Intro to rapamycin

Hello everyone,

Rapamycin is an mTOR inhibitor. It has been used for years to prevent organ transplant rejection in humans, in part because mTOR inhibition also inhibits the immune system. 

mTOR is a pro-growth factor that is involved in cellular growth and protein synthesis. Its inhibition has been associated with longer lifespans in certain organisms (not yet humans). 

Rapamycin administration has been shown to extend the remaining lifespan of middle-aged mice, making it an interesting life-extension candidate for use in middle-aged humans. 

Has anyone tried rapamycin? What were the results? 

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  • I have been in the study now for about 8 months now.  I can't tell any difference, but I do get the side effect of mouth sores once in a while.  The study is a year long with many blood tests to monitor us.  We should be meeting soon as a group.  We haven't done that since the beginning of the study.  We can compare notes.

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    • loveyouyrlongevity .... there is a study on c. Eligans and fruit flies where the the food component allantoin found in sprouting wheat germ and allo Vera, doubles the life extension effect of rapamycin... summary...actually there were many synergistic drug combinations graphs. Odly metformin was absent.

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    • are we there yet  ....  The study is over now.  I am waiting to see what the results of the year show, if anything.  I have read that they now think that the 5 mg a week is not enough.  We shall see when the results are tabulated what that dosage meant for participants.  I have not heard about what you bring up, but I am sure as we travel down this road we shall find more refinements to the regimine .  

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    • loveyouyrlongevity ..... my self experimenting with sirolimus (rapamycin) has shown a clear near elimination of left knee arthritus pain. I am 70 on a 10 day interval of 2mg.

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    • are we there yet I've just started my self-experiment with rapamycin. I'm 73 and it would be a stunning endpoint if I shared your achievement of elimination of arthritic pain. I am curious about your dosage. From prior readings, I would think 2mg would be too small a dose to show efficacy. If you don't mind, would you share your weight and how long you've been on your regiment? Also, how long did it take prior to you feeling noticeable pain relief? Thanks.

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    • Sanford Finley 

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    • Sanford Finley I will give what you ask. I am 280 pounds 5 ft 8 in, 71 yo normal blood work. Used to have significant arthritis in left knee and right hip. I am a physicist with intellectual seduntary lifestyle. No notable health issues. Normal blood work. I currently take 1.5 to 2 mg metformin daily with noticibly good effect, 2 mg sirolimus every 7 to 10 days unless I get a vaccination or travel on an airplane to lecture. I am told my guessed age is mid fifties. Less if I shave off my grey facial hair.

      my latest health device that I am excited about is a vibration plate for mostly static exercise. It appears to work. My legs are sore the next day. 

      Sirolimus seems to help regenerate cartridge and joint tissue as well as improve heart mussle myocite health in animal studies as well as improved stamina I find noticible. I started noticing arthritis pain go away if I walk less than a half mile after about 2 weeks. Note: take b12 supplements to counter metformin reduction in b12 absorption. What are you medication plans?

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    • are we there yet Thank you for the information. RE: my medication plan, I took my 1st dosage of 4mg Rapamycin one week ago and plan to take it weekly unless I experience an adverse effect. I also take metformin 500 mg. 1 daily, fisetin 1 g. once monthly. Additionally, I take b12, fish oil, pomegranate tabs 250 mg. daily. I am 73 yrs. old, 5' 11 and 170 pounds. I am healthy except for spinal osteoporosis which presents with hip pain when walking long distances. Since the introduction of the Rapamycin into my routine, I have experienced a profound placebo  (I assume) effect. I feel considerably less hip pain and feel more energetic. As an interesting aside, I started my 13-year-old dog on 1/4 mg of Rapamycin weekly at the same time I began. He too suffers from arthritis. Concurrent with my increase in well being he now is able to jump in the back seat of my car without assistance, whereas he previously needed to be helped. Who knows? Do dogs experience placebo effects? Finally, I purchased a neutral face cream and made a compounded mixture of 20mg. of Rapamycin with the 4 oz. cream which I apply to my "turkey" neck 2x daily. I will monitor this for any change. I plan to update the forum as to future outcomes.

