Sources of dasatinib

Hello everyone, 

We’ve received reports from Age Reversal Network members about lower-cost sources of dasatinib. This post is intended to aggregate this information into a single forum post for easy reference and sharing.

The two sources we’re excited about are:

1. MedLab: A pharmacy that will compound dasatinib specifically for your body weight. They offer a customized dasatinib two capsule dose for $225.  This represents a one-year supply for most people.

The physician may advise that you take the first dasatinib capsule week one along with the dose-adjusted amount of quercetin and the second dose-adjusted dasatinib capsule week two along with the dose-adjusted amount of quercetin. (Doses are based on your body weight.)

The chart below describes current dosing for senolytic purposes. This requires a prescription and the pharmacy can only ship to Florida addresses. You can contact the pharmacy at 954-400-0560 or email the pharmacist at rxemailbox@gmail.com.

2. International Antiaging Systems (IAS): By July 31st of this year, IAS plans to offer 12 x 40 mg tablets of dasatinib for $99. This represents an average one-year dose that can be individually dosed based on numbers of 40 mg dasatinib tablets you need for your body weight.

For instance, if you weigh 175 pounds, you might want to take 5 of these 40 mg dasatinib tablets to match current dosing suggestions of 2.5 mg of dasatinib per kilogram of body weight. When your weight does not match exactly with the 40 mg dose, members of our private association report taking the additional tablet (making the dose slightly high for your body weight) to achieve desired senolytic effects.

We’ve been told that these dasatinib tablets will be available after July 31, 2019 by logging on to antiaging.clinic (Use password = research, then click the green button saying that you accept the terms and conditions, "T&C", after you've reviewed them).

IAS has pledged to donate 15% of the purchase price from all orders placed on this site (antiaging.clinic) to support human age reversal research. IAS posted this information just a few days ago on the forum here.

While our private association does not have the resources to vouch for these various options, we are grateful that some of our members have independently evaluated (assayed them by an independent analytical lab) them for their personal use, and have then worked with their physician to ensure proper prescribing.

The PowerPoint slide below summarizes dasatinib and quercetin dosing most people are currently self-experimenting with.

 

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  • Thanks, Maximus.

    As I noted elsewhere, I have seen two certificates of analysis for the dasatinib that IAS is offering. Both COAs showed that it's excellent quality (contains the indicated amount, without impurities) and is manufactured in an EU country. So this would be an excellent option for people not in Florida.

    Brian

    Like 2
  • Max Peto said:
    Before July 31, 2019, we’ve been told that these dasatinib tablets will be available by logging on to antiaging.clinic (Use password = research, then click the green button saying that you accept the terms and conditions, "T&C", after you've reviewed them).

     Here is the info on the IAS website: 

    This product is temporarily out of stock

    Sprycel (Dasatinib)

    US$1,499.99

    60 tablets x 20mg

     

    So, it is out of stock and a tad more expensive than the $99 price point. Will this change after July 31st?

    Thanks,

    Michael

    Like
      • Max Petomoderator
      • Researcher, website & forum admin
      • Maximus
      • 9 mths ago
      • Reported - view

      Michael Avenoso Hi Michael, 

      Thanks for the message. I made an error in my post: it is after July 31st. These are not yet available. 

      I will change my original post. 

      Like
  • Dasatinib - DasaPro - is now available from www.antiaging.clinic (password = research) at US $99.99 for 12 x 40mg double scored tablets.

    As stated elsewhere all orders via www.antiaging.clinic will donate 15% to the Age Reversal charity. Other products available from this site include RapaPro (rapamycin), MetPro (metformin), DepPro (deprenyl) and OxyPro (oxytocin).

    Like 2
  • Thanks so much for the update; just placed an order! 

    Like 1
  • Did you get the Western Union payment options to work, or request an invoice?  I tried Western Union, but the information seemed insufficient for their form.  Also, have you had any response from them?

     

    TIA;

    Pat

    Like
      • angie4life
      • angie4life
      • 7 mths ago
      • Reported - view

      Patrick McHargue 

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      • angie4life
      • angie4life
      • 7 mths ago
      • Reported - view

      Patrick McHargue , I was able to get an order thorough, and confirmation of payment accepted , by going to the website. There they linked me to the approved IAS store , and I paid using check2pay, as I’ve done in the past ordering other products from them .

