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Re: Spermidine: a physiological autophagy inducer acting as an anti-aging vitamin inhumans?
@chuck stanley yes 2,4 mg per 10 gr. Thanks for correcting my typo.
- Staffan_Olsson
- 3 yrs ago
- General Discussion
- Reported - view
Re: Spermidine: a physiological autophagy inducer acting as an anti-aging vitamin inhumans?
@chuck stanley 10 grams of wheatgerm contains on average 2,4 grams of spermidine. 30 grams of wheatgerms should provide approximately 7,5 grams of spemidine. https://spermidin-kapseln.…
- Staffan_Olsson
- 3 yrs ago
- General Discussion
- Reported - view
Re: Fisetin experimentation one year (reposted as topic for info purposes)
@John Ramos yes I am not sure I can understand the part where they write about (oss-128167) an inhibitor of sirt6. I leave that and don't want to guess what they write.…
- Staffan_Olsson
- 3 yrs ago
- Senolytics Discussion
- Reported - view
Re: Fisetin experimentation one year (reposted as topic for info purposes)
@John Ramos “icariin impaired the activation of the NF-κB/EMT pathway, as evidenced by upregulation of SIRT6, resulting in inhibition of migration and invasion of breast cancer cells.…
- Staffan_Olsson
- 3 yrs ago
- 1
- Senolytics Discussion
- Reported - view
Re: Anyone actually experience marked increased energy from NMN?
@Bart Balder Thank you for reporting agitation when taking NMN. I will be observant, this since I am considering supplementing with NMN. I have had similar experiences with Q10 and Vitamin K1.…
- Staffan_Olsson
- 3 yrs ago
- 1
- Self-Experimentation
- Reported - view
Re: Fisetin experimentation one year (reposted as topic for info purposes)
@John Ramos A recent paper show that Icariin (a substance found in horney goat weed) can reverse the macrobiota of old mice to a youthful state and other positive effects as well.…
- Staffan_Olsson
- 3 yrs ago
- Senolytics Discussion
- Reported - view
Re: Spermidine: a physiological autophagy inducer acting as an anti-aging vitamin inhumans?
@MAC. Many thanks :)
- Staffan_Olsson
- 3 yrs ago
- General Discussion
- Reported - view
Re: Spermidine: a physiological autophagy inducer acting as an anti-aging vitamin inhumans?
@MAC. I often eat dried shiitake, (usually in soups). But I don't know the spermidine content in shiitake or different kinds of mushrooms.
- Staffan_Olsson
- 3 yrs ago
- General Discussion
- Reported - view
Re: Spermidine: a physiological autophagy inducer acting as an anti-aging vitamin inhumans?
@MAC. My favourite food for increasing my intake of spermidine is mango. 150 gr Mango give me approx 5 mg spermidine. Broccoli is another good source (for me).…
- Staffan_Olsson
- 3 yrs ago
- General Discussion
- Reported - view
Re: Apigenin: An Alternative Way of Boosting NAD+
@Fred Cloud Sinclair have used CD38 knockout mice. I think that is a good strategy to use. In other words inhibiting Cd38 in the cells.