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      • Karl
      • Karl.1
      • 9 mths ago
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      Sanford Finley regular feedback will be greatly appreciated.  Good luck.

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    • Karl Thank you for your good wishes in my endeavor. Be assured I shall provide ongoing feedback barring an unexpected endpoint (fatality) is encountered. 😉

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    • Sanford Finley 

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    • Sanford Finley Just wanted to comment on the topical cream. The concentration of 20mg in 4 ounces will be around 1.8 micro molar (approximate). The recent study of topical rapamycin which found significant benefit for senescent clearing and improved appearance etc used a 0.1 micromolar concentration (approximate). Studies on hair (fur) growth in mice using topical found effectiveness at 0.1 - 1.7 micromolar concentrations. At concentrations above this there was mention of non-healing wounds. In tuberous sclerosis patients they use 10 micromolar to inhibit growth. Just wanted you to be aware that there may be some unwanted effects at higher concentrations. Reading through the literature I believe what you want to do is influence autophagy moreso than inhibit growth. In cell cultures they use about 0.2 micromolar concentrations to influence autophagy. I've been using this concentration (approximate) for a topical (2mg in 4 Oz) for a while and see some marked improvements and feel safe in doing so. You may be fine with the 10X higher concentration but sometimes to much may not be as good. 

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    • Mark Thimineur Your point is well taken; more is not necessarily better. Perhaps I will add more cream to dilute my alchemy. If you could share a link to the mice study you referenced it would be greatly appreciated. Thank you.

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    • Sanford Finley The link is

      Cell Reports Volume 27, Issue 12, 18 June 2019, Pages 3413-3421.e3

      A relevant paragraph below:

      (G) Rapamycin (1.6 μM) induces hair regeneration. Male mice were shaved on postnatal day 43 and treated topically every other day. Photographs were taken on day 37 post-treatment. Number of animals: control, n = 18; rapamycin, n = 17. Rapamycin at 100 nM gave similar results as 1.6 μM (Figure S2). Similar effects by rapamycin were seen in female mice (Figure S2B). Rapamycin at 16 μM, however, resulted in hair loss and open wounds (data not shown), consistent with a previous vascular grafts study in rats receiving high-dose rapamycin (Walpoth et al., 2001); this may be due to more severe inhibition of mTOR, which was reported to be required for hair follicle stem cell activation (Castilho et al., 2009Kellenberger and Tauchi, 2013Deng et al., 2015).

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    • Sanford Finley Just wanted to let you know that my math was off. mixing 20mg of rapamycin in 4 ounces (assume U.S.) comes out to be a concentration of 185 micro molar. If it is UK ounce it is 192 micro molar. For reference, the recent study of topical rapamycin for skin was a concentration of 10 micro molar. I've been using 27 micro molar (2mg in 4 Oz).  Should be careful with this stuff - the topical can cause skin ulceration etc. Useful tool for molarity concentration is https://www.omnicalculator.com/chemistry/Molarity

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    • Mark Thimineur Per your previous caution, I compounded a new batch with 2mg. in 8oz. It has now been 3 weeks of oral (4mg, 1x week) and topical administration. To date, I cannot reliably attest to any significant change but will be having blood work done in February. However, I can report that the topical application has resulted in a rather amazing effect. I have male pattern baldness and there is now "peach fuzz" growing in my previously bald spot. Also, my scalp has considerably less dryness and flaking. I have yet to experience any adverse reactions. I would be most interested to read your experience.