      Like
    • angie4life At the www.antiaging.clinic website, there were only the 'invoice' and 'Western Union' payment options shown when I tried ordering.  I tried WU and failed miserably.  I'll try again and select the invoice option.  Maybe that will bring up the link you mentioned.

      Like
    • angie4life I managed to complete payment for this using TransferWise.  I figured out how to turn on international calling on my phone, and spoke with them to confirm the details.  I have blood-work before, we'll see how this tests out a few months after.

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      • angie4life
      • angie4life
      • 7 mths ago
      • Reported - view

      Patrick McHargue Patrick McHargue , so happy you got it to work ; the payment page I used allowed me to pay using my checking account , which I’ve done many times in the past .  Hoping for a restock with them for NalPro ( has been out for months ), and RapaPro which has been out for several weeks .  The Profound products are of excellent quality in my experience, and I’m so happy IAS carries them .

      Like
  • I have a question about the Quercetin used in combo with this. I weigh 120, so I’m supposed to take 1360 mg according to the chart.

    One capsule of LEF’s Optimized Quercetin is 250 mg, so should I take 5 to 6 of those? Or...

    LEF’s Bio-Quercetin, on the other hand, is only 10 mg, but supposedly “up to 50 times more bioavailable.” Does that mean each capsule is equivalent to 500 mg? Should I take 3 of those instead? Or some higher number, since “up to” 50 times is vague? (I assume I shouldn’t take 136 of these 10 mg capsules—lol!)

    Is one of these formulations better than the other for use with Dasatinib? Color me confused! Any advice would be very welcome—thanks!

    Like 1
      • Larry
      • Larry.1
      • 6 mths ago
      • 2
      • Reported - view

      Lauren Royal-Gordon Thorne Research is what was used in the study so that's what I used. It was effective for me at 2000 mg for a 176 pound male. 

      Like 2
    • Larry Thanks so much, Larry!

      Like
  • FYI MedLab is now shipping to more states, see updated information here. I received my first treatment and will be reviewing it on that thread. 

    Like 1
  • Based upon other posters here, IAS's rapapro may be phony based upon the experience of other posters.  Has anyone had reason to doubt the authenticity of their Dasatinib.  I have taken my first two doses and could not tell one way or the other.

    Like
  • What is the latest thinking about how often the current Senolytic Dose Schedule should be performed?  Once a year, once every 10 months, etc.  I'm getting mixed signals and wonder if there's anything definitive.

    Like
      • Larry
      • Larry.1
      • 5 mths ago
      • Reported - view

      Jerry You're right. There is nothing definitive and it maybe 5-10 years before we know with any certainty. Who's going to pay for the studies? 

      Like
      • Jerry
      • Steady_Rider
      • 5 mths ago
      • Reported - view

      Larry Unfortunately, I believe you're exactly right; thanx for the reply and I'll just keep hoping an accurate measurement for the presence of senescent cells arrives on the scene

      Like
  • Does anyone know where Dr Green's patient's get their Dasatinib?

    Like
  • Yes, from a pharmacy that he must contact, they would not take the script directly from me at all, so Dr. Green had to send it.  I highly recommend becoming a patient of Dr. Green understanding that this is all off label and not supported by human clinical trials. I am a patient of his for 2 years ....seen him twice now. Second time with my wife....came in from Houston area.

    So I just did D&Q in a totally un-recommended way...that likely made it 50-100% stronger than recommended....made me feel quite sick but not with the emergency type issues that could arise.....peaked my arthritis too....did not feel like a flu vaccine response...more like a double Shingrex vaccine response without your arm falling off....very similar to a mild flu....and I picked busy weekend to do this....so only did two of three days.  I will not discuss what I did to potentiate the treatment as it carries additional risks that need to be understood far better than I can explain.  Nevertheless I am confident I got the senescent cell removal response, but not as much clearly as a three day treatment.

