSV ratio was 4 to 1 in the study with mice.

Procyanidin C1 is a natural agent with senolytic activity against aging and age-related diseases
https://doi.org/10.1101/2021.04.14.439765

Resveratrol potentiates grape seed extract induced human colon cancer cell apoptosis
https://doi.org/10.2741/e352

Grape compounds suppress colon cancer stem cells in vitro and in a rodent model of colon carcinogenesis
https://doi.org/10.1186/s12906-016-1254-2

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  • Would be nice if we could get a dosage on this. I'm also wondering if it's something that would need to be cycled

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  • If using it as a senolytic I’d think you’d want to cycle it.

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