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Re: Fisetin to Clear Senescent Cells
D+F+P Side Effects with BioFisetin Yesterday my wife and I did a senolytic session for the first time since September-2020. We took 10 mg of BioPerine, followed in an hour by 200 mg of Dasatinib (4 x…
- Retired Professor of Physics
- JGC
- 5 yrs ago
- 3
- Self-Experimentation
- Reported - view
Re: GlyNAC
@Staffan Olsson BulkSupplements.com also sells NAC powder, but it's a bit more expensive: $50/kg.
- Retired Professor of Physics
- JGC
- 5 yrs ago
- 1
- Self-Experimentation
- Reported - view
Re: Gamma-Linolenic Acid (GLA), Blood Autophagy, and Phenotypic Age
@Jimmy2 Another anti-aging bubble burst!☹️ Perhaps the blood autophagy effect requires a larger dose than 400 mg/day. Or perhaps the problem is GLA insolubility and low bioavailability.…
- Retired Professor of Physics
- JGC
- 5 yrs ago
- 1
- Self-Experimentation
- Reported - view
Re: GlyNAC
@Andrew The Baylor Med paper says that the 8 old (71-80) and the 8 young (21-30) participants were given prepared capsules containing the GlyNAC dosages,…
- Retired Professor of Physics
- JGC
- 5 yrs ago
- 2
- Self-Experimentation
- Reported - view
Re: GlyNAC
I just calculated the dosage of the GlyNAC supplements that was used in the Baylor Med study. They say that they administered glycine (1.33 mmol/kg/day) and cysteine (0.81 mmol/kg/day).…
- Retired Professor of Physics
- JGC
- 5 yrs ago
- 2
- Self-Experimentation
- Reported - view
Re: GlyNAC
The study quoted above indicates that the GlyNAC benefits go away when the supplement is halted. That suggests that no epigenetic reprogramming has been achieved.
- Retired Professor of Physics
- JGC
- 5 yrs ago
- 2
- Self-Experimentation
- Reported - view
Re: GlyNAC
That's very interesting. The only source that I see online seems to be Celltrient. They sell 112 x 600 mg + 600 gm caps, taken 2/day, for $60.79. However, I see that Life Extension sells Glycine ($9.…
- Retired Professor of Physics
- JGC
- 5 yrs ago
- 1
- Self-Experimentation
- Reported - view
Re: Gamma-Linolenic Acid (GLA), Blood Autophagy, and Phenotypic Age
@Jimmy Did the -16.24 years come from my Levine Phenotypic Age spreadsheet? It's very hard to get such a low age from that calculation, because Calendar Age is one of the most influential inputs.…
- Retired Professor of Physics
- JGC
- 5 yrs ago
- Self-Experimentation
- Reported - view
Re: Gamma-Linolenic Acid (GLA), Blood Autophagy, and Phenotypic Age
@Jimmy After your new bloodwork, I look forward to learning what difference there is, if any, in your old and new MCV and RDW values. If there is blood autophagy going on, these should drop.…
- Retired Professor of Physics
- JGC
- 5 yrs ago
- 1
- Self-Experimentation
- Reported - view
Re: Gamma-Linolenic Acid (GLA), Blood Autophagy, and Phenotypic Age
@Jimmy At some point soon, you should arrange for blood tests as inputs for the Levine Phenotypic Age calculation, in order to see if the GLA you have been taking has had any "blood rejuvenating"…
- Retired Professor of Physics
- JGC
- 5 yrs ago
- 2
- Self-Experimentation
- Reported - view
Dihomo-15d-PGJ2: A New Test for Senolytic Effectiveness

The Campisi Group at the Buck Institute has published a paper in the journal Cell Metabolism showing that the presence of the molecule dihomo-15d-PGJ2 in blood or urine samples definitively…
- Retired Professor of Physics
- JGC
- updated 5 yrs ago
- 1reply
- 200
- 2
- Test Results Discussions
Gamma-Linolenic Acid (GLA), Blood Autophagy, and Phenotypic Age