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    • Sanford Finley Your new batch will be about 8-9 micromolar depending on wastage. I've used topical at 16-18 micromolar (2mg/4ounces) and repeated the experiment treating the back of my right hand with active and left hand with just vehicle twice daily for 6 weeks. There is already a noticable difference in the skin of the treated side compared to the untreated. I plan to do this for at least 4 months for comparison.  At the same time I have used it on face and neck twice daily for same amount of time. I don't have a comparison but it appears to me that anti-aging effect on skin is apparent. I have mixed a new batch at 3mg/4oz which is about 25 micromolar due to a probable 10% wastage and will begin using this in the same areas. I feel that it is safe at 25 micromolar or less. I have also used a 2.2 micromolar solution (0.2mg in 100ml DMSO) on scalp for about 6 weeks. I have a pretty full head of hair but mostly gray. The gray hairs are thinner and less coarse than the remaining black hair. To early to tell but there may be proportionally more coarse black hair at 6 weeks. I keep it cut very short (2-3mm) so it is easy to see. I think this concentration is safe on the hair as the follicle bulbs need mtor activity to generate but benefit from autophagy activation. This is about the same concentration as the rodent fur studies showing anagen phase of hair(fur) stimulated at 0.1 - 1.7 micromolar. Concentration of 17 micromolar caused fur loss due to mtor inhibition overriding autophagy effect. Keep me posted on observations and I'll do same.

      At the same time I have been on oral weekly doses of 0.05mg/kg cycling with 0.1mg/kg doseage (3.5-7.0mg) for about 12 months. Have experienced many positive effects which are more pronounced at the higher dose. I am going to do the same cycling with a 0.1mg/kg - 0.2mg/kg and see what the differences are. In particular I am looking for any side effects such as stomatitis developing at the higher dose vs enhancement of the positive effects. It seems to me that one reaches a relative stability after about 6 months based on my experiences with self, family members, friends, and patients.

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    • Mark Thimineur , Sanford Finley   Dosage is critical which really emphasizes the importance of consistent quality in the product.  Having other than reliable pharmaceutical grades frankly scares me a quite a bit.  But, very much looking forward to your results and success.

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    • Dorian Gray Agree. All persons that I have responsibility for are using Rappamune (Pfizer) or Sirolimus (Biocon) which assures pharmaceutical grade. One can assume variable amounts of impurity from non-pharmacetical suppliers.

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    • Mark Thimineur Are you able to share how do you make the cream? My Sirolimus is in tablet form so Do you take the pill and break it down as fine as possible
      and then mix it in a cream? I feel like I’m missing something possibly a way to dissolve the tablet? Thanks 

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    • John Mcgough Mortor and pestle to reduce the pills to powder. Place the powder in a vessel for dissolving in DMSO. I use a test tube with a secure plug. Dissolve in DMSO thoroughly by shaking and letting sit for 10 minutes or so. You only need 2 ml of DMSO but you could use more if you want. There are insoluble fillers in the pills but the rapa is highly soluble so even though it appears milky it is OK. The vehicle cream (I use a 70% DMSO, 30% Aloe base) put in a small mixing vessel like a cereal bowl. Add the dissolved rapa into the base and mix thoroughly. Put base cream back in original container and label.

      3mg of rapamycin in 4 ounces will provide a 25 micromolar concentration allowing 10% wastage in the whole process. This is 2.5 times stronger than the 10 micromolar concentration used in the recent study on skin. It seems to work well applied once or twice daily. Two months of daily application to back of right hand has now produced a noticable difference from the appearance of the left hand (hands have some issues from years of performing procedures under xray guidance). Two months of application to face and neck are showing quite surprising disapearance of wrinkles. The women relatives in my life are quite demanding that I keep them supplied. 

      If used on scalp for hair the concentration should be much less. In this case 1/4 tablet dissolved in 100ml DMSO provides about 2.2 micromolar. In the case of hair, anagen phase (growth) is encouraged by autophagy induction and inhibited by to much mtor block. In the case of rodent fur, a 1.6 micromolar concentration was effective for anagen phase induction but a 16 micromolar concentration caused problems. So far, my hair seems thicker and has more black course hairs but it is to early to know. Hope this helps

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    • Mark Thimineur that is very helpful and I will let you know how my skin and scalp experiment goes. I can’t express to you enough my gratitude and I’m sure others feel the same about the useful information you are providing. To have somebody in addition to Dr. Green who has experience with other patients is invaluable and I’m sure it gives others including myself more confidence to follow  your footsteps. The impact you’re having on others and the ripples it creates are beneficial for  so many which I’m sure is your intent. But I applaud your courage as many others for liability reasons might be afraid to share this information or subject themselves to such scrutiny. Thank you for being such a good and inspiring person!

