Fisetin experimentation one year (reposted as topic for info purposes)
Hello everyone I wanted to make my first post here as I have been doing a fisetin routine for a year now just about and I have results that are not placebo and very profound. I honestly do not know if this is the senylotic effect or some kind of interaction with fisetin in other ways.
To get it out of the way, I will give the fast and short version. I am taking Swanson’s Fisetin. I take around 2g a day for 3 days( now 2.5g). I repeat this for 3 or 4 times with varying intervals (I was trying to find optimal intervals).
My my first regimen was 3 days treatment with a 2 week delay, then a 3 week delay, then a 4 week delay, then a 2 month delay. I am now convinced a 3 week delay is the minimal amount of time you want taking this the way I am, though I will continue with 4 week delay for safety sake and because of my own observations.
So results. Well I feel like this must play on hormone levels in the short term. Immediately after starting a 3 day regimen, usually on day 2 or 3 I feel strong as hell. In particular my legs are tight and super strong. My muscles in general are firmer and overall strength is amazing. My mind is clear, thinking concise anddynamic. I feel more dominant, self confident, and aggressive. Libido is enhanced as well. This all led me to believe that this acts as a testosterone mimic or elevates testosterone in the blood which is why I cycle monthly and then take a few months off every so often.
i can tell you that at the age of 43 this makes me legitimately remember what early 20s feels like. The effects of one 3 day regimen last strongly for 2 weeks and even on for 4 weeks. In particular during week one and two I was amazed at the amount of pure emotion and clarity of the world around me. I could hear and appreciate sounds and colors seemed more vibrant. Mentally I am on overdrive with super memory and crystal clear logical thinking. I remember the first time I took this I was shocked. I was in a cafe just looking at a coke I had bought in a glass amazed at how more real and present it looked. A small thing but it was profound just how the world seemed more alive. It literally felt like going back in time 20 years.
So for long term effects. A stronger posture, better muscle tone, improved gum health, vastly more energy, in fact this has become all the norm after around 8 months of this. Many of the effects I described in the first two weeks following a 3 day regimen do taper off to an extent, but never completely.
As far as side effects there has not been anything thus far. When you are taking the 3 day dose you might get amped up a little jittery but that gives way quickly after the last dosage and it normalizes into a even effect that is positive in nature. I was very concerned about hair loss as I could not believe how impactful this was. But I have noticed no hair loss at all. I cycle it with a 3 or 4 week break to ensure that there is no negative effect on hair or otherwise. With a two week interval I had some scalp itchiness. That was enough to back me off to to four week intervals.
I honestly think that most of what I experienced is not the senylotic effect. It’s way too fast and profound. But I have no ill effects and feel incredible. And overall I have a youthful vigor and look and feel younger. I think a senylotic evaluation, as far as a laymen just observing himself goes ,can only really be done after 2 years or so. However the initial results ( especially gum health) and from what else I can observe are overwhelmingly positive.
I can tell you that this does have an affect and it is profound and noticeable. How much of this is hormone I do not know. But I have other improved health as well, however it’s always tricky to quantify this objectively yourself sometimes.
Good luck on your experiments. Let me know if this has the same effect for you. I just bought Swanson’s with nouvestein. Nothing fancy. Cheap and on amazon.
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Thanks for sharing your experience. Sounds like great results. Now, if only we knew what happens after you do this for 10-20 yrs.
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Karl yea that is the issue with senolytics in humans you need a very long time line. It’s one thing if you had a control body double of yourself to compare to, but obviously we don’t. But I can honestly recommend fisetin for the other benefits anyways. It’s the closest thing to a miracle supplement that I’ve ever taken.
I will I’ll continue to use until such time other senolytics become more advanced and accessible.
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I’d add that if you look at people taking male to female hormones that maybe this gives us a rough estimate at how fast senescent cell clearance in humans might show results. In both of these scenarios cells receive different signals and must adapt and change.
Typically with hormone treatments you see results in around 6 months. It stands to reason that the absence of SASP from senescent cells might affect cells in a rough timeline similar to this. There have been a lot of health benefits that are now the norm for me that showed up more or less around the 6 month mark. A year and a half ago I was a different person.
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Quick question.... did you use any oil with the fisetin? How about any of the other synelytics? Mayo clinic mixed the Fisetin with oil which supposedly enhanced the assimilation.... sounds like you just used it on an empty stomach? Pretty amazing report...thanks for the Guidance...
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Yea I just took it pretty much in line with how they did the mouse experiments. I upped it to 3g for each dosage. So every month I take 3g three days in a row. With Swansons that is a bottle every day. I am certain a lot of the effect is elevated testosterone levels so I am a bit cautious with the frequency.
Before I started this regimen I was lethargic, easily tired, and had brain fog. Also it seems as you get older you tend to slowly fade out so you are not as present in the world perceptually as you once were. It’s something you may never notice really as it’s a slow effect.
Taking Fisetin turned the lights back on and suddenly I remembered how it was to see the world when I was in my early twenties. The sounds became clear and vibrant and interesting, the colors were amazing in the world. It was a little overwhelming at first. Now up I am kind of used to it but still get a mini effect when I do a new dosage.
My mind is as sharp as it has ever been. My memory is ridiculously good. I feel as if I have never been more intelligent in my whole life. And I can stay up way into the early morning hours.
its a game changer if you have started to feel the ravages if time. Also when I work out I get ripped pretty easy now.
