Fisetin experimentation one year (reposted as topic for info purposes)
Hello everyone I wanted to make my first post here as I have been doing a fisetin routine for a year now just about and I have results that are not placebo and very profound. I honestly do not know if this is the senylotic effect or some kind of interaction with fisetin in other ways.
To get it out of the way, I will give the fast and short version. I am taking Swanson’s Fisetin. I take around 2g a day for 3 days( now 2.5g). I repeat this for 3 or 4 times with varying intervals (I was trying to find optimal intervals).
My my first regimen was 3 days treatment with a 2 week delay, then a 3 week delay, then a 4 week delay, then a 2 month delay. I am now convinced a 3 week delay is the minimal amount of time you want taking this the way I am, though I will continue with 4 week delay for safety sake and because of my own observations.
So results. Well I feel like this must play on hormone levels in the short term. Immediately after starting a 3 day regimen, usually on day 2 or 3 I feel strong as hell. In particular my legs are tight and super strong. My muscles in general are firmer and overall strength is amazing. My mind is clear, thinking concise anddynamic. I feel more dominant, self confident, and aggressive. Libido is enhanced as well. This all led me to believe that this acts as a testosterone mimic or elevates testosterone in the blood which is why I cycle monthly and then take a few months off every so often.
i can tell you that at the age of 43 this makes me legitimately remember what early 20s feels like. The effects of one 3 day regimen last strongly for 2 weeks and even on for 4 weeks. In particular during week one and two I was amazed at the amount of pure emotion and clarity of the world around me. I could hear and appreciate sounds and colors seemed more vibrant. Mentally I am on overdrive with super memory and crystal clear logical thinking. I remember the first time I took this I was shocked. I was in a cafe just looking at a coke I had bought in a glass amazed at how more real and present it looked. A small thing but it was profound just how the world seemed more alive. It literally felt like going back in time 20 years.
So for long term effects. A stronger posture, better muscle tone, improved gum health, vastly more energy, in fact this has become all the norm after around 8 months of this. Many of the effects I described in the first two weeks following a 3 day regimen do taper off to an extent, but never completely.
As far as side effects there has not been anything thus far. When you are taking the 3 day dose you might get amped up a little jittery but that gives way quickly after the last dosage and it normalizes into a even effect that is positive in nature. I was very concerned about hair loss as I could not believe how impactful this was. But I have noticed no hair loss at all. I cycle it with a 3 or 4 week break to ensure that there is no negative effect on hair or otherwise. With a two week interval I had some scalp itchiness. That was enough to back me off to to four week intervals.
I honestly think that most of what I experienced is not the senylotic effect. It’s way too fast and profound. But I have no ill effects and feel incredible. And overall I have a youthful vigor and look and feel younger. I think a senylotic evaluation, as far as a laymen just observing himself goes ,can only really be done after 2 years or so. However the initial results ( especially gum health) and from what else I can observe are overwhelmingly positive.
I can tell you that this does have an affect and it is profound and noticeable. How much of this is hormone I do not know. But I have other improved health as well, however it’s always tricky to quantify this objectively yourself sometimes.
Good luck on your experiments. Let me know if this has the same effect for you. I just bought Swanson’s with nouvestein. Nothing fancy. Cheap and on amazon.
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John Ramos One thing seems pretty clear and that is that fats may help with absorption....for both Fisetin and Kaempferol. For that reason, I make smoothies with the powder with 2 tablespoons of olive oil. I use vanilla flavored whey protein to make the shakes tastier and to get that protein... especially if I use it as a meal. My shakes are varieties of organic berries, including strawberries, blueberries, and red/black raspberries. Plus water, which helps with congealing
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Thomas E Eliopulos Which brand of Fisetin are you taking, I have some bulk but when I did 3g/day for 3 days, I didn't notice anything....Got some coming from Swanson... and Kaempferol is expensive...I'm also taking Quercetin, Luteolin, and Fucoidan among other things...
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Yes, I did read David C's posts...
Regarding Fisetin, I bought from a bulk supplier, was the right color, light yellow, supposed to be 98%, sang all the right bells. So, I did 3g/day for 3days with a month off. I felt nothing. Some say the have positive reactions to doing this protocol.