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      • Ed
      • indigo_kettle
      • 6 mths ago
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      Mark Thimineur 
      Hi Mark...Can I use any vehicle cream for a new batch or should it specifically be the "70% DMSO/30% Aloe" you recommend? I live in Europe and can't get the application. I'd appreciate your help. tx

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    • Ed probably OK with other vehicles. I use DMSO base because the rapamycin is highly soluble in that but it likely OK in any sort of oily base

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      • JOHN
      • JOHN.1
      • 5 mths ago
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      Mark Thimineur  Hello Mark.  I was reading that rapamycin is fat soluble. I also think fisetin is good for this experiment as well so I wanted to mix these 2 together with alpha lipoic acid into Emu Oil. I heard emu oil was great at getting deep into the skin.  What do you think of this idea?  Also, I have read that DMSO is dangerous at certain amounts. 70% seems high.  The label on these bottles with dmso and aloe say that it should only be used as a solvent. What are your thoughts?

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      • curious
      • curious
      • 1 mth ago
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      Mark Thimineur MMark Thimineur 

      Do you use the rapamycin cream on your face and does it reverse wrinkles or just slow them down?

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      • curious
      • curious
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      Mark Thimineur Do transplant patients get antiaging benefits of sirolimus even though they are on a high dose?

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      • Michael
      • Michael.1
      • 2 wk ago
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      John, How are your results? Thank you

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      • Michael
      • Michael.1
      • 21 hrs ago
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      Sanford Finley Can you share an update, specifically on the topical?

      Thank you!

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  • loveyouyrlongevity Thanks for sharing your story. I think many people will be very interested to hear your ongoing experiences, especially that chat with the group when you can compare notes. 

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  • I am now in Year 2 of Rapamycin @ 5mg daily.  Have observed a 10 pound weight loss.  No problems other that at about 10 months in I developed periodic nausea with vomiting which I contribute to thinning of the mucosal  tissues.  I cannot be certain that Rapamycin was the cause and my conventional  doc said he though it was but didn't know anything about Rapamycin as a life-extension protocol.  Of course I provided him all of the DR. Blagsklonny studies,information as well as Dr. Green's website.  Bottom line I took several months off, the problem resolved and I am back on Rapamycin....BTW I am now purchasing from the new site referenced in the blog.  Paid via an e check and received the product withing two weeks.  Smooth transaction. I am also taking NAD+ via electrophoresis  patches. I have an account under NAD+ Blog.

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      • AWaller
      • AWaller
      • 1 yr ago
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      David Michel I am assuming 5mg daily was a typo? Surely you mean weekly, no?

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      • djmichel
      • CDR Phx
      • djmichel
      • 1 yr ago
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      David Michel Yes, a type,  should be 5mg weekly

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      • djmichel
      • CDR Phx
      • djmichel
      • 1 yr ago
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      David Michel Typo, should be 5mg weekly.

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      • nealfg
      • nealfg
      • 1 yr ago
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      djmichel .....Would you please spell out your pharmacy source for Rapamycin, please. 

      And how $ much?  I'm just starting my self-trial and looking for $$$-saving source.

      The suspense is terrible; hope it lasts.....nealfg

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  • Web MD has this to say in part about Rapamycin:  Rapamycin can cause mouth sores, cataracts, and diabetes. It can also raise the risks of infection, bleeding, and some types of cancers, such as skin cancer. It can cause high blood pressurefever, and anemia. How big of a concern are this potential issues? https://www.webmd.com/special-reports/anti-aging-science/20170329/anti-aging-pill

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      • AWaller
      • AWaller
      • 1 yr ago
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      Marc Someone who knows better should either correct me, or confirm what I write, but it was my interpretation that the WebMD article refers to side effects that may be observed in patients who have undergone organ transplant surgery, and are not only taking higher doses of Rapamycin daily, but also other powerful drugs in combination.
      The article does not specify the actual dose nor the frequency of Rapamycin they are prescribed (it really should!) nor what healthy people wanting anti-aging benefits should take. So in that respect I find the WebMD article a little vague in evaluating the actual dangers, and thereby potentially misleading to the downside.
      What I can gleam from reading the research on https://rapamycintherapy.com is that the longevity benefits for healthy humans relies on a strict dosage protocol of no more than 5mg per week.
      Like the old adage; the poison is in the dose. Any substance can be a lethal if taken in excess; even water (hyponatremia). 

