Fisetin experimentation one year (reposted as topic for info purposes)
Hello everyone I wanted to make my first post here as I have been doing a fisetin routine for a year now just about and I have results that are not placebo and very profound. I honestly do not know if this is the senylotic effect or some kind of interaction with fisetin in other ways.
To get it out of the way, I will give the fast and short version. I am taking Swanson’s Fisetin. I take around 2g a day for 3 days( now 2.5g). I repeat this for 3 or 4 times with varying intervals (I was trying to find optimal intervals).
My my first regimen was 3 days treatment with a 2 week delay, then a 3 week delay, then a 4 week delay, then a 2 month delay. I am now convinced a 3 week delay is the minimal amount of time you want taking this the way I am, though I will continue with 4 week delay for safety sake and because of my own observations.
So results. Well I feel like this must play on hormone levels in the short term. Immediately after starting a 3 day regimen, usually on day 2 or 3 I feel strong as hell. In particular my legs are tight and super strong. My muscles in general are firmer and overall strength is amazing. My mind is clear, thinking concise anddynamic. I feel more dominant, self confident, and aggressive. Libido is enhanced as well. This all led me to believe that this acts as a testosterone mimic or elevates testosterone in the blood which is why I cycle monthly and then take a few months off every so often.
i can tell you that at the age of 43 this makes me legitimately remember what early 20s feels like. The effects of one 3 day regimen last strongly for 2 weeks and even on for 4 weeks. In particular during week one and two I was amazed at the amount of pure emotion and clarity of the world around me. I could hear and appreciate sounds and colors seemed more vibrant. Mentally I am on overdrive with super memory and crystal clear logical thinking. I remember the first time I took this I was shocked. I was in a cafe just looking at a coke I had bought in a glass amazed at how more real and present it looked. A small thing but it was profound just how the world seemed more alive. It literally felt like going back in time 20 years.
So for long term effects. A stronger posture, better muscle tone, improved gum health, vastly more energy, in fact this has become all the norm after around 8 months of this. Many of the effects I described in the first two weeks following a 3 day regimen do taper off to an extent, but never completely.
As far as side effects there has not been anything thus far. When you are taking the 3 day dose you might get amped up a little jittery but that gives way quickly after the last dosage and it normalizes into a even effect that is positive in nature. I was very concerned about hair loss as I could not believe how impactful this was. But I have noticed no hair loss at all. I cycle it with a 3 or 4 week break to ensure that there is no negative effect on hair or otherwise. With a two week interval I had some scalp itchiness. That was enough to back me off to to four week intervals.
I honestly think that most of what I experienced is not the senylotic effect. It’s way too fast and profound. But I have no ill effects and feel incredible. And overall I have a youthful vigor and look and feel younger. I think a senylotic evaluation, as far as a laymen just observing himself goes ,can only really be done after 2 years or so. However the initial results ( especially gum health) and from what else I can observe are overwhelmingly positive.
I can tell you that this does have an affect and it is profound and noticeable. How much of this is hormone I do not know. But I have other improved health as well, however it’s always tricky to quantify this objectively yourself sometimes.
Good luck on your experiments. Let me know if this has the same effect for you. I just bought Swanson’s with nouvestein. Nothing fancy. Cheap and on amazon.
I’d add that if you look at people taking male to female hormones that maybe this gives us a rough estimate at how fast senescent cell clearance in humans might show results. In both of these scenarios cells receive different signals and must adapt and change.
Typically with hormone treatments you see results in around 6 months. It stands to reason that the absence of SASP from senescent cells might affect cells in a rough timeline similar to this. There have been a lot of health benefits that are now the norm for me that showed up more or less around the 6 month mark. A year and a half ago I was a different person.
Yea I just took it pretty much in line with how they did the mouse experiments. I upped it to 3g for each dosage. So every month I take 3g three days in a row. With Swansons that is a bottle every day. I am certain a lot of the effect is elevated testosterone levels so I am a bit cautious with the frequency.
