Fisetin experimentation one year (reposted as topic for info purposes)

Hello everyone I wanted to make my first post here as I have been doing a fisetin routine for a year now just about and I have results that are not placebo and very profound. I honestly do not know if this is the senylotic effect or some kind of interaction with fisetin in other ways. 

 

To get it out of the way, I will give the fast and short version. I am taking Swanson’s Fisetin. I take around 2g a day for 3 days( now 2.5g). I repeat this for 3 or 4 times with varying intervals (I was trying to find optimal intervals).  

 

My my first regimen was 3 days treatment with a 2 week delay, then a 3 week delay, then a 4 week delay, then a 2 month delay. I am now convinced a 3 week delay is the minimal amount of time you want taking this the way I am, though I will continue with 4 week delay for safety sake and because of my own observations. 

 

So results. Well I feel like this must play on hormone levels in the short term. Immediately after starting a 3 day regimen, usually on day 2 or 3 I feel strong as hell. In particular my legs are tight and super strong. My muscles in general are firmer and overall strength is amazing. My mind is clear, thinking concise anddynamic. I feel more dominant, self confident, and aggressive. Libido is enhanced as well. This all led me to believe that this acts as a testosterone mimic or elevates testosterone in the blood which is why I cycle monthly and then take a few months off every so often. 

 

i can tell you that at the age of 43 this makes me legitimately remember what early 20s feels like. The effects of one 3 day regimen last strongly for 2 weeks and even on for 4 weeks. In particular during week one and two I was amazed at the amount of pure emotion and clarity of the world around me. I could hear and appreciate sounds and colors seemed more vibrant. Mentally I am on overdrive with super memory and crystal clear logical thinking. I remember the first time I took this I was shocked. I was in a cafe just looking at a coke I had bought in a glass amazed at how more real and present it looked. A small thing but it was profound just how the world seemed more alive. It literally felt like going back in time 20 years. 

 

So for long term effects. A stronger posture, better muscle tone, improved gum health, vastly more energy, in fact this has become all the norm after around 8 months of this. Many of the effects I described in the first two weeks following a 3 day regimen do taper off to an extent, but never completely. 

 

As far as side effects there has not been anything thus far. When you are taking the 3 day dose you might get amped up a little jittery but that gives way quickly after the last dosage and it normalizes into a even effect that is positive in nature. I was very concerned about hair loss as I could not believe how impactful this was. But I have noticed no hair loss at all. I cycle it with a 3 or 4 week break to ensure that there is no negative effect on hair or otherwise. With a two week interval I had some scalp itchiness. That was enough to back me off to to four week intervals.

 

I honestly think that most of what I experienced is not the senylotic effect. It’s way too fast and profound. But I have no ill effects and feel incredible. And overall I have a youthful vigor and look and feel younger. I think a senylotic evaluation, as far as a laymen just observing himself goes ,can only really be done after 2 years or so. However the initial results ( especially gum health) and from what else I can observe are overwhelmingly positive. 

 

I can tell you that this does have an affect and it is profound and noticeable. How much of this is hormone I do not know. But I have other improved health as well, however it’s always tricky to quantify this objectively yourself sometimes. 

 

Good luck on your experiments. Let me know if this has the same effect for you. I just bought Swanson’s with nouvestein. Nothing fancy. Cheap and on amazon. 

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  • Thanks for sharing your experience. Sounds like great results. Now, if only we knew what happens after you do this for 10-20 yrs.

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      • David C
      • David_C
      • 7 mths ago
      • 1
      • Reported - view

      Karl yea that is the issue with senolytics in humans you need a very long time line. It’s one thing if you had a control body double of yourself to compare to, but obviously we don’t. But I can honestly recommend fisetin for the other benefits anyways. It’s the closest thing to a miracle supplement that I’ve ever taken. 

       

      I will I’ll continue to use until such time other senolytics become more advanced and accessible.

      Like 1
  • I’d add that if you look at people taking male to female hormones that maybe this gives us a rough estimate at how fast senescent cell clearance in humans might show results. In both of these scenarios cells receive different signals and must adapt and change.