    I will note I discussed D&Q with Dr. Green in May of 2017 at my first visit as I do alot of crude medical research. At that time, he scoffed at it....I brought it up again to him in May of this year ('19) and he recommended it after doing more research....and his research as a pathologist is far more complete than mine could ever be being an IT manager in 'real' life.  So that was rewarding, and I still do Fisetin.  I intend to find a more convenient time to take another round of D&Q and intend to again take it with Sirolimus, Quercetin, curcumin with bieperine and take it all with Fisetin.....  I think of this approach in the same terms of the HIV cocktails used to 'carpet-bomb' the target virus.    I'd glad to have this in my arsenal along with the full cocktail Dr. Green prescribes (metformin, sirolimus, etc)

    At age 66, it make far more sense given the long term prognosis we all older people face.  Dr. Peter Atia in his 40s is a great resource or check box of another brilliant mind taking sirolimus.....but I know he has fewer results in his 40s as I do at my age.  Please share your results.....and thoughts.

    Like
      • Karl
      • Karl.1
      • 3 mths ago
      • Reported - view

      GEdwards thanks for all the info. Good luck with your senolytic Armageddon.  The problem with many of these drugs and supplements is that human dosing is mostly unknown.

      Like
      • GEdwards
      • GEdwards
      • 3 mths ago
      • Reported - view

      Karl To some extent, human dosing is somewhat unknown...but in the sense that most of these meds are already in long term use, we have a ton of information for side effects etc.....eg. Metformin has been in general public use since 1958.  Sirolimus since the '90s. etc.

      Like
    • GEdwards But then there are studies that seem to question to use of metofrmin later in life. (like me)

       

      https://www.biorxiv.org/content/10.1101/863357v1

      Like
  • There is a dasatinib related drug caller niotinib that also treats leukemia just like dasatinib. It is being used in a Parkinson’s study because of its strong effect on increasing the part of autophagy that cleans out cellular waste.  Niotinib may be useful for anti aging  but no direct studies so far beyond autophagy for age reversal. 

    Like 1
      • Karl
      • Karl.1
      • 3 mths ago
      • Reported - view

      are we there yet so not FDA approved or for sale yet?

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  • WARNING

     

    If you have purchased products such as Rapamycin from the

    Anti-Aging store you need to be aware that their check or draft processor

    has been hacked.   I received an email which had all of my Check

    Draft information attached.  It was from a hacker who was trying to extort me

    for payment through Bit Coin or my personal information would be placed online.

    I received this scam email last week.  The letter claimed that I had bought Cialis when

    I actually bought Rapamycin.  The letter had a pdf attachment, which I scanned for

    Virus with two anti-virus programs.  The letter goes into great detail as to how to pay

    approximately 800 dollars in Bit Coin to these scammer.  I have deleted the mail and

    pdf and am contacting my Bank as to a change in my account.   Also did a complete

    scan of my computer.

    Like
      • RobH
      • RobH
      • 2 mths ago
      • Reported - view

      djmichel  I received a similar email attempting to extort a similar amount. They have the correct check payment data, but they got the item purchased wrong.  It's really annoying, but hasn't reached actual theft yet.  Everyone you've ever sent a check to has the same account data.  I'm going to watch my online bank checking report, but nothing else unless something pops up.  That and keeping the amount in the checking account close to actual checks written.

      Checking is an old technology designed long before many of today's exposures.  Best we can do is watch the account and challenge anything out of order. 

      Like
  • I got this email, too. Since I’m female, they didn’t mention Cialis, but instead said “something embarrassing”—lol! I filed an alert on Equifax (which I know will go elsewhere automatically), and notified both Antiaging and Check2Pay, then just let it go. I’m not really worried about this.

    Like
  • A source in India (New Delhi) is BonHoa Health.  They sell a number of drugs including dasatinib at a dose of 50 mg x 60 tabs for $362.  Upon searching if this is a reliable company I did not come up with any red flags.  I am checking with some colleagues to see if they have heard anything negative about this company.   They also sell different doses of dasatinib such as 20 mg and 70 mg tabs.  I would imagine that if there were a number of people using dasatinib that shared in one purchase that this would be a very inexpensive source at $6 a tab.  Bill Faloon cited Lucidas as a reliable product.  BonHoa carries this brand. 

    See https://www.bonhoahealth.com/leukemia/167-lucidas-sprycel-dasatinib-50mg.html and let me know if any of you has used this company.  I will follow-up with any new info I get on BonHoa Health. 

     

    Like
  • Good info , Dr; thanx; do you know anything regarding DasaPro--another competitive product? 

