Self-experimentation with variety of supplements and drugs


I am 67, male, with type 2 diabetes, heart disease and high blood pressure. Current prescription drugs I take per doctor's order: 2000 mg metformin, 45 mg actos, 80 mg lipitor, 2.5 mg of glyburide, 20 mg lisinipril.

Current supplements not including b vitamins and big multivitamin/mineral tab with reason why bolded after each: (some doses split, take supplements breakfast, lunch, or dinner)

600 mg nicotinamide riboside nad+ precursor

150 mg pterostilbene sirtuins

500 mg resveratrol complex sirtuins

200 mg ubiquinol mitochondria

8 mg astaxanthin antioxidant

20 mg pqq (pyrroloquinoline quinone) mitochondria

800 mg NAC (n-acetyl cysteine) glutathione precursor

700 mg glycine glutathione precursor

250 mg quercetin antioxidant

probiotic gut bacteria

500 mg acetyl l-carnitine mitochondria, antioxidant

200 mg alpha lipoic acid mitochondria, antioxidant

50 mg dhea hormones

1700 mg msm complex joints

1000 mg fisetin 3 times a month senolytic

To be added soon: 700 mg olive leaf extract antioxidant

supplements recently discontinued: niacin, curcuminoids.


supplements which have had the most impact in the last 18 months:

Nicotinamide riboside. At 250 mg per day after 2 weeks experienced complete remission of joint and back pain, improved joint mobility, better lung function, better recovery from exercise, better sleep, better skin condition, fewer spring and fall allergy symptoms.


n-acetyl cysteine. Worked effectively as a mucolytic during a cold, seemed to help short circuit the cold to many fewer days than normal. (4 days versus the usual 10)

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