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David C How often do you do the 3 day senolytic treatments? Do you take the fisetin with a meal or between meals when you do the 3 day treatments? Do you eat like you normally do during those days? Thanks
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David C Do you have an update for us? I wish we could know what the optimal interval/dosage is. Anyway, I'd love to hear an update!
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ripeideas
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Joe F my PSA is still extr
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Joe F extremely low ( good). Twice a month, 500 3 t
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Joe F times a day, rv
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ripeideas After a lot of research on Fisetin, the dose I finalized is 20mg/kilo of bodyweight, I do 3 days of that dose, 2,100mg in my case - 2.1g and give it a break for 3-4 months, it not good to clean out the senescent cells completely, some small amount is beneficial. I consider this optimal! David C's dose is too much. I hope this helps.
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Joe F Are you referring to a substance that lowers your PSA or looking for something to bring it down?
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John Ramos
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Joe F Huh?
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John Ramos Thank you, John. I'm concerned that 3 months may even be too often, but that's just a hunch not based on facts. Have you read the recent article about Viagra possibly helping to prevent Alzheimer's by up to 70%?! I'm a woman so I can't get a prescription. Viagra is a vasodilator so I'm going to go the natural route and take Horny Goat Weed...
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ripeideas Here's one article about it- Can Women Take Horny Goat Weed? | livestrong https://www.livestrong.com/article/460069-can-women-take-horny-goat-weed/
And another interesting one - Grape seed chemical allows mice to live longer by killing aged cells https://www.newscientist.com/article/2300346-grape-seed-chemical-allows-mice-to-live-longer-by-killing-aged-cells/
I take Grape Seed Extract daily.
Also look at AKG, I take CA-AKG(Calcium AKG) but they say it's the AKG, not necessarily the Calcium version, greatly increases lifespan. It's cheap.
I've done a lot of research... Fisetin is somewhat confusing...
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John Ramos hey, thanks!
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John Ramos
A recent paper show that Icariin (a substance found in horney goat weed) can reverse the macrobiota of old mice to a youthful state and other positive effects as well. It is an interesting substance and that Icarrin is also a sirt6 activator.
https://www.sciencedirect.com/science/article/abs/pii/S1043661821001717
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5644024/
And Icarrin might be useful for females since it inhibits (at least some cell lines of) breast cancer.
“Icariin-induced inhibition of SIRT6/NF-κB triggers redox mediated apoptosis and enhances anti-tumor immunity in triple-negative breast cancer”
https://pubmed.ncbi.nlm.nih.gov/32926492/
The thought that Grape seed extract contains a substance that kill senescent cells is in line with the findings that some substances in grape seed extracts has been shown to have cytotoxic effects on some prostate cancers.
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John Ramos Ok, back from vacation. Had bad luck trying to respond via cell phone. Prostate cells produce PSA that is measured in my blood. Since I no longer have a prostate my PSA should be zero but the test results indicate a tiny amount. This indicates the presence of cancerous cells somewhere in my body, not nearly enough to be seen using any kind of imaging. The fisetin helps keep the PSA number very low so it is killing or inhibiting the cancer from multiplying.
I take it for two days every two weeks. 500 3 times a day, every 8 hours.
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Joe F If Fisetin works for you but where did you get information that fisetin lowers PSA scores?
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John Ramos Excellent question. I heard about fisetin from another member of a prostate cancer group. I ran a course of fisetin and my PSA went down the next test. In the absence of any curative medicines (chemo, radiation, etc.) PSA normally goes up not down as cancer cells multiply and produce more serum PSA. I am not on any medications at they time. The presence of some PSA means I still have cancer cells in me somewhere as my PSA is not zero. Killing them or keeping them in a senescent/dormant state prevents the cancer from progressing and eating me for lunch.
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Joe F Prostate cancer is infamous for learning "workarounds" for the various cancer therapies, that is to say when one therapy becomes ineffective you move on to the next until all therapies have been used to the failure point. Great strides have been made in this area in the past 20 years. I have no idea if the fisetin will fail sometime in the future. It must be noted, person-to-person the cancers are very different. A treatment that works for one person might not for another. I also take high THC cannabis oil rectally. Home grown so I know what is in it. This avoids the "high" that is produced when one eats or smokes it in turn permitting a much higher blood level to be attained. It too works as evidenced in my PSA tests. My PSA is tested every 3 months.
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Joe F Did you also look at a increased PSA due to an enlarged prostate? What age are you? It's common in older men, I believe I have an enlarged one, very low flow, small amount, urgency etc. just not like it was...I know it's not cancer, I've been scanned, MRI, PET, CT...have or had cancer of the liver. I had 2 ablations and a chemoembolization. The AFP was very high, might be "0" in the last test a few days ago, getting the results in a couple of days.
Did anything light up(whitespots) in any of your scans?
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I was asymptomatic. Went for annual physical high PSA, biopsy Gleason 9. Radical prostatectomy, salvage radiation+7months androgen deprivation. The only way to know if it is cancerous is with a biopsy. Unpleasant but not bad. I had full body scans in between the biopsy and the radical prostatectomy. No light-ups, thank God. If your body is riddled with cancer they won't do an R.P. I was 67. Get a urologist to get you a PSA test. Every male 60 and up needs a PSA test annually. 1 in 7 men get prostate cancer. Early detection is extremely critical as the cancer loves to leak out of the prostate and spread all over. Don't fear it, learn about it.
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