Fisetin experimentation one year (reposted as topic for info purposes)

Hello everyone I wanted to make my first post here as I have been doing a fisetin routine for a year now just about and I have results that are not placebo and very profound. I honestly do not know if this is the senylotic effect or some kind of interaction with fisetin in other ways. 

 

To get it out of the way, I will give the fast and short version. I am taking Swanson’s Fisetin. I take around 2g a day for 3 days( now 2.5g). I repeat this for 3 or 4 times with varying intervals (I was trying to find optimal intervals).  

 

My my first regimen was 3 days treatment with a 2 week delay, then a 3 week delay, then a 4 week delay, then a 2 month delay. I am now convinced a 3 week delay is the minimal amount of time you want taking this the way I am, though I will continue with 4 week delay for safety sake and because of my own observations. 

 

So results. Well I feel like this must play on hormone levels in the short term. Immediately after starting a 3 day regimen, usually on day 2 or 3 I feel strong as hell. In particular my legs are tight and super strong. My muscles in general are firmer and overall strength is amazing. My mind is clear, thinking concise anddynamic. I feel more dominant, self confident, and aggressive. Libido is enhanced as well. This all led me to believe that this acts as a testosterone mimic or elevates testosterone in the blood which is why I cycle monthly and then take a few months off every so often. 

 

i can tell you that at the age of 43 this makes me legitimately remember what early 20s feels like. The effects of one 3 day regimen last strongly for 2 weeks and even on for 4 weeks. In particular during week one and two I was amazed at the amount of pure emotion and clarity of the world around me. I could hear and appreciate sounds and colors seemed more vibrant. Mentally I am on overdrive with super memory and crystal clear logical thinking. I remember the first time I took this I was shocked. I was in a cafe just looking at a coke I had bought in a glass amazed at how more real and present it looked. A small thing but it was profound just how the world seemed more alive. It literally felt like going back in time 20 years. 

 

So for long term effects. A stronger posture, better muscle tone, improved gum health, vastly more energy, in fact this has become all the norm after around 8 months of this. Many of the effects I described in the first two weeks following a 3 day regimen do taper off to an extent, but never completely. 

 

As far as side effects there has not been anything thus far. When you are taking the 3 day dose you might get amped up a little jittery but that gives way quickly after the last dosage and it normalizes into a even effect that is positive in nature. I was very concerned about hair loss as I could not believe how impactful this was. But I have noticed no hair loss at all. I cycle it with a 3 or 4 week break to ensure that there is no negative effect on hair or otherwise. With a two week interval I had some scalp itchiness. That was enough to back me off to to four week intervals.

 

I honestly think that most of what I experienced is not the senylotic effect. It’s way too fast and profound. But I have no ill effects and feel incredible. And overall I have a youthful vigor and look and feel younger. I think a senylotic evaluation, as far as a laymen just observing himself goes ,can only really be done after 2 years or so. However the initial results ( especially gum health) and from what else I can observe are overwhelmingly positive. 

 

I can tell you that this does have an affect and it is profound and noticeable. How much of this is hormone I do not know. But I have other improved health as well, however it’s always tricky to quantify this objectively yourself sometimes. 

 

Good luck on your experiments. Let me know if this has the same effect for you. I just bought Swanson’s with nouvestein. Nothing fancy. Cheap and on amazon. 

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    • JGC
    • Retired Professor of Physics
    • JGC
    • 4 yrs ago
    • Reported - view

    You mention buying "Swanson’s with nouvestein" (it's actually Fisetin with Novusetin sold by Doctor's Best).  I was wondering just what Novusetin is, so I did an Internet search.  Turns out, Novusetin is just a commercial name for fisetin and nothing special.

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      • JGC
      • Retired Professor of Physics
      • JGC
      • 4 yrs ago
      • Reported - view

      BobM 

      OK, but when I search for "fisetin" on the Swanson site, I get two items.  The Swanson brand says "Novusetin" in small letters under the title, and the Doctor's Best brand says "Fisetin with Novusetin", implying that Novusetin is some additional ingredient.  That's incorrect.  It's just a brand name for Fisetin.  That's my point.

