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Self-Experimentation

Share your story of trying or designing a promising age-reversal protocol.

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Rapamycin cost
Well-studied results show a huge increase in lifespan across the board among mammals with rapamycin (sirolimus CAS 53123-88-9) dosing. Why is not everyone taking it?…
- Bart Bear
- Bart_Bear
- 3 yrs ago
- 3replies
- 281
- 1
- Last replyLaur2 yrs ago
- Self-Experimentation
IV R-Lipoic Acid Therapy
IV drip R-Lipoic administration seems to have benefits in the treatment of peripheral neuropathy (studies in diabetics) but other positive health affects to so it is widely taken in oral form but…
- Dorian Gray
- Dorian_gray
- 2 yrs ago
- 45
- Self-Experimentation
Yeast-Displayed GDF11 and Oral Delivery
Through the work of Steve Perry, it appears that taking growth differentiation factor 11 (GDF11) provides definite health benefits and some evidence of rejuvenation.…
- JGC
- Retired Professor of Physics
- JGC
- 2 yrs ago
- 4replies
- 133
- 1
- Last replyJay Orman2 yrs ago
- Self-Experimentation
Tracking daily steps
Just got on the steps band wagon. Who is tracking their daily steps? What are you averaging? What changes have you noticed? To provide some value, here's a link. https://www.nih.…
- Michael
- Michael.1
- 2 yrs ago
- 4replies
- 87
- Last replyMichael2 yrs ago
- Self-Experimentation
Blood Test #1 in 2022: Supplements, Fitness, Diet
https://www.youtube.com/watch?v=46_Xkj9xQug
- michael lustgarten
- michael_lustgarten
- 3 yrs ago
- 3replies
- 94
- 1
- Last replyshirleyscaringi2 yrs ago
- Self-Experimentation
Current longevity protocol: Should I add rapamycin?
This is my first post here, and I’m hoping to get some insights from people with similar protocols. In particular, I’m curious to hear people’s perspective on rapamycin given my current regimen.…
- Simon Smith
- Simon_Smith
- 3 yrs ago
- 26replies
- 593
- 2
- Last replyPeter H. Howe2 yrs ago
- Self-Experimentation
Self Administered Anesthetic Dental Injections
Anyone have experience with it? Any recommendations on administration and compounds used? Thank you, CHAMPIONS!
- Michael
- Michael.1
- 3 yrs ago
- 3replies
- 127
- Last replyMichael3 yrs ago
- Self-Experimentation
Biomarkers for those taking Rapamycin....?
Hi all, can I ask what biomarkers those of you who are taking Rapamycin are testing and frequency etc? I've had a quick search but can't seem to find anything.…
- Natalie S
- Natalie_S
- 2 yrs ago
- 3replies
- 84
- Last replyBrin Chikovski2 yrs ago
- Self-Experimentation
Self-experimentation with variety of supplements and drugs
Greetings, I am 67, male, with type 2 diabetes, heart disease and high blood pressure. Current prescription drugs I take per doctor's order: 2000 mg metformin, 45 mg actos, 80 mg lipitor, 2.…
- Kim Mackey
- Kim_Mackey
- 5 yrs ago
- 4replies
- 589
- Last replyJOHN5 yrs ago
- Self-Experimentation
Cosmetic Peptides
Anyone have experience with any of the (cosmetic) peptides on this site or equivalent? Tried the rapa cream formula suggested on the forum here with zero benefit.…
- Michael
- Michael.1
- 4 yrs ago
- 3replies
- 219
- 1
- Last replyRick Tolk2 yrs ago
- Self-Experimentation
Protocol which makes senescent cells start to function and hair to grow
https://johnhemming.blogspot.com/2022/06/protocol-which-makes-senescent-cells.html I have put a link to my blog post about my new protocol which is designed to get senescent cells to exit senescence…
- John Hemming
- John_Hemming
- 2 yrs ago
- 2replies
- 216
- 2
- Last replyJohn Hemming2 yrs ago
- Self-Experimentation
Dasatinib update
Just finished a 3 day course of D & Q. The Dasatinib was purchased from Taylor Made Compounding. Dosage was 100 mg D &1000 mg Q. Cost for 6 @50 mg capsules, including shipping was USD $33.…
- Charles Grashow
- Charles_Grashow
- 4 yrs ago
- 21replies
- 743
- 1
- Last replyJared2 yrs ago
- Self-Experimentation
Where to buy rapamycin?
