The purity of Lucidias-brand Dasatinib
Last year I obtained a 60-tablet bottle of 50 mg Lucidias-brand Dasatinib from BonHoa Pharmacy in New Deli, India, link https://www.bonhoa.com. It seems to be manufactured by Lucius Pharmaceuticals of Columbo, Siri Lanka.
There has been some concern about the purity of such a generic pharmaceutical obtained abroad, as an end-tun around the rapacious prices charged by Bristol Meyers-Squibb for their Sprycel-brand of Dasatinib.
I recently contributed one of my Lucidias-brand 50 mg Dasatinib tablets for testing, and the Gerontology Research Group funded a chromatogram test of it by Echelon Biosciences. The test result shows a large peak at the molecular weight of Dasatinib, as expected for a pure product. There is also a much smaller peak (<0.05%) at a slightly higher molecular weight. This might represent a slight impurity, but according to the lab it shouldn't be a problem.
Thus, we have verified that Lucidias-brand Dasatinib seems to be completely equivalent to the much more expensive Sprycel product.
JGC, thanks for sharing the findings. I, and others, have taken Lucidas dasatinib, so the assay results are reassuring (though one wonders what the impurity might be...).
IAS is currently working on compounding a version that will by only a bit more expensive than Lucidas, but – I'm quite certain – will be a more reliably high-quality product. There will be an announcement here when it is available.
Thank you John and Brian.
I had sent the original reference samples along with dasatinib tablets purchased from various sources to the testing lab, and later facilitated testing of John's tablet.
I strongly suggest you to have anything purchased from an offshore source tested for purity and content. And suggest that testing one pill probably assures the rest in the bottle is OK, and the entire lot is probably OK – but that does not necessarily mean that all future tablets purchased from that source will be pure and contain the indicated content.
If you go the offshore route let me know. I would be glad to facilitate the testing. The lab we use already has the HPLC (high-performance liquid chromatography) data for testing samples against a generic (known) quality of dasatinib acquired from Sigma, as well as from a US pharmacy. That up front work is done so cost would be low. Cost for John's was $200, and if that's a problem our group could possibly share in the cost or cover it completely.
Contact info JAdams@grg.org (949)922-9786
We could also have other aging therapies/pharmaceuticals tested.
Years ago I learned counterfeiting is a huge international issue – not just Gucci bags and GI Joes, but pharmaceuticals, airplane parts, etc. It’s probably only grown worse. Appearance and packaging are VERY convincing. A phony Apple store was opened in China with real looking Apple products.
The lab is Echelon Biosciences, and my contact is Mark Nelson at 801-588-0455 ex 308 -- but since I have a working relationship with them and went through a lot of time to locate, screen, and engage their services, I urge you to have me involved.