Senolytic Self-experiments and COVID-19
There is evidence that the TOP2 receptor that the COVID-19 virus uses to enter cells is more prevalent in senescent cells. Also, clearing accumulated senescent cells from the immune system probably boosts immunity. Both effects should make it more difficult to contract COVID-19.
Therefore, I was wondering if anyone participating in the Forum has (a) engaged in senolytic self-experiments with D+Q and/or Fisetin, and (b) actually come down with the COVID-19 virus?
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You may be interested in this paper by Prof. Sinclair in which he discusses C-19.
https://www.preprints.org/manuscript/202004.0548/v1
There's a lot of information on immunity which you can hopefully skip through and still get at the meat of the discussion. It may be useful to have a copy of Kuby's Immunology nearby.
NMN cured my immune dysfunction in term of making me no longer allergic to peanut butter. I think this also means I'm better in resisting virus.
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I experimented with all the above. Been traveling all over in 2 months -Fl, GA, SC, NC, TN, KY and now WV -since and feel 100%
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Paul Beauchemin Boldly going were most fear to tread now! Are you flying, RVing or walking? Just wondering having crossed that many states for comparison, what feel are you getting for things since the shutdown?
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Dorian Gray Interesting experience. We got to be in TN when it opened it businesses and ate in a real sit down restaurant. Was an hour wait to get in and half empty inside, but manager was so grateful we came - thanked us 3 times!
Experienced national and state parks closed. National forest was open and enjoyed that.
As we head further northeast, its getting harder to find RV sites open. State regs are keeping them closed up. Even in the southern states even though the private RV parks were open they were empty. People just not going out.
We full time RV so have no "home" to go to. Just have to keep moving.
Heading up to PA, MA, and VT in the coming weeks
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Paul Beauchemin Quite an adventure, certainly must seem surreal at times. Safe travels!
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JGC said:
There is evidence that the TOP2 receptor that the COVID-19 virus uses to enter cells is more prevalent in senescent cells.Abstract
Cellular senescence is often considered a protection mechanism triggered by conditions that impose cellular stress. Continuous proliferation, DNA damaging agents or activated oncogenes are well-known activators of cell senescence. Apart from a characteristic stable cell cycle arrest, this response also involves a proinflammatory phenotype known as senescence-associated secretory phenotype (SASP). This, together with the widely known interference with senescence pathways by some oncoviruses, had led to the hypothesis that senescence may also be part of the host cell response to fight virus. Here, we evaluate this hypothesis using vesicular stomatitis virus (VSV) as a model. Our results show that VSV replication is significantly impaired in both primary and tumor senescent cells in comparison with non-senescent cells, and independently of the stimulus used to trigger senescence. Importantly, we also demonstrate a protective effect of senescence against VSV in vivo. Finally, our results identify the SASP as the major contributor to the antiviral defense exerted by cell senescence in vitro, and points to a role activating and recruiting the immune system to clear out the infection. Thus, our study indicates that cell senescence has also a role as a natural antiviral defense mechanism.
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Andrew P K Yap
I read on Wikipedia about the vesicular stomatitis virus (VSV). It appears to be apples-to-oranges to compare it to COVID-19. It's a rabies-like negative-sense RNA virus (COVID is positive sense), and it uses a completely different mechanism to gain entry to cells (not TOP2). Therefore, I don't think your reference to VSV and senescent cells is relevant to my question.
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Andrew P K Yap
The paper you reference argues that senescent cells protect against the vesicular stomatitis virus (VSV). In that sense, senescence is antiviral. However, as I said, VSV is qualitatively different from the corona virus in its structure and method of entering cells. So perhaps cellular senescence protects you from getting rabies, but probably not COVID-19.
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November 4th, 2016
Senescent Cells May Enhance Viral Replication, Making Infections More Dangerous