      Like 1
      • BobM
      • BobM
      • 4 yrs ago
      • Reported - view

      JGC 

      FYI, here is what I am using now and referred to:

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    • David C
    • David_C
    • 4 yrs ago
    • Reported - view

    Well swansons was just the first I went with. I can vouch for this stuff. I absolutely love fisetin. Best thing I ever found.

     

    3g day 1

    3g day 2

    3g day 3 

    Like 4
      • Dean W.
      • Dean_W
      • 1 yr ago
      • Reported - view

      David C    3 grams is a whole bottle of the Swanson's fisetin. Quite a bit more than the 1.5 grams daily dose that the Mayo clinic recomended for 70kg body weight. What do you weigh? And are you still taking this regime once a month?

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    • Dean W. I do it by bodyweight, 20mg/kilo of bodyweight and 1-2 month break, don't know what's right.

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      • Dean W.
      • Dean_W
      • 1 yr ago
      • Reported - view

      John Ramos Yes, that is the milligram number I use too. But John C. said he is taking 3 grams a day for 3 days (see his post from 2 years ago). 3 grams is twice as much as I take so I was wondering if he weighes twice as much as me. (That would mean 140 kg or 308 lb.) Or maybe he weighs much less and just decided to greatly increase the dose on his own.

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    • Dean W. 20mg/kilo of body weight is a real number, I think his was a guesstimate. That amount done 2 days is a pretty easy amount to find. 1-2 months break...you don't want to completely keep them cleaned out, some are beneficial.

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      • Dean W.
      • Dean_W
      • 1 yr ago
      • Reported - view

      John Ramos From what I have read no senolytic will "clear out" all senecent cells. It is far from 100% efficent, more like 25 to 50%. Also different cells in the body are not affected by the same senolytic. We might need different ones for different cells.

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    • Dean W. For now without knowing more about which cells it works on, I'm sticking with Fisetin.

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      • Michael_123
      • A is A
      • Michael_123
      • 1 yr ago
      • Reported - view

      Dean W. Entire field is new, & nobody has definitive answers.  However, IMO entire allopathic field prescribes mostly based on weight, while not only age, but particular health conditions are more impt.  Re age, for instance, a 30 year old, could take more time for experimentation, while a 70 y.o. may need to have results sooner.

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      • David C
      • David_C
      • 1 yr ago
      • Reported - view

      Dean W. My body weight is 104 kg. I take 30 capsules = 3g a day for three days straight. Fisetin is fairly safe, you'd really have to take an enormous amount to do any damage. Mice models were taking way way up there. No ill effects. I started taking 1.8g and then moved to 3g. Zero issues. 

      So take whatever you feel comfortable with. And move up if you like. 1.5g is not bad for 70g weight. It's actually pretty consistent with how I calculated back when I first started. 

      I have found repeating every 3-4 weeks is the ideal time. 

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      • Dean W.
      • Dean_W
      • 1 yr ago
      • Reported - view

      David C Thanks for confirming your post from 2 years ago. Are you still seeing the great effects that you mentioned back then or has that tapered off?

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      • Brian Valerie
      • Semi-Retired Health Education Teacher
      • Brian_Valerie
      • 1 yr ago
      • Reported - view

      David C  Thanks for sharing, David.  May I ask your (or other readers') opinion of Life Extension Foundation's recommendation of the equivalent (of their bioavailable fisetin, along with their bioavailable quercetin and theaflavins) of 1.4g of fisetin once weekly?  Of course, they don't consider one's body weight!  I agree with the reasoning that we want to overload the body's ability to metabolize it, so I've worked up over the past year or so to taking a single dose of between 3.5 and 4 grams of fisetin about once every two or three weeks.  I weigh 84 kg.  No noticeable effects at all, but perhaps we shouldn't expect to notice a somewhat diminished rate of aging!   