     

    Typically with hormone treatments you see results in around 6 months. It stands to reason that the absence of SASP from senescent cells might affect cells in a rough timeline similar to this. There have been a lot of health benefits that are now the norm for me that showed up more or less around the 6 month mark. A year and a half ago I was a different person. 

    Like 1
  • Quick question.... did you use any oil with the fisetin? How about any of the other synelytics? Mayo clinic mixed the Fisetin with oil which supposedly enhanced the assimilation.... sounds like you just used it on an empty stomach? Pretty amazing report...thanks for the Guidance...

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  • Yea I just took it pretty much in line with how they did the mouse experiments. I upped it to 3g for each dosage. So every month I take 3g three days in a row. With Swansons that is a bottle every day. I am certain a lot of the effect is elevated testosterone levels so I am a bit cautious with the frequency. 
     

    Before I started this regimen I was lethargic, easily tired, and had brain fog. Also it seems as you get older you tend to slowly fade out so you are not as present in the world perceptually as you once were. It’s something you may never notice really as it’s a slow effect.

     

    Taking Fisetin turned the lights back on and suddenly I remembered how it was to see the world when I was in my early twenties. The sounds became clear and vibrant and interesting, the colors were amazing in the world. It was a little overwhelming at first. Now up I am kind of used to it but still get a mini effect when I do a new dosage. 
     

    My mind is as sharp as it has ever been. My memory is ridiculously good. I feel as if I have never been more intelligent in my whole life. And I can stay up way into the early morning hours.

     

    its a game changer if you have started to feel the ravages if time. Also when I work out I get ripped pretty easy now.

    Like 3
      • David H
      • David_Hanson
      • 6 mths ago
      • Reported - view

      David C  How often do you do the 3 day senolytic treatments?  Do you take the fisetin with a meal or between meals when you do the 3 day treatments?  Do you eat like you normally do during those days? Thanks

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  • To be honest I don't take it with a meal, I usually take it around 2 or 3 hours after just as a matter of habbit. I eat normally as well, I don't go out of my way much more than I do when taking Tylenol or something of the like.  I do the 3 day treatment once a month usually.

     

    I have tried various intervals. What I found was that 2 weeks seems to be too fast, and at 3 weeks you can repeat. But I choose to do it every month and at some points I do take a 3 month break sort as a reset just for safety's sake. But in short every month is more than sufficient.

     

    The thing is Fisetin obviously has some other effects that are not purely senylotic. The very first time I took Fisetin like this I remember being very fatigued the next day in a good way.  Also I had white stool, which I have never had since. Another effect is the firming up of muscles. And the first place I noticed strength and activity was in the thighs. 

     

    The only side effects might be some headaches but I chalk that up to dehydration. Drinking a lot of water with it makes it not a thing. 

     

    As far as when you should feel effects. It's fairly fast, but it was after the 2nd day of the very first 3 day supplement that I noticed how much strength my legs had and how my perceptions, mood, and presence were affected. By day three I was walking around the city marveling at how different the world looked. 

     

    I honestly would be interested to hear if this has the same effect for others. But as a rule I repeat the entire treatment every month. Which is the 3 day routine. 

    Like 2
    • David C You don't mention quercetin which is often recommended for senolytic treatments - do you take it or just the fisetin?  and what is your dosage per Kg of weight?

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      • David C
      • David_C
      • 6 mths ago
      • 1
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      Paul Beauchemin Well, I bought some Quercetin but as I understand it its less effective than Fisetin and I don't have access to Dastanib. Fisetin alone was proven to be a fairly potent senylotic and at my age I was looking for something easy that will remove a good part of senescent cells..theoretically.  

       

      My feeling is that within 5 years time we will have some new methods from people like Osin and other companies. So if I can do a little something now until the more tailored interventions come out I am fine with it.

       

      I weight 110kg so 3g for that weight. To be honest I sort of felt like I'd prefer go with a smaller dosage over multiple days rather than say a super dose of 5g. And I did get an effect with the dosage I am using. I do not have the resources to test pre and post SASP or senescent cell counts. So I have to rely on the lab results with rats like the rest of us for the time being. 

