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The "Reprogramming" of Aging Cells
Researchers associated with the company Turn.bio have a new publication that describes the "reprogramming" and rejuvenation of aging cell cultures by infusing them with a "cocktail" of six different…
- JGC
- Retired Professor of Physics
- JGC
- 5 yrs ago
- 6replies
- 270
- 3
- General Discussion
Re: DMSO for Increased Flavenoid Solubility and Bioavailability? Followup on my DMSO Question Dr. John Sanderson sent me an email answering my question in some detail. He said that "using penetration enhancers such as DMSO may improve the picture slightly,…
- JGC
- Retired Professor of Physics
- JGC
- 5 yrs ago
- Self-Experimentation
- Reported - view
DMSO for Increased Flavenoid Solubility and Bioavailability?
The problem with the bio-delivery of senolytic flavenoids like Quercetin and Fisetin is that they are insoluble in water. Therefore, there is a good chance that if taken orally,…
- JGC
- Retired Professor of Physics
- JGC
- 5 yrs ago
- 3replies
- 420
- 1
- Self-Experimentation
Re: Fisetin to Clear Senescent Cells @JPA The purity issues are (a) does the product actually contain the molecule of interest and (b) does the product contain contaminants that might have negative effects.…
- JGC
- Retired Professor of Physics
- JGC
- 5 yrs ago
- 8
- Self-Experimentation
- Reported - view
Re: J. W. Campbell's 1949 Editorial on Life Extension Another J. W. Campbell Editorial on Aging and Bio-Life I notice from the same Astounding archive that John W. Campbell, Jr. also wrote another editorial, this one in the September-1948 Astounding SF,…
- JGC
- Retired Professor of Physics
- JGC
- 5 yrs ago
- General Discussion
- Reported - view
J. W. Campbell's 1949 Editorial on Life Extension
When I was an impressionable 14-year-old I recall reading a very impressive editorial in the April-1949 issue of Astounding Science Fiction, the then-flagship magazine of the Golden Age of Science…
- JGC
- Retired Professor of Physics
- JGC
- 5 yrs ago
- 3replies
- 71
- 1
- General Discussion
Re: Bloodwork for a baseline For monitoring "blood age" calculated from Aging AI and young.ai, and for using the spreadsheet that calculates the Levine Phenotypic Age, I have used values from bloodwork arranged by LifeExtension.…
- JGC
- Retired Professor of Physics
- JGC
- 5 yrs ago
- General Discussion
- Reported - view
Re: How to increase the bioavailability of Fisetin @iunn It isn't clear to me why you think that suppressing the production of the drug breakdown-compound P-glycoprotein should be related to the permeability of the blood-brain barrier.…
- JGC
- Retired Professor of Physics
- JGC
- 5 yrs ago
- 3
- Self-Experimentation
- Reported - view
The purity of Lucidias-brand Dasatinib
Last year I obtained a 60-tablet bottle of 50 mg Lucidias-brand Dasatinib from BonHoa Pharmacy in New Deli, India, link https://www.bonhoa.com. It seems to be manufactured by Lucius Pharmaceuticals…
- JGC
- Retired Professor of Physics
- JGC
- 5 yrs ago
- 12replies
- 474
- 5
- Self-Experimentation
Re: Monitoring Senescent Cell Clearance with Cytokine Levels @murray flewelling The journal publication describing the senolytic tests of Fisetin on mice is available HERE. The difference between taking small doses of Fisetin regularly as a health supplement…
- JGC
- Retired Professor of Physics
- JGC
- 5 yrs ago
- 1
- Self-Experimentation
- Reported - view
Re: Monitoring Senescent Cell Clearance with Cytokine Levels @murray flewelling I think that it would be good for you to give a senolytic like Fisetin (or D+Q if you can obtain the Dasatinib) to your mother, but there are no guarantees.…
- JGC
- Retired Professor of Physics
- JGC
- 5 yrs ago
- 1
- Self-Experimentation
- Reported - view
Re: Monitoring Senescent Cell Clearance with Cytokine Levels @murray This is dismayingly off the topic here, but in my opinion Unity Bio has distinguished themselves mainly by extracting large contributions from aging billionaires.…
- JGC
- Retired Professor of Physics
- JGC
- 5 yrs ago
- 2
- Self-Experimentation
- Reported - view
Monitoring Senescent Cell Clearance with Cytokine Levels
Many of us have been attempting to clear our senescent cells with large senolytic doses of Fisetin and/or Dasatinib plus Quercetin. There have been many anecdotal reports of "feeling better" or…
