Skip to main content

Age Reversal Forum

Latest Posts

Fisetin to Clear Senescent Cells

Following studies with mice that showed significant senolytic clearance of senescent cells following large doses of the readily available flavenoid supplement Fisetin,…
- Retired Professor of Physics
- JGC
- updated 5 yrs ago
- 766replies
- 19801
- 20
- Self-Experimentation
Re: A Spreadsheet for Calculating Your Levine Phenotypic Age
@albedo That's interesting. I note that the "blood age" version 3.0 calculation on the Aging AI website doesn't even include RDW as one of its input variables.
- Retired Professor of Physics
- JGC
- 6 yrs ago
- Assessing Biological Age
- Reported - view
Re: A Spreadsheet for Calculating Your Levine Phenotypic Age
@albedo To modify my hypothesis slightly, the blood geometry factors may not reflect senescent blood cells per se, since the body replaces blood cells fairly regularly.…
- Retired Professor of Physics
- JGC
- 6 yrs ago
- Assessing Biological Age
- Reported - view
Re: A Spreadsheet for Calculating Your Levine Phenotypic Age
@albedo Dr. Steve Horvath answered, saying that they did not have any explanation of the relative weight strengths because it was a numerical optimization that didn't involve human judgement.…
- Retired Professor of Physics
- JGC
- 6 yrs ago
- Assessing Biological Age
- Reported - view
A Spreadsheet for Calculating Your Levine Phenotypic Age

