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Re: Fisetin to Clear Senescent Cells
@Zisos Katsiapis It is confusing. Let me see if I can make it clearer. Aging.AI takes bloodwork vs. calendar age data from as many people as possible, does a linear fit,…
- Retired Professor of Physics
- JGC
- 5 yrs ago
- 1
- Self-Experimentation
- Reported - view
Re: Fisetin to Clear Senescent Cells
@Van The paper to which Dr. Green refers in his interview, by Sargiacomo, Sotgia, and Lisanti, makes an interesting case for a strong link between COVID-19 mortality and age-related senescent cells.…
- Retired Professor of Physics
- JGC
- 5 yrs ago
- 2
- Self-Experimentation
- Reported - view
Re: Introduction to Young Plasma Infusions
@Fred Cloud Yes. But he won't before they do animal tests. Their plan is to get $50M of venture capital and set up a branch in California that rejuvenates dogs and cats.…
- Retired Professor of Physics
- JGC
- 5 yrs ago
- Young Plasma Infusions
- Reported - view
Re: Introduction to Young Plasma Infusions
I just looked up the size of TET1, which is the smallest of the three TET proteins. It has a mass of 80,000 Daltons (which we physicist call 80,000 AMU).…
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- Retired Professor of Physics
- JGC
- 5 yrs ago
- 1
- Young Plasma Infusions
- Reported - view
Re: Introduction to Young Plasma Infusions
@Joe smith Thanks, Joe. I will ask Katcher to deny (as he did for GDF11) that the TET enzymes play a role in Elixir, and see what he says.
- Retired Professor of Physics
- JGC
- 5 yrs ago
- 2
- Young Plasma Infusions
- Reported - view
Re: Introduction to Young Plasma Infusions
@Fred Cloud One can peer a bit behind the Elixir curtain. Harold Katcher has commented that their Elixir does not contain GDF11, which is downstream from the effects they are producing.…
- Retired Professor of Physics
- JGC
- 5 yrs ago
- 2
- Young Plasma Infusions
- Reported - view
Re: Introduction to Young Plasma Infusions
"Elixir" Resets Horvath's Clock This is the work being referred to above. A preprint was recently placed on BioRXiv at https://www.biorxiv.org/content/10.1101/2020.05.07.…
- Retired Professor of Physics
- JGC
- 5 yrs ago
- 3
- Young Plasma Infusions
- Reported - view
Re: Senolytic Self-experiments and COVID-19
@Andrew P K Yap The paper you reference argues that senescent cells protect against the vesicular stomatitis virus (VSV). In that sense, senescence is antiviral.…
- Retired Professor of Physics
- JGC
- 5 yrs ago
- Self-Experimentation
- Reported - view
Re: Senolytic Self-experiments and COVID-19
@Andrew P K Yap I read on Wikipedia about the vesicular stomatitis virus (VSV). It appears to be apples-to-oranges to compare it to COVID-19. It's a rabies-like negative-sense RNA virus (COVID is…
- Retired Professor of Physics
- JGC
- 5 yrs ago
- Self-Experimentation
- Reported - view
Senolytic Self-experiments and COVID-19