Here is the interesting thing, I have a supplier in China that I have been buying from since 2015, always the right paperwork and excellent pricing. But, I have to buy 1kg at a time, some of these supplements are ether expensive or so much quantity that that you won't use it in a year or 2.
Here is their pricing, notice 50%, how many of the suppliers say it's 98%, we may be buying 50% in some cases. Shipping is $35 single kilo.
For Fisetin 98%,the price is $ 890/kg FOB Shanghai.
For Fisetin 50%,the price is $359/kg FOB Shanghai.I have some from Vitacost(60 caps) which I know to be real, some from Wellness Resources(90 caps) and some coming from Swanson's(60 caps). So far I took the bulk from another supplier, AgeLessExtracts that I didn't have a reaction from but they have 5 star feedback. Doesn't mean it's not good but no reaction in my case.
What brand are you taking that you're getting a reaction from and what kind of reaction did you get?
Thanks, John
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John Ramos I use Swansons. Its worked for me from the beginning. So I stick with it. Not saying its the best supplier but I can vouch for this one.
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In addition to my PSA becoming undetectable, I find that colors are a little more intense. This is slight and you might miss it.
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Joe F I wish I could do the same thing with AFP numbers...😟
We need to wake this forum up, most is from a year ago.
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Wake up forum. It has been said that everybody has cancer but when you get older the immune system fails and the cancer runs free. On a different web site many of my fellow prostate cancer survivors developed the cancer when in the mid 40s. Breast cancer can appear in women in the mid 30s.
I am Gleason 9/3b but my PSA can't be detected! This is a miracle.
I strongly believe taking monthly rounds of fisetin when you are younger just might result in a far better life -perhaps cancer free- as you age. 1 in 7 men will get prostate cancer.
Just because you can't notice or feel something after taking fisetin does not mean it was a waste of time. The great benefit might happen later on in life.
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Yea this is definitely possible. We just lack the studies to support it definitively. I am glad this has helped you. I lean towards Fisetin definitely being an anti cancer compound just by how it helps clean up the tissue environment.
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Staffan Olsson said:
Just to add to your post...A recent paper show that Icariin (a substance found in horney goat weed) can reverse the macrobiota of old mice to a youthful state and other positive effects as well. It is an interesting substance and that Icarrin is also a sirt6 activator.
SIRT6 ACTIVATOR - FUCOIDAN Which I takeI noticed in the papers below, they don't say the % strength- I found these...Not Amazon where the strength is about 10%
( Epimedium ) Horny Goat Weed Extract ( 50%Icariin )
( Epimedium ) Horny Goat Weed Extract ( 95%Icariin )
So, a bit confusing and they say they administered 100mg/Kilo of body weight in mice, that would be a pretty huge amount of the HGWE?
https://www.sciencedirect.com/science/article/abs/pii/S1043661821001717
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5644024/
And Icarrin might be useful for females since it inhibits (at least some cell lines of) breast cancer.
“Icariin-induced inhibition( why inhibition of Sirt6?) of SIRT6/NF-κB triggers redox mediated apoptosis and enhances anti-tumor immunity in triple-negative breast cancer” Don't you want to activate, not inhibit?
https://pubmed.ncbi.nlm.nih.gov/32926492/
The thought that Grape seed extract contains a substance that kill senescent cells is in line with the findings that some substances in grape seed extracts has been shown to have cytotoxic effects on some prostate cancers.-
John Ramos
“icariin impaired the activation of the NF-κB/EMT pathway, as evidenced by upregulation of SIRT6, resulting in inhibition of migration and invasion of breast cancer cells. Additionally, oss-128167, an inhibitor of SIRT6, dramatically attenuated anti-migration and anti-invasion effects of icariin. Transcriptomic analysis verified that impairment of NF-κB led to the selective function of icariin in breast cancer cells”
My understanding is that Icariin impaired activation of NF-kB (which promote development of cancer) and upregulated Sirt6. And using a Sirt6 inhibitor (oss-128167) reduce the effects of Icariin.
