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Re: Fisetin experimentation one year (reposted as topic for info purposes)
@Andrew Whitfield Last year I ordered 100 gm of >98% pure powdered Fisetin from VitaSpace for $190 plus $6 shipping. I put Trader Joe's Extra Virgin Olive Oil in a shot glass,…
- Retired Professor of Physics
- JGC
- 5 yrs ago
- 1
- Senolytics Discussion
- Reported - view
A New Seonlytic - PZ?

Navitoclax (aka ABT-263) is an experimental orally active anti-cancer drug, with some unpleasant side effects (it produces nausea and diarrhea, kills blood platlets,…
- Retired Professor of Physics
- JGC
- 5 yrs ago
- 1reply
- 90
- General Discussion
Re: Fisetin to Clear Senescent Cells
@Simone Maher Interesting, but perhaps not very useful. The product provides 75 mg of liposomal Fisetin for $75. If it is 4 times more effective than powder form,…
- Retired Professor of Physics
- JGC
- 5 yrs ago
- Self-Experimentation
- Reported - view
Re: Fisetin to Clear Senescent Cells
@Van What is the contact link for the Chinese firm you dealt with?
- Retired Professor of Physics
- JGC
- 5 yrs ago
- 1
- Self-Experimentation
- Reported - view
Re: Are epigenetic tests accurate?
@Kathleen Klosterman I'm not sure that one can judge the accuracy of bio-age measurements done with DNA methylation simply by how many site-methylations are measured.…
- Retired Professor of Physics
- JGC
- 5 yrs ago
- 2
- Assessing Biological Age
- Reported - view
Re: Recent Plasma-Replacement Results
@Fred Cloud Yes, I have had my methylation age done, and it was a just a couple of years lower than my calendar age. As I understand Irina C's argument,…
- Retired Professor of Physics
- JGC
- 5 yrs ago
- 1
- Young Plasma Infusions
- Reported - view
Re: Recent Plasma-Replacement Results
@Fred Cloud I think that replacing 50% of your plasma with saline + 5% albumin would certainly be controversial. Essentially all standard plasmapharesis involves much smaller dilution fractions,…
- Retired Professor of Physics
- JGC
- 5 yrs ago
- 2
- Young Plasma Infusions
- Reported - view
Re: Recent Plasma-Replacement Results
@Larry Yes, by email I had directly asked Irina Conboy why they hadn't measured before-and-after Horvath ages of their mice. Here's part of her reply: "A simple answer is that we have done something…
- Retired Professor of Physics
- JGC
- 5 yrs ago
- 2
- Young Plasma Infusions
- Reported - view
Re: Recent Plasma-Replacement Results
@Jim N I would be surprised if anyone would pay me for my 85 year old blood plasma.
- Retired Professor of Physics
- JGC
- 5 yrs ago
- 1
- Young Plasma Infusions
- Reported - view
Re: Recent Plasma-Replacement Results
@Fred Cloud No, what I'm saying is that there is a definite possibility that the Conboy plasma dilution, like Katcher's Elixir, resets the Horvath clock. If it does, that's really important.…
- Retired Professor of Physics
- JGC
- 5 yrs ago
- Young Plasma Infusions
- Reported - view
Re: Recent Plasma-Replacement Results
@Fred Cloud It matters a lot to know if the Conboy plasma-dilution treatment resets the epigenetic clock, because it would be the most readily-accessible technique that would do that.
- Retired Professor of Physics
- JGC
- 5 yrs ago
- 1
- Young Plasma Infusions
- Reported - view
Re: Recent Plasma-Replacement Results
@Fred Cloud In my opinion, it matters a lot. Most of the available anti-aging therapeutics (e.g., D+Q, Fisetin, NR, etc.) fix some problems but have no effect on the epigenetic clock.…
- Retired Professor of Physics
- JGC
- 5 yrs ago
- Young Plasma Infusions
- Reported - view
Re: Recent Plasma-Replacement Results
@Fred Cloud Does Conboy plasma dilution reset the Horvath clock? That's an experimental question, and someone needs to do the experiment. I have asked Irina Conboy by email why they didn't do…
- Retired Professor of Physics
- JGC
- 5 yrs ago
- 1
- Young Plasma Infusions
- Reported - view
Re: Recent Plasma-Replacement Results
@Fred Cloud I think Harold Katcher's Elixir is rather different from (and more effective than) what you would get from Ambrosia, but since the Elixir contents are proprietary, I don't really know.…
- Retired Professor of Physics
- JGC
- 5 yrs ago
- 1
- Young Plasma Infusions
- Reported - view
Re: Recent Plasma-Replacement Results
@Fred Cloud In the case of the Conboy treatment, I don't understand why you suggest that one might need to "buy some plasma from the ambrosia company".…
- Retired Professor of Physics
- JGC
- 5 yrs ago
- 1
- Young Plasma Infusions
- Reported - view
Recent Plasma-Replacement Results