An excellent paper by M. E. Levine, et al, entitled "An epigenetic biomarker of aging for lifespan and healthspan" describes a technique for combining nine blood-work values with calendar age to…
- Retired Professor of Physics
- JGC
- 6 yrs ago
- 113replies
- 5464
- 15
- Assessing Biological Age
Re: New blood tests can reveal your life expectancy
@albedo I updated the Excl spreadsheet HERE to include the correction for the DNAm age and the corresponding mortality score.
- Retired Professor of Physics
- JGC
- 6 yrs ago
- Assessing Biological Age
- Reported - view
Re: New blood tests can reveal your life expectancy
@Iðunn In the Levine paper they report two approaches, which they connect. Their Step 1 is based on blood work and Step 2 on methylation of DNA. In the latter,…
- Retired Professor of Physics
- JGC
- 6 yrs ago
- Assessing Biological Age
- Reported - view
Re: New blood tests can reveal your life expectancy
@albedo The Lervine data for very old individuals is sparse, but it's consistently below the linear dependence line, so I take it seriously. I read some points off the Levine graph and then used the…
- Retired Professor of Physics
- JGC
- 6 yrs ago
- Assessing Biological Age
- Reported - view
Re: Introduction to senolytics
Followup: My order of Lucidas Dasatinib from BonHoa Pharmacy of New Delhi, India arrived on October 24 (my birthday). I paid a total of $307 including shipping for 60 tablets of 50 mg Dasatinib…
- Retired Professor of Physics
- JGC
- 6 yrs ago
- 1
- Senolytics Discussion
- Reported - view
Re: New blood tests can reveal your life expectancy
@albedo On the Phenotypic Age graph from the Levin talk that you show, it is interesting that in the 80+ region (where I am) the data leaves the red line and flattens as the Phenotype Age begins to…
- Retired Professor of Physics
- JGC
- 6 yrs ago
- Assessing Biological Age
- Reported - view
Re: New blood tests can reveal your life expectancy
@albedo Thanks for the corrections and suggestions, which I implemented. I replaced the old spreadsheet with the updated one, which is HERE. In the "Terms" row of the spreadsheet,…
- Retired Professor of Physics
- JGC
- 6 yrs ago
- Assessing Biological Age
- Reported - view
Re: New blood tests can reveal your life expectancy
@albedo OK I made an Excel spreadsheet that does the DNAm PhenoAge calculation from blood test inputs. The link to the spreadsheet is HERE. On the blue INPUT line,…
- Retired Professor of Physics
- JGC
- 6 yrs ago
- 2
- Assessing Biological Age
- Reported - view
Re: New blood tests can reveal your life expectancy
@albedo Thanks for asking this question, which caused me to realize I had made an error. The entry in Table 1 and Table S1 of the paper for C-reactive protein wants the value on mg/dL and has a…
- Retired Professor of Physics
- JGC
- 6 yrs ago
- 1
- Assessing Biological Age
- Reported - view
Re: New blood tests can reveal your life expectancy
@Iðunn The formulas needed are given in Supplement 1 of the Levine paper. My Mathematica notebook has two "vectors", one containing the blood-work values for me and the other for my wife,…
- Retired Professor of Physics
- JGC
- 6 yrs ago
- Assessing Biological Age
- Reported - view
Re: New blood tests can reveal your life expectancy
OK, I now have the results of our LifeExtension blood work done four days ago in preparation for calculating our DNAm PhenoAge from the Levine, et al paper referenced above.…
- Retired Professor of Physics
- JGC
- 6 yrs ago
- 2
- Assessing Biological Age
- Reported - view
Re: New blood tests can reveal your life expectancy
@albedo Our recent blood tests, LifeExtension's CBC Chemistry Profile and C Reactive Protein measurement, provide all the values needed for the DNAm PhenoAge calculation and for Aging AI 3.…
- Retired Professor of Physics
- JGC
- 6 yrs ago
- Assessing Biological Age
- Reported - view
Re: [Important]: Conditions that confuse biological age
i'm not sure that I can agree that a measure of inflammation confuses the estimate of biological age. I think that if you have inflammation present, for whatever reason,…
- Retired Professor of Physics
- JGC
- 6 yrs ago
- 1
- Test Results Discussions
- Reported - view
Re: New blood tests can reveal your life expectancy
@albedo FYI, we used Aging AI 3.0, which they claim is just as accurate as the earlier versions but needs fewer input variables. In my opinion, what is critically missing from all three Aging AI…
- Retired Professor of Physics
- JGC
- 6 yrs ago
- Assessing Biological Age
- Reported - view
Re: New blood tests can reveal your life expectancy
@albedo I'll be glad to share the results of our DNAm PhenoAge values before and after fisetin and D+Q, but it may be several months before the results are available.…
- Retired Professor of Physics
- JGC
- 6 yrs ago
- 1
- Assessing Biological Age
- Reported - view
Re: Sources for Metformin?
The pharmaceutical industry in India produces generic metformin that is inexpensive and available without a prescription. Just search on "metformin India" and you will find many sources.…
- Retired Professor of Physics
- JGC
- 6 yrs ago
- 1
- Self-Experimentation
- Reported - view
Re: Rapamycin in humans
@albedo In Step 3, you might want to consider whether fisetin should be suggested as an alternative to D+Q. It's much reputed to be very effective in senescent cell clearance (at least in mice),…
- Retired Professor of Physics
- JGC
- 6 yrs ago
- Self-Experimentation
- Reported - view
Re: New blood tests can reveal your life expectancy
@albedo I have found that all of the blood variables needed to calculate the DNAm PhenoAge given in Morgan Levine’s paper can be obtained from blood work provided by LifeExtension with their…
- Retired Professor of Physics
- JGC
- 6 yrs ago
- Assessing Biological Age
- Reported - view
Re: Rapamycin in humans
OK, your point is that we should shut up about work on healthspan probably increasing the maximum lifespan, because it gets in the way of desirable funding.…
- Retired Professor of Physics
- JGC
- 6 yrs ago
- Self-Experimentation
- Reported - view
Re: Rapamycin in humans
As you say, "Their messaging is that they work on health span, not life, and that's what they use in their funding pitches." That's exactly my point. It is not in the narrow interest of…
- Retired Professor of Physics
- JGC
- 6 yrs ago
- Self-Experimentation
- Reported - view
Re: Rapamycin in humans
I am very suspicious of the lifespan vs. healthspan dichotomy that Dan states above. I believe it is a cop-out employed by age-treatment researchers to convince the FDA and NIH that they are working…
- Retired Professor of Physics
- JGC
- 6 yrs ago
- Self-Experimentation
- Reported - view

1 13 14 15 16 17 18 19

Back to top

Forum Home

- Questions & Answers
- Ideas

View all topics