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PCC1 is senolytic and senomorphic

Procyanidin C1 (PCC1 or PC-C1), which is found in grape seed extract (GSE), is senolytic, senomorphic, and has been proven to increase the lifespan of mice.…
- Florin
- updated 4 yrs ago
- 3replies
- 316
- 2
- Senolytics Discussion
Re: Fisetin to Clear Senescent Cells
@Dan Nave It should cost a few hundred per year, not thousands. Remember that 60 mg/kg = 5 mg/kg HED (human equivalent dose) per day.
- Florin
- 5 yrs ago
- Self-Experimentation
- Reported - view
Re: Fisetin to Clear Senescent Cells
@Fairy8i8 The only empirically-proven endpoints is that the chronic group had increased longevity and health. So, there's going to be a risk in assuming that intermittent or acute admin will provide…
- Florin
- 5 yrs ago
- Self-Experimentation
- Reported - view
Re: Fisetin to Clear Senescent Cells
A clinical trial run by the Mayo Clinic and aimed at improving skeletal health in elderly women is upping the fisetin dosing schedule from two days to three and from one or two consecutive months to…
- Florin
- 5 yrs ago
- 1
- Self-Experimentation
- Reported - view
Re: Fisetin to Clear Senescent Cells
@Fairy8i8 It's the same study that this entire discussion is based on. Here's the relevant info: Ercc1−/∆;p16Ink4a-luciferase mice were fed a standard Teklad 2020 chow diet with or without…
- Florin
- 5 yrs ago
- 2
- Self-Experimentation
- Reported - view
Re: Fisetin to Clear Senescent Cells
Why aren't more of you guys taking fisetin at 60 mg/kg (5 mg/kg HED) per day, everyday? Chronic (daily, dietary) administration of fisetin has been demonstrated to extend the median and maximum…
- Florin
- 5 yrs ago
- 1
- Self-Experimentation
- Reported - view
Blood test results after using senolytics?

After using any senolytics, has anyone's blood test results significantly changed—either improved or deteriorated? I'm especially interested in results for kidney and liver function after using…
- Florin
- updated 5 yrs ago
- 1reply
- 298
- 1
- Test Results Discussions
Re: Fisetin to Clear Senescent Cells
Is anyone concerned that fisetin might be contaminated with the cytotoxin hinokiflavon? https://forum.age-reversal.net/t/63bxk5?r=x1ay46
- Florin
- 5 yrs ago
- Self-Experimentation
- Reported - view
Re: 732 BILLION USD SPENT ON MADNESS
But trillions have already been spent on medical research and very little can be prevent or cured.
- Florin
- 5 yrs ago
- General Discussion
- Reported - view
Re: Preparations for self-treating COVID-19
@Karl Of course. An RCT could still crash the hype train.
- Florin
- 5 yrs ago
- Self-Experimentation
- Reported - view
Re: Preparations for self-treating COVID-19
The revenge of the HCQ(+Z) hype train has begun. Hydroxychloroquine and azithromycin plus zinc vs hydroxychloroquine and azithromycin alone: outcomes in hospitalized COVID-19 patients https://www.…
- Florin
- 5 yrs ago
- 1
- Self-Experimentation
- Reported - view
Re: Preparations for self-treating COVID-19
Fortunately, a few H+Z and zinc-focused clinical trials for COVID-19 have already been started. https://clinicaltrials.gov/ct2/results?cond=&term=hydroxychloroquine+zinc https://medicalxpress.…
- Florin
- 5 yrs ago
- Self-Experimentation
- Reported - view
Re: Preparations for self-treating COVID-19
@Steven Jacobs How about this: the NA2P's mission is to cure, prevent, or manage all diseases. This discussion needs its own separate thread.
- Florin
- 5 yrs ago
- Self-Experimentation
- Reported - view
Re: Preparations for self-treating COVID-19
@Karl No zinc, no effect.
- Florin
- 5 yrs ago
- Self-Experimentation
- Reported - view
Re: Preparations for self-treating COVID-19
@Steven Jacobs How about this for a NA2P mission statement: the NA2P's mission is to enhance health, lengthen life, and reduce illness and disability.
- Florin
- 5 yrs ago
- Self-Experimentation
- Reported - view
Re: Preparations for self-treating COVID-19
@Steven Jacobs What anti-aging plan would the NA2P use? Why isn't that anti-aging plan being already used by the NIH or NIA? What's going to prevent the NA2P from turning into just another version…
- Florin
- 5 yrs ago
- Self-Experimentation
- Reported - view
Re: Preparations for self-treating COVID-19
@Dan Nave An IC doc in the Netherlands claims that quercetin + zinc is giving good results with his CODIV-19 patients.…
- Florin
- 5 yrs ago
- 2
- Self-Experimentation
- Reported - view
Re: Preparations for self-treating COVID-19
@Karl Of course, I realize that it has a ton of problems (and even in the best of times, most medical research is supposedly junk anyway), but if we're really at war here,…
- Florin
- 5 yrs ago
- 1
- Self-Experimentation
- Reported - view
Re: Preparations for self-treating COVID-19
@Karl Dr. Anthony Cardillo claims that: Hydroxychloroquine + zinc = all of his severely-ill COVID-19 patients became symptom-free in 8 to 12 hours Hydroxychloroquine + nothing = nothing Are you or…
- Florin
- 5 yrs ago
- Self-Experimentation
- Reported - view
Re: Which Dasatinib and Quercetin dosing regimen for longevity?
@Randall James Fasting doesn't clear senescent cells.
- Florin
- 5 yrs ago
- Self-Experimentation
- Reported - view
Re: Dasatinib testing -- Information about ordering testing for dasatinib and rapamycin, and other compounds
Why isn't fisetin mentioned as an alternative to D+Q? I also didn't see any mention of possible liver damage due to senolytics.
- Florin
- 5 yrs ago
- Self-Experimentation
- Reported - view

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