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Re: Fisetin to Clear Senescent Cells @BobM For high doses, as far as I can tell, the largest Fisetin capsules available are 100 mg (which means that you have to take a lot of them). In contrast, one can get Quercetin in 1,…
- JGC
- Retired Professor of Physics
- JGC
- 5 yrs ago
- 1
- Self-Experimentation
- Reported - view
The Initial D+Q Study
I became curious as to just how it was determined that the combination of Dasatinib and Quercetin in a 1:10 combination was an effective senolytic treatment.…
- JGC
- Retired Professor of Physics
- JGC
- 5 yrs ago
- 327
- 6
- Senolytics Discussion
Re: A Spreadsheet for Calculating Your Levine Phenotypic Age @DanMcL @albedo You may recall that a month ago I made 5% variations in all the variables and generated a table that is shown above. This indicated the importance of age, RCDW, MCV,…
- JGC
- Retired Professor of Physics
- JGC
- 5 yrs ago
- 1
- Assessing Biological Age
- Reported - view
Re: A Spreadsheet for Calculating Your Levine Phenotypic Age @albedo I take her reply to mean that the weights came out of an inscrutable digital optimization, with no input from the researchers as to what the importance of the input factors should be.…
- JGC
- Retired Professor of Physics
- JGC
- 5 yrs ago
- Assessing Biological Age
- Reported - view
Re: Is Young Plasma Really a Worthwhile Treatment for Aging? @Dennis The Huffington Post article that I referenced above points out that transfusing two liters of plasma into the bloodstream of an otherwise healthy individual is not without its own risks.…
- JGC
- Retired Professor of Physics
- JGC
- 5 yrs ago
- General Discussion
- Reported - view
Re: Fisetin to Clear Senescent Cells My wife and I did our second D+Q+P session yesterday (Dec. 29, 2018). This time I experienced mild diarrhea in the morning, a mild headache for most of the day and evening,…
- JGC
- Retired Professor of Physics
- JGC
- 5 yrs ago
- 2
- Self-Experimentation
- Reported - view
Is Young Plasma Really a Worthwhile Treatment for Aging?
The RAADFest 2018 Special Report of September 20, 2018 lists administration of blood plasma taken from young donors as one alternative in Step 4 in dealing with aging.…
- JGC
- Retired Professor of Physics
- JGC
- 5 yrs ago
- 30replies
- 332
- 1
- General Discussion
Re: A Spreadsheet for Calculating Your Levine Phenotypic Age Note about Downloading the Spreadsheet In Chrome, if you click on the LINK above, a non-functional version of the spreadsheet appears on the screen in a new tab.…
- JGC
- Retired Professor of Physics
- JGC
- 5 yrs ago
- 1
- Assessing Biological Age
- Reported - view
Re: Bizarre that I can't pay for an order from the site Similar sites sometimes can use PayPal. Is that a possibility?
- JGC
- Retired Professor of Physics
- JGC
- 5 yrs ago
- Self-Experimentation
- Reported - view
A Senolytic Alternative: D+F+P?
It has been suggested to me that an alternative to the now-standard D+Q senolytic treatment might be a D+F treatment, i.e., substituting Fisetin for Quercetin.…
- JGC
- Retired Professor of Physics
- JGC
- 5 yrs ago
- 2replies
- 522
- 1
- Self-Experimentation
Re: Fisetin to Clear Senescent Cells @karl kuffner Two days after D+Q+P, no cramps, no headache, no feeling of unwellness. In fact, I feel very good. Further, I do dog agility on weekends with my 5 year old Shetland Sheepdog Taliesin…
- JGC
- Retired Professor of Physics
- JGC
- 5 yrs ago
- 1
- Self-Experimentation
- Reported - view
Re: Fisetin to Clear Senescent Cells @karl kuffner The 2018 RAADFest Age Reversal Update document advised administering D+Q on an empty stomach, so we did ours before breakfast yesterday. The senolytic research on mice seems to favor…
- JGC
- Retired Professor of Physics
- JGC
- 5 yrs ago
- 1
- Self-Experimentation
- Reported - view
Re: Fisetin to Clear Senescent Cells D+Q+P Side Effects? I do seem to notice some side effects from our D+Q+P (Dasatinib+Quercetin+Piperine) senolytic dose, taken about 24 hours ago. I had early morning stomach cramps and a mild…
- JGC
- Retired Professor of Physics
- JGC
- 5 yrs ago
- 1