A recent study published in Nature indicates that as mice age, the autophagy mechanism that clears old and damaged red blood cells falters, reducing the effectiveness of their blood circulation.…
- Retired Professor of Physics
- JGC
- 5 yrs ago
- 22replies
- 383
- 3
- Self-Experimentation
Re: Anti-Aging Self-Experiment with Epitalon (AEDG)
@JOHN Epitalon is a quad-peptide that is just the kind of amino-acid complex that our digestive systems were designed to break up into individual amino acids.…
- Retired Professor of Physics
- JGC
- 5 yrs ago
- 2
- Self-Experimentation
- Reported - view
Re: Apigenin Increases Muscle Mass And Improves Muscle Function In Both Young And Old Mice
@Jack Black Interesting. LifeExtension does sell Bio-Quercetin (30 x 29 mg caps for $9). Their blurb says this: "Our Bio-Quercetin supplement uses a quercetin encased in a plant-derived phytosome,…
- Retired Professor of Physics
- JGC
- 5 yrs ago
- General Discussion
- Reported - view
Re: Apigenin Increases Muscle Mass And Improves Muscle Function In Both Young And Old Mice
I take apigenin as a daily supplement. The problem is that apigenin is a flavenoid (like fisetin and quercetin) that has low solubility in water and tends to be broken down by the digestive system,…
- Retired Professor of Physics
- JGC
- 5 yrs ago
- General Discussion
- Reported - view
Re: Has anyone tried urolithin A?
@Geoff Welch What is your source of urolithin A? Amazon sells Celltrient Strength Capsules that list it as an ingredient, but it costs about $50 for a 2-week supply at 500 mg/day.
- Retired Professor of Physics
- JGC
- 5 yrs ago
- 1
- Self-Experimentation
- Reported - view
Anti-Aging Self-Experiment with Epitalon (AEDG)

There is a body of evidence, coming primarily from the publications of Vladimir Kh. Khavinson and his group at the Institute of Bioregulation and Gerontology (IB&G) in Moscow,…
- Retired Professor of Physics
- JGC
- 5 yrs ago
- 25replies
- 1441
- 6
- Self-Experimentation
Re: How to increase the bioavailability of Fisetin
@Chuck Frasher It does seem to be the same New Delhi pharmacy. Their prices seem to have gone up.
- Retired Professor of Physics
- JGC
- 5 yrs ago
- Self-Experimentation
- Reported - view
Re: Micro-Dosing Lithium for Life Extension - How to Divide 300mg Tablet?
@Brin Chikovski I notice that the low-dose Li study involves the subjects drinking water containing a lithium concentration level of 0.1 mg/liter. That means that for a 5 mg dose,…
- Retired Professor of Physics
- JGC
- 5 yrs ago
- 1
- Self-Experimentation
- Reported - view
Re: Micro-Dosing Lithium for Life Extension - How to Divide 300mg Tablet?
Life Extension sells 100 x 1,000 mcg (i.e. 1 mg) capsules of lithium orotate for $10.80. That's a lower dose than your 5-10 mg, but I suppose you could take 5/day.…
- Retired Professor of Physics
- JGC
- 5 yrs ago
- 1
- Self-Experimentation
- Reported - view
Re: How to increase the bioavailability of Fisetin
@RRC Two years ago Johnny Adams arranged for Echelon Biosciences to do a molecular weight check on generic Lucidas Dasatinib supplied by Lucius Pharmaceuticals that I had bought from BonHoa Pharmacy…
- Retired Professor of Physics
- JGC
- 5 yrs ago
- 1
- Self-Experimentation
- Reported - view
Re: How to increase the bioavailability of Fisetin
@RRC I don't have a lab to recommend, but any lab that can determine the molecular weight of a sample, e.g., by mass spectrometry/chromatography, should do. Fisetin has a molecular weight of 286.…
- Retired Professor of Physics
- JGC
- 5 yrs ago
- Self-Experimentation
- Reported - view
Re: How to increase the bioavailability of Fisetin
@JPA The last senolytic session that my wife and I did, last September, was done with Life Extension's new Bio-Fisetin. We assumed that their x25 bio-enhancement claim was valid,…
- Retired Professor of Physics
- JGC
- 5 yrs ago
- 5
- Self-Experimentation
- Reported - view
Re: Recent Plasma-Replacement Results
@Zisos Katsiapis In my opinion, the serious deficiency in the Conboys' plasma dilution work is that they didn't do Horvath methylation clock measurements on their mice before and after.…
- Retired Professor of Physics
- JGC
- 5 yrs ago
- 1
- Young Plasma Infusions
- Reported - view
Re: Fisetin experimentation one year (reposted as topic for info purposes)
@Andrew Whitfield The problem is that flavenoids like Fisetin, Quercetin, and Curcumin are fairly insoluble in water, and only slightly more soluble in oils.…
- Retired Professor of Physics
- JGC
- 5 yrs ago
- 2
- Senolytics Discussion
- Reported - view

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