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  • Out of all the risks you list, the only one I have known is the mouth sores once in a while.  Our study will wrap up very soon.  I am told we will meet again as a group at the end of this.  At least one of us comes from Canada.  As with all things, I imagine what you experience will have to do with individual DNA and lifestyle choices.

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  • I just received my first delivery of Rapamycin today. Should I take it on an empty stomach or with food? Is it best in the morning or at night before retiring, or does it not matter?

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  • I take it after breakfast.  I don't recall anyone saying anything about a best time, so I take it with the rest of my supplements.

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  • I take 5mg every Monday morning,  I take it on an empty stomach as I do not want it competing with other supplements.  That way I am assured I am getting the full dose.  Does not cause any distress.

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      • AWaller
      • AWaller
      • 1 yr ago
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      David Michel I just spotted in another thread on this site about rapamycin in which 'BrianMDelaney' suggested taking 5 mg with a fatty meal, because of 30% better absorption than on empty stomach.

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      • djmichel
      • CDR Phx
      • djmichel
      • 1 yr ago
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      AWaller Interesting, I'll try that.

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  •     I think Bill is now recommending that if you're suppressing AMPK sufficiently via lifestyle and Metformin then the Rapamycin isn't necessary. 

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      • AWaller
      • AWaller
      • 1 yr ago
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      DanMcL correct me if I'm wrong, but shouldn't one be activating AMPK rather than suppressing it?
      Typos aside, (and there seem to be a few on this thread :-)) please point me to where this particular recommendation of Bill's was voiced, as I have just started Rapamycin 5 weeks ago, and would like to know if he has made any such revision since.
      I am sure you must be aware of the site pointed out to us on other places on this site, but in case not: https://rapamycintherapy.com

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      • Danmoderator
      • skipping my funeral
      • dantheman
      • 1 yr ago
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      AWaller Yes thanks, typo. 

      I believe it was a recent update at the COPL channel. Worth going through the videos there, IIRC a recent talk by Bill is where he mentioned that they're finding that folks in these studies who already practice healthy lifestyles and are taking metformin that the Rapa step can be skipped. Pretty sure I've heard him say this on a few occasions, I'll dig around and see if I can find references but worth joining COPL if you haven't It's wacky, but my kind of wacky. 

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      • AWaller
      • AWaller
      • 1 yr ago
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      DanMcL Ok, I'll check it out. Thanks

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      • Danmoderator
      • skipping my funeral
      • dantheman
      • 1 yr ago
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      AWaller OK Bill and team just sent out a email update where he says

       

      "Rapamycin update


      A drug called rapamycin has been shown to markedly increase lifespan in every animal model tested.

      Initial reports from a pioneering doctor indicated substantive regenerative benefits in response to 5 mg a week of rapamycin taken along with daily metformin and other AMPK-activating compounds.

      Interim results from a clinical study, and feedback from our supporters, indicate that this dose of rapamycin (5 mg/week) may be too low.

      A clinical study on higher-dose weekly rapamycin is being planned.

      Until we verify safety/efficacy of this higher rapamycin dose, please consider lowering mTOR by using AMPK-activating interventions such as:

      • Metformin and/or
      • Restricted eating (including various forms of intermittent fasting) and/or
      • Nutrients like gynostemma pentaphyllum and hesperidin.

      When AMPK activity is increased in cells, mTOR is indirectly suppressed and autophagy is initiated. Autophagy is the removal of accumulated waste from inside old cells. It is an important step in restoring cellular functionality.

      When excess mTOR is lowered, autophagy can help rid old cells of toxic debris.

      We made a change in my video presentation to reflect our current view that the first step to age reversal is to boost AMPK activity via several validated methods."

       

      So it looks from this that the 5mg/week dosing of Rapamycin is too low, and that it is important to activate AMPK via metformin. WIP.

