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Re: Rapamycin Cost
@Steve Roedde I note that the lab tests available at low cost through LifeExtension do not include a test for the serum Sirolimus (Rapamycin) level. Too bad.
- Retired Professor of Physics
- JGC
- 5 yrs ago
- Self-Experimentation
- Reported - view
Re: How to increase the bioavailability of Fisetin
Folllowup on Nature's Essentials use of Cyclodextrins My order of Nature's Essentials Tumeric/Curcumin just arrived. They are long-ish orange tablets, about an inch long and 1/3 inch wide.…
- Retired Professor of Physics
- JGC
- 5 yrs ago
- 1
- Self-Experimentation
- Reported - view
Re: How to increase the bioavailability of Fisetin
@David Hanson I just ordered their liposome + cyclodextrin enhanced Resveratrol and Curcumin products from Nature's Essentials. I'll report any observations when I've received it and taken some.…
- Retired Professor of Physics
- JGC
- 5 yrs ago
- 1
- Self-Experimentation
- Reported - view
Re: How to increase the bioavailability of Fisetin
@JOHN I think a couple of grams of Fisetin in olive oil taken a couple of times would be good for him. I'm not aware of med conflicts with Fisetin.
- Retired Professor of Physics
- JGC
- 5 yrs ago
- Self-Experimentation
- Reported - view
Re: How to increase the bioavailability of Fisetin
@Dan Nave I don't have any publication to back it up, but I reason that the drug breakdown-compound P-glycoprotein, which breaks down polyphenols and is resident in the small intestine,…
- Retired Professor of Physics
- JGC
- 5 yrs ago
- 1
- Self-Experimentation
- Reported - view
Re: How to increase the bioavailability of Fisetin
More on Cyclodextrin A little further research indicates a problem in what I suggested. Apparently, ß-cyclodextrin is about x10 less soluble in water than its molecular relatives alpha and gamma…
- Retired Professor of Physics
- JGC
- 5 yrs ago
- Self-Experimentation
- Reported - view
Re: Rapamycin Cost
@Steve Roedde OK, that link takes me to Wuhan Hengheda Pharma Co. Limited. They do seem to sell Rapamycin powder for $1-5 per gram in minimum lots of 100 grams.…
- Retired Professor of Physics
- JGC
- 5 yrs ago
- 1
- Self-Experimentation
- Reported - view
Re: Rapamycin Cost
@Steve Roedde What is the contact information for your Chinese source of rapamycin?
- Retired Professor of Physics
- JGC
- 5 yrs ago
- Self-Experimentation
- Reported - view
Re: How to increase the bioavailability of Fisetin
@JOHN I'm a physicist, not an MD, so my opinion is not worth much in this area. However, if it were me deciding, I'd do it, since the only known side effects of burst-doses of Fisetin and D+Q are…
- Retired Professor of Physics
- JGC
- 5 yrs ago
- Self-Experimentation
- Reported - view
Re: How to increase the bioavailability of Fisetin
@Staffan Olsson That's an interesting article. Near the end, it discusses techniques for the delivery of polyphenols, and mentions the use of cyclodextrins.…
- Retired Professor of Physics
- JGC
- 5 yrs ago
- 2
- Self-Experimentation
- Reported - view
Re: How to increase the bioavailability of Fisetin
@Staffan Olsson The Fisetin metabolites may perhaps play a role in the in vivo results with animal models. However, in the initial work on human senescent cell cultures that indicated the senolytic…
- Retired Professor of Physics
- JGC
- 5 yrs ago
- Self-Experimentation
- Reported - view
Re: Resveratrol -- value, dose, source?
@Dan Nave OK, I think I have the Resveratrol situation sorted out, and I plan to proceed as follows: I just ordered 2 bottles of Nitro Super Micronized Resveratrol (Nitro250) caps (30 x 250 mg) from…
- Retired Professor of Physics
- JGC
- 5 yrs ago
- 2
- Self-Experimentation
- Reported - view
Re: Resveratrol -- value, dose, source?