      Like 1
  • I forgot to add, when I first started Fisetin I was aiming at hitting the Senylotic threshold. So I took it like this:

    3 days treatment - wait two weeks - 3 day treatment - wait 3 weeks - 3 day treatment - wait 4 weeks - 3 day treatment -wait 2 months

     

    And I had every intention of maybe doing this every 3 months just to keep the senescent cell clearing occurring regularly. However I found the other benefits of Fisetin to be too enticing to wait 3 months between treatments. So now I am at once a month.  

    Like 2
      • David H
      • David_Hanson
      • 5 mths ago
      • Reported - view

      David C Do you take a smaller amount of fisetin every day, also?

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  • David C I've only done one course of a 3 day fisiten treatment.  However, what stood out for me was short term relief of mild to moderate chronic pain over that three day period.  Perhaps you don't have any pain, but if so, did you notice this effect?

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      • David C
      • David_C
      • 5 mths ago
      • Reported - view

      Dorian Gray it would not surprise me as it’s a anti inflammatory in some ways. 

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  • No because as I understood there were two ways to take it: Moderate amounts every day or periodic high doses. As far as the other benefits of Fisetin I can feel the effects for 3 weeks acutely, and during the 4th week there is waning down of the effects. I expect this is hormonal so I do like to let my system normalize before taking another treatment.

     

    As I have said my baseline health has risen significantly after starting this regimen, so it clearly has had a lasting effect as well. But I definitely get a jolt every time I do the treatment. I am more or less careful because I'd rather not cause premature male pattern baldness or something.

    As far as I can tell at around week 4 my body is normalizing fully from the previous dosage. So if I took even more Fistein daily it would alter that balance. 

    Like 1
  • You mention buying "Swanson’s with nouvestein" (it's actually Fisetin with Novusetin sold by Doctor's Best).  I was wondering just what Novusetin is, so I did an Internet search.  Turns out, Novusetin is just a commercial name for fisetin and nothing special.

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      • BobM
      • BobM
      • 5 mths ago
      • 1
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      JGC 

      Just FYI, Dr’s Best brand and the one from Swanson are different. Swansons is better, and lower cost.
      In my tests to check for how products dissolve in various mediums, comparing Dr Best, Swanson brand and pure powder), I found Dr Best to contain a Lot of non dissolving fillers. 

      Like 1
      • JGC
      • JGC
      • 5 mths ago
      • 1
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      BobM 

      OK, but when I search for "fisetin" on the Swanson site, I get two items.  The Swanson brand says "Novusetin" in small letters under the title, and the Doctor's Best brand says "Fisetin with Novusetin", implying that Novusetin is some additional ingredient.  That's incorrect.  It's just a brand name for Fisetin.  That's my point.

      Like 1
      • BobM
      • BobM
      • 5 mths ago
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      JGC 

      FYI, here is what I am using now and referred to:

      Like 1
  • Well swansons was just the first I went with. I can vouch for this stuff. I absolutely love fisetin. Best thing I ever found.

     

    3g day 1

    3g day 2

    3g day 3 

    Like 3
  • @David C      Thanks for all the feedback on your fisetin experiment - much appreciated. 

    Just one point, do you take the 3g fisetin in one mega dose or are you taking several smaller doses throughout the day? 

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  • One dose. I just take 30 pills one after another drinking water. My reasoning is you want to overload the body’s ability to metabolize it and get it circulating in the blood to affect as many senescent cells as possible.

     

    The half life on this stuff even with large doses is like 3.1 hours, so it should be out of your system effectively in around 9 hours. 
     

    If you do take it this way, the first place I notice an effect is the outer thighs. It gets tight and might twitch a little. Leg strength is something I noticed first as well. Drink plenty of water, I used to get some head aches that were not painful just uncomfortable, but that does not happen anymore.

    Like 2
    • David C      Thanks for the reply.

      I'm definitely going to give this a shot.......but I will probably start with a 2g dose to be on the safe side and then work my way up.

