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Re: Dr. Sinclair claims he reversed his Horvath clock by 29 years!
@Fred Cloud I see. About a year ago, aging.ai said that based on my blood analysis, my age was 35. It's actually 85.9. It isn't clear what their algorithm is, but it's noisy and inaccurate.…
- Retired Professor of Physics
- JGC
- 5 yrs ago
- 1
- General Discussion
- Reported - view
Re: Dr. Sinclair claims he reversed his Horvath clock by 29 years!
@Fred Cloud Maybe the closed-caption speech-to-text AI thing renders it as "actually I was", but if you listen carefully with your own ears, he says "let's say I was".…
- Retired Professor of Physics
- JGC
- 5 yrs ago
- General Discussion
- Reported - view
Re: Dr. Sinclair claims he reversed his Horvath clock by 29 years!
@Fred Cloud Maybe we weren't watching the same video. I just watched it again, and I think you must have misunderstood what he was saying. He said "I'm 50 now... But I might be biologically 60.…
- Retired Professor of Physics
- JGC
- 5 yrs ago
- General Discussion
- Reported - view
Re: Dr. Sinclair claims he reversed his Horvath clock by 29 years!
I just watched the video. David Sinclair did NOT say that he had reprogrammed his own epigenetic clock from 60 to 31 years. That was his example of what might be accomplished sometime in the future.…
- Retired Professor of Physics
- JGC
- 5 yrs ago
- 2
- General Discussion
- Reported - view
Re: MedLab Compounded Dasatinib/Rapamycin/NAD/hormones
@Paul Beauchemin Apparently dropshipmd.com want's to be paid by Western Union. How does that work?
- Retired Professor of Physics
- JGC
- 5 yrs ago
- New Dasatinib Sources
- Reported - view
Re: Rejuvant?
@Jim N Next week you should be able to view the recording of his talk yourself on the ARDD site. From my understanding and memory, what his group did was this: (1) injure a mouse in a particular way;…
- Retired Professor of Physics
- JGC
- 5 yrs ago
- 1
- General Discussion
- Reported - view
Re: Rejuvant?
@Iðunn On the matter of bio-clocks, in his 2020 ARDD Meeting talk on Friday, David Sinclair presented evidence from his mouse-based experiments that when his OSK cocktail of Yamanaka factors is used…
- Retired Professor of Physics
- JGC
- 5 yrs ago
- 2
- General Discussion
- Reported - view
Re: Rejuvant?
@Iðunn About your "stocastic events": there is likely some random methylation that happens to DNA in particular cells, but that should be extremely unlikely to effect all DNA,…
- Retired Professor of Physics
- JGC
- 5 yrs ago
- 1
- General Discussion
- Reported - view
Re: Rejuvant?
Questionable 13-Site DNAm Clock? On fightingaging.org, Reason says the following: "The important point to consider here is that the TrueMe Labs assay is not a relabeling of any of the more…
- Retired Professor of Physics
- JGC
- 5 yrs ago
- 1
- General Discussion
- Reported - view
The ARDD 2020 Meeting

I have spent the last four mornings watching the Copenhagen-based Aging Research and Drug Discovery (AARD) Meeting. Here are some comments on what I learned.…
- Retired Professor of Physics
- JGC
- 5 yrs ago
- 4replies
- 155
- 6
- General Discussion
Re: FDA not allowing drugs in?
@Randy B Hey, it's great that you are a rule-following Law-Abiding Citizen, but the FDA Rules are based on the antique and disproved view that aging is a natural and inevitable condition that…
- Retired Professor of Physics
- JGC
- 5 yrs ago
- 2
- General Discussion
- Reported - view
Re: FDA not allowing drugs in?
@Paul Beauchemin The FDA at JFK did the same thing to me, seizing a shipment to me of MetPro Metformin purchased for about $40 from the AntiAging Store in Singapore.…
- Retired Professor of Physics
- JGC
- 5 yrs ago
- 1
- General Discussion
- Reported - view
Re: Fisetin to Clear Senescent Cells
@JGC My order of Zithromax from the Online Drugstore finally arrived two weeks ago, after a 3 month + delay. I guess one just has to be patient in this era for the Plague.