- Staffan_Olsson
- 3 yrs ago
- Self-Experimentation
- Reported - view
Re: Apigenin: An Alternative Way of Boosting NAD+
My question from the beginning was: how do we know that increased NAD+ in the blood will cause increased NAD+ levels in the target cells in the healthy ageing human body.…
- Staffan_Olsson
- 3 yrs ago
- 1
- Self-Experimentation
- Reported - view
Re: Apigenin: An Alternative Way of Boosting NAD+
@Fred Cloud But how do we know that NAD+ actually enters the human liver, muscles, brain, kidney etc? In other words how do we know that injected NAD+ can circulate in the body to be absorbed in…
- Staffan_Olsson
- 3 yrs ago
- 2
- Self-Experimentation
- Reported - view
Re: Apigenin: An Alternative Way of Boosting NAD+
@Staffan Olsson "In the healthy subjects, niacin did not increase muscle NAD+, despite the 5-fold increase in the blood. These results suggest that in healthy muscle the NAD+ amounts are close to…
- Staffan_Olsson
- 3 yrs ago
- 2
- Self-Experimentation
- Reported - view
Re: Apigenin: An Alternative Way of Boosting NAD+
Niacin as primary NAD booster?…
- Staffan_Olsson
- 3 yrs ago
- 1
- Self-Experimentation
- Reported - view
Re: Regulation of the one carbon folate cycle as a shared metabolic signature of longevity
@Staffan Olsson I post a link to the talk. This of course early cutting-edge research and the translation to humans are a bit in the future. But the talk puts a light on an approach that can be very…
- Staffan_Olsson
- 3 yrs ago
- Ideas
- Reported - view
Re: Regulation of the one carbon folate cycle as a shared metabolic signature of longevity
@Staffan Olsson And there is an upcoming webinar this thursday 11th Nov. Brian Kennedy and Andrea Maier will have a discussion with Dr Adam Antebi. https://nus-sg.zoom.…
- Staffan_Olsson
- 3 yrs ago
- Ideas
- Reported - view
Re: Regulation of the one carbon folate cycle as a shared metabolic signature of longevity
@Jack Black The video from Adan Antebi's presentation at the AARD meeting is public now. Adam Antebi presents at ARDD 2021 - YouTube
- Staffan_Olsson
- 3 yrs ago
- Ideas
- Reported - view
Repurposed old drugs for rejuvenation of the brain?

Has a treatment for Alzheimer's been sitting on pharmacy shelves for decades? Scientists have two possible candidates (medicalxpress.com) Rapamycin, Metformin, Dasatinib.…
- Staffan_Olsson
- 3 yrs ago
- 76
- Ideas
Re: Rapamycin Cost
@Stefan Ihlberg I am interested if you consider buying a large quantity from India?
- Staffan_Olsson
- 3 yrs ago
- Self-Experimentation
- Reported - view
Re: Rapamycin Cost
@Brin Chikovski Which brand to buy? I found several Indian companies that produce rapamycin – sirolimus. The most well-known names are Zydos Cadila and Biocon.…
- Staffan_Olsson
- 3 yrs ago
- 1
- Self-Experimentation
- Reported - view
Re: Fisetin to Clear Senescent Cells
@karl kuffner I have had similar feelings of high spirit and a very good mood after taken the original senolytic activator + increased capacity for endurance exercise the next day.
- Staffan_Olsson
- 3 yrs ago
- 1
- Self-Experimentation
- Reported - view
Re: Apigenin: An Alternative Way of Boosting NAD+
@JGC It looks like there are apigenin nano-formulations in use in medical research. (The last two sections in this paper from 2021 mentions a few.) https://www.ncbi.nlm.nih.…
- Staffan_Olsson
- 3 yrs ago
- Self-Experimentation
- Reported - view
Re: Apigenin: An Alternative Way of Boosting NAD+
@JGC I wonder if piperine can have any effect on the absorption of Apigenin. I have not found any research at all about piperine and apigenin.
- Staffan_Olsson
- 3 yrs ago
- Self-Experimentation
- Reported - view
Re: The ARDD 2020 Meeting
A link to the videos from the 2021 AARD. https://www.youtube.com/channel/UClOnplI2mzpJlwdX3vlOMJA/videos
- Staffan_Olsson
- 3 yrs ago
- 1
- General Discussion
- Reported - view
Re: Apigenin: An Alternative Way of Boosting NAD+
@Fred Cloud @JGC When Apigenin is Co-administrated with resveratrol the plasmalevel of Apigenin increase 2,39 fold. (at least in mice). https://www.ncbi.nlm.nih.…
- Staffan_Olsson
- 3 yrs ago
- 2
- Self-Experimentation
- Reported - view

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