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KLOTHO and GABA for Brain Enhancement
There is an article in today's NY Times about the wonders of KLOTHO, a recently discovered brain hormone that, at least in mice, increases lifespan, wards off Alzheimer's,…
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The "Reprogramming" of Aging Cells
Researchers associated with the company Turn.bio have a new publication that describes the "reprogramming" and rejuvenation of aging cell cultures by infusing them with a "cocktail" of six different…
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DMSO for Increased Flavenoid Solubility and Bioavailability?
The problem with the bio-delivery of senolytic flavenoids like Quercetin and Fisetin is that they are insoluble in water. Therefore, there is a good chance that if taken orally,…
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J. W. Campbell's 1949 Editorial on Life Extension
When I was an impressionable 14-year-old I recall reading a very impressive editorial in the April-1949 issue of Astounding Science Fiction, the then-flagship magazine of the Golden Age of Science…
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The purity of Lucidias-brand Dasatinib
Last year I obtained a 60-tablet bottle of 50 mg Lucidias-brand Dasatinib from BonHoa Pharmacy in New Deli, India, link https://www.bonhoa.com. It seems to be manufactured by Lucius Pharmaceuticals…
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Monitoring Senescent Cell Clearance with Cytokine Levels
Many of us have been attempting to clear our senescent cells with large senolytic doses of Fisetin and/or Dasatinib plus Quercetin. There have been many anecdotal reports of "feeling better" or…
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DPP4 Assay - A Suggestion for Senescent-Cell-Burden Estimation
In doing self-experimentation with senolytic drugs like Fisetin and/or D+Q, we are attempting to reduce the body's burden of senescent cells to promote health and anti-aging.…