Two recent results have been published that are worth reporting here and are recommended for careful reading. The first of these is a paper by Dr. Harold Katcher, Dr.…
- Retired Professor of Physics
- JGC
- 5 yrs ago
- 113replies
- 1559
- 2
- Young Plasma Infusions
Re: Fisetin to Clear Senescent Cells
@JOHN As Staffan implied, we have no direct way to measure senolytic effects (that's done by staining tissue biopsies and counting senescent cells viewed in a microscope),…
- Retired Professor of Physics
- JGC
- 5 yrs ago
- 1
- Self-Experimentation
- Reported - view
Re: DNA methylation test
Questions about Horvath's DNAm Age Steve Horvath's DNA methylation clock is based on the presence or absence of methylation at 353 (out of many thousand) CpG sites on a human or animal genome.…
- Retired Professor of Physics
- JGC
- 5 yrs ago
- Assessing Biological Age
- Reported - view
Re: Fisetin to Clear Senescent Cells
@Fred Cloud From which pharmacy in India did you order your azithromycin? On March 21, 2020, I ordered some Zithromax for $85.35 from the Online Drugstore, and it has never arrived.…
- Retired Professor of Physics
- JGC
- 5 yrs ago
- Self-Experimentation
- Reported - view
Re: Fisetin to Clear Senescent Cells
@Fred Cloud Thanks, Fred. That's very useful info. Where/how did you get the azithromycin? Did you have a prescription? And what dose did you use in the senolytic sessions?
- Retired Professor of Physics
- JGC
- 5 yrs ago
- 1
- Self-Experimentation
- Reported - view
Re: Fisetin to Clear Senescent Cells
@David H I don't find ageless.one on ebay. Do you have a link?
- Retired Professor of Physics
- JGC
- 5 yrs ago
- Self-Experimentation
- Reported - view
Re: Fisetin to Clear Senescent Cells
@Van So can anyone here report results from having used Zithromycin as a senolytic? In particular, its effect on skin tone from clearing senescent fibriblasts in aging skin?
- Retired Professor of Physics
- JGC
- 5 yrs ago
- 1
- Self-Experimentation
- Reported - view
Re: Fisetin to Clear Senescent Cells
@Joe smith I have posted here all the test results and calculated bio-ages (see above) that we have. For our last few sessions (done in NY last Summer and during the COVID-19 lock-down),…
- Retired Professor of Physics
- JGC
- 5 yrs ago
- Self-Experimentation
- Reported - view
Re: Fisetin to Clear Senescent Cells
@Antonia Gauer Last year I ordered 100 gm of >98% pure powdered Fisetin from VitaSpace for $190 plus $6 shipping. That's $0.19 for 100 mg, still a lot better than $0.47 per 100 mg from Drs Best.…
- Retired Professor of Physics
- JGC
- 5 yrs ago
- 1
- Self-Experimentation
- Reported - view
Re: Fisetin to Clear Senescent Cells
Followup My experiment with Hydroxypropyl-Beta-Cyclodextrin (HBC) and Quercetin was a failure. I dissolved the HBC in water, warmed it in the microwave,…
- Retired Professor of Physics
- JGC
- 5 yrs ago
- Self-Experimentation
- Reported - view

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