KLOTHO and GABA for Brain Enhancement

  There is an article in today's NY Times about the wonders of KLOTHO, a recently discovered brain hormone that, at least in mice, increases lifespan, wards off Alzheimer's, and increases mental acuity.  Researchers are using gene manipulation to increase KLOTHO production in mice, with spectacular results.

  A bit of internet research turned up a paper entitled "The anti-aging protein Klotho is induced by GABA therapy ...", which indicates that the dietary supplement GABA (GAMMA-AMINOBUTYRIC ACID)  boosts the production of KLOTHO in mice.

  On the basis of that, today we ordered four bottles of 60 x 750 mg GABA (maximum strength) from Swanson's for $4.79 a bottle.  In a month or so, I'll report whether my brain feels "enhanced".

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  • Exercise stimulates Klotho too.

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  • I’ve been taking GABA for years, usually just 750mg a day, but for workout purposes I’ve taken 3,000mg a day per cycle. I feel like I get the benefits of a half year’s worth of meditation in one bottle! 

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  • Thanks for the recommendation, JGC!  I just added this to my supplement regimen.

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  • Hi JGC, it’s been about a month, curious to hear about your experience/results 🤓

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  • We had ordered four bottles of 60 x 750 mg GABA (maximum strength) from Swanson's for $4.79 a bottle.  Pauline and I took 750 mg twice a day until we ran out.  We didn't really notice any big effects on memory or mental sharpness, positive or negative.  I haven't reordered yet, but I may do so soon.

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  • JGC I decided to finally try the klotho, I have been taking 3.5pg per week by injection and absolutely loving it. The cognition improvements are very noticeable, works well with GDF11.

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    • Fred Cloud that’s pretty exciting. Are you a participant in a human trial? If not, and you are doing this on your own, I assume it must be with physician oversight?

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      • Fred Cloud
      • Fred_Cloud
      • 5 days ago
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      chuck stanley Why would you assume it was with a trial or physician oversight?

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    • Fred Cloud I guess my real questions were if it was a clinical trial, how would one participate?  If you did this based on your own research, how did you calculate the dosage? how did you obtain or prepare injectable klotho? and what if any markers would you be watching for in later blood tests.  I didnt find answers to those questions in the studies that I reviewed. 

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      • Fred Cloud
      • Fred_Cloud
      • 5 days ago
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      chuck stanley I just googled it and found other people using it and followed their dose and protocol and source just like I did with GDF11. I would join the facebook klotho group and you can find all the answers and support there too.

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  • Am very interested after hearing Vince mention it activates JMJD3

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  • Klotho is an exciting treatment option, though a lot needs to be learned about dosing. Too much may be risky, given that KL-VS homozygosity is associated with cognitive decline, smaller brain regions, and all-cause mortality. See for example:

    https://www.researchgate.net/publication/271538717_Variation_in_longevity_gene_KLOTHO_is_associated_with_greater_cortical_volumes/figures?lo=1

    https://link.springer.com/article/10.1007/s11682-018-9990-1

    https://www.ahajournals.org/doi/10.1161/01.res.0000157171.04054.30

    Brian

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