      I started Metformin for multiple reasons, did NAD patches, and will approach Rapamycin soon as more is known about dosing. 

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      • Danmoderator
      • skipping my funeral
      • dantheman
      • 1 yr ago
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      Update from the linked video; hot off the press "There is a change in the first step to substitute metformin and various forms of calorie reduction in lieu of rapamycin

      Current studies indicate a higher dose of rapamycin may be needed and a clinical trial is needed to validate safety and efficacy of the higher rapamycin dose

       

      So, hold off on the Rapaymycin until higher dosage safety can be established. 

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      • Iðunn
      • Iunn
      • 1 yr ago
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      DanMcL As I've posted elsewhere, it's not clear that metformin inhibits mTOR to any significant degree outside of the liver, and it clearly cannot substitute for rapamycin.

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      • Danmoderator
      • skipping my funeral
      • dantheman
      • 1 yr ago
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      Iðunn Just relaying Bills message, and regardless he’s not saying Met replaces Rapa.

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      • Iðunn
      • Iunn
      • 1 yr ago
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      DanMcL Huh? You quoted him as saying "There is a change in the first step to substitute metformin and various forms of calorie reduction in lieu of rapamycin"

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  • There are many people here who are uninformed about the science of anti-ageing using Rapamycin and Metformin.  Here is an article by Mikhail V. Blagosklonny, MD.

    He is considered the number one leading authority on ageing and treatment of such. Rapa and Metformin complement each other. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6286826/

    also: https://www.aging-us.com/

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  • Has anyone used everolimus instead of rapamycin? Everolimus appears to have lower side effects in studies. https://jim.bmj.com/content/64/4/932.2 Anyone know an inexpensive source?

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  • I have been taking 5mg/wk for 5mo; only noticeable effect is body hair (arms, legs, abdomen) has become very dark; has this happened to others?

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  • Another study on rapamycin his hit the news today, see https://www.eurekalert.org/pub_releases/2019-11/uoth-srp110619.php

    It shows that young mice given a daily dose of rapamycin preserve their good blood flow to the brain and memory into very old age.

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      • Laurence R
      • Laurence_R
      • 11 mths ago
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      Koo I read in Science Daily in a publication dated July 25, 2013:
      "[Rapamycin's] impact on aging itself is limited. The life-extending effect seems to be related to rapamycin's suppression of tumors, which represent the main causes of death in these mouse strains".
      https://www.sciencedaily.com/releases/2013/07/130725141715.htm

      I ask: How much of Rapamycin's life extension properties can really be extrapolated to humans?

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      • Koo
      • Koo
      • 11 mths ago
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      Laurence R I'm a newbie to this field of research, and I'm sure there are others that could answer you better. It seems to me that there are quite a lot of papers that demonstrate  that rapamycin down-regulates mTOR in both human cell cultures and animals. The mTOR pathways are conserved across species, so it seems likely that there will be similar effects in humans, and the human cell cultures support that. However I think that human clinical trials are still underway to see how effective rapamycin is for treating ageing in people, others on this forum will know more about these.

      Rapamycin is known to suppose at least one part of mTOR, TOR1, which controls the timing and rate of cell division, other aspects of cell metabolism and protein products. mTOR plays a key role in fibrosis, one of the major disease mechanisms in aging (eg heart disease, vascular disease, lung disease, kidney disease etc etc), and mTOR is also one pathway by which senescent cells resist cell death. So it seems that down-regulating it would be beneficial for the problems associated with aging. This is supported by a large body of research on fasting, which has similar beneficial effects. 

      Rapamycin reduces the amount of inflammatory cytokines produced by cells. Increased levels of inflammatory cytokines are associated with ageing and are made by senescent cells. The inflammatory cytokines harm healthy cells in the body, eventually turning them senescent as well, like zombies. Rapamycin also reduces the numbers of Th17 cells in people with rheumatoid arthritis, see the abstract “RAPAMYCIN INDUCES REMISSION IN PATIENTS WITH NEWLY DIAGNOSED RHEUMATOID ARTHRITIS” by Chen et . al. 2018. Th17 adds to the inflammatory feedback cascade of ageing and disease. But at the end of the day we are all experimenting here, and some of us may respond better than others.