      Like
      • Chris
      • Chris.1
      • 4 mths ago
      • Reported - view

      David C 

      Trying this my first time, started yesterday at 3g, and 2.2g today and tomorrow (all I have left).  I experienced some great energy, and clear mind all day yesterday.  Last night I did get super tired and have been lethargic today.  Is this normal?  Thanks!

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      • David C
      • David_C
      • 4 mths ago
      • Reported - view

      Chris  yes it was like this for me my first time especially. So on day 3 or so things should be better. I slept a lot and by about day 3 is when I realized it had really kicked in.

       

      If you were knocking out 25 to 50% of senescent cells in tissues it might mean the body would like to rebuild and restructure. Not only to replace those cells but now the environment for cell replication and restoration would me much more free of SASP which hinders maintenance. In other words your body has a lot to do, and suddenly.

       

      Now when I take it I don’t get that same fatigue as when I first did it. Pay attention to leg strength. It’s the first sign I had that this was doing something beneficial. You should get boosts of energy, increased mood, and muscle firming if it’s like me. Give it a day or so then just go for a walk. I had increased perception and presence in the world. Good energy and impressive leg strength. Like hills that would make me groan were fun to just bounce over.

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      • Chris
      • Chris.1
      • 4 mths ago
      • Reported - view

      David C Thanks!  Pretty excited about this and your schedule.  I do plan 3g a day for 3 days in the future, every 4 weeks.  Have you tweaked anything (like add other compounds, take in olive, oil, etc)?

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      • David C
      • David_C
      • 4 mths ago
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      Chris Well I recently added NMN to the whole regime. I am careful not to add too much because then it becomes to costly and I am afraid there will be interactions that nobody has forseen.

      I hope it works well for you. At the very least it's a harmless regimen. It has proven results in the lab and I really love the stuff.

       

      If you do notice increased muscle density, energy, mood, and all the other stuff it usually lasts like 2 weeks solid and then by week 3 it normalizes a bit and then I let it go another week and repeat. You could possibly do it more often than 4 weeks. At 3 weeks I think its fine. I tried it every 2 weeks and had some scalp itching so I went back to every 4 weeks.

      The thing is, if this does increase testosterone levels it does it via your own body's functions. Because the bioavailability is fairly fast. It should be out of your system in like 12 hours for each does. So it's not like a steroid that adds literally the hormone itself it only encourages production of testosterone via your own body's functions. That is if indeed it does increase hormone levels. But it should be safe even if it does because you should theoretically be getting testosterone meant for your specific body.

      The main use of this stuff is to clear senescent cells. Just like you I was tired at first, I just slept alot and it goes away. I think your first run through will clear out the vast majority of senescent cells that fisetin is able to eliminate which would cause some fatigue as the body has some restructuring to do afterwards.

      But later on when you are doing repeat doses monthly it's just a maintenance dose and there is just not as many senescent cells to clear, meaning really no fatigue. 

       

      Glad to see you are trying it out. Human studies do I think next month on this. So we will have a little more data to go off soon. 

      Like 1
      • Chris
      • Chris.1
      • 4 mths ago
      • Reported - view

      David C Thanks!  Been taking NMN for awhile :-) So I dosed my last dose this morning, I'll report back here on the next few days.  I am not nearly as tired today as I was yesterday.  Also, I would assume to not exercise/lift on the week of doing this, correct?  Not like I really can anyways with the quarantine.  I'll probably try this again in 3-4 weeks but with olive oil or MCT oil just to see.  Cheers!

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      • David C
      • David_C
      • 4 mths ago
      • Reported - view

      Chris I lift while taking. I used to not do so on the days I dosed. But i figured I’d try it and see. I noticed I might get more muscle soreness but other than that seems fine. I mean I guess the concern is that fisetin might eliminate those transient senescent cells that are created to attract immune cells for wound healing. Which I guess is the mechanism by which the muscle rebuilds after a workout.

       

      Seemed to me not to be harmful at all to workout though. I feel like I get a good rip to be honest with it.