    Like
  • Thank you for informing me of another source.  It all comes down to (a) reliability of company and (b) how quickly you get the product and (c) affirmation that the product is what it says it is.  If you have information concerning this that would help.  The cost of DasaPro per their website is $4 a mg.  The cost of Lucidas dasatinib via BonHoa Health for 50 mg tab x 60 = $382 is $5 a mg.  The latter is shipped out of New Delhi, India.  I am not sure where the former is shipped from (UK, Japan?), nor do I know the shipping costs.   But I think what is badly needed is a trustworthy independent company to assess drugs made and shipped from countries outside the USA to American consumers.  This would lower drug prices and open up a free enterprise and competitive market.   And this should be done not just for the relatively exotic drugs we are interested in but many drugs whose prices are just damn ridiculous.  

    Like 2
  • Hi All. New member to this forum, but not to the overall topic we're all here for...

    Question. Where does the 2.5mg/kg dasatinib dosing schedule come from? The mouse studies at 5mg/kg translate into about 25mg to 35mg total dastinib for a human, using the standard Human Equivalent Dose conversion factor of 1/12.3. Some human studies have used 50mg total, and of some have used the full "average" 100mg dose used to treat leukemia.

    Looking instead at the effective blood concentrations reached in the mouse studies, I understand the human dose to achieve concentrations in the same area brings us again to about 100mg total.

    So far, other than here, the only place I've seen higher doses suggested is on the antiaging.clinic/store site, which suggests 2.5 to 5 mg/kg.

    Is this dosage supported anywhere else? Don't want to underdose, but obviously don't want to take a wildly-outsized dose either.

    Like
  • Excellent topic and observation.  When I was doing human research on 3BP (bromopyruvate) I created an Excel program that automates this conversion from mouse to human.  In the spirit of collaboration and collegiality I share that effort with you here. I am 70 kg and for the mouse dosing at 5 mg/kg my calculated dose would be at 28.7 mg, which is consistent with your post above.  What we aspire to in all studies in health is Primum Non Nocere or First (above all) Do No Harm.  Therefore, this post by you is of prime importance and should be addressed by those recommending a higher dose.  What's the basis?

    Like 1
  • Bonhoa informed me yesterday that they will not ship to US or EU.  See attached screen shot of their email.

    Like
  •  I am trying to order Dasatinib and metformin from IAS (using antiaging.clinic).  They only accept wire transfer from a bank.  The problem is that my bank (USAA) requires a physical address for Antiaging (which antiaging.clinic gave me as the name of the account owner) and antiaging.clinic is not providing a physical address.  They did provide the physical address for their bank in Hong Kong but not their own physical address.  I have written to them twice, once by email and once using their website communication tool, and they have not responded.  Perhaps one of the forum members here  has their physical address?

    Like
      • Mel
      • Mel
      • 2 wk ago
      • 1
      • Reported - view

      David H I ordered 3 weeks ago and used the address of their bank.  Worked fine for me.

      Like 1
  • I ordered this week and, like Mel, used the address of their bank. My bank (BofA) was fine with that. They wanted to charge me $45 to send in US funds, but they were willing to send in EU funds for free. Weird. Anyway, order is in the mail and it wasn’t difficult once I figured out what to do. Good luck!

    Like 1
  • I ordered 3 days ago paid by check order from theantiaging.store 

    Like
      • David H
      • David_Hanson
      • 2 wk ago
      • Reported - view

      Paul Beauchemin That worked!  Thank you!  I have metformin and dasatinib on order from theantiaging.store.   Waiting for rapamycin to get back in stock so I can put in an order that also.

      Like
    • David H I’ve always ordered my Metformin from the anti-aging store  and ordered Dasatinib from them when it first came out .  These products are made by ProFound Products , as was the rapamycin I used to get from them . Always a nice company to order from ; just that the rapamycin they carried was found to be a lower dosage than what the bottle claimed . I do hope  the metformin and dasatinib dosages are correct as described , but I get my rapamycin elsewhere now .  Good luck !

      Like
      • David H
      • David_Hanson
      • 2 wk ago
      • Reported - view

      angie4life Thank you for the comments.  Where are you buying rapamycin now?  I am open to an alternative - especially when I don't have to visit an MD.

      Like
    • David H I get mine from All Day Chemist, a company I’ve ordered many different things from over the years . Their product is Siromus , and it is a bit expensive, I’ll say . The tablets are 1 mg each , so does make it easy to take the dose you prefer .  

      Like
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