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  • I've been taking Sirolimus for 4 weeks in amounts of 3x2mg once a week. The side effects didn't take long to show. "Commonly reported side effects of Sirolimus include: upper respiratory tract infection... extreme fatigue". I'm reducing my frequency of intake and may quit if the symptoms don't clear out. I don't see immune-suppression as a pathway to immortality. 
    See below for a comprehensive list of adverse effects.
    https://www.drugs.com/sfx/sirolimus-side-effects.html

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    • Laurence R recommend you start on a lower dose maybe 1 or 2 mg along with metformin from my experience.

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  • 2013 is long ago re: rapamycin; much newer analysis!

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  • So I came across rapamycin when I was reading a Betteraging article, and had interest in it ever since. I haven't visited the doctor yet but I'm very interested in it. Has anyone discussed this with their doctor and got recommendations to starting using it? Are doctors pro or anti rapamycin overall?

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      • Karl
      • Karl.1
      • 9 mths ago
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      Aaron Lahm It is unlikely that you will find, unless you specifically search for, a doctor that is up to speed on anti-aging therapy, and Rapamycin use.  There is even less of a chance that a doctor will prescribe a potentially dangerous drug for a non indicated condition.  Your best bet is to use referral list on this website.

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      • Laurence R
      • Laurence_R
      • 9 mths ago
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      Aaron Lahm I found my doctor through the age-reversal.net directory https://age-reversal.net/physician-directory/ . I called, doctor's assistant told me to just walk in on any Monday, waited 10 minutes in the waiting room while filling the paper work... 20 minutes later, I had my prescription for metformin and Rapamycin plus some very valuable advice. I feel lucky that he holds office only 7 miles down the road in Oldsmar (Tampa Bay area). Before that, given the potency of Rapamycin and its heavy side effects, I could not resolve myself to obtain it from a shady online pharmacy with no guidance and no assurance for quality.

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      • David H
      • David_Hanson
      • 9 mths ago
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      Laurence R If possible, would you tell me what he charged you?  I live about 30 miles from Oldsmar.

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      • Laurence R
      • Laurence_R
      • 9 mths ago
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      David Hanson Howard Chipman, $150. Very good contact. General exam + interview.

      The expensive part is the Sirolimus (Rapamycin). But a Good RX coupon slashed the price in half to a little under $500 for a 5 months supply, which will last me 6.5 months since I took on me to pass the prescribed weekly dose every 3rd week to recover from the Rapamycin nasty side effects.

      Like 1
  • This topic seems to continue at this link with a lot of relevant information.  https://forum.age-reversal.net/t/h4s991/rapamycin-self-experimentation

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  • Cross-posting from my self-experimentation

    Update on blood work after 3 months on Rapamycin and one D & Q treatment.

    For about 5 years now I've been getting poor results on kidney functions - low eGfr and high creatine. My grandfather and aunt both died of kidney disease, so i figured that was hereditary.

    My eGfr increased from averaging 52 to 89 and my Creatine dropped from 1.41 to 0.88

    I am ecstatic about these results! Didn't exercise much over the last 3 months either due to winter, so maybe able to improve.

    Using the Levine spreadsheet provided by others on this forum my predicted DNAage dropped from 63.5 with last years blood work to 51.3. Hopefully there is some validity to this! Best part is my predicted mortality risk dropped from 16.6% to 5.8% over the next 10 years

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      • Van
      • Van
      • 7 mths ago
      • 2
      • Reported - view

      Paul Beauchemin 

      Paul congratulations, I have also seen positive results with my kidney function.  If you have ever been to a kidney dialysis center, you will be very motivated to take care of your renal health.  

      Like 2
  • I am 69 yrs. old and have taken rapamycin for seven months. After three months of 5 MG. Per week, Wow. My youthful energy returned, my prostate problem improved. Before rapamycin I was sleeping 12 hrs. a day, then sitting in a chair. After 3 months rapamycin joined a jazzercise class. God be my witness. 

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