- Self-Experimentation
- Reported - view
Re: Metformin in practice @karl kuffner My metformin pills from India come in 10-pill bubble packs. The pills are white, about 3/4" long, 3/8" wide, and 3/16" thick, with rounded ends and a groove across the middle to make…
- JGC
- Retired Professor of Physics
- JGC
- 5 yrs ago
- 1
- General Discussion
- Reported - view
Re: Fisetin to Clear Senescent Cells Fisetin vs. D+Q My wife and I have been starting our new senolytic doses on the 22nd of the month. In October and November, we took large doses of Fisetin, as reported above.…
- JGC
- Retired Professor of Physics
- JGC
- 5 yrs ago
- 5
- Self-Experimentation
- Reported - view
Re: Metformin in practice @karl kuffner Our daily 850 mg Metformin doses have been taken over about 30 months, and taking these has at least helped my wife and I lose weight and keep our glucose levels low,…
- JGC
- Retired Professor of Physics
- JGC
- 5 yrs ago
- 1
- General Discussion
- Reported - view
Re: Fisetin to Clear Senescent Cells @Iðunn I refer you to https://www.isotrope.com/bioperine/ . It says that: "P-glycoprotein is a protein the body uses to break down exogenous compounds found in the body.…
- JGC
- Retired Professor of Physics
- JGC
- 6 yrs ago
- 5
- Self-Experimentation
- Reported - view
Re: How to increase the bioavailability of Fisetin I refer you to https://www.isotrope.com/bioperine/ . It says that: "P-glycoprotein is a protein the body uses to break down exogenous compounds found in the body.…
- JGC
- Retired Professor of Physics
- JGC
- 6 yrs ago
- 4
- Self-Experimentation
- Reported - view
Re: How to increase the bioavailability of Fisetin It is claimed that taking 10 mg of BioPerine, a supplement that is reputed to magnify the effects and potency of flavenoids and other supplements, along with a dose of Fisetin will greatly increase…
- JGC
- Retired Professor of Physics
- JGC
- 6 yrs ago
- 3
- Self-Experimentation
- Reported - view
Re: Metformin in practice My wife and I have been taking 850 mg of Metformin per day tor the past 30 months, with no apparent side effects, no palpitations, and considerable improvement in our yearly physical exams.…
- JGC
- Retired Professor of Physics
- JGC
- 6 yrs ago
- 3
- General Discussion
- Reported - view
Re: Fisetin to Clear Senescent Cells Bloodwork Results of Two Fisetin Sessions As I stated in my first post on this topic, in the past two months my wife and I have taken two massive doses of Fisetin in an effort to clear our senescent…
- JGC
- Retired Professor of Physics
- JGC
- 6 yrs ago
- 13
- Self-Experimentation
- Reported - view
Re: Fisetin to Clear Senescent Cells @nealfg It's Dasatinib that is supposed to be taken with Quercetin, not, to my knowledge, Fisetin. The mouse studies involved large doses of Fisetin administered alone.…
- JGC
- Retired Professor of Physics
- JGC
- 6 yrs ago
- 3
- Self-Experimentation
- Reported - view
Re: A Spreadsheet for Calculating Your Levine Phenotypic Age @Iðunn The last two boxes on the last line of the spreadsheet are based on my fit to the methylation profile and are labeled with "est." indicating that it is an estimate.…
- JGC
- Retired Professor of Physics
- JGC
- 6 yrs ago
- Assessing Biological Age
- Reported - view
Fisetin to Clear Senescent Cells
Following studies with mice that showed significant senolytic clearance of senescent cells following large doses of the readily available flavenoid supplement Fisetin,…
- JGC
- Retired Professor of Physics
- JGC
- updated 4 yrs ago
- 766replies
- 19457
- 20
- Self-Experimentation
Re: A Spreadsheet for Calculating Your Levine Phenotypic Age @albedo That's interesting. I note that the "blood age" version 3.0 calculation on the Aging AI website doesn't even include RDW as one of its input variables.
- JGC
- Retired Professor of Physics
- JGC
- 6 yrs ago
- Assessing Biological Age
- Reported - view

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Retired Professor of Physics

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Joined: Mon Aug 13 01:22:01 UTC 2018

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http://faculty.washington.edu/jcramer/