      Like
  • Just ordered some.  We'll see what it does to someone's who's pushing 70.  I understand that the right dose is 20 milligrams per kilogram.  At 190lbs that's 17 one hundred milligram tablets. 

    Like 1
  • Well yea. I guess start with that much and see. I started with 18 and now I do 30. There are no side effects and the dosage is not noticeably different at all. Fisetin seems to be quite safe. 
     

    let us know if it has an effect. I’d like some backup on this. I swear by this stuff but it’s always nice to see other people say the same.

    Like 1
      • garland
      • garland
      • 5 mths ago
      • Reported - view

      David C 

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    • David C 

      I'm not going gentle into that good night.   I'm fasting now from dinner to lunch and sometimes a little longer.  I've been trying to figure out when the effect of autophagy take place as I understand the first things the body chows down on in senescent cells.   That almost too good to believe.  But I can't find any consensus on how long the fast needs to be or if shorter intermittent fasting can work.

      Like 1
      • David C
      • David_C
      • 5 mths ago
      • 1
      • Reported - view

      Robert Olin For fasting I hear it's at least two days, this was from David Sinclair. 

      Like 1
  • But does that mean that autophagy begins on the 48th hour and does it stop the minute your eat?

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  • I honestly don’t think anyone knows. From what I can tell it likely starts earlier  and to get some benefit 48 hours fasting is what is required. There really has not been in depth human testing so far. Everything is theoretical and translated from mouse models.

    Like 1
  • Hi David,

    Thanks for your posts! I actually found them in a google search and your post led me to give Fisetin a try. I have completed my first 3 day round of Fisetin at 3 grams per day. 

    A question if I may:

    You mentioned that you saw improvements in some areas at around the 6 month mark. Could you share what those were? I am eager to have a roadmap to measure progress again if possible.

    About me: 49 yr old male. On TRT since 2018.

    Some notes about my experience so far (2 weeks after first dose):

    1. I feel like I had a few hairs go from gray to not gray. Not sure if it’s related or I just noticed it.

    2. I noticed that I got a bit ...drier...I think this might be an anti-inflammatory effect. Maybe I had a bit of bloat. That seemed to go away quickly and improved a bit more over the last week.

    3. Improved energy. My workouts are more intense and more enjoyable. I have more energy left over after I complete the workout than I did before the first round of Fisetin.

    4. Muscles seem generally harder. I believe David noted this above but I am also experiencing this.

    5. A weird twitch in my right eye. That seemed to last throughout the first week and is going away now. Not sure if it’s related or not.

     

    Thanks again!

    Best, 

    Another David C.

    Like 1
      • David C
      • David_C
      • 4 mths ago
      • 1
      • Reported - view

      DavidCo11 be sure to hydrate a lot. I do usually when taking this. Which means I just drink the amount of water they say we are supposed to anyways

      Like 1
  • I just got some 500 mg fisetin so I take 1.5 grams a day with querctin.  Any idea how many days on and off.  

     

    Thanks,

     

    Bob

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  • Well with 1.5 grams I would do 3 days 1.5 plus querctin then pause 2 or 3 weeks and repeat. I honestly don’t think it will be harmful if you wait at least 2 weeks.

     

    personally I found that when taking 2.2 or 3 grams three days in a row that at about week 3 is when I feel like I am normalizing. I then let it go another weeek to allow the body to rest just in case this is affecting hormone levels.

     

    Since there really is no data and that’s a lesser dose. I would try taking it 3 times daily then wait three weeks and repeat. At some point it’s not a bad idea to take two months off then start again. This gives your body time to naturally reset.

    Like 1
  • So you feel that after taking fisetin and querctin for three days, your body need some time to flush out these senescent cells?  Do you recall the time protocol used by the Mayo Clinic for the rats?

    Thanks,

     

    Bob

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  • Well here is my feeling on it. I believe fisetin raises testosterone levels somehow. This is more the reason I am careful than anything else. With the rat experiments they did it two different ways.

     

    one was mega dose and the other was daily. I chose to mega dose just in case the body adapts and builds a tolerance somehow or becomes dependent. I’d have to go back and look at the study again, but it seems with the dose you are taking it’s somewhere between the mega dose and the daily dose.