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      • David C
      • David_C
      • 1 yr ago
      • Reported - view

      Brian Valerie Well, for myself personally I just keep taking what I know works. The bioavailable versions are probably just as good but then you have to trust their calculations on whether or not it works and at what dosage. I like plain fisetin because the mouse studies used this and we can translate dosage to humans fairly easily.

       

      Quercetin is very closely related to fisetin in its chemical structure. So I "hypothesize" that its mechanism of action is similar and it probably acts on the same pathway as fisetin. And we know that fisetin alone was much more potent that quercetin (studies have shown). So I never saw the need to replace fisetin with quercetin even in a mix and match scenario because it's almost like mixing in a weaker version of fisetin with full strength fisetin. Now this could be completely wrong and I even bought quercetin at one point. The real problem is it gets expensive when you add in other items and for the reason mentioned above I just felt quercetin was doing more of the same, just poorly.  

       

      If memory serves me right in the mouse studies they did essentially the equivalent of 3g (for your weight 84kg) a day for two days then waited like two to three weeks and repeated. Now no one knows the real effects or optimal dosage and frequency but I also still notice increased energy, clarity, muscular firmness, and less inflammation around the neck and face. Almost as if my face is at rest from something always agitating it and attacking it at a low level. These positive effects last for 3 weeks on average and then I think about doing another round of fisetin.

       

      For some of the others asking if I still get positive effects, yes I do. But my baseline has raised significantly so its a less glaring improvement than from the first time I used it. Indicating some level of permanent effects took place. I believe fisetin is both a senolytic and senomorphic compound. That is to say it both causes apoptosis in senescent cells and suppresses SASP (the harmful signaling from senescent cells).

       

      This means fisetin both kills a portion of senescent cells and can disrupt the ones it does not kill outright so that for a time they don't emit SASP. This would explain my experience with fisetin if so. Keep in mind I am no scientist, but even scientists don't have all the answers as we have yet to really have a human study with fisetin although I hear one is ongoing now. 

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      • David C
      • David_C
      • 1 yr ago
      • Reported - view

      Dean W. I still get the same effects. The benefits last for two weeks steady and then wane during week three. By the end of week three I plan for my next dosage. I can occur immediately at three weeks or even a week later. 

       

      I have tried to explain how it works/worked for me. The initial dosing way back when was very effective. My baseline was low. Low energy, fatigue, malaise, and so on. After I took my first round of fisetin my entire energy spectrum changed. I felt I could see colors more vividly, hear sounds more acutely, and had increased strength and muscle firmness all over. I could also stay up till the wee hours of night without getting tired. 

      All of these things did not go away. Alot of it remains permanent. So now when I take fisetin its more of a maintenance effect, however I still get heightened benefits as listed above but the difference is not as stark as my baseline has been raised overall.

      This is my experience with it. I also gave some to a friend who is 37 years old. It was funny because the guy was running around doing house projects for days. A person that usually lays on the couch after work defeated and plays on his phone or watches TV. He had so much energy and drive he could not contain it. He also noticed muscle firmness. 

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      • Dean W.
      • Dean_W
      • 1 yr ago
      • Reported - view

      David C Thank you for that very interesting update. I will increase my fisetin dose next time I do my semi-annual course. If I see results I will most likely take it every 2 months.

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      • Michael_123
      • A is A
      • Michael_123
      • 1 yr ago
      • Reported - view

      David C Also, thanks, David for all the detailed info.  Few points:  1.  Mayo studies -- despite testing fisetin -- is not known for using natural substances, vs pharmaceuticals -- and if they are adding quercetin to the fisetin, probably for good reasons.

      2.  Rarely mentioned on this site at all, but probably as impt as any supplement, is what is your diet?  I assume based on your exercise / leg info, more protein than carbs.  Likely the closer to an organic paleo or organic keto, the better for senolytics to function.

      3. Even try monitoring reactions, etc., via muscle testing, a.k.a. applied kinesiology?  Also, I have not seen mentioned on site.  I will probably start a separate topic.

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  • @David C      Thanks for all the feedback on your fisetin experiment - much appreciated. 