Hey everyone, I’m new to the group. Really cool to see everyone’s experience with Rapamycin. I’m looking to get some myself. I’m actually more interested in it for my cat’s heart condition.…
- Stefan Pougatchev
- Stefan_Pougatchev
- 3 yrs ago
- 21replies
- 1179
- 2
- Last replyKarina2 yrs ago
- Self-Experimentation
Has anyone tried urolithin A?
Urolithin A is a bacterial metabolite that enhances mitophagy, which declines as we age and allows dysfunctional mitochondria to accumulate. I just wanted to see if anyone has experimented with…
- Will Hunter
- Will_Hunter
- 4 yrs ago
- 31replies
- 2169
- 2
- Last replyKarl2 yrs ago
- Self-Experimentation
Rapamycin Cost
Let me clear some things up for people considering rapamycin (generic sirolimus). I am taking it and so are my dogs!! (I have a very open-minded vet who trusts my judgement.) Dr.…
- Rob8311
- Rob8311
- 7 yrs ago
- 599replies
- 14312
- 14
- Last replySteve Roedde2 yrs ago
- Self-Experimentation
Sea squirts, mussels and longevity
https://neurosciencenews.com/aging-sea-squirts-20570/#:~:text=They%20found%20that%20the%20supplements,impairments%20in%20the%20aging%20brain. As the article suggests,…
- Juan Daw
- saxxnviolins
- 2 yrs ago
- 5replies
- 188
- Last replyFred Cloud2 yrs ago
- Self-Experimentation
Gingernone A is a Better-than-D+Q Senolytic
A post in Lifespan.io discusses a recent paper published last month in PLoS One in which the polyphenol Gingernone A, a strong component of Ginger Root Extract,…
- JGC
- Retired Professor of Physics
- JGC
- 3 yrs ago
- 8replies
- 393
- 3
- Last replyKarl2 yrs ago
- Self-Experimentation
wrinkle reduction
has anyone noticed wrinkle reduction in systemic use of sirolimus?
- curious
- curious
- 4 yrs ago
- 107replies
- 2242
- 3
- Last replyHello World3 yrs ago
- Self-Experimentation
Just Ordered Rapamycin w/ No Prescription
When I was at Raadfest18, it was announced that there was a vendor in the Exhibition Hall from whom Rapamycin could be ordered at a good price. Later I found out exactly what vendor from someone…
- Mermaid
- Mermaid
- 6 yrs ago
- 80replies
- 7313
- 5
- Last replySteve Roedde3 yrs ago
- Self-Experimentation
Testosterone Trials
The Testosterone Trials were a set of seven randomized placebo-controlled trials that evaluated the efficacy of testosterone replacement therapy (TRT) in older men with low testosterone levels,…
- Michael
- Michael.1
- 3 yrs ago
- 6replies
- 255
- 1
- Last replyMichael3 yrs ago
- Self-Experimentation
Recent constellation has had an effect... again
I wish I had more scientific data to bring, but in messy real life we end up trying various things and it muddies the waters. I've got existing benefits from a heap of stuff already,…
- Jack Black
- Jack_Black
- 3 yrs ago
- 1reply
- 130
- 1
- Last replyJack Black3 yrs ago
- Self-Experimentation
Methylene blue
I wonder if somebody in this forum has experimented with Methylene blue and can report about the experiences made?
- Staffan Olsson
- Staffan_Olsson
- 3 yrs ago
- 100
- Self-Experimentation
blood work
OKAY BRAINIACS! After putting off doing blood Dr. Green requested for over a month, and going without fasting, what do these results indicate. 1) heavy smoker 2) Whiskey drinker 3) No breakfast.…
- Michael
- Michael.1
- 4 yrs ago
- 21replies
- 233
- Last replyMichael3 yrs ago
- Self-Experimentation
Autophagy / fasting
I've recently become aware of the importance of autophagy in the cells and the ability to promote or trigger this through fasting. Just started a 3 day fast yesterday (I'm doing the apple fast,…
- Phoebe Saffold
- Phoebe_Saffold
- 3 yrs ago
- 3replies
- 256
- Last replyJack Black3 yrs ago
- Self-Experimentation
Rapamycin & Covid
Recently the new Omicron BA2 variant busted through the triple vaxed fortress my family had built. I was ill for a few days, but never felt in danger. When the illness subsided I suffered from…
- Jack Black
- Jack_Black
- 3 yrs ago
- 1reply
- 76
- 1
- Last replyJay Orman3 yrs ago
- Self-Experimentation

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