- Retired Professor of Physics
- JGC
- 5 yrs ago
- 3
- Self-Experimentation
- Reported - view
Re: NUCHIDO
Parsley extract powder is supposed to be 13% Apigenin. I just ordered enough powder forms of all the NCD201.2 ingredients to make about 100 doses from VitaSpace.com.…
- Retired Professor of Physics
- JGC
- 5 yrs ago
- 1
- NAD+ Restoration
- Reported - view
Re: NUCHIDO
Primary Source of NCD201 Ingredients I found the primary source of the NCD201.1 ingredients listed above. It is from a patent application by Conlon, and can be viewed at this LINK.…
- Retired Professor of Physics
- JGC
- 5 yrs ago
- NAD+ Restoration
- Reported - view
Re: Introduction to Young Plasma Infusions
@Dan Nave That is the work of Prof. Irina Conboy's group at UC Berkeley. It's good stuff, and it can probably be put into practice without a lot of FDA red tape.…
- Retired Professor of Physics
- JGC
- 5 yrs ago
- 1
- Young Plasma Infusions
- Reported - view
Re: Introduction to Young Plasma Infusions
There is an interesting article about Harold Katcher's "Elixir" experiment (unknown young-rat plasma fraction rejuvenating old rats) that was posted last June on LongeCity.…
- Retired Professor of Physics
- JGC
- 5 yrs ago
- 1
- Young Plasma Infusions
- Reported - view
Re: NUCHIDO
@Fred Cloud I think the "parsley leaf powder" is supposed to supply the Apigenin. And the "green tea extract" is supposed to provide the flavenoids. However,…
- Retired Professor of Physics
- JGC
- 5 yrs ago
- 1
- NAD+ Restoration
- Reported - view
Re: NUCHIDO
NAD+ vs Age FYI, here's a graph of some measurements of NAD+ vs age in humans.
- Retired Professor of Physics
- JGC
- 5 yrs ago
- 2
- NAD+ Restoration
- Reported - view
Re: NUCHIDO
I can think of two reasons: (1) They could patent their Proprietary Blend or keep it a trade secret, and (2) boosting NAD+ by almost a factor of 10 is possibly dangerous overkill,…
- Retired Professor of Physics
- JGC
- 5 yrs ago
- 1
- NAD+ Restoration
- Reported - view
Re: NUCHIDO
Update: In the above post, I was implicitly assuming that the Interventions NCD201.1 and NCD201.2, as described in the 2019 poster, and Nuchido's commercial Time+ product had more or less the same…
- Retired Professor of Physics
- JGC
- 5 yrs ago
- 3
- NAD+ Restoration
- Reported - view
Re: NUCHIDO
I have spent some time going over the Nuchido site and chasing down some interviews with its CEO Dr. Nichola Conlon. They are at the very beginning of their commercial operation,…
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- Retired Professor of Physics
- JGC
- 5 yrs ago
- 1
- NAD+ Restoration
- Reported - view
Re: Biological Age Test #4 in 2020: Getting Better or Getting Worse?
@Paul Beauchemin I have said before that I think including calendar age as a parameter in an estimate of phenotypic age is, in a way, cheating. However, that's what Levine & Co did,…
- Retired Professor of Physics
- JGC
- 5 yrs ago
- Self-Experimentation
- Reported - view
Re: Biological Age Test #4 in 2020: Getting Better or Getting Worse?
Michael, Your analysis ignores the fact that some of the inputs to the Levine phenotypic age calculation have a much bigger impact than do others. Here are the results of doing a 5% variation on…
- Retired Professor of Physics
- JGC
- 5 yrs ago
- 1
- Self-Experimentation
- Reported - view
Re: FDA not allowing drugs in?
I had a shipment from Singapore of Metformin seized by the FDA at JFK airport last year. I complained to the supplier, the Anti-Aging Store, and they sent me a replacement that arrived OK.…
- Retired Professor of Physics
- JGC
- 5 yrs ago
- 1
- General Discussion
- Reported - view

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