     

    thats why i was think every two weeks maybe. Since no one knows how this affects humans just yet you have to play it by ear. I’d take the dose 3 times over 3 days then repeat in two weeks. See how you feel with it.

     

    id take fisetin every 3 weeks optimally I just don’t want my hair to fallout from too much Testosterone.  And that’s a just in case. I think the first human studies with humans are wrapping up this month so we might have more data here soon.

    Like 1
  • i read somewhere that one of the reasons you don't clear senescent cells is that your immune system that does the work, gets clogged up with them as we age.   Let's hope clearing them out helps restore our ability to do apoptosis.    Also - we need a strong immune system with this new virus.    I'm guessing the people who only have a mild reaction to it have strong immune systems.        I believe it was Dylan Thomas that said not to go gentle  into that good night.

    Like 1
  • I think it’s a combination of a failing immune system and the prevalence of more senescence. Kind of like a feedback loop where both aggravate each other and a downward spiral starts with both speeding up the demise of the other faster and faster.

    Not sure apoptosis will be encouraged or not if there are less SASP and other senescent cells. Not even sure there is good data on why apoptosis does not occur in some senescent cells. Assumedly it’s DNA damage or out of the ordinary circumstances otherwise that cause this to fail.

     

    DNA damage makes sense since it seems the SASP signaling is primarily to attract immune cells to destroy SASP emitting cells and likely a good portion of other cells in the immediate SASP environment. And that would make sense if a somatic cell with a cancerous or apoptosis resistant profile had proliferated it would be best to kill them all off to reduce the chances of a much larger problem down the road.

     

    We really need a way to improve the immune system and the quality and number of stem cells for anything terribly meaningful to occur. What’s interesting about our stem cells is that they are quiescent and protect their DNA, only activating and replicating when certain signal demands are met. I am sure a SASP rich environment causes stem cells to remain quiescent much longer as there seems to be a rather delicate signaling criteria for replication. 
     

    In the end all of this signaling us just every cell emitting it’s own proteins routinely and these flip switches in surrounding cells as certain thresholds are met. SASP seems to muddy everything up and cause cells to go senescent as a precaution since their proximity to a SASP emitting cell implicates them as possibly being compromised as well due to recent somatic replication.

    Like 1
  • Just did my second 3 day regimen of fisetin. First time did 1.5 gms, this time 2.5.

    felt no effect from either. Hoping it is clearing senescent cells

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  • That is so crazy. I definitely get effects. Took first day of three day regimen yesterday and feel the same effects as usual. In any case you really aren’t supposed to feel anything if it’s clearing senescent cells. 
     

    it’s very odd you don’t feel any if the effects I do. To me it’s unmistakable.

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      • Joe smith
      • Joe_smith
      • 3 mths ago
      • Reported - view

      David C  do you guys have any blood tests before and then during the treatment?

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      • David C
      • David_C
      • 3 mths ago
      • 1
      • Reported - view

      Joe smith No, someone really should. I am more interested (in regards to fisetin) in hormone levels. I am not sure how well bloodtests would show senescence. I guess looking for SASP factors and some of the other signalling that sencecent cells give off.

       

      I feel like they'd almost have to cut people open and take biopsies to really understand to what effect it's working or not. Not to mention the time required to have a noticeable effect is likely years. 

       

      You almost have to take it at blind faith and be consistent with it for a number of years. That's why I am doing fisetin. It's cheap, accessible, safe, and has some laboratory results behind it.

       

      I don't doubt that some other compounds might be  more effective. But usually it's me looking at the longterm. Can I afford to take this routinely for 5 years or so? If I can does the cost outweigh the possibility of it not working? Am I able to buy this without a doctor prescribing it? And so on...

      I think we will get more information on sencesent cell removal in general very soon as there is a lot of human trials underway, some even using fisetin.   

      Like 1
      • Fred Cloud
      • Fred_Cloud
      • 2 mths ago
      • Reported - view

      David C I think he meant before and after blood tests for hormone levels. How often do you check your test levels?

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