Spermidine: a physiological autophagy inducer acting as an anti-aging vitamin inhumans?
My wife and I eat natto (fermented soybeans) daily which contains a relatively large amount of spermidine.
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Spermidine: a physiological autophagy inducer acting as an anti-aging vitamin inhumans?
Autophagy. 2019; 15(1): 165–168.
Published online 2018 Oct 11. doi: 10.1080/15548627.2018.1530929
ABSTRACT
Spermidine is a natural polyamine that stimulates cytoprotective macroautophagy/autophagy. External supplementation of spermidine extends lifespan and health span across species, including in yeast, nematodes, flies and mice. In humans, spermidine levels decline with aging, and a possible connection between reduced endogenous spermidine concentrations and age-related deterioration has been suggested. Recent epidemiological data support this notion, showing that an increased uptake of this polyamine with spermidine-rich food diminishes overall mortality associated with cardiovascular diseases and cancer. Here, we discuss nutritional and other possible routes to counteract the age-mediated decline of spermidine levels.
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Another article:
Cardioprotection and lifespan extension by the natural polyamine spermidine
Nat Med. 2016 December ; 22(12): 1428–1438. doi:10.1038/nm.4222.
AbstractAging is associated with an increased risk of cardiovascular disease and death. Here we show that oral supplementation of the natural polyamine spermidine extends the lifespan of mice and exerts cardioprotective effects, reducing cardiac hypertrophy and preserving diastolic function in old mice. Spermidine feeding enhanced cardiac autophagy, mitophagy and mitochondrial respiration, and it also improved the mechano-elastical properties of cardiomyocytes in vivo, coinciding with increased titin phosphorylation and suppressed subclinical inflammation. Spermidine feeding failed to provide cardioprotection in mice that lack the autophagy-related protein Atg5 in cardiomyocytes. In Dahl salt-sensitive rats that were fed a high-salt diet, a model for hypertension-induced congestive heart failure, spermidine feeding reduced systemic blood pressure, increased titin phosphorylation and prevented cardiac hypertrophy and a decline in diastolic function, thus delaying the progression to heart failure. In humans, high levels of dietary spermidine, as assessed from food questionnaires, correlated with reduced blood pressure and a lower incidence of cardiovascular disease. Our results suggest a new and feasible strategy for the protection from cardiovascular disease
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24mg / 100 gm of wheat germ x 1/8 of 340gm jar of toasted wheat germ per day is about 10mg spermidina per day. Plus 1tblsp viobin oil is 15ml is 15 mg vit E -not sure how much spermidina in the oil though… 15 gms wheat germ has 2.8mg vitE == 18mg/100gm according to kretsctmer bottle, so spermidina/vitE about 1.2, i.e., 18mg spermidina assuming vitE/spermidina ratio same in wheat germ as in the oil extract. So thats 28mg per day(all mental arithmetic here..). What are clinically effective doses?
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Donald Slowik You used to be able to purchase research grade pure free base spermidine on amazon until someone burned a whole in their tongue with it.
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Fred Cloud People with holes in their tongues ruined it for everyone. If it could also disintegrate teeth, perhaps that could assist with less food consumption and consequently result in calorie restriction.
I just bought the wheat germ though and never planned to take isolated spermidine.
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brad Update, that was the freebase that burned a hole, now there is spermidine trichloride and you can get it in capsules mixed with filler and is safe and super effective.
So the wheat germ is obsolete, get this instead, its way more potent. You can see changes in your skin and how you feel way more than the wheat germ products.
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I think you may be overestimating the amount of spermidine you are actually getting. It is reported that heating spermidine above 100 Celsius will reduce/degrade it, so who knows what is the content in toasted wheat germ, and it also impossible to know how much spermidine is in the wheat germ oil extract if it’s not indicated on the bottle. The additional processing involved would cost more and be reflected in the price.
Here is a good video by Michael Lustgarten discussing the amount of spermidine we would like to consume for anti- aging and cognitive effects:
https://www.youtube.com/watch?v=w7lqncPch8c
Lustgarten reports that in a randomized controlled trial of oldest adults at risk for dementia, a spermidine supplement of 1.2 mg/d had a positive impact on memory, and in another RCT with subjects actually suffering from dementia, supplemental spermidine of ~ 1mg/d showed a clear correlation between spermidine intake and improved cognitive performance.