    Just one point, do you take the 3g fisetin in one mega dose or are you taking several smaller doses throughout the day? 

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    • Kaptain Asia 20mg/kilo of bodyweight - What I take now is that dose for 2 days with a 1-2 month break.

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    • David C
    • David_C
    • 4 yrs ago
    • Reported - view

    One dose. I just take 30 pills one after another drinking water. My reasoning is you want to overload the body’s ability to metabolize it and get it circulating in the blood to affect as many senescent cells as possible.

     

    The half life on this stuff even with large doses is like 3.1 hours, so it should be out of your system effectively in around 9 hours. 
     

    If you do take it this way, the first place I notice an effect is the outer thighs. It gets tight and might twitch a little. Leg strength is something I noticed first as well. Drink plenty of water, I used to get some head aches that were not painful just uncomfortable, but that does not happen anymore.

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    • David C      Thanks for the reply.

      I'm definitely going to give this a shot.......but I will probably start with a 2g dose to be on the safe side and then work my way up.

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      • Chris
      • Chris.1
      • 4 yrs ago
      • Reported - view

      David C 

      Trying this my first time, started yesterday at 3g, and 2.2g today and tomorrow (all I have left).  I experienced some great energy, and clear mind all day yesterday.  Last night I did get super tired and have been lethargic today.  Is this normal?  Thanks!

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      • David C
      • David_C
      • 4 yrs ago
      • Reported - view

      Chris  yes it was like this for me my first time especially. So on day 3 or so things should be better. I slept a lot and by about day 3 is when I realized it had really kicked in.

       

      If you were knocking out 25 to 50% of senescent cells in tissues it might mean the body would like to rebuild and restructure. Not only to replace those cells but now the environment for cell replication and restoration would me much more free of SASP which hinders maintenance. In other words your body has a lot to do, and suddenly.

       

      Now when I take it I don’t get that same fatigue as when I first did it. Pay attention to leg strength. It’s the first sign I had that this was doing something beneficial. You should get boosts of energy, increased mood, and muscle firming if it’s like me. Give it a day or so then just go for a walk. I had increased perception and presence in the world. Good energy and impressive leg strength. Like hills that would make me groan were fun to just bounce over.

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      • Chris
      • Chris.1
      • 4 yrs ago
      • Reported - view

      David C Thanks!  Pretty excited about this and your schedule.  I do plan 3g a day for 3 days in the future, every 4 weeks.  Have you tweaked anything (like add other compounds, take in olive, oil, etc)?

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      • David C
      • David_C
      • 4 yrs ago
      • Reported - view

      Chris Well I recently added NMN to the whole regime. I am careful not to add too much because then it becomes to costly and I am afraid there will be interactions that nobody has forseen.

      I hope it works well for you. At the very least it's a harmless regimen. It has proven results in the lab and I really love the stuff.

       

      If you do notice increased muscle density, energy, mood, and all the other stuff it usually lasts like 2 weeks solid and then by week 3 it normalizes a bit and then I let it go another week and repeat. You could possibly do it more often than 4 weeks. At 3 weeks I think its fine. I tried it every 2 weeks and had some scalp itching so I went back to every 4 weeks.

      The thing is, if this does increase testosterone levels it does it via your own body's functions. Because the bioavailability is fairly fast. It should be out of your system in like 12 hours for each does. So it's not like a steroid that adds literally the hormone itself it only encourages production of testosterone via your own body's functions. That is if indeed it does increase hormone levels. But it should be safe even if it does because you should theoretically be getting testosterone meant for your specific body.

      The main use of this stuff is to clear senescent cells. Just like you I was tired at first, I just slept alot and it goes away. I think your first run through will clear out the vast majority of senescent cells that fisetin is able to eliminate which would cause some fatigue as the body has some restructuring to do afterwards.

      But later on when you are doing repeat doses monthly it's just a maintenance dose and there is just not as many senescent cells to clear, meaning really no fatigue. 

       

      Glad to see you are trying it out. Human studies do I think next month on this. So we will have a little more data to go off soon. 

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