- JGC
- Retired Professor of Physics
- JGC
- 5 yrs ago
- 20replies
- 514
- 2
- Self-Experimentation
Re: DPP4 Assay - A Suggestion for Senescent-Cell-Burden Estimation I see from their website that Pacific Biomarkers, which seems to be located in Seattle not far from the Space Needle, lists DPPIV (i.e., DPP4) as one of the biomarkers they can do an assay on.…
- JGC
- Retired Professor of Physics
- JGC
- 5 yrs ago
- 1
- Assessing Biological Age
- Reported - view
Re: Metformin in practice @CSC I note that Antiaging Clinic sells 60 x 20 mg Dasatinib (Sprycel) tablets for a mere $1,499.99. I guess that's better than $2k for 4 pills, but it still reflects the rapacious pricing of…
- JGC
- Retired Professor of Physics
- JGC
- 5 yrs ago
- 2
- General Discussion
- Reported - view
DPP4 Assay - A Suggestion for Senescent-Cell-Burden Estimation
In doing self-experimentation with senolytic drugs like Fisetin and/or D+Q, we are attempting to reduce the body's burden of senescent cells to promote health and anti-aging.…
- JGC
- Retired Professor of Physics
- JGC
- 5 yrs ago
- 4replies
- 137
- 1
- Assessing Biological Age
Re: Dasatinib @Peter5.0 Here's what the Wikipedia article on Dasatinib has to say about Bristol-Meyers Squibb pricing: "The Union for Affordable Cancer Treatment objected to the price of dasatinib,…
- JGC
- Retired Professor of Physics
- JGC
- 5 yrs ago
- 2
- Self-Experimentation
- Reported - view
Re: Dasatinib @Peter5.0 I did purchase a bottle of Lucidas Pharmaceuticals brand 60 Dasatinib 50 mg tablets from BonHoa for a bit over $200. I have no way of evaluating the quality as compared to the…
- JGC
- Retired Professor of Physics
- JGC
- 5 yrs ago
- 4
- Self-Experimentation
- Reported - view
Re: Fisetin to Clear Senescent Cells @karl kuffner Fisetin by itself has been shown in a publication in a refereed journal to cause senescent cells to go in to aptosis and disappear. Further Fisetin is relatively cheap ($12.…
- JGC
- Retired Professor of Physics
- JGC
- 5 yrs ago
- 3
- Self-Experimentation
- Reported - view
Re: Fisetin to Clear Senescent Cells @LISBETH Prieto Correction: "senescent cells", not "senolytic cells". JGC
- JGC
- Retired Professor of Physics
- JGC
- 5 yrs ago
- Self-Experimentation
- Reported - view
Re: Fisetin to Clear Senescent Cells @LISBETH Prieto I have not tried LifeExtension's Senolytic Activator. Its main senolytic ingredient is the flavenoid Quercetin. I have taken Quercetin along with Dasatinib and Bioperine (a…
- JGC
- Retired Professor of Physics
- JGC
- 5 yrs ago
- 2
- Self-Experimentation
- Reported - view
Re: Fisetin to Clear Senescent Cells Senolytic Bloodwork Results from 2 Fisetin and 3 D+Q+... Sessions A while back I reported on the bloodwork results for my wife (PBC) and I (JGC) taken before and after two large-dose sessions of…
- JGC
- Retired Professor of Physics
- JGC
- 5 yrs ago
- 5
- Self-Experimentation
- Reported - view
Re: Fisetin to Clear Senescent Cells @BobM Yes, that capsule looks just like the 100 mg fisetin capsules that I have bought from Swanson and from Doctor's Best/Amazon. However, my point was that for senolytic doses one needs to take on…
- JGC
- Retired Professor of Physics
- JGC
- 5 yrs ago
- 4
- Self-Experimentation
- Reported - view
Re: Is Young Plasma Really a Worthwhile Treatment for Aging? @Jungle Joel I think we are comparing apples with oranges here, as they say. I suspect that your Thai physician transfused a half-liter (1.1 pints) of whole blood (cells and all) from your GF's son…
- JGC
- Retired Professor of Physics
- JGC
- 5 yrs ago
- General Discussion
- Reported - view
Re: A Senolytic Alternative: D+F+P? We just did D+Q+F+P. On careful consideration, after having done two rounds of D+Q+P a week apart, my wife and I decided to finish off the series a week later by adding Fisetin and doing a round of…
- JGC
- Retired Professor of Physics
- JGC
- 5 yrs ago
- 3
- Self-Experimentation
- Reported - view

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JGC

Retired Professor of Physics

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Joined: Mon Aug 13 01:22:01 UTC 2018

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