For longevity effects, he indicates that if you take 30 grams of wheat germ/day you would get 12 mg of spermidine. That is the cut off for lowest all-cause mortality, the minimum for the longevity effect. He states that is also an amount associated with lowest incidence of future cognitive impairment.
If you need 30 grams of wheat germ to get 12 mg spermidine, and since a tablespoon of wheat germ weighs about 6 grams, you would need to eat about 5 tablespoons of raw wheat germ. That’s too much for me. I find that I can easily mix in 1 Tablespoon in a smoothie. Since I like wild mushrooms and aged cheddar that will give me some more, but that’s not something I could do on a daily basis.
Until someone can give me a tasty recipe as a way to consume 5 tablespoons of wheat germ daily, I will continue to settle for ~ 1mg spermidine per day.
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chuck stanley https://www.amazon.com/dp/B0771PZQ62/
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Fred Cloud how would one go about making that into a consumable product?
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chuck stanley I dont know, throw it in your shake?
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chuck stanley 10 grams of wheatgerm contains on average 2,4 grams of spermidine. 30 grams of wheatgerms should provide approximately 7,5 grams of spemidine.
https://spermidin-kapseln.de/en/spermidine-in-food/#The_Spermidine_Food_List
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Staffan Olsson 2.4 mg per 10g.
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chuck stanley yes 2,4 mg per 10 gr. Thanks for correcting my typo.
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chuck stanley 5 tablespoons is easy for me when I mix it with cacao nibs.
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My favorite way to consume the wheat germ is to pour some in a bowl with walnuts, almonds any other supps, slices of banana or raisins, add water or milk. I enjoy the taste of that as cereal. chuck stanley yes, I’m not sure if spermidine is more or less fragile than vitE so my estimates are uncertain, but I guess I’m in the 10-30mg/day ballpark.
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Donald Slowik I tried the raw wheat germ with apple, banana, nuts and raisins and I agree it tasted pretty good.
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going to try this
https://botany.bio/product/spermidine-3hcl-powder/#product-description
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Paul Beauchemin that looks like a great find. Please post a review once you try it!
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Paul Beauchemin I saw that but did you notice that company's note that they are going out of business soon?
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Hello World thanks for noting that. I decided I better go ahead and order the spermidine powder, and also ordered some EGCG powder while I was at it. I wonder why they are going out of business... good prices and a nice website.
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chuck stanley I found this post on Reddit
science-bio Science.bio • 3 days ago
Hi, indeed we had announced the unfortunate news of our closing Please see more information here: https://science.bio/closure/
We appreciate your ardent support and loyalty through the years. Unfortunately, there is a bill for further regulation and control of SARMs and related compounds: https://www.congress.gov/bill/116th-congress/senate-bill/2895 Although it has not passed yet, we believe that the best business decision is to be proactive and stay ahead of the curve. And since our synthetic metabolics line at Science.Bio will be affected, it will not be viable for us anymore to keep our natural line, so we have made the decision to liquidate the whole company, including Botany.Bio.
We are still accepting orders on both websites for the next couple of months, so you still have a chance to stock up, all at a steep discount especially for the coming Christmas and New Year holiday. So please stay tuned for the promo codes in your mailbox!
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Paul Beauchemin Have you received your order yet?
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Hello World yes, have to figure out how to measure it and ingest
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chuck stanley They discuss reasons for going out of business a bit in their faqs…
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A further bit of information re wheat germ oil: I asked the people at Viobin if they had any information on spermidine content, and they (very helpfully) replied that they would expect it, as a water-soluble amine, to end up in the defatted product rather than the oil extract.
I find regular wheat germ ok in a smoothie, but seem to remember reading that spermidine content is quite variable according to strain etc - no idea if this was just supplement promotion, or maybe it's a reason to go for a variety of food sources.
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Bobby Do they sell the ‘defatted product’?
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Bobby thanks for the information from Viobin. Good point about its water solubility. It does look like they sell their defatted product, maybe just for commercial use?
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