Before I started this regimen I was lethargic, easily tired, and had brain fog. Also it seems as you get older you tend to slowly fade out so you are not as present in the world perceptually as you once were. It’s something you may never notice really as it’s a slow effect.
Taking Fisetin turned the lights back on and suddenly I remembered how it was to see the world when I was in my early twenties. The sounds became clear and vibrant and interesting, the colors were amazing in the world. It was a little overwhelming at first. Now up I am kind of used to it but still get a mini effect when I do a new dosage.
My mind is as sharp as it has ever been. My memory is ridiculously good. I feel as if I have never been more intelligent in my whole life. And I can stay up way into the early morning hours.
its a game changer if you have started to feel the ravages if time. Also when I work out I get ripped pretty easy now.
To be honest I don't take it with a meal, I usually take it around 2 or 3 hours after just as a matter of habbit. I eat normally as well, I don't go out of my way much more than I do when taking Tylenol or something of the like. I do the 3 day treatment once a month usually.
I have tried various intervals. What I found was that 2 weeks seems to be too fast, and at 3 weeks you can repeat. But I choose to do it every month and at some points I do take a 3 month break sort as a reset just for safety's sake. But in short every month is more than sufficient.
The thing is Fisetin obviously has some other effects that are not purely senylotic. The very first time I took Fisetin like this I remember being very fatigued the next day in a good way. Also I had white stool, which I have never had since. Another effect is the firming up of muscles. And the first place I noticed strength and activity was in the thighs.
The only side effects might be some headaches but I chalk that up to dehydration. Drinking a lot of water with it makes it not a thing.
As far as when you should feel effects. It's fairly fast, but it was after the 2nd day of the very first 3 day supplement that I noticed how much strength my legs had and how my perceptions, mood, and presence were affected. By day three I was walking around the city marveling at how different the world looked.
I honestly would be interested to hear if this has the same effect for others. But as a rule I repeat the entire treatment every month. Which is the 3 day routine.
I forgot to add, when I first started Fisetin I was aiming at hitting the Senylotic threshold. So I took it like this:
3 days treatment - wait two weeks - 3 day treatment - wait 3 weeks - 3 day treatment - wait 4 weeks - 3 day treatment -wait 2 months
And I had every intention of maybe doing this every 3 months just to keep the senescent cell clearing occurring regularly. However I found the other benefits of Fisetin to be too enticing to wait 3 months between treatments. So now I am at once a month.
No because as I understood there were two ways to take it: Moderate amounts every day or periodic high doses. As far as the other benefits of Fisetin I can feel the effects for 3 weeks acutely, and during the 4th week there is waning down of the effects. I expect this is hormonal so I do like to let my system normalize before taking another treatment.
As I have said my baseline health has risen significantly after starting this regimen, so it clearly has had a lasting effect as well. But I definitely get a jolt every time I do the treatment. I am more or less careful because I'd rather not cause premature male pattern baldness or something.
As far as I can tell at around week 4 my body is normalizing fully from the previous dosage. So if I took even more Fistein daily it would alter that balance.
One dose. I just take 30 pills one after another drinking water. My reasoning is you want to overload the body’s ability to metabolize it and get it circulating in the blood to affect as many senescent cells as possible.
The half life on this stuff even with large doses is like 3.1 hours, so it should be out of your system effectively in around 9 hours.
If you do take it this way, the first place I notice an effect is the outer thighs. It gets tight and might twitch a little. Leg strength is something I noticed first as well. Drink plenty of water, I used to get some head aches that were not painful just uncomfortable, but that does not happen anymore.
Well yea. I guess start with that much and see. I started with 18 and now I do 30. There are no side effects and the dosage is not noticeably different at all. Fisetin seems to be quite safe.
let us know if it has an effect. I’d like some backup on this. I swear by this stuff but it’s always nice to see other people say the same.
Thanks for your posts! I actually found them in a google search and your post led me to give Fisetin a try. I have completed my first 3 day round of Fisetin at 3 grams per day.