@Staffan Olsson Careful! Their caps are 250 mg, NOT 500 mg. For some reason, these pill peddlers misrepresent their product by putting the "serving size" (500 mg) on the label instead of the capsule…
- Retired Professor of Physics
- JGC
- 5 yrs ago
- 3
- Self-Experimentation
- Reported - view
Re: Resveratrol -- value, dose, source?
@David Hanson Interesting. That chart looks promising, in that they achieve 200 micromoles per milliliter at the peak. However, it lasts for only about 20 minutes.…
- Retired Professor of Physics
- JGC
- 5 yrs ago
- 2
- Self-Experimentation
- Reported - view
Re: Resveratrol -- value, dose, source?
Resveratrol Bioavailability? A bit of literature search on resveratrol indicates that it has a serious bioavailability problem. If one takes ~1000 mg capsules orally,…
- Retired Professor of Physics
- JGC
- 5 yrs ago
- 1
- Self-Experimentation
- Reported - view
Re: The "Reprogramming" of Aging Cells
@Robert Reny Blood Protiens and Age The blood protein study done by a Stanford group and published in Nature gives the following twenty blood proteins as those with the highest correlations with…
- Retired Professor of Physics
- JGC
- 5 yrs ago
- 1
- General Discussion
- Reported - view
Re: How to increase the bioavailability of Fisetin
@JOHN I agree that DMSO, while it does dissolve flavenoids, may produce problems on its own. If you do try it on your face, start with a very small patch.…
- Retired Professor of Physics
- JGC
- 6 yrs ago
- 1
- Self-Experimentation
- Reported - view
Re: Fisetin to Clear Senescent Cells
@Koo That's very interesting. My wife and I had used 2000 mg in warm olive oil for 2 days. We didn't notice any symptoms as extreme as those you describe.…
- Retired Professor of Physics
- JGC
- 6 yrs ago
- Self-Experimentation
- Reported - view
Re: A Spreadsheet for Calculating Your Levine Phenotypic Age
@Dennis I haven't actually tried it, but I believe that OpenOffice, which is free, provides an Excel-like alternative that will execute my spreadsheet.
- Retired Professor of Physics
- JGC
- 6 yrs ago
- 1
- Assessing Biological Age
- Reported - view
Re: Sources for Metformin?
@Patrick McHargue Thanks for the link, Patrick. Yesterday I used it to place an order for Metformin. No prescription (outside the EU) is required, and it has already been shipped.…
- Retired Professor of Physics
- JGC
- 6 yrs ago
- Self-Experimentation
- Reported - view
Re: Cell Death Mechanisms Behind D+Q and Fisetin Senolytics
Correction: 2,000 mg/day (not 2,000 gram/day)
- Retired Professor of Physics
- JGC
- 6 yrs ago
- Self-Experimentation
- Reported - view
Cell Death Mechanisms Behind D+Q and Fisetin Senolytics

After having done about 9 months of self-experimentation with the effects of D+Q and Fisetin senolytic burst-treatments, I and others in my family have noticed that senolytics with D+Q tends to…
- Retired Professor of Physics
- JGC
- 6 yrs ago
- 45replies
- 1080
- 2
- Self-Experimentation
Re: NAD+ and Cancer
An article was just published in the Scientific American that highlights the emerging evidence that NAD+ fuels the rapid growth of cancer cells. For me,…
- Retired Professor of Physics
- JGC
- 6 yrs ago
- 1
- Self-Experimentation
- Reported - view
Re: Fisetin to Clear Senescent Cells
@BobM My wife and I have close to the sam body weight and had done three sessions of Bioperine (10 mg/day) and Fisetin (2,000 mg/day in olive oil) about August 15-17,…
- Retired Professor of Physics
- JGC
- 6 yrs ago
- Self-Experimentation
- Reported - view
Re: Fisetin to Clear Senescent Cells
Unpleasant Side-Effects from a D+Q+F+P Session Yesterday morning, my wife, daughter, and I did D+Q-based senolytic sessions. I took 10 mg of Bioperine, followed in 2 hours by 200 mg of Dasatinib, 2,…
- Retired Professor of Physics
- JGC
- 6 yrs ago
- 3
- Self-Experimentation
- Reported - view

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