There is evidence that the TOP2 receptor that the COVID-19 virus uses to enter cells is more prevalent in senescent cells. Also, clearing accumulated senescent cells from the immune system probably…
- Retired Professor of Physics
- JGC
- 5 yrs ago
- 10replies
- 263
- 1
- Self-Experimentation
Re: Introduction to GDF-11
Needle-free Injection and GDF11 On reading an article by Reason on his FightAging site about another kind of self-experimentation, I learned that one can now buy needle-free injection devices that…
- Retired Professor of Physics
- JGC
- 5 yrs ago
- GDF11 Restoration
- Reported - view
Re: Introduction to GDF-11
@Fred Cloud If there are reliable instructions for dissolving, diluting, and storing GDF11 on Facebook, It would be nice if they could be re-posted here.
- Retired Professor of Physics
- JGC
- 5 yrs ago
- GDF11 Restoration
- Reported - view
Re: Preparations for self-treating COVID-19
@albedo She should take a zinc supplement too.
- Retired Professor of Physics
- JGC
- 5 yrs ago
- 2
- Self-Experimentation
- Reported - view
Re: Preparations for self-treating COVID-19
@Karl I agree with your statement. The French study was far from perfect and is at best a positive indication of a possible treatment. However, it's important not to confuse the side effects of…
- Retired Professor of Physics
- JGC
- 5 yrs ago
- Self-Experimentation
- Reported - view
Re: Preparations for self-treating COVID-19
@Karl Wrong. The followup Chinese study used only hydroxychloroquine, for some reason.
- Retired Professor of Physics
- JGC
- 5 yrs ago
- Self-Experimentation
- Reported - view
Re: Preparations for self-treating COVID-19
@Gary Gilley Last week I bought the azithromycin from the Online Drugstore, and the hydrochloroquine from Trust Pharmacy. I found the latter after trying various other Indian pharmacies that were…
- Retired Professor of Physics
- JGC
- 5 yrs ago
- 2
- Self-Experimentation
- Reported - view
Re: Preparations for self-treating COVID-19
First, chloroquine (recently promoted by Trump) has some known negative side effects like liver damage and macular degeneration of the eyes that would be best to avoid.…
- Retired Professor of Physics
- JGC
- 5 yrs ago
- 1
- Self-Experimentation
- Reported - view
Preparations for self-treating COVID-19

The mortality rate of the aged population from COVID-19 is very high, around 20% for the over-80 group of which I and my wife are members. Further, if medical facilities are limited and physicians…
- Retired Professor of Physics
- JGC
- 5 yrs ago
- 88replies
- 1159
- 3
- Self-Experimentation
Re: A Spreadsheet for Calculating Your Levine Phenotypic Age
@Patrick Jane The unit x10^9/L is the same as x10^3/uL because there are 10^6 uL in 1 L. There is no obvious way to convert x10^9/L to a %, unless you know the concentration of the other blood cell…
- Retired Professor of Physics
- JGC
- 5 yrs ago
- Assessing Biological Age
- Reported - view
Re: Fisetin to Clear Senescent Cells
@Jacques Mathieu That's really interesting work, Jacques. I received my order of 25 g of 2-Hydroxypropyl-beta-cyclodextrin last week, but I haven't done anything with it yet.…
- Retired Professor of Physics
- JGC
- 5 yrs ago
- Self-Experimentation
- Reported - view
Re: Fisetin to Clear Senescent Cells
@Philip V. Anstett It's deja vu all over again. If you scroll up to posts from one year ago, you will find that I already answered this question, as asked by Iðunn, and gave a reference.
- Retired Professor of Physics
- JGC
- 5 yrs ago
- 2
- Self-Experimentation
- Reported - view
Re: A Spreadsheet for Calculating Your Levine Phenotypic Age
@Zisos Katsiapis The spreadsheet actually calculates the mortality score first and then converts that to the phenoage. The relation for the conversion, supplied by the Levine group,…
- Retired Professor of Physics
- JGC
- 5 yrs ago
- 1
- Assessing Biological Age
- Reported - view
Re: A Spreadsheet for Calculating Your Levine Phenotypic Age
@Zisos Katsiapis Based on the input parameters, among other things the spreadsheet calculates the "Mortality Score", which is the probability that you will die of age-related causes in the next "t"…
- Retired Professor of Physics
- JGC
- 5 yrs ago
- Assessing Biological Age
- Reported - view
Re: Fisetin to Clear Senescent Cells
Partial Answer I found a paper by some researchers in Thailand in which they actually do a computer simulation to investigate how Fisetin threads through the hole in Beta-Cyclodextrin and how this…
- Retired Professor of Physics
- JGC
- 5 yrs ago
- 1
- Self-Experimentation
- Reported - view
Re: Fisetin to Clear Senescent Cells
Fisetin + Hydroxypropyl-Beta-Cyclodextrin? Some of you may understand more about the arcane subject of biochemistry and molecular structure than does a simple-minded nuclear physicist like me,…
- Retired Professor of Physics
- JGC
- 5 yrs ago
- Self-Experimentation
- Reported - view

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