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Re: Fisetin to Clear Senescent Cells
@Moonlitnight Doctor's Best Fisetin featuring Novusetin is the brand that I have used. Others have used Swanson's fisetin and gotten positive results. The fact is that we don't know which brands…
- Staffan_Olsson
- 4 yrs ago
- 1
- Self-Experimentation
- Reported - view
Re: Fisetin to Clear Senescent Cells
@Moonlitnight I get a different experience (placebo?) if I take fisetin with black pepper or if I take fisetin with piper longum (long pepper). Piper longum contains both piperlongumines and…
- Staffan_Olsson
- 4 yrs ago
- 2
- Self-Experimentation
- Reported - view
Re: Weekly rapamycin and protein/resistance training regimen
@David There are mTOR independant ways to build and to conserve muscles. In vivo and in vitro studies indicate that citrulline can have a positive impact on muscle protein syntesis independantly of…
Attachment
- Staffan_Olsson
- 4 yrs ago
- 1
- Rapamycin Discussion
- Reported - view
Re: Intermittent doxycycline and life extension in mice
@Jimmy2 Without knowing how much they drank it is not possible (or at least very difficult/speculative) to estimate human equivalent dose (HED). Here is a paper about basic dose conversions between…
- Staffan_Olsson
- 4 yrs ago
- 1
- General Discussion
- Reported - view
Re: Anyone actually experience marked increased energy from NMN?
@Sebastian Gastrointestinal discomfort has been reported. Negative Effects of Resveratrol | Livestrong.com
- Staffan_Olsson
- 4 yrs ago
- Self-Experimentation
- Reported - view
Re: Normalized Nitric oxide, Citrulline and a youthful endothelial function.
@Staffan Olsson Another perspective on the importance ot a healthy vascular system and its role in antiaging. Hyperbaric oxygen therapy reduces brain hypoxia and improves cerebral functions.…
- Staffan_Olsson
- 4 yrs ago
- 2
- General Discussion
- Reported - view
Re: Regulation of the one carbon folate cycle as a shared metabolic signature of longevity
@Jack Black Yesterday I attended AARD virtually. ARDD 2021 (agingpharma.org) thats where I heard Adam Antebe. I think that they will post the 2021 presentations for future online viewing.…
- Staffan_Olsson
- 4 yrs ago
- Ideas
- Reported - view
Regulation of the one carbon folate cycle as a shared metabolic signature of longevity

https://www.nature.com/articles/s41467-021-23856-9 "Regulation of the one carbon folate cycle as a shared metabolic signature of longevity" I heard a fascinating talk today.…
- Staffan_Olsson
- updated 4 yrs ago
- 5replies
- 106
- 1
- Ideas
Re: Rapamycin - progress so far
@David H An interview with Dr Green. About dosing. Rapamycin: Practical Dosage & Benefits | Dr Alan Green Episode 4 - YouTube
- Staffan_Olsson
- 4 yrs ago
- Self-Experimentation
- Reported - view
Re: Variability Among Horvath-type DNA Methylation Age Tests
I am impressed. You have a good exercise regimen. Can you tell us something about your diet en supplement regimen?
- Staffan_Olsson
- 4 yrs ago
- Assessing Biological Age
- Reported - view
Re: Normalized Nitric oxide, Citrulline and a youthful endothelial function.
@Staffan Olsson I would like to follow up on the importance of a rejuvenated vascular system with this paper. The paper does not provide us with a direct action to take,…
- Staffan_Olsson
- 4 yrs ago
- 2
- General Discussion
- Reported - view
Re: Normalized Nitric oxide, Citrulline and a youthful endothelial function.
Endothelial function and decreasing production of nitric oxide are signs of ageing and are correlated to multiple diseases. It is a well-known fact that targeting the levels nitric oxide can have an…
- Staffan_Olsson
- 4 yrs ago
- 1
- General Discussion
- Reported - view
Normalized Nitric oxide, Citrulline and a youthful endothelial function.

Nitric oxide (NO) is an important signaling molecule and the natural production of it decreases due to ageing. And this impacts or organism in a age related negative way.…
- Staffan_Olsson
- 4 yrs ago
- 4replies
- 225
- General Discussion
Re: Replacing Hormones to Optimal Levels
@Allen Citrulline has a lot going for it when it comes to prevent the muscle wasting and the low nitric oxide levels that Come with aging. It could need a section of its own.…
- Staffan_Olsson
- 4 yrs ago
- Self-Experimentation
- Reported - view
Re: Replacing Hormones to Optimal Levels
@MAC @Sharon Smith I have had an interest in the effects of Citrulline and found that there are indications that it prevent muscle wasting and promote muscle building in a mTOR independent way as…
- Staffan_Olsson
- 4 yrs ago
- Self-Experimentation
- Reported - view
Re: Intro to rapamycin
@Steve Roedde Thank you for the advice, I will email "Sabrina" if needed.
- Staffan_Olsson
- 4 yrs ago
- Rapamycin Discussion
- Reported - view
Re: Intro to rapamycin
@Steve Roedde Hi Steve. Have you had the Rapamycin from Wuhan Hengheda tested? PS: I am trying to etablish contact with Wuhan Hengheda. I have used the mail service on their homepage.…
- Staffan_Olsson
- 4 yrs ago
- Rapamycin Discussion
- Reported - view
Re: Which Rapamycin brand to buy versus which to avoid?
@John I can load their site now. As far as I know they only sell in powder. I have not yet bought from them. I mailed them two days ago, still no respons.
- Staffan_Olsson
- 4 yrs ago
- 1
- Rapamycin Discussion
- Reported - view
Re: Which Rapamycin brand to buy versus which to avoid?
I am also looking for a company to deliver to Europe. And yes testing seems to be crucial. I have contacted http://www.hhdpharm.com/. Other people on the forum has bought from them (not me).
- Staffan_Olsson
- 4 yrs ago
- 1
- Rapamycin Discussion
- Reported - view
Re: Fisetin to Clear Senescent Cells
@JGC What you write should be about optimal, at least according to what the research can tell us now. There is an obvious advantage of using piperine, this since it makes it possible to use exact…
- Staffan_Olsson
- 4 yrs ago
- Self-Experimentation
- Reported - view
Re: Fisetin to Clear Senescent Cells
@Jay Orman There are many ways to improve prostate health with natural substances. To name a few: Grape seed extracts, quercetin in combination with green tea and gamma tocotrienol.…
- Staffan_Olsson
- 4 yrs ago
- Self-Experimentation
- Reported - view
Re: Fisetin to Clear Senescent Cells
@JGC Piperine acts as a bioenhancer both in the Gastrointestinal tract and in the liver and in othter metabolic processes responsible for the elimination of substances: https://www.ncbi.nlm.nih.…
- Staffan_Olsson
- 4 yrs ago
- Self-Experimentation
- Reported - view
Re: Has anyone tried taking fietin as a suppository?
@Robert Uomini The most consistent cognitive / emotional effects from senolytic therapy have been improved levels of mood and energy. I an indirect way these alterations makes it possible to work…
- Staffan_Olsson
- 4 yrs ago
- Senolytics Discussion
- Reported - view
Re: Has anyone tried taking fietin as a suppository?
I have tried taking Fisetin as a suppository. I made capsules with 500 mg fisetin with oil and then had them sit in the freezer to make them solid. I did not experince those sessions to be different…
- Staffan_Olsson
- 4 yrs ago
- Senolytics Discussion
- Reported - view
Re: Rapamycin Cost
@Liam_Cohen I see this "Unless otherwise indicated, solutions are probably best prepared fresh and protected from light." R0395pis.DOC (sigmaaldrich.com) It would suit me to have rapamycin in DMSO…
- Staffan_Olsson
- 4 yrs ago
- Self-Experimentation
- Reported - view

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