A question if I may:
You mentioned that you saw improvements in some areas at around the 6 month mark. Could you share what those were? I am eager to have a roadmap to measure progress again if possible.
About me: 49 yr old male. On TRT since 2018.
Some notes about my experience so far (2 weeks after first dose):
1. I feel like I had a few hairs go from gray to not gray. Not sure if it’s related or I just noticed it.
2. I noticed that I got a bit ...drier...I think this might be an anti-inflammatory effect. Maybe I had a bit of bloat. That seemed to go away quickly and improved a bit more over the last week.
3. Improved energy. My workouts are more intense and more enjoyable. I have more energy left over after I complete the workout than I did before the first round of Fisetin.
4. Muscles seem generally harder. I believe David noted this above but I am also experiencing this.
5. A weird twitch in my right eye. That seemed to last throughout the first week and is going away now. Not sure if it’s related or not.
Another David C.
Well with 1.5 grams I would do 3 days 1.5 plus querctin then pause 2 or 3 weeks and repeat. I honestly don’t think it will be harmful if you wait at least 2 weeks.
personally I found that when taking 2.2 or 3 grams three days in a row that at about week 3 is when I feel like I am normalizing. I then let it go another weeek to allow the body to rest just in case this is affecting hormone levels.
Since there really is no data and that’s a lesser dose. I would try taking it 3 times daily then wait three weeks and repeat. At some point it’s not a bad idea to take two months off then start again. This gives your body time to naturally reset.
Well here is my feeling on it. I believe fisetin raises testosterone levels somehow. This is more the reason I am careful than anything else. With the rat experiments they did it two different ways.
one was mega dose and the other was daily. I chose to mega dose just in case the body adapts and builds a tolerance somehow or becomes dependent. I’d have to go back and look at the study again, but it seems with the dose you are taking it’s somewhere between the mega dose and the daily dose.
thats why i was think every two weeks maybe. Since no one knows how this affects humans just yet you have to play it by ear. I’d take the dose 3 times over 3 days then repeat in two weeks. See how you feel with it.
id take fisetin every 3 weeks optimally I just don’t want my hair to fallout from too much Testosterone. And that’s a just in case. I think the first human studies with humans are wrapping up this month so we might have more data here soon.
i read somewhere that one of the reasons you don't clear senescent cells is that your immune system that does the work, gets clogged up with them as we age. Let's hope clearing them out helps restore our ability to do apoptosis. Also - we need a strong immune system with this new virus. I'm guessing the people who only have a mild reaction to it have strong immune systems. I believe it was Dylan Thomas that said not to go gentle into that good night.
I think it’s a combination of a failing immune system and the prevalence of more senescence. Kind of like a feedback loop where both aggravate each other and a downward spiral starts with both speeding up the demise of the other faster and faster.
Not sure apoptosis will be encouraged or not if there are less SASP and other senescent cells. Not even sure there is good data on why apoptosis does not occur in some senescent cells. Assumedly it’s DNA damage or out of the ordinary circumstances otherwise that cause this to fail.
DNA damage makes sense since it seems the SASP signaling is primarily to attract immune cells to destroy SASP emitting cells and likely a good portion of other cells in the immediate SASP environment. And that would make sense if a somatic cell with a cancerous or apoptosis resistant profile had proliferated it would be best to kill them all off to reduce the chances of a much larger problem down the road.
We really need a way to improve the immune system and the quality and number of stem cells for anything terribly meaningful to occur. What’s interesting about our stem cells is that they are quiescent and protect their DNA, only activating and replicating when certain signal demands are met. I am sure a SASP rich environment causes stem cells to remain quiescent much longer as there seems to be a rather delicate signaling criteria for replication.
In the end all of this signaling us just every cell emitting it’s own proteins routinely and these flip switches in surrounding cells as certain thresholds are met. SASP seems to muddy everything up and cause cells to go senescent as a precaution since their proximity to a SASP emitting cell implicates them as possibly being compromised as well due to recent somatic replication.