Link to the paper in full text
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7648025/
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Staffan Olsson To tell you truth, I don't understand this one.
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John Ramos yes I am not sure I can understand the part where they write about (oss-128167) an inhibitor of sirt6. I leave that and don't want to guess what they write. I rest with the understanding that "the activation of the NF-κB/EMT pathway, as evidenced by upregulation of SIRT6, resulting in inhibition of migration and invasion of breast cancer cells.".
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Staffan Olsson I don't understand the inhibition of SIRT6 either, you want to activate SIRT6, Fucoidan does activate it. It's all bunk on Amazon, I use this one Absunutrix Fucoidan 500mg/cap on Ebay and take 1g/day.
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Started this regimen 5 days ago. 1 gram of nmn and resveratrol along with 3 grams of fisetin and 1 gram of quercetin daily. Plan on dropping back to 500 mg fisetin and quercetin daily but continuing with the dosage of nmn and resveratrol. I'm a very active 66 year old male in excellent shape, but have experienced a decrease in energy levels over the past several years. I'm here to tell you, I felt and immediate reaction to taking these supplements, developed a weird muscle twitch in my left forearm that lasted for 3 days, and a tingling burning sensation on the bottom of my left foot! On the plus side felt a sustained increase in energy, libido, and an overall sense of well being. I do find it that I don't sleep as sound but maybe I don't need the sleep. I had given up drinking cause it often left me feeling dehydrated the next morning, but even had a couple of beers the last few days and felt great!
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Van Moore That's similar to David Sinclair's current protocol except he's also taking spermidine and metformin.
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Kaptain Asia Exactly, not going to add spermidine, but I'm also taking 500mg of berberine 2 to 3 times daily
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Van Moore Let us know how you get on when you reduce down to 500 mg fisetin & quercetin daily. I am definitely interested in following that as a maintenance dose.
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Van Moore Dosing, it should be 20mg/kilo body weight and for 2 days with a 3 month break. You don't want to have "0" all the time. Some senescent cells protect against cancer. Get your Fisetin from Swanson and save some money too!
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John Ramos I've seen studies all over the place, from 2 to 5 days, with varying amounts of Fisetin. With the life I've led I'm sure I got way tooo many senescent cells and really wanted to do an initial shock to the system. LOL! Plan on playing it day to day and seeing how I feel.
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Van Moore I'm not taking Spermidine either, cost and I don't know if it's adding enough to justify the cost. NMN, Trans-Resveratrol and AKG are big ones that don't break the bank. From what I've researched, Berberine taken at 500mg per day is sufficient. I can't get Metformin prescribed but I can buy a Kilo for $15, it's dirt cheap. I don't know it they can see it in a blood test, I'm with the VA and they are super careful.
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Van Moore The latest I've seen from reputable sources is the 2 days 20mg/day/kilo body weight with 3 months off.
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John Ramos Also began a morning ritual of a 60 to 90 second blast of cold water before getting out of shower. Have a 400' well and it's really cold! Really makes u feel invigorated!
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John Ramos One can get what may be a reasonable amount of spermidine from raw wheat germ.
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Van Moore After 18 days of this routine, I've noticed some significant changes. Muscles feel tighter, feel more limber, less fatique, loss 3 lbs. I was eating alot of honey with my morning tea or coffee, I completely loss the desire to eat it anymore. Skin and hair feel and look more vibrant, and just feel better mentally and physically.
Will start the fisetin, quercetin 5 day routine in about another week.
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Van Moore Interesting... Have you noticed any improvement in you eyesight? I had 2 pairs of glasses, one for computer and reading and 1 for distance which I had to use for TV, now I can use the computer glasses for both, no long distance, just for outside now.
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John Ramos I'm hoping for that also! How long did it take for you to notice an improvement? Over the past 4 years my eyesight has gotten steadily worse. Had 20/20 prior to that. Nothing is sharp like it used to be. I've only been on this protocol for around 3 weeks and have noticed that glare, bright lights, etc. do not bother me as much as before. Haven't noticed any significant improvement in vision yet.
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