Human Placental Extract (Laennec or JBP)

Has anyone experimented personally with these human placental hydrolysate products--if so can you share your experience and results?  Traditionally used primarily in cosmetic applications, but quite a few human studies in Korea and Japan indicating off label usage for liver rejuvenation, hemochromatosis treatment, healing of soft tissue and joint injuries, reversal of chronic fatigue, general rejuvenation of sleep and energy levels, etc.   Protocols range from subcutaneous to IM injections of one to two 2ml ampules twice a week or even multiple daily dosing for more complex or resistant cases of injury.  Product has been used since the 60s in Japan and Korea, more recently becoming popular in the West as folks experiment more with stem cell treatments, exosome therapies, and other human biological injections.  Some AI bullets output below:

• Origin and Safety: Laennec is manufactured in Japan from human placentas sourced from full-term deliveries. Stringent safety measures are in place to screen donors and ensure the absence of harmful microorganisms. The manufacturing process includes high-pressure steam sterilization to inactivate potential viruses.
• Composition: Laennec is a complex mixture containing various biologically active substances, including growth factors, cytokines, peptides, amino acids, antioxidants, vitamins, and minerals. These components work together to promote cellular metabolism and rejuvenation.
• Primary Indications: Laennec's main indications include improvement of hepatic function in chronic liver diseases and anti-aging and aesthetic applications, such as skin rejuvenation and treatment of various skin conditions.
• Mechanism of Action: Laennec works by stimulating cellular regeneration, enhancing collagen and elastin production, and improving blood circulation. It can also reduce inflammation and modulate the immune system.

• Areas of Off-Label Use Supported by Korean Research:

• Chronic Fatigue Syndrome (CFS): Studies have shown that Laennec can significantly reduce the severity of symptoms in patients with CFS, including improvements in quality of life, anxiety, depression, exercise performance, and lipid metabolism.
• Skin Health and Anti-Aging: Laennec is widely used in Korea for skin whitening, anti-aging, and improving skin elasticity. While its official approval is for improving liver function and menopausal symptoms, its application in cosmetics and anti-aging treatments is prevalent.
• Ligament Healing: A Korean study using a rodent model showed that Laennec enhances wound healing of damaged ligaments by suppressing immune responses and reducing degenerative changes. It also promoted the regeneration of damaged ligaments by inducing the gene expression of collagen type I, scleraxis (Scx), and tenomodulin (Tnmd).
• COVID-19: In a Phase-2a clinical trial, Laennec was investigated for its antiviral effect in patients hospitalized for moderate COVID-19 infection. Although this was a study, it indicates research into Laennec's potential in treating viral infections.
• Neurodegenerative Diseases: Research explores the effects of Laennec on memory improvement and neuritic regeneration in Alzheimer's disease models, suggesting a potential role in neurodegenerative conditions.
• Iron Overload (Hemochromatosis): A Korean study demonstrated that Laennec induced hepcidin production, which could potentially substitute phlebotomy